Some Considerations regarding the Family History of Insanity in the Highlands

1915 ◽  
Vol 61 (252) ◽  
pp. 95-98
Author(s):  
T. C. Mackenzie
Keyword(s):  
Family History ◽  
The Other ◽  
Other Hand ◽  
The Family ◽  
History Of ◽  
Degree Of Isolation

The Inverness Lunacy District, which was formed after the passing of the Lunacy Act of 1857, comprises the four counties of Nairn, Inverness, Ross, and Sutherland, and is of very large extent. Its area is, roughly, one-third of the total area of Scotland, and includes the greater part of the Highlands. Its population, on the other hand, is extremely sparse, and has been steadily decreasing during the last fifty years. It is a district in which there has been much intermarriage of relatives, and which is less open and accessible than most of the rest of Scotland to the factors that have brought about such great changes in the general life of the country during the last fifty years. In recent years, however, the extension of railways, and the wide use of motor cars, have done much to diminish this degree of isolation and remoteness.

“Appear gorgeous, quiet Osuga…”: originality of country “estate topos” in Dmitry Merezhkovsky’s play “Romantics”

2020 ◽  
pp. 228-238
Author(s):  
Elena A. Andrushchenko ◽  
Keyword(s):  
Family History ◽  
Point Of View ◽  
The Other ◽  
Other Hand ◽  
The Family ◽  
History Of ◽  
The Creation ◽  
The Rich ◽  
Rich Material ◽  
The One

D.S. Merezhkovsky’s play “Romantics” (1917) rarely attracts a researcher’s interest, although it is a notable attempt to revisit the rich material on the family history of the Bakunins contained in A.A. Kornilov’s work “Mikhail Bakunin’s young years. From the history of Russian romanticism” (1915). Merezhkovsky’s “bookishness” in the play is apparent in the creation of the idyllic image of Pryamukhino, where he relied on Kornilov’s book and composed a stylization, in which he handled “someone else’s” text and “point of view”. The stylization is reflected in the “estate topos”, which acts as a decoration for the characters’ intellectual aspirations. Coupled with intertext and mythopoetics, it establishes a myth of the intelligentsia’s religious communality, which Merezhkovsky had been developing in his fiction and public writings of those years. These have common motives of paradise, sacrifice, celibacy, unconscious Christianity, duality, detachment. The properties of the “estate topos” in “Romantics” are such that, on the one hand, it is related to the source, while on the other hand each of its elements is integrated into a particular sequence identifiable by its purpose in “estate” literature. This purports to reflect the reality, but is actually the reflection of its reflection; it binds the events to a concrete time and space, yet also affirms the idea of a timeless, universal realization, which is in line with Merezhkovsky’s mythopoetic creative consciousness.

Schleicher, Čelakovský, and the Family-Tree Diagram

1975 ◽  
Vol 2 (3) ◽  
pp. 299-333 ◽  
Author(s):  
T. M. S. Priestly
Keyword(s):  
The Other ◽  
Family Tree ◽  
Slavic Languages ◽  
Other Hand ◽  
The Family ◽  
Tree Diagram ◽  
History Of Linguistics ◽  
History Of ◽  
Common Interests ◽  
And Linguistics

Summary The first family-tree diagram in August Schleicher’s (1821–68) published work appeared in 1853, seven years after his first printed discussion of the family-tree concept. In 1853 there also appeared Čteni o srovnavaci mluvnici slovanské by the Czech scholar František Ladislav Čelakovský (1799–1852); this book also contained a family-tree diagram. Since Čelakovský and Schleicher were contemporaries in Prague for over two years, their interrelationship is of interest: was this rivalry of collaboration? At first sight, a coincidence seems improbable. In the available work on and by Schleicher, Čelakovský is never mentioned; in the writings on and by Čelakovský, Schleicher’s name is never linked to his. However, the two had very many common interests. Apart from being colleagues at Charles University, they shared the same friends and enemies, were both interested in music and botany, and so on. Moreover, both were working on Slavic Historical Linguistics during the period in question. On the other hand, their personalities were such that the possibility of a mutual antipathy must not be excluded. Given the background to Čelakovský’s life and work, including the legends of the common origin of the Slavs and the obviously close interrelationships of the Slavic languages; the burgeoning of interest in Slavic history and linguistics, and in Panslavicism; the popularity of genealogy; and the developments in classificatory techniques along natural scientific lines, it is argued that Čela-kovský’s depiction of a family-tree for the Slavic languages could be quite naturally expected from him at this point in time, without any influence from Schleicher. On the other hand, Schleicher’s first family-tree diagrams were the next logical step in his own development. Moreover, the actual form of the diagrams in question suggests that they may indeed have been developed independently. This puzzle in the history of linguistics remains unsolved: collaboration, rivalry, and coincidence are all possible.

Severe prekallikrein deficiency due to a compound heterozygosis in the KLKB1-gene

2009 ◽  
Vol 29 (02) ◽  
pp. 187-189 ◽  
Author(s):  
L. Kochhan ◽  
P. Heuchel ◽  
J. Jenderny ◽  
B. Maak
Keyword(s):  
Family History ◽  
Reference Range ◽  
The Other ◽  
Paternal Allele ◽  
Thrombin Time ◽  
Base Exchange ◽  
Coagulation Study ◽  
The Family ◽  
Prolonged Aptt ◽  
History Of

SummaryA 14 year old boy was referred to us for a detailed coagulation study because a previously performed aPTT has been found prolonged. The boy had no history of bleeding symptoms and also the family history was negative for bleeding or thrombotic events. The aPTT in the patient was 96 s (reference range: 24–36 s), prothrombin time and thrombin time were both normal.As the cause for the prolonged aPTT we identified a severe prekallikrein deficiency (prekallikrein activity < 1%). The prekallikrein deficiency results from two mutations in the KLKB 1-gene: first, an insertion of 1 bp in codon 149 in exon 5 and, second, a base exchange Cys 548 (TGC) > Tyr (TAC) in exon 14. The boy inherited the first mutation from his father and the second from his mother. The mutation in the paternal allele was not described before the completion of our study. There are two brothers of the propositus, one with normal prekallikrein activity and no mutations in the KLKB1-gene, the other showed the same constellation as the propositus.

An oncogenetics consultation dedicated to children suffering from cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e20006-e20006
Author(s):  
Véronique Mari ◽  
Marie Amelie Met Domestici ◽  
Christine Soler ◽  
Anne Deville ◽  
Nicolas Sirvent ◽  
...  
Keyword(s):  
Genetic Mutation ◽  
Paediatric Oncology ◽  
The Other ◽  
Familial Data ◽  
Other Hand ◽  
Oncology Service ◽  
The Family ◽  
Strong Bound ◽  
History Of ◽  
Pediatric Consultation

e20006 Background: When a child suffers from a cancer, parents worry about a probable hereditary cause. If a cancer occurs in the context of a genetic mutation, this can worsen the situation and make it more complicated. On the other hand, when the hereditary cause is rejected, the reinsurance for the family is clear. Methods: A partnership has been set between the Oncogenetics department in Centre Antoine Lacassagne Hospital in Nice and the Archet hospital in Nice (CHU) who takes in charge the children suffering from a cancer. Fifty little patients are seen every year in the paediatric oncology service at the Archet hospital (CHU). A consultation in oncogenetics is suggested to each family and insistently when a known syndrome is suspected. This consultation is also about to provide an other kind of care, in an other hospital, focused on the family with the aim to free of guilt the parents. Psychological care for families is in backdrop as they can express freely their questioning. Results: Twenty one families have been seen and fifteen different types of cancers recorded: mostly haematological cancers and neurological cancers. For each family, a pedigree was drawn. Data concerning the child’s disease and familial data were gathered. Most of the time, these information led to reassure the families. Therefore two Li and Fraumeni syndrome have been evoked. The first child suffered from a plexus choroid carcinoma and the second one had two distinct cancers: a nephroblastoma and a medulloblastoma. On the other hand, 2 children had had a LAL within a family with history of malignant haemopaties. Interestingly, 3 children with isolated LAL in the family where suggested to contribute to a research trial. Conclusions: This oncogenetic pediatric consultation allows to detect known hereditary predisposition syndromes and to contribute to researches in paediatric oncology. Above all, this strong bound between the oncogentics department and the pediatric oncology service permitted to reach an objective: offering families a specialised consultation with psychological support with a gap from disease.

Three Cases of Polydactylism [Tre Cast di Polidactilia]. (Arch, di Psichiat vol. xxii, fasc. 6.) Portigliotti

1902 ◽  
Vol 48 (201) ◽  
pp. 345-345
Author(s):  
W. C. Sullivan
Keyword(s):  
Family History ◽  
The Other ◽  
The Third ◽  
Three Generations ◽  
The Family ◽  
History Of ◽  
Hands And Feet

The three cases of this anomaly reported by the author, were met with in a population of about 2700 persons. In two of the cases, both hands and feet presented six digits; in the third case the condition existed in the feet only. An exhaustive examination of the family history of the cases through three generations failed to disclose any hereditary tendency to polydactylism or any degenerative taint. In only one of the cases were the parents of kin second cousins. One of the subjects was above the average in intelligence, the other two were somewhat weak-minded.

scholarly journals Maute Group dan Jaringan Keluarga dalam Kelompok Islam Radikal di Filipina Selatan

2017 ◽  
Vol 13 (2) ◽  
pp. 187
Author(s):  
Putu Agung Nara Indra
Keyword(s):  
The Other ◽  
Other Hand ◽  
The Family ◽  
History Of ◽  
Militant Groups ◽  
Group Family ◽  
Abu Sayyaf

<p><strong>Abstrak</strong></p><p>Perjalanan konflik antara pemerintah Filipina dengan kelompok-kelompok separatis di Filipina Selatan memunculkan beragam kelompok militan Islam seperti MILF, Abu Sayyaf, dan yang paling mutakhir, Kelompok Maute. .Banyaknya kelompok militan yang muncul berawal dari perpecahan-perpecahan di dalam kelompok-kelompok militan tradisional di Filipina Selatan khususnya MNLF dan MILF. Fenomena perpecahan ini akhirnya memunculkan kelompok-kelompok sempalan yang kerap terlibat pertempuran di antara mereka sendiri. Di sisi lain, kelompok-kelompok tersebut justru memiliki latar belakang ikatan keluarga yang sangat erat. Tulisan ini menyoroti tentang peranan jaringan keluarga di dalam keberadaan kelompok-kelompok militan di Filipina Selatan khususnya Kelompok Maute. Kelompok Maute dapat berkembang pesat karena pendiri dan sebagian besar anggotanya memiliki hubungan keluarga dengan kelompok Moro Islamic Liberation Front. Ikatan keluarga ini akhirnya menjadi pelindung sekaligus faktor penting bagi berkembangnya radikalisme Kelompok Maute.</p><p>Kata kunci: <em>Filipina Selatan, kelompok radikal Islam, MILF, Kelompok Maute, ikatan keluarga.</em></p><p> </p><p><strong>Abstract</strong></p><p>The history of conflict between Philippines government and separatist group in Southern Phillipines area has formed many radical Islamic groups such as, MILF, Abu Sayyaf, and Maute group. The emergence of these groups was caused by the schism in the older militant groups such as MNLF and MILF. However, the disunity of the older militant groups and the emergence of the so called “splinter groups” finally created conflicts among them. On the other hand, those groups bear resemblance in their family origins. This article highlighted the family networking inside the radical Islamic groups especially the Maute group. This group can grow rapidly because of the family bond between their founders and members with the Moro Islamic Liberation Front (MILF). The family bond became their protector and also vital point for the rise of radicalism in the Maute group.</p>Keyword: <em>Southern Philippines, radical Islamic groups, MMILF, Maute group, family bond. </em>

On Commutation Properties of the Composition Relation of Convergent and Divergent Permutations (Part I)

2014 ◽  
Vol 58 (1) ◽  
pp. 13-22
Author(s):  
Roman Wituła ◽  
Edyta Hetmaniok ◽  
Damian Słota
Keyword(s):  
Finite Order ◽  
Convergent Series ◽  
The Other ◽  
Other Hand ◽  
The Family ◽  
Composition Relation ◽  
The Continuum

Abstract In the paper we present the selected properties of composition relation of the convergent and divergent permutations connected with commutation. We note that a permutation on ℕ is called the convergent permutation if for each convergent series ∑an of real terms, the p-rearranged series ∑ap(n) is also convergent. All the other permutations on ℕ are called the divergent permutations. We have proven, among others, that, for many permutations p on ℕ, the family of divergent permutations q on ℕ commuting with p possesses cardinality of the continuum. For example, the permutations p on ℕ having finite order possess this property. On the other hand, an example of a convergent permutation which commutes only with some convergent permutations is also presented.

Women-Friendly Policies being adopted by Organizations: An Innovative aspect

2016 ◽  
Vol 3 (01) ◽  
Author(s):  
Shlesha Singh ◽  
Mrinalini Pandey
Keyword(s):  
Sexual Harassment ◽  
Glass Ceiling ◽  
Gender Stereotype ◽  
The Other ◽  
Family Responsibilities ◽  
Other Hand ◽  
The Family ◽  
Workplace Barriers ◽  
Women In The Workforce ◽  
And Gender

Organizations are these days realizing the importance of women in the workforce and to tap that talent, organizations are now-a-days putting extra efforts. Workplaces were designed keeping men in mind and which has been intercepting women from continuing the competitive jobs and career along with the family responsibilities. On the other hand, there are various workplace barriers which are adding to the other problems. Women face several barriers at the workplace like sexual harassment, glass ceiling and gender stereotype.

scholarly journals Novel SCN5A p.Val1667Asp Missense Variant Segregation and Characterization in a Family with Severe Brugada Syndrome and Multiple Sudden Deaths

2021 ◽  
Vol 22 (9) ◽  
pp. 4700
Author(s):  
Michelle M. Monasky ◽  
Emanuele Micaglio ◽  
Giuseppe Ciconte ◽  
Ilaria Rivolta ◽  
Valeria Borrelli ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Family History ◽  
Risk Stratification ◽  
Brugada Syndrome ◽  
Electrophysiological Study ◽  
Functional Characterization ◽  
The Family ◽  
Novel Variant ◽  
History Of ◽  
Scn5a Gene

Genetic testing in Brugada syndrome (BrS) is still not considered to be useful for clinical management of patients in the majority of cases, due to the current lack of understanding about the effect of specific variants. Additionally, family history of sudden death is generally not considered useful for arrhythmic risk stratification. We sought to demonstrate the usefulness of genetic testing and family history in diagnosis and risk stratification. The family history was collected for a proband who presented with a personal history of aborted cardiac arrest and in whom a novel variant in the SCN5A gene was found. Living family members underwent ajmaline testing, electrophysiological study, and genetic testing to determine genotype-phenotype segregation, if any. Patch-clamp experiments on transfected human embryonic kidney 293 cells enabled the functional characterization of the SCN5A novel variant in vitro. In this study, we provide crucial human data on the novel heterozygous variant NM_198056.2:c.5000T>A (p.Val1667Asp) in the SCN5A gene, and demonstrate its segregation with a severe form of BrS and multiple sudden deaths. Functional data revealed a loss of function of the protein affected by the variant. These results provide the first disease association with this variant and demonstrate the usefulness of genetic testing for diagnosis and risk stratification in certain patients. This study also demonstrates the usefulness of collecting the family history, which can assist in understanding the severity of the disease in certain situations and confirm the importance of the functional studies to distinguish between pathogenic mutations and harmless genetic variants.

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