Longitudinal relationships between cognition and functioning over 2 years in euthymic patients with bipolar disorder: a cross-lagged panel model approach with the FACE-BD cohort

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Mickael Ehrminger ◽  
Eric Brunet-Gouet ◽  
Anne-Sophie Cannavo ◽  
Bruno Aouizerate ◽  
Irena Cussac ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Functional Outcome ◽  
Cognitive Performance ◽  
Psychosocial Functioning ◽  
Causal Effect ◽  
Causal Structure ◽  
Cognitive Remediation ◽  
Bipolar Disorders ◽  
Causal Link

Background Longitudinal studies of the relationship between cognition and functioning in bipolar disorder are scarce, although cognition is thought to be a key determinant of functioning. The causal structure between cognition and psychosocial functioning in bipolar disorder is unknown. Aims We sought to examine the direction of causality between cognitive performance and functional outcome over 2 years in a large cohort of euthymic patients with bipolar disorder. Method The sample consisted of 272 adults diagnosed with bipolar disorder who were euthymic at baseline, 12 and 24 months. All participants were recruited via the FondaMental Advanced Centers of Expertise in Bipolar Disorders. We used a battery of tests, assessing six domains of cognition at baseline and 24 months. Residual depressive symptoms and psychosocial functioning were measured at baseline and 12 and 24 months. The possible causal structure between cognition and psychosocial functioning was investigated with cross-lagged panel models with residual depressive symptoms as a covariate. Results The analyses support a causal model in which cognition moderately predicts and is causally primary to functional outcome 1 year later, whereas psychosocial functioning does not predict later cognitive performance. Subthreshold depressive symptoms concurrently affected functioning at each time of measure. Conclusions Our results are compatible with an upward causal effect of cognition on functional outcome in euthymic patients with bipolar disorder. Neuropsychological assessment may help specify individual prognoses. Further studies are warranted to confirm this causal link and evaluate cognitive remediation, before or simultaneously with functional remediation, as an intervention to improve functional outcome. Declaration of interest None.

Determinants of Functioning in Euthymic Patients with Bipolar Disorder: A Structural Equation Modelling Approach

2017 ◽  
Vol 41 (S1) ◽  
pp. S77-S77
Author(s):  
L. Samalin ◽  
L. Boyer ◽  
A. Murru ◽  
I. Pacchiarotti ◽  
M. Reinares ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Cognitive Performance ◽  
Psychosocial Functioning ◽  
Structural Equation ◽  
Sleep Disturbances ◽  
Path Coefficient ◽  
Residual Symptoms ◽  
Equation Modelling

BackgroundEuthymic patients with bipolar disorder (BD) experience residual symptoms. Interestingly, residual symptoms appear to impact the natural course of BD and represent potential predictors of recurrence and functional impairment.ObjectivesThe study aimed to analyse the relationship between residual depressive symptoms, sleep disturbances and cognitive impairment as determinants of psychosocial functioning in a large sample of euthymic BD patients.MethodsWe performed a cross-sectional study of 468 BD outpatients in clinical remission for at least 6 months. Bipolar Depression Rating Scale (BDRS), Pittsburgh Sleep Quality Index (PSQI) scale, Visual Analogic Scales (VAS) evaluated cognitive impairment and functioning assessment short test were used to assess residual symptomatology and functioning of patients. We evaluated functioning with. Structural equation modelling (SEM) was used to describe the relationships among the residual depressive symptoms, sleep disturbances, perceived cognitive performance and functioning.ResultsSEM showed good fit. This model revealed that residual depressive symptoms (path coefficient = 0.37) and perceived cognitive performance (path coefficient = 0.27) were the most important features significantly related to psychosocial functioning. Sleep disturbances were indirectly associated with functioning via residual depressive symptoms and perceived cognitive performance (path coefficient = 0.23).ConclusionsThis study contributes to a better understanding of the determinants of psychosocial functioning during the interepisodic periods of BD patients. These findings should have implications for the improvement of functioning of BD patients in a personalized approach to treatment.Disclosure of interestCOI: Dr. Samalin reports personal fees and nonfinancial support from Astra-Zeneca, Bristol Myers Squibb, Janssen, Lundbeck, and Otsuka.The authors L. Boyer, A. Murru, I. Pacchiarotti, M. Reinares, C.M. Bonnin, C. Torrent, V. Norma, P. Corinna, I. de Chazeron, M. Boucekine, P.A. Geoffroy, F. Bellivier, P.M. Llorca, E. Vieta have have not supplied their declaration of competing interest.

The effects of cognitive reserve and depressive symptoms on cognitive performance in major depression and bipolar disorder

2020 ◽  
Vol 274 ◽  
pp. 813-818
Author(s):  
André Ponsoni ◽  
Laura Damiani Branco ◽  
Charles Cotrena ◽  
Flávio Milman Shansis ◽  
Rochele Paz Fonseca
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Cognitive Performance ◽  
Cognitive Reserve

scholarly journals Impulsivity as a Clinical Marker for Bipolar Affective Disorder

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A M Omar ◽  
A N Elbatrawy ◽  
W M Sabry ◽  
H A Elkholy ◽  
W A Farrag
Keyword(s):  
Bipolar Disorder ◽  
Affective Disorder ◽  
Behavioral Problems ◽  
Psychosocial Functioning ◽  
Bipolar Affective Disorder ◽  
Bipolar Disorders ◽  
First Degree Relatives ◽  
Adult Psychiatry ◽  
Healthy Functioning ◽  
Substantial Morbidity

Abstract Background Bipolar disorder is one of the world’s 10 most disabling conditions, taking away years of healthy functioning from individuals, all bipolar disorders are chronically recurring illnesses associated with substantial morbidity and mortality. Impulsivity considered an integral part of bipolar disorder. Operationalized as a predisposition to action without reflection or regard for consequences. Potential consequences of this increased impulsivity include substance abuse, suicidal attempts, and other serious behavioral problems. Aim of the Study The aim of the current study was to measure impulsivity in both BD euthymic patients and in healthy first-degree relatives of BD patients. And to assess the functional implications of impulsiveness, on psychosocial functioning and in bipolar disorder patients, their first-degree relatives. Patients and Methods A convenient sample of 50 patients; diagnosed with bipolar affective disorder according to DSM-IV diagnostic criteria were selected from the general adult psychiatry clinics and a convenient sample of 50 healthy first degree relatives of BD patients. Results We concluded by the end of this study that both cases and relatives have high overall impulsivity, and cases have higher impulsivity in comparison to relatives. Conclusion We suggest that impulsivity may be a potentially valuable candidate endophenotype for bipolar disorder.

Cognitive performance and psychosocial functioning in unaffected siblings of bipolar disorder patients in comparison with healthy controls

2020 ◽  
Vol 54 ◽  
pp. 102246
Author(s):  
Vigneshvar Chandrasekaran ◽  
Shivanand Kattimani ◽  
Karthick Subramanian ◽  
Venkatalakshmi Penchilaiya ◽  
Arivazhagan Karunanithi
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Performance ◽  
Psychosocial Functioning ◽  
Healthy Controls

The causal relationships between neurocognition, social cognition and functional outcome over time in schizophrenia: a latent difference score approach

2012 ◽  
Vol 42 (11) ◽  
pp. 2287-2299 ◽  
Author(s):  
M. Hoe ◽  
E. Nakagami ◽  
M. F. Green ◽  
J. S. Brekke
Keyword(s):  
Social Cognition ◽  
Functional Outcome ◽  
Psychosocial Functioning ◽  
Factor Model ◽  
Causal Structure ◽  
Difference Score ◽  
Rehabilitation Programs ◽  
Confirmatory Factor ◽  
Latent Difference Score ◽  
Over Time

BackgroundSocial cognition has been identified as a significant construct for schizophrenia research with relevance to diagnosis, assessment, treatment and functional outcome. However, social cognition has not been clearly understood in terms of its relationships with neurocognition and functional outcomes. The present study sought to examine the empirical independence of social cognition and neurocognition; to investigate the possible causal structure among social cognition, neurocognition and psychosocial functioning.MethodThe sample consists of 130 individuals diagnosed with schizophrenia. All participants were recruited as they were admitted to four community-based psychosocial rehabilitation programs. Social cognition, neurocognition and psychosocial functioning were measured at baseline and 12 months. The empirical independence of social cognition and neurocognition was tested using confirmatory factor analysis (CFA) and the possible causal structure among social cognition, neurocognition and psychosocial functioning was investigated using latent difference score (LDS) analysis.ResultsA two-factor model of social cognition and neurocognition fit the data very well, indicating the empirical independence of social cognition, whereas the longitudinal CFA results show that the empirical independence of neurocognition and social cognition is maintained over time. The results of the LDS analysis support a causal model that indicates that neurocognition underlies and is causally primary to social cognition, and that neurocognition and social cognition are causally primary to functional outcome.ConclusionsSocial cognition and neurocognition could have independent and distinct upward causal effects on functional outcome. It is also suggested that the approaches for remediation of neurocognition and social cognition might need to be distinct.

Bipolar Affective Disorders: Diagnostic and Treatment Situation in Lithuania

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
V. Adomaitiene ◽  
A. Kunigeliene ◽  
K. Dambrauskiene ◽  
V. Danileviciute
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Affective Disorders ◽  
Bipolar Disorders ◽  
Male Population ◽  
Female Population ◽  
Bipolar Ii Disorder ◽  
Treatment Situation ◽  
Bipolar Ii ◽  
Bipolar Affective Disorders

Introduction:Bipolar disorder is one of the most important psychiatric diseases. This is a lifelong illness which increases disability, bad social, employment, and functional outcomes. Bipolar disorder causes dramatic mood swings - from overly “high” and irritable to sad and hopeless, often with periods of normal mood between. Bipolar I disorder is characterized by a history of at least one manic episode, with or without depressive symptoms. Bipolar II disorder is characterized by the presence of both depressive symptoms and a less severe form of mania.Objective:To review diagnostic and treatment situation of bipolar affective disorders in Lithuania.Method:A review of bipolar affective disorders in Lithuania: the prevalence of bipolar disorders, the differences between genders, the clinical features between genders.Results:Studies have suggested, that the prevalence of bipolar disorder in Lithuania is 1 % of population. The rates of bipolar disorder: in 2003 was 1131 cases, in 2004 - 1133 cases, in 2005 - 1147 cases, in 2006 - 1255 cases, in 2007 - 1257 cases. Distribution of bipolar disorders between males and females: males - 35,88 %, females - 64,12 %.Conclusion:The rates of Bipolar I disorder are equal between female and male population, but bipolar II disorder is more frequent in female population (bipolar depression, mixed manic disorder). Bipolar disorder with alcohol and drug abuse are very common among male population. Bipolar disorders are very common with somatic disease (thyroid disease, migraine, obesity of medication), anxiety disorders are more frequent in female population.

Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder

2014 ◽  
Vol 160 ◽  
pp. 50-54 ◽  
Author(s):  
Caterina del Mar Bonnín ◽  
Ana González-Pinto ◽  
Brisa Solé ◽  
María Reinares ◽  
Itxaso González-Ortega ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Functional Outcome ◽  
Verbal Memory ◽  
The Relationship

scholarly journals Impact of subthreshold symptoms on cognitive performance and psychosocial functioning in patients with bipolar disorder

2017 ◽  
Vol 8 ◽  
Author(s):  
Dimosthenis Tsapekos ◽  
Tim Mantingh ◽  
Rebecca Strawbridge ◽  
Rafaela-Iro Schiza ◽  
John Hodsoll ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Performance ◽  
Psychosocial Functioning

scholarly journals Homicide attempt due to medication induced mania

2021 ◽  
Author(s):  
Jordan Berry ◽  
Naghmeh Mokhber ◽  
Arun Prakash ◽  
Ajay Prakash ◽  
Julie Zamprogna
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Symptoms ◽  
Mental Disorders ◽  
Bipolar Depression ◽  
Bipolar Disorders ◽  
Depressive State ◽  
Major Depressive ◽  
Difficult Situation ◽  
Serotonergic Antidepressant

Bipolar disorders are a group of mental disorders characterized by fluctuations in mood, with depressive symptoms generally dominating the course of disorder. Research on the efficacy of serotonergic antidepressants in bipolar depression is controversial and as a result, treatment of depressive symptoms in bipolar disorder is difficult. A particularly difficult situation arises when bipolar disorder is unrecognized and the depressive state is treated as major depressive disorder with the use of serotonergic antidepressants, which can result in the phenomenon of antidepressant induced mania (AIM). In this report, we present a case of antidepressant induced mania (AIM) with homicidal ideation after initiation of serotonergic antidepressants. Here, we discuss the importance of monitoring for bipolar disorder after prescribing serotonergic antidepressant therapy as well as medico-legal considerations.

Misdiagnose bipolar disorder: About a case report

2017 ◽  
Vol 41 (S1) ◽  
pp. S425-S425
Author(s):  
C. Novais ◽  
M. Marinho ◽  
M. Mota Oliveira ◽  
M. Bragança ◽  
A. Côrte-Real ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Depressive Disorders ◽  
Psychiatric Inpatient ◽  
Bipolar Disorders ◽  
Manic Episode ◽  
Inpatient Unit ◽  
Cranial Computed Tomography ◽  
Major Depressive ◽  
Competing Interest

IntroductionEarly stages of bipolar disorder are sometimes misdiagnosed as depressive disorders. This symptomatology can lead to misinterpretation and under diagnosis of bipolar disorders.Objectives/aimsTo describe a patient with a new diagnosis of bipolar disorder after 23 years of psychiatric care.MethodsWe report a case of a 66-year-old man, with a previous psychiatric diagnosis of recurrent depressive disorder for the last 23 years, after a hospitalization in a psychiatric inpatient unit because of a major depressive episode. In subsequent years, he was regularly followed in psychiatric consultation with description of recurrent long periods of depressed mood requiring therapeutic setting, alternating with brief remarks of not valued slightly maladjusted behaviour. At 65, he came to the emergency room presenting with observable expansive and elevated mood, disinhibited behaviour, grandiose ideas and overspending, leading to his hospitalization with the diagnosis of a manic episode. In the inpatient unit care, we performed blood tests, cranial-computed tomography (CT) and a cognitive assessment. His medication has also been adjusted.ResultsLaboratory investigations were unremarkable. Cranial-CT showed some subcortical atrophy of frontotemporal predominance, without corroboration by the neuropsychological evaluation. The patient was posteriorly transferred to a residential unit for stabilization, where he evolved with major depressive symptoms that needed new therapeutic adjustment. Later he was discharged with the diagnosis of bipolar disorder.ConclusionsOur case elucidates the importance of ruling out bipolar disorder in patients presenting with depressive symptoms alternating with non-specific maladjusted behaviour, which sometimes can be a challenging task.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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