The Iodine Content of Thyroid Gland

1925 ◽  
Vol 71 (295) ◽  
pp. 703-720 ◽  
Author(s):  
F. A. Pickworth
Keyword(s):  
Thyroid Gland ◽  
Annual Meeting ◽  
Iodine Content ◽  
Histological Structure ◽  
Minimum Expenditure ◽  
Bodily Condition

At the Annual Meeting of this Association held at Belfast last July, Sir Frederick Mott gave you an address on the thyroid gland and promised a further contribution with regard to the iodine content. This paper is an attempt to correlate the iodine content with histological structure and with the mental and bodily condition of the patient. I must apologize for the work being far from complete, as most of the time since then has been taken up with the examination of the published methods for the estimation of iodine in the gland, and owing to certain objections to these methods it has been necessary to invent a process without these objections, and which, at the same time, is carried out with a minimum expenditure of time and material.

scholarly journals Iodine and iodothyronine content in human neonate thyroid gland

2002 ◽  
Vol 54 (3-4) ◽  
pp. 69-74 ◽  
Author(s):  
Svetlana Savin-Zegarac ◽  
Dubravka Cvejic ◽  
Olgica Nedic ◽  
R. Radosavljevic ◽  
Ivana Petrovic
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Postnatal Life ◽  
Total Iodine ◽  
Mean Values ◽  
Human Neonate ◽  
The Mean ◽  
Human Neonates

A few years after the iodine content of salt in Serbia was increased from 7 to 15 mg/kg NaCI, iodine, thyroxine (T4) and triiodothyronine (T3) concentrations were measured in thyroid tissue obtained at autopsy from 21 human neonates who died within 30 days after birth. The thyroidal iodine as well as T4 and T3 content per gland in?creased progressively with gestational age of human neonates (r = 0.73, 0.70 and 0.67 respectively, p < 0.001). In seven newborns (gestational age 36 to 41 weeks) the mean values for total iodine, T4 and T3 per gland were 109.1 ?g, 52.2 ?g and 4.4 ?g respectively. The results of iodine and iodothyroninc content found in neonatal thyroid gland, particularly at the end of gestation and a few days of postnatal life, indicates that the iodine supply was satisfactory.

scholarly journals Alterations of the thyroid structure and function in experimental hypopinealism

2011 ◽  
Vol 57 (2) ◽  
pp. 32-35
Author(s):  
L A Bondarenko ◽  
L Iu Sergienko ◽  
N N Sotnik ◽  
A N Cherevko
Keyword(s):  
Thyroid Gland ◽  
Structural Changes ◽  
Structure And Function ◽  
Initial Increase ◽  
Histological Structure ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
And Function ◽  
Sexually Mature

The pituitary-thyroid axis of young sexually mature rabbits kept under a 24-hour daylight photoperiod was shown to undergo phase-modulated variations of hormonal activity with its initial increase (during the first month) and subsequent progressive decrease (within 2-5 months after the onset of exposure to light). These changes correlated with the time-dependent fall in the blood T3, T4, and TSH levels. Simultaneously, the animals developed pathological changes in the histological structure of the thyroid gland similar to those in patients with secondary or tertiary hypothyroidism. It is concluded that hormonal and structural changes in the thyroid gland during long-term hypopinealism should be regarded as an experimental model of hypothyroidism of neuroendocrine origin.

STUDIES OF IODINE METABOLISM IN ICELAND

1964 ◽  
Vol 46 (4) ◽  
pp. 679-683 ◽  
Author(s):  
W. D. Alexander ◽  
Th. Veiger Gudmundsson ◽  
M. M. Bluhm ◽  
R. McG. Harden
Keyword(s):  
Thyroid Gland ◽  
Iodine Content ◽  
Iodine Uptake ◽  
Hormone Production ◽  
High Iodine ◽  
Iodine Level ◽  
Iodine Metabolism ◽  
Inorganic Iodine

ABSTRACT The relation between plasma inorganic iodine level, thyroid clearance and absolute iodine uptake of the thyroid gland has been studied in Iceland and compared with results obtained in Glasgow using identical methods. In Iceland the plasma inorganic iodine (PII) is higher than in Glasgow due to the high iodine content of the diet and the thyroid clearance lower. This adjustment is, however, incomplete, relatively high PII levels being associated with a low thyroid clearance and a raised absolute uptake by the thyroid. There was no evidence of increased hormone production as reflected in the serum PBI.

THE ROLE OF PROLACTIN IN THE SLOUGHING CYCLE OF THE LIZARD, GEKKO GECKO L.

1971 ◽  
Vol 49 (4) ◽  
pp. 625-634 ◽  
Author(s):  
K. W. CHIU ◽  
J. G. PHILLIPS
Keyword(s):  
Thyroid Gland ◽  
Histological Structure ◽  
Gekko Gecko

SUMMARY Prolactin injected into hypophysectomized geckos restored the length of the sloughing cycle to normal (about 35 days) when given in doses of 0·26 i.u./g body wt on alternate days. When the doses of prolactin were increased to 0·4 i.u. the length of the sloughing cycle was reduced to about 30 days. Prolactin given to thyroidectomized geckos shortened the length of the sloughing cycle to about 28 days when administered in doses of 0·4 i.u./g on alternate days. Prolactin probably acts directly on the epidermis and not through the thyroid gland, since prolactin restored sloughing in thyroidectomized animals. Moreover, prolactin had no effect on the activity of the thyroid gland in the hypophysectomized animals as judged by the percentage uptake of 131I or the histological structure. Prolactin in doses of 0·4 i.u./g on alternate days reduced the length of the resting phase of the sloughing cycle; the renewal phase remained unaltered.

The thyroidal response to chronic goitrogenic stimulation and the persistence of effects of early goitrogenic stimulation

1976 ◽  
Vol 54 (4) ◽  
pp. 583-589 ◽  
Author(s):  
Peter Leung ◽  
B. E. March
Keyword(s):  
Thyroid Gland ◽  
Coupling Efficiency ◽  
Iodine Content ◽  
Rapeseed Meal ◽  
Epithelial Tissue ◽  
Radioiodine Uptake ◽  
Growing Period ◽  
Follicle Diameter ◽  
Thyroid Glands ◽  
Production Characteristics

The effects of overstimulation of the thyroid gland induced by the feeding of rapeseed meal or thiouracil during the growing period persisted for as long as 75 weeks after withdrawal of the source of goitrogen from the diet. Thyroid weight, thyroid iodine content and radioiodine uptake were all increased in birds which had received goitrogen during the growing period. Follicle diameter was greater and the height of epithelial cells was lower than in control birds. The thyroid changes in these birds were deduced to be compensatory because production characteristics were normal and distribution of a dose of radioiodine into thyronines (T3 + T4) was similar in the birds which had received goitrogen during the growing period and in the control birds. Birds which were being fed rapeseed meal at the time the thyroid glands were examined showed effects which varied in magnitude according to the length of time over which rapeseed meal had been fed. Thyroid weight, follicle diameter, amount of epithelial tissue present and the total amount of iodine in the thyroid glands increased, whereas coupling efficiency (radioiodine-labelled T3 + T4)/(monoiodotyrosine/diiodotyrosine) declined with time.

THE RELATION BETWEEN THE STAINING PROPERTIES OF THE THYROIDAL COLLOID AND ITS IODINE CONTENT

1962 ◽  
Vol 40 (1) ◽  
pp. 227-236 ◽  
Author(s):  
A. DesMarais ◽  
Q. N. LaHam
Keyword(s):  
Amino Acids ◽  
Thyroid Gland ◽  
Epithelial Cell ◽  
Connective Tissue ◽  
Iodine Content ◽  
Staining Technique ◽  
Biologically Active ◽  
Aniline Blue ◽  
Cell Height ◽  
Orange G

A new staining technique has been developed for the thyroid gland involving the use of two components of the Mallory connective tissue stain, aniline blue and orange G in reversed proportions.Various indices such as incorporation of radioiodine, epithelial cell height, and number of blue and yellow staining follicles and total number of follicles have been used to test the validity of the color reaction in the colloid. The comparison of these diverse indices strongly suggests that the colloid material which stains with aniline blue corresponds to iodinated thyroglobulin, while the yellow staining material appears to be devoid of biologically active iodinated amino acids.

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