Late-Life Depressive Disorder in the Community

BackgroundIn previous studies, dementia was linked to a family history of dementia and Down's syndrome. This study tested the hypothesis that late-life depression accompanied by cognitive impairment in elderly individuals with no history of psychiatric illness is also associated with these family histories.MethodWe investigated an age-stratified sample of 4051 elderly people in the community aged 65–84 (AMSTEL). The relationship between family history (CAMDEX questionnaire) and depression (GMS-AGECAT diagnosis) was studied.ResultsA family history of mental health problems was associated with all subtypes of depression. Family history of dementia was associated with depression in subjects with a psychiatric history, but a family history of Down's syndrome was only associated with the combination of depression and cognitive impairment in subjects with no history of psychiatric illness.ConclusionsThe heritability pattern confirms the concept of a dementia-related subtype of late-life depression.

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Mania and Down's Syndrome

The British Journal of Psychiatry ◽

10.1192/bjp.162.6.739 ◽

1993 ◽

Vol 162 (6) ◽

pp. 739-743 ◽

Cited By ~ 11

Author(s):

Sally-Ann Cooper ◽

Richard A. Collacott

Keyword(s):

Learning Disabilities ◽

Family History ◽

Affective Disorder ◽

Clinical Features ◽

Case Reports ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Atypical Presentation ◽

Rapid Cycling ◽

History Of

Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning disabilities due to other causes. However, all reported cases are male and none has a family history of affective disorder. In two of the seven men reported, the illness followed a rapid cycling pattern. Hypothyroidism and monoamine biochemistry in people with Down's syndrome are discussed in the context of these atypical features.

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Intrinsic connectivity identifies the sensory-motor network as a main cross-network between remitted late-life depression- and amnestic mild cognitive impairment-targeted networks

Brain Imaging and Behavior ◽

10.1007/s11682-019-00098-4 ◽

2019 ◽

Vol 14 (4) ◽

pp. 1130-1142 ◽

Cited By ~ 3

Author(s):

Jiu Chen ◽

Hao Shu ◽

Zan Wang ◽

Yafeng Zhan ◽

Duan Liu ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Late Life ◽

Amnestic Mild Cognitive Impairment ◽

Late Life Depression ◽

Motor Network ◽

Intrinsic Connectivity ◽

Sensory Motor

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The natural history of late-life depression

European Psychiatry ◽

10.1016/s0924-9338(02)80564-8 ◽

2002 ◽

Vol 17 ◽

pp. 127

Author(s):

R. Schoevers ◽

A. Beekman ◽

D. Deeg ◽

C. Hooije ◽

C. Jonker ◽

...

Keyword(s):

Natural History ◽

Late Life ◽

Late Life Depression ◽

History Of

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The Alice in Wonderland Syndrome in Juvenile Migraine

PEDIATRICS ◽

10.1542/peds.63.4.517 ◽

1979 ◽

Vol 63 (4) ◽

pp. 517-519

Author(s):

Gerald S. Golden

Keyword(s):

Body Image ◽

Family History ◽

Psychiatric Illness ◽

Visual Analysis ◽

Drug Ingestion ◽

Alice In Wonderland ◽

History Of

Two children are reported who had recurrent attacks of impairment of time sense, body image, and visual analysis of the environment. These occurred with a clear state of consciousness and in the absence of any evidence of an encephalitic process, seizures, drug ingestion, or psychiatric illness. Both children had recurrent headaches; one was clearly migrainous. There was a family history of migraine in both cases. These children represent examples of the Alice in Wonderland syndrome in juvenile migraine.

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Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness

Journal of Affective Disorders ◽

10.1016/j.jad.2006.05.022 ◽

2006 ◽

Vol 96 (1-2) ◽

pp. 127-131 ◽

Cited By ~ 10

Author(s):

Richard Rende ◽

Boris Birmaher ◽

David Axelson ◽

Michael Strober ◽

Mary Kay Gill ◽

...

Keyword(s):

Bipolar Disorder ◽

Family History ◽

Psychiatric Illness ◽

Psychotic Symptoms ◽

Pediatric Bipolar Disorder ◽

History Of

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Mild cognitive impairment, poor episodic memory, and late-life depression are associated with cerebral cortical thinning and increased white matter hyperintensities

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2014.00306 ◽

2014 ◽

Vol 6 ◽

Cited By ~ 36

Author(s):

Motonobu Fujishima ◽

Norihide Maikusa ◽

Kei Nakamura ◽

Masahiro Nakatsuka ◽

Hiroshi Matsuda ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

Episodic Memory ◽

White Matter Hyperintensities ◽

Late Life ◽

Late Life Depression ◽

Cortical Thinning

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A 48‐year‐old female, with a family history of AD PSEN1 mutation, who developed mild cognitive impairment and tried ketogenic diet‐associated medium‐chain triglyceride as treatment

Alzheimer s & Dementia ◽

10.1002/alz.039482 ◽

2020 ◽

Vol 16 (S6) ◽

Author(s):

Gustavo Melo de Andrade Lima ◽

Marta Corrado ◽

Marcela Marques de Oliveira Gregório ◽

Paulo Henrique Ferreira Bertolucci

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Family History ◽

Ketogenic Diet ◽

Medium Chain Triglyceride ◽

Medium Chain ◽

Psen1 Mutation ◽

History Of

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Cognitive impairment in remitted late-life depression is not associated with Alzheimer's disease-related CSF biomarkers

Journal of Affective Disorders ◽

10.1016/j.jad.2020.03.166 ◽

2020 ◽

Vol 272 ◽

pp. 409-416

Author(s):

Júlia C. Loureiro ◽

Florindo Stella ◽

Marcos V. Pais ◽

Marcia Radanovic ◽

Paulo R. Canineu ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Late Life ◽

Csf Biomarkers ◽

Late Life Depression

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Association between physical frailty and cognition in late-life depression

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.037 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S84-S84

Author(s):

M. Arts ◽

R. Collard ◽

H. Comijs ◽

M. Zuidersma ◽

S. de Rooij ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Functioning ◽

Processing Speed ◽

Verbal Memory ◽

Late Life ◽

Interference Control ◽

Late Life Depression ◽

Physical Frailty ◽

Cognitive Frailty ◽

Frailty Criteria

IntroductionCognitive frailty has recently been defined as the co-occurrence of physical frailty and cognitive impairment. Late-life depression is associated with both physical frailty and cognitive impairment, especially processing speed and executive functioning.Aim and objectivesIn this study, we investigated the association between physical frailty and cognitive functioning in depressed older persons.MethodsIn a total of 378 patients (> 60 years) with depression according to DSM-IV criteria and a MMSE score of 24 points or higher, the physical frailty phenotype as well as its individual criteria (weight loss, weakness, exhaustion, slowness, low activity) was studied. Cognitive functioning was examined in 4 domains: verbal memory, working memory, interference control, and processing speed.ResultsOf the 378 depressed patients (range 60–90 years; 66.1% women), 61 were classified as robust (no frailty criteria present), 214 as prefrail (1 or 2 frailty criteria present), and 103 as frail (> 3 criteria). Linear regression analyses, adjusted for confounders, showed that the severity of physical frailty was associated with poorer verbal memory, slower processing speed, and decreased working memory, but not with changes in interference control.ConclusionIn late-life depression, physical frailty is associated with poorer cognitive functioning, although not consistently for executive functioning. Future studies should examine whether cognitive impairment in the presence of physical frailty belongs to cognitive frailty and is indeed an important concept to identify a specific subgroup of depressed older patients, who need multimodal treatment strategies integrating physical, cognitive, and psychological functioning.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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