Carcinogenic effects of polychlorinated biphenyls

2001 ◽  
Vol 17 (2) ◽  
pp. 41-62 ◽  
Author(s):  
Obaid M Faroon ◽  
Sam Keith ◽  
Dennis Jones ◽  
Christopher De Rosa
Keyword(s):  
Polychlorinated Biphenyls ◽  
Health Impact ◽  
Toxic Substances ◽  
Environmental Response ◽  
Disease Registry ◽  
Mechanisms Of Toxicity ◽  
Department Of Health ◽  
Toxicity Biomarkers ◽  
Toxicological Profile ◽  
Carcinogenic Effects

As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of an important section of the Toxicological profile for polychlorinated biphenyls [ATSDR. 2000: Toxicological profile for polychlorinated biphenyls. Atlanta, GA: US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry.] into the scientific literature. This article focuses on the carcinogenic effects of this group of synthetic organic chemicals (polychlorinated biphenyls) in humans and animals. Information on other health effects, toxicokinetics, mechanisms of toxicity, biomarkers, interactions, chemical and physical properties, potential for human exposure, and regulations and advisories is detailed in the profile.

ATSDR evaluation of the health effects of zinc and relevance to public health

2006 ◽  
Vol 22 (10) ◽  
pp. 423-493 ◽  
Author(s):  
Nickolette Roney ◽  
Mark Osier ◽  
Sari J. Paikoff ◽  
Cassandra V. Smith ◽  
Malcolm Williams ◽  
...  
Keyword(s):  
Public Health ◽  
Health Impact ◽  
Toxic Substances ◽  
Environmental Response ◽  
Disease Registry ◽  
Toxicological Profile ◽  
Toxicological Studies ◽  
Public Health Officials ◽  
Industrial Health ◽  
Toxicokinetic Data

As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites, which have the greatest public health impact. These profiles comprehensively summarise toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Zinc. The primary purpose of this article is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of zinc. It contains descriptions and evaluations of toxicological studies and epidemiological investigations, and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. Toxicology and Industrial Health 2006; 22: 423-493.

Toxicological Profile for Perfluoroalkyls: Draft for Public Comment

2018 ◽  
Keyword(s):  
Environmental Protection ◽  
Environmental Protection Agency ◽  
Toxic Substances ◽  
Protection Agency ◽  
Disease Registry ◽  
Federal Register ◽  
Public Comment ◽  
Toxicological Profile

This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA).The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary.

ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate

1998 ◽  
Vol 14 (5) ◽  
pp. 571-766 ◽  
Author(s):  
Mike Fay ◽  
Carol Eisenmann ◽  
Sanjivani Diwan ◽  
Christopher De Rosa
Keyword(s):  
Public Health ◽  
Health Effects ◽  
Environmental Fate ◽  
Animal Health ◽  
Environmental Information ◽  
Toxic Substances ◽  
Environmental Response ◽  
Disease Registry ◽  
The Public ◽  
Printing Ink

Xylenes, or dimethylbenzenes, are among the highest-volume chemicals in production. Common uses are for gasoline blending, as a solvent or component in a wide variety of products from paints to printing ink, and in the production of phthalates and polyester. They are often encountered as a mixture of the three dimethyl isomers, together with ethylbenzene. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that are of greatest concern for public health purposes. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of the bulk of this profile (ATSDR, 1995) into the mainstream scientific literature. An extensive listing of known human and animal health effects, organized by route, duration, and end point, is presented. Toxicological information on toxicokinetics, biomarkers, interactions, sensitive subpopulations, reducing toxicity after exposure, and relevance to public health is also included. Environmental information encompasses physical properties, production and use, environmental fate, levels seen in the environment, analytical methods, and a listing of regulations. ATSDR, as mandated by CERCLA (or Superfund), prepares these profiles to inform and assist the public.

scholarly journals Validation of an analytical methodology to determine polychlorinated biphenyls in samples from blood plasma

Biomédica ◽  
2017 ◽  
Vol 37 (4) ◽  
pp. 561 ◽  
Author(s):  
Boris Santiago Ávila ◽  
Carolina Ramírez
Keyword(s):  
Polychlorinated Biphenyls ◽  
Blood Plasma ◽  
Human Serum ◽  
Organic Contaminants ◽  
Human Biomonitoring ◽  
Toxic Substances ◽  
Disease Registry ◽  
Analytical Methodology ◽  
Freeze Dried

Introducción. Los bifenilos policlorados se encuentran entre los cinco contaminantes orgánicos persistentes más tóxicos para los organismos vivos, según la Agency for Toxic Substances and Disease Registry (ATSDR) de los Estados Unidos.Objetivo. Estandarizar y validar un método analítico para la determinación y cuantificación de los bifenilos policlorados indicadores en muestras de plasma sanguíneo, mediante cromatografía de gases acoplada a espectrometría de masas.Materiales y métodos. Se fortificó un pool de plasma para hacer los ensayos en la matriz. Además, se utilizó el material de referencia NIST SRM® 1958 (Organic Contaminants in Fortified Human Serum, Freeze-Dried) para los ensayos de veracidad y precisión intermedia.Resultados. Los porcentajes de recuperación obtenidos con la metodología estuvieron entre 88,4 y 97,5 %, y el sesgo fue menor del 20 %. Los límites de detección y cuantificación de los bifenilos policlorados indicadores policlorados fueron de 0,04 μg/L y 0,10 μg/L, respectivamente. La linealidad representada por el coeficiente de determinación (R2) varió entre 0,9866 y 0,9886. La precisión expresada como desviación estándar relativa fue menor del 20 % en todo el rango lineal de trabajo (0,5-500 μg/L). Por último, se analizaron 115 muestras de población colombiana de diferentes zonas del país y se encontraron 65 muestras positivas, de las cuales dos estuvieron por encima de los valores de control biológico en humanos (Human Biomonitoring Values, HBM- II): 7,0 μg/L, 2XΣPCB 138, 153, 180, y otras dos, por encima del HBM-I: 3,5 μg/L, 2XΣPCB 138, 153, 180.Conclusión. El método desarrollado resultó ser preciso para el análisis de los bifenilos policlorados en muestras de plasma sanguíneo y se puede utilizar para el control biológico de estos contaminantes en población colombiana.

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