Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder

2014 ◽  
Vol 160 ◽  
pp. 50-54 ◽  
Author(s):  
Caterina del Mar Bonnín ◽  
Ana González-Pinto ◽  
Brisa Solé ◽  
María Reinares ◽  
Itxaso González-Ortega ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Functional Outcome ◽  
Verbal Memory ◽  
The Relationship

scholarly journals Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort

2017 ◽  
Vol 211 (6) ◽  
pp. 381-387 ◽  
Author(s):  
Paul Roux ◽  
Aurélie Raust ◽  
Anne-Sophie Cannavo ◽  
Valérie Aubin ◽  
Bruno Aouizerate ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cognitive Component ◽  
Cognitive Components ◽  
The Face ◽  
Sources Of Variation ◽  
The Relationship

BackgroundThe relationship between residual depressive symptoms, cognition and functioning in patients with euthymic bipolar disorder is a subject of debate.AimsTo assess whether cognition mediates the association between residual depressive symptoms and functioning in patients with bipolar disorder who were euthymic.MethodWe included 241 adults with euthymic bipolar disorder in a multicentre cross-sectional study. We used a battery of tests to assess six cognition domains. A path analysis was then used to perform a mediation analysis of the relationship between residual depressive symptoms, cognitive components and functioning.ResultsOnly verbal and working memory were significantly associated with better functioning. Residual depressive symptoms were associated with poorer functioning. No significant relationship was found between residual depressive symptoms and any cognitive component.ConclusionsCognition and residual depressive symptoms appear to be two independent sources of variation in the functioning of people with euthymic bipolar disorder.

scholarly journals Functional outcome and social cognition in bipolar disorder: Is there a connection?

2018 ◽  
Vol 52 ◽  
pp. 116-125 ◽  
Author(s):  
Maria Vlad ◽  
Delphine Raucher-Chéné ◽  
Audrey Henry ◽  
Arthur Kaladjian
Keyword(s):  
Bipolar Disorder ◽  
Social Cognition ◽  
Functional Outcome ◽  
Social Functioning ◽  
Emotion Processing ◽  
Exclusion Criteria ◽  
Literature Searches ◽  
Attribution Bias ◽  
The Relationship ◽  
Improve Patient

AbstractBackground:Interest in social cognition in bipolar disorder (BD) has increased considerably over the past decade, with studies highlighting major impairments, especially in mental state reasoning, even during euthymia. A causal relationship between social cognition deficits and social functioning has already been established in individuals with schizophrenia, but there is still little information about links between social cognition and social functioning in BD. Our aim was therefore to review the relationship between functional outcome and social cognition in patients with BD.Methods:We conducted a systematic review of the literature. Relevant articles were identified through literature searches in the MEDLINE/PubMed, EBSCOHost and Google Scholar databases for the years 2000–2017, using the keywordsbipolar, social cognition, theory of mind, mentalizing, emotion recognition, emotion processing, andfunctioning.A total of 20 studies met our inclusion/exclusion criteria.Results:We found that functioning was significantly correlated with three domains of social cognition (ToM, emotion processing, and attribution bias). Twelve of 13 studies reported a correlation with emotion processing, but a correlation with ToM was only found in three of the 11 studies that assessed it. Six studies found an effect of depressive symptoms on emotion processing and no significant association was found with manic symptomatology.Conclusions:To the best of our knowledge, the present review is the first to specifically explore the relationship between social cognition and social functioning in patients with BD. This exploration is of interest, as it enhances current understanding of this disorder and, by so doing, should improve patient outcomes.

The relationship between “Eyes Reading” ability and verbal memory in bipolar disorder

2019 ◽  
Vol 273 ◽  
pp. 42-51 ◽  
Author(s):  
N. Dalkner ◽  
S.A. Bengesser ◽  
A. Birner ◽  
F.T. Fellendorf ◽  
C. Hamm ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Verbal Memory ◽  
Reading Ability ◽  
The Relationship

scholarly journals Perceived stigma and depression among caregivers of patients with bipolar disorder

2007 ◽  
Vol 190 (6) ◽  
pp. 535-536 ◽  
Author(s):  
Deborah A. Perlick ◽  
David J. Miklowitz ◽  
Bruce G. Link ◽  
Elmer Struening ◽  
Richard Kaczynski ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Perceived Stigma ◽  
Patient Status ◽  
Coping Effectiveness ◽  
Clinical And Functional Status ◽  
Dsm Iv ◽  
Socio Demographic Factors ◽  
And Coping ◽  
The Relationship

SummaryThis study investigates the associations between perceived stigma, depressive symptoms and coping among caregivers of people with bipolar disorder. Caregivers of 500 people with DSM–IV bipolar disorder responded to measures of these constructs at study entry Patients' clinical and functional status were evaluated within 30 days of the caregiver assessment. Perceived stigma was positively associated with caregiver depressive symptoms, controlling for patient status and socio-demographic factors. Social support and avoidance coping accounted for 63% of the relationship between caregiver stigma and depression. Results suggest that caregivers' perceptions of stigma may negatively affect their mental health by reducing their coping effectiveness.

Long-term outcome predictors after functional remediation in patients with bipolar disorder

2020 ◽  
pp. 1-9 ◽  
Author(s):  
B. Solé ◽  
C. M. Bonnín ◽  
J. Radua ◽  
L. Montejo ◽  
B. Hogg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Functional Outcome ◽  
Verbal Memory ◽  
Psychosocial Interventions ◽  
Clinical Variable ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Partial Correlations

Abstract Background Improving functioning in patients with bipolar disorder (BD) is one of the main objectives in clinical practice. Of the few psychosocial interventions that have been specifically developed to enhance the psychosocial outcome in BD, functional remediation (FR) is one which has demonstrated efficacy. The aim of this study was to examine which variables could predict improved functional outcome following the FR intervention in a sample of euthymic or subsyndromal patients with BD. Methods A total of 92 euthymic outpatients were included in this longitudinal study, with 62 completers. Partial correlations controlling for the functional outcome at baseline were calculated between demographic, clinical and neurocognitive variables, and functional outcome at endpoint was assessed by means of the Functioning Assessment Short Test scale. Next, a multiple regression analysis was run in order to identify potential predictors of functional outcome at 2-year follow-up, using the variables found to be statistically significant in the correlation analysis and other variables related to functioning as identified in the previous scientific literature. Results The regression model revealed that only two independent variables significantly contributed to the model (F(6,53): 4.003; p = 0.002), namely verbal memory and inhibitory control. The model accounted for 31.2% of the variance. No other demographic or clinical variable contributed to the model. Conclusions Results suggest that patients with better cognitive performance at baseline, especially in terms of verbal memory and executive functions, may present better functional outcomes at long term follow-up after receiving functional remediation.

Processing speed mediates the relationship between verbal memory, verbal fluency, and functional outcome in chronic schizophrenia

2008 ◽  
Vol 101 (1-3) ◽  
pp. 225-233 ◽  
Author(s):  
Natalia Ojeda ◽  
Javier Peña ◽  
Pedro Sánchez ◽  
Edorta Elizagárate ◽  
Jesús Ezcurra
Keyword(s):  
Functional Outcome ◽  
Processing Speed ◽  
Verbal Memory ◽  
Verbal Fluency ◽  
Chronic Schizophrenia ◽  
The Relationship

scholarly journals Social-Cognitive Bias and Depressive Symptoms in Outpatients with Bipolar Disorder

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Guillermo Lahera ◽  
Adolfo Benito ◽  
Ana González-Barroso ◽  
Rocío Guardiola ◽  
Sara Herrera ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Social Cognition ◽  
Functional Outcome ◽  
Cognitive Bias ◽  
Social Cognitive ◽  
Matched Control ◽  
Statistical Significance ◽  
Global Functioning ◽  
Bipolar Patients

A deficit of social cognition in bipolar disorder has been shown, even when patients are stable. This study compares the attribution of intentions (social-cognitive bias) in a group of 37 outpatients with bipolar disorder with 32 matched control subjects. Bipolar patients scored significantly higher in the Ambiguous Intentions Hostility Questionnaire, showing an angry and intentionality bias (P=.001,P=.02). Differences in blame scale and hostility bias did not reach statistical significance, but a trend was found (P=.06). Bipolar patients with depressive symptoms presented a higher score in the angry bias scale (P=.03) and aggressivity bias scale (P=.004). The global functioning (GAF) correlates significantly with intentionality (P=.005), angry (P=.027), and aggressivity (P=.020) biases. Bipolar patients show a social-cognitive bias that may play a role in their functional outcome.

scholarly journals Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson’s Disease

2017 ◽  
Vol 24 (3) ◽  
pp. 269-282 ◽  
Author(s):  
Sarah M. Szymkowicz ◽  
Vonetta M. Dotson ◽  
Jacob D. Jones ◽  
Michael S. Okun ◽  
Dawn Bowers
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Function ◽  
Depressive Symptoms ◽  
Verbal Memory ◽  
Somatic Symptoms ◽  
Cognitive Domain ◽  
Specific Symptom ◽  
Symptom Dimensions ◽  
The Relationship

AbstractObjectives: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson’s disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. Methods: A sample of 138 non-demented individuals with PD (mean age=64.51±7.43 years) underwent neuropsychological testing and completed the Beck Depression Inventory, 2nd Edition, and Apathy Scale. Separate hierarchical regression models examined the relationship between symptom dimensions of depression and apathy (“pure” depressive symptoms, “pure” apathy, loss of interest/pleasure [anhedonia], and somatic symptoms) and three cognitive domain composites: immediate verbal memory, delayed verbal memory, and executive function. Results: After adjusting for general cognitive status and the influence of the other symptom dimensions, “pure” depressive symptoms were negatively associated with the delayed verbal memory composite (p<.034) and somatic symptoms were positively associated with the executive function composite (p<.026). No symptom dimensions were significantly related to the immediate verbal memory composite. Conclusions: Findings suggest that specific mood symptoms are associated with delayed verbal memory and executive function performance in non-demented patients with PD. Further research is needed to better understand possible mechanisms through which specific symptom dimensions of depression and apathy are associated with cognition in PD. (JINS, 2018, 24, 269–282)

Neurocognitive predictors of functional outcome in patients with bipolar disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 928-928
Author(s):  
S. Hauska ◽  
A. Erfurth ◽  
G. Lenz ◽  
G. Sachs
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Functional Outcome ◽  
Verbal Memory ◽  
Early Recurrence ◽  
Clinical Impression ◽  
Healthy Controls ◽  
Neurocognitive Deficits ◽  
Treatment Conditions ◽  
Global Clinical Impression

IntroductionNeurocognitive deficits are known as a core feature in bipolar disorder (BPD). Persisting neurocognitive impairment is associated with low self-reported quality of life and low psychosocial functioning. Current findings indicate the importance of adjunctive psychosocial interventions in the treatment of BPD patients to enhance symptomatic and functional outcome.ObjectivesTo assess whether functional outcome in patients with BPD is affected by cognitive psychoeducational therapy, clinical parameters and cognitive impairment.AimsTo identify potential predictors of functional outcome, global clinical impression and early recurrence in patients with BPD.MethodsUsing a neurocognitive test battery 43 patients with BPD in euthymic state were compared to 40 healthy controls. Patients were assigned to two treatment Conditions cognitive psychoeducational therapy over 14 weeks (n = 19, 12 female, age) and treatment-as-usual (n = 24, 14 female). Predictors for functional disability, global clinical impression and early recurrence including clinical and cognitive variables as well as treatment conditions were examined using logistic regression.ResultsCompared to healthy controls patients with BPD showed lower performance in executive function (p < 0.01) and sustained attention (p < 0.001). Cognitive psychoeducation (p < 0.05) and subthreshold depressive symptoms (p < 0.05) were predictors for occupational functioning. Age (p < 0.05), delayed verbal memory (p < 0.05) and word fluency (p < 0.05) predicted global clinical impression. Recurrence in the follow-up period of 12 months was predicted by delayed verbal memory (p < 0.05).ConclusionsPatients with BPD seem to benefit from cognitive psychoeducational training mainly in areas of working life. The extent of cognitive impairment appears to impact clinical outcome and recurrence rate.

Longitudinal relationships between cognition and functioning over 2 years in euthymic patients with bipolar disorder: a cross-lagged panel model approach with the FACE-BD cohort

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Mickael Ehrminger ◽  
Eric Brunet-Gouet ◽  
Anne-Sophie Cannavo ◽  
Bruno Aouizerate ◽  
Irena Cussac ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Functional Outcome ◽  
Cognitive Performance ◽  
Psychosocial Functioning ◽  
Causal Effect ◽  
Causal Structure ◽  
Cognitive Remediation ◽  
Bipolar Disorders ◽  
Causal Link

Background Longitudinal studies of the relationship between cognition and functioning in bipolar disorder are scarce, although cognition is thought to be a key determinant of functioning. The causal structure between cognition and psychosocial functioning in bipolar disorder is unknown. Aims We sought to examine the direction of causality between cognitive performance and functional outcome over 2 years in a large cohort of euthymic patients with bipolar disorder. Method The sample consisted of 272 adults diagnosed with bipolar disorder who were euthymic at baseline, 12 and 24 months. All participants were recruited via the FondaMental Advanced Centers of Expertise in Bipolar Disorders. We used a battery of tests, assessing six domains of cognition at baseline and 24 months. Residual depressive symptoms and psychosocial functioning were measured at baseline and 12 and 24 months. The possible causal structure between cognition and psychosocial functioning was investigated with cross-lagged panel models with residual depressive symptoms as a covariate. Results The analyses support a causal model in which cognition moderately predicts and is causally primary to functional outcome 1 year later, whereas psychosocial functioning does not predict later cognitive performance. Subthreshold depressive symptoms concurrently affected functioning at each time of measure. Conclusions Our results are compatible with an upward causal effect of cognition on functional outcome in euthymic patients with bipolar disorder. Neuropsychological assessment may help specify individual prognoses. Further studies are warranted to confirm this causal link and evaluate cognitive remediation, before or simultaneously with functional remediation, as an intervention to improve functional outcome. Declaration of interest None.

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