The Role of the Amadori Product in the Complications of Diabetes

2008 ◽  
Vol 1126 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Vincent M. Monnier ◽  
David R. Sell ◽  
Zhenyu Dai ◽  
Ina Nemet ◽  
Francois Collard ◽  
...  
Keyword(s):  
Complications Of Diabetes ◽  
Amadori Product

Surgical Therapy in Diabetic Macular Edema and Diabetic Intravitreal Hemorrhage

2018 ◽  
pp. 194-201
Keyword(s):  
Risk Factors ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Surgical Therapy ◽  
Current Literature ◽  
Preventive Measures ◽  
Timing Of Surgery ◽  
Intravitreal Injections ◽  
Complications Of Diabetes

Diabetic macular edema and diabetic intravitreal hemorrhage are frequent complications of diabetes. In selected cases of diabetic macular edema which is primarily treated with intravitreal injections, surgery may be performed. In this review, the role of surgery in diabetic macular edema will be discussed in light of the current literature. Moreover, changes in the timing of surgery in diabetic intravitreal hemorrhage since DRVS and risk factors and the efficacy of preventive measures for post vitrectomy intravitreal hemorrhage will be discussed.

scholarly journals Potential Role of Metal Chelation to Prevent the Cardiovascular Complications of Diabetes

2019 ◽  
Vol 104 (7) ◽  
pp. 2931-2941
Author(s):  
Rossana Calderon Moreno ◽  
Ana Navas-Acien ◽  
Esteban Escolar ◽  
David M Nathan ◽  
Jonathan Newman ◽  
...  
Keyword(s):  
Potential Role ◽  
Cardiovascular Complications ◽  
Metal Chelation ◽  
Complications Of Diabetes

scholarly journals The Role of Endothelial Microparticle in Coronary Heart Disease as The Complications of Diabetes Mellitus

2019 ◽  
Vol 4 (1) ◽  
pp. 31-39
Author(s):  
Eka Fithra Elfi ◽  
Yose Ramda Ilhami ◽  
Eryati Darwin
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Endothelial Dysfunction ◽  
Cell Activation ◽  
Inflammatory Factors ◽  
Endothelial Cell Activation ◽  
Complications Of Diabetes

  Coronary heart disease (CHD) is caused by obstruction of coronary blood flow due to endothelial dysfunction triggered by various genetic and non-genetic risk factors such as hyperlipidemia, hypertension, hyperglycemia and obesity. Endothelial cell activation due to hyperglycaemia in diabetes mellitus induces production of pro-inflammatory factors that damage the cell membrane triggering the formation of membrane particles called microparticles. Endothe-lial microparticles contain proteins including endothelial nitric oxide synthase (eNOS) which plays a role in the production of nitric oxide (NO). To determine the role of microparticles in the occurrence of coro-nary heart disease in diabetes mellitus due to endothelial dysfunction, a study was conducted by comparing the levels of eNOS and NO in DM patients who had CHD with DM patients who had no CHD. Blood samples from 20 DM patients who had CHD and 20 DM patients who had no CHD of the outpatients in Cardiology Department and Inter-nal Medicine department of regional public hospital were included in this study. All patients were fulfilled inclusion and exclusion criteria and diagnosed by the appropriate specialist. The eNOS and NO lev-els were measured using the ELISA method. The results of this study show that eNOS levels in the group of DM patients who had CHD (21,292±12,415 ng/ml) were significantly lower (p <0.05) than those in the group of DM patients who had no CHD (29,721±11,952 ng/ml). Nitric oxide levels in DM patients who had CHD (0,053±0,021 nmol/ μl) were not statistically different to the levels in DM patients who had no CHD (0,047±0,032 nmol/μl). From the results of this study we concluded that endothelial microparticle protein eNOS plays a role in the occurrence of CHD due to the complications of diabetes mellitus 

Prevention and management of type II diabetes chronic complications: the role of polyphenols (Mini-Review)

2021 ◽  
Vol 28 ◽  
Author(s):  
Arianna Pani ◽  
Francesco Baratta ◽  
Daniele Pastori ◽  
Mattia Coronati ◽  
Francesco Scaglione ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Damage ◽  
Chronic Complications ◽  
Complications Of Diabetes ◽  
Search Terms ◽  
Prevention And Treatment ◽  
Constant State ◽  
Treatment Of Diabetes ◽  
Ischemic Events

: The numerous complications of diabetes may be at least in part generated by the oxidative stress associated with the constant state of hyperglycemia. Polyphenols are plant based secondary metabolites that have high potentials in the prevention and treatment of some diseases, in particular those that involve oxidative stress, such as complications of diabetes. The purpose of this narrative review is to show the main evidence regarding the role of polyphenols in treating and preventing these complications. For the bibliographic research, the papers published up to March 15, 2021 were considered and the search terms included words relating to polyphenols, their classes and some more known compounds, in association with the complications of diabetes. There are numerous studies showing how polyphenols are active against endothelial damage induced by diabetes, oxidative stress and hyperinflammatory states that are at the origin of the complications of diabetes. Compounds such as flavonoids, but also anthocyanins, stilbenes or lignans slow the progression of kidney damage, prevent ischemic events and diabetic nephropathy. Many of these studies are preclinical, in cellular or animal models. The role of polyphenols in the prevention and treatment of diabetes complications is undoubtedly promising. However, more clinical trials need to be implemented to understand the real effectiveness of these compounds.

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