Multiples: Signal or noise?

Geophysics ◽  
2016 ◽  
Vol 81 (4) ◽  
pp. V283-V302 ◽  
Author(s):  
Arthur B. Weglein

Migration and migration inversion are the seismic processing methods for structural determination and subsequent amplitude analysis, respectively. To date, the most well-founded and physically interpretable migration method is based on predicting a coincident source and receiver experiment at depth at time equals zero. We have extended that migration method for heterogeneous media and to accommodate two-way propagation in a local sense at every point from the source to the target reflector and back from the reflector to the receiver and in a global sense, separately for each of the two legs from the source to the reflector and from the reflector to the receiver. That provides the first migration method that avoids high-frequency assumptions in the imaging principle and how it is implemented, and hence, it is equally effective at all frequencies at the target or reservoir. This advance for two-way wave propagation migration then provides a tool to quantitatively, unambiguously, and definitively define the role of primaries and multiples in migration. Our conclusion was that with data consisting of primaries and multiples, for an accurate discontinuous velocity model, only primaries contribute to migration with the same image and inversion results independent of whether multiples are kept or removed. However, for a smooth and continuous velocity model (i.e., generally assumed in practice), every multiple will result in a false, misleading, and potentially injurious subsurface image and hence must be removed before migration. In practice, we migrate with a smooth velocity model, and hence multiples must be removed. When the collection of primaries is incomplete, a multiple can be used to provide an approximate image of an unrecorded primary. However, it is always the migration of primaries that provides subsurface structure and amplitude information.

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Arthur B. Weglein

The removal and use of multiples have a single shared goal and objective: the imaging and inversion of primaries. There are two kinds of primaries: recorded primaries and unrecorded primaries. For imaging recorded primaries using an industry standard practice smooth velocity model, recorded multiples must be removed, to avoid false and misleading images due to the multiples. Similarly, to find an approximate image of an unrecorded primary, that is a subevent of a recorded multiple, unrecorded multiples that are subevents of the recorded multiple must be removed, for exactly the same problem and reason that recorded multiples are needed to be eliminated. Direct inverse methods are employed to derive this new comprehensive perspective on primaries and multiples. Direct inverse methods not only assure that the problem of interest is solved, but equally important, that the problem of interest is the relevant problem that we (the petroleum industry) need to be interested in.


Geophysics ◽  
2001 ◽  
Vol 66 (5) ◽  
pp. 1551-1568 ◽  
Author(s):  
Jéro⁁me H. Le Rousseau ◽  
Maarten V. de Hoop

The phase‐screen and the split‐step Fourier methods, which allow modeling and migration in laterally heterogeneous media, are generalized here so as to increase their accuracies for media with large and rapid lateral variations. The medium is defined in terms of a background medium and a perturbation. Such a contrast formulation induces a series expansion of the vertical slowness in which we recognize the first term as the split‐step Fourier approximation and the addition of higher‐order terms of the expansion increases the accuracy. Employing this expansion in the one‐way scalar propagator yields the scalar one‐way generalized‐screen propagator. We also introduce a generalized‐screen representation of the reflection operator. The interaction between the upgoing and downgoing fields is taken into account by a Bremmer series. These results are then cast into numerical algorithms. We analyze the accuracy of the generalized‐screen method in complex structures using synthetic models that exhibit significant multipathing: the IFP 2‐D Marmousi model and the SEG‐EAGE 3‐D salt model. As compared with the split‐step Fourier method, in the presence of lateral medium variations, the generalized‐screen methods exhibit an increased accuracy at wider angles of propagation and scattering. As a result, in the process of migration, we can choose a member of the family of our generalized‐screen algorithms in accordance with the complexity of the medium (velocity model).


2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Yufeng Sun ◽  
Wenchao Li ◽  
Shiqi Shen ◽  
Xuejing Yang ◽  
Bing Lu ◽  
...  

Abstract Background Accumulated studies reported abnormal gene expression profiles of hepatocellular carcinoma (HCC) by cDNA microarray. We tried to merge cDNA microarray data from different studies to search for stably changed genes, and to find out better diagnostic and prognostic markers for HCC. Methods A systematic review was performed by searching publications indexed in Pubmed from March 1, 2001 to July 1, 2016. Studies that reporting cDNA microarray profiles in HCC, containing both tumor and nontumor data and published in English-language were retrieved. The differentially expressed genes from eligible studies were summarized and ranked according to the frequency. High frequency genes were subjected to survival analyses. The expression and prognostic value of alanine-glyoxylate and serine-pyruvate aminotransferase (AGXT) was further evaluated in HCC datasets in Oncomine and an independent HCC tissue array cohort. The role of AGXT in HCC progression was evaluated by proliferation and migration assays in a human HCC cell line. Results A total of 43 eligible studies that containing 1917 HCC patients were included, a list of 2022 non redundant abnormally expressed genes in HCC were extracted. The frequencies of reported genes were ranked. We finally obtained a list of only five genes (AGXT; ALDOB; CYP2E1; IGFBP3; TOP2A) that were differentially expressed in tumor and nontumor tissues across studies and were significantly correlated to HCC prognosis. Only AGXT had not been reported in HCC. Reduced expression of AGXT reflected poor differentiation of HCC and predicts poor survival. Knocking down of AGXT enhanced cell proliferation and migration of HCC cell line. Conclusions The present study supported the feasibility and necessity of systematic review on discovering new and reliable biomarkers for HCC. We also identified a list of high frequency prognostic genes and emphasized a critical role of AGXT deletion during HCC progression.


Geophysics ◽  
1989 ◽  
Vol 54 (8) ◽  
pp. 1006-1011 ◽  
Author(s):  
F. Wenzel ◽  
D. Menges

Employing appropriate high‐frequency approximations, we find that frequency‐wavenumber migration of spherically corrected data coincides with Born inversion for the reflectivity function. We consider zero‐offset seismic data in a 2.5-dimensional medium that consists of a homogeneous reference velocity with embedded reflectors. For marine data, where the pressure is measured, migration and inversion are identical. For land data, where vertical particle velocity is measured, modifications are required in order to match inversion and migration. The modifications become important only if dips larger than 30°are to be migrated.


2018 ◽  
Vol 15 (3) ◽  
pp. 389-398
Author(s):  
Ruchi Singh

Rural economies in developing countries are often characterized by credit constraints. Although few attempts have been made to understand the trends and patterns of male out-migration from Uttar Pradesh (UP), there is dearth of literature on the linkage between credit accessibility and male migration in rural Uttar Pradesh. The present study tries to fill this gap. The objective of this study is to assess the role of credit accessibility in determining rural male migration. A primary survey of 370 households was conducted in six villages of Jaunpur district in Uttar Pradesh. Simple statistical tools and a binary logistic regression model were used for analyzing the data. The result of the empirical analysis shows that various sources of credit and accessibility to them play a very important role in male migration in rural Uttar Pradesh. The study also found that the relationship between credit constraints and migration varies across various social groups in UP.


2017 ◽  
Author(s):  
Serena Martinelli ◽  
Vanessa D'Antongiovanni ◽  
Susan Richter ◽  
Letizia Canu ◽  
Tonino Ercolino ◽  
...  

2019 ◽  
Vol 106 (3) ◽  
pp. 250-260 ◽  
Author(s):  
DN Nandakumar ◽  
P Ramaswamy ◽  
C Prasad ◽  
D Srinivas ◽  
K Goswami

Purpose Glioblastoma cells create glutamate-rich tumor microenvironment, which initiates activation of ion channels and modulates downstream intracellular signaling. N-methyl-D-aspartate receptors (NMDARs; a type of glutamate receptors) have a high affinity for glutamate. The role of NMDAR activation on invasion of glioblastoma cells and the crosstalk with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is yet to be explored. Main methods LN18, U251MG, and patient-derived glioblastoma cells were stimulated with NMDA to activate NMDAR glutamate receptors. The role of NMDAR activation on invasion and migration and its crosstalk with AMPAR were evaluated. Invasion and migration of glioblastoma cells were investigated by in vitro trans-well Matrigel invasion and trans-well migration assays, respectively. Expression of NMDARs and AMPARs at transcript level was evaluated by quantitative real-time polymerase chain reaction. Results We determined that NMDA stimulation leads to enhanced invasion in LN18, U251MG, and patient-derived glioblastoma cells, whereas inhibition of NMDAR using MK-801, a non-competitive antagonist of the NMDAR, significantly decreased the invasive capacity. Concordant with these findings, migration was significantly augmented by NMDAR in both cell lines. Furthermore, NMDA stimulation upregulated the expression of GluN2 and GluA1 subunits at the transcript level. Conclusions This study demonstrated the previously unexplored role of NMDAR in invasion of glioblastoma cells. Furthermore, the expression of the GluN2 subunit of NMDAR and the differential overexpression of the GluA1 subunit of AMPAR in both cell lines provide a plausible rationale of crosstalk between these calcium-permeable subunits in the glutamate-rich microenvironment of glioblastoma.


2019 ◽  
Vol 85 (1(I)) ◽  
pp. 64-71 ◽  
Author(s):  
M. M. Gadenin

The cycle configuration at two-frequency loading regimes depends on the number of parameters including the absolute values of the frequencies and amplitudes of the low-frequency and high-frequency loads added during this mode, the ratio of their frequencies and amplitudes, as well as the phase shift between these harmonic components, the latter having a significant effect only with a small ratio of frequencies. Presence of such two-frequency regimes or service loading conditions for parts of machines and structures schematized by them can significantly reduce their endurance. Using the results of experimental studies of changes in the endurance of a two-frequency loading of specimens of cyclically stable, cyclically softened and cyclically hardened steels under rigid conditions we have shown that decrease in the endurance under the aforementioned conditions depends on the ratio of frequencies and amplitudes of operation low-frequency low-cycle and high-frequency vibration stresses, and, moreover, the higher the level of the ratios of amplitudes and frequencies of those stacked harmonic processes of loading the greater the effect. It is shown that estimation of such a decrease in the endurance compared to a single frequency loading equal in the total stress (strains) amplitudes can be carried out using an exponential expression coupling those endurances through a parameter (reduction factor) containing the ratio of frequencies and amplitudes of operation cyclic loads and characteristic of the material. The reduction is illustrated by a set of calculation-experimental curves on the corresponding diagrams for each of the considered types of materials and compared with the experimental data.


2020 ◽  
Author(s):  
Lungwani Muungo

TRIM44 has oncogenic roles in various cancers. However, TRIM44 expression andits function in renal cell carcinoma (RCC) are still unknown. Here in this study, weinvestigated the clinical significance of TRIM44 and its biological function in RCC.TRIM44 overexpression was significantly associated with clinical M stage, histologictype (clear cell) and presence of lymphatic invasion (P = .047, P = .005, and P = .028,respectively). Moreover, TRIM44 overexpression was significantly associated withpoor prognosis in terms of cancer-specific survival (P = .019). Gain-of-function andloss-of-function studies using TRIM44 and siTRIM44 transfection showed thatTRIM44 promotes cell proliferation and cell migration in two RCC cell lines, Caki1and 769P. To further investigate the role of TRIM44 in RCC, we performed integratedmicroarray analysis in Caki1 and 769P cells and explored the data in the Oncominedatabase. Interestingly, FRK was identified as a promising candidate target gene ofTRIM44, which was downregulated in RCC compared with normal renal tissues. Wefound that cell proliferation was inhibited by TRIM44 knockdown and then recoveredby siFRK treatment. Taken together, the present study revealed the associationbetween high expression of TRIM44 and poor prognosis in


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