Intraductal carcinoma of the breast: results of treatment with excisional biopsy and irradiation.

1985 ◽  
Vol 3 (10) ◽  
pp. 1339-1343 ◽  
Author(s):  
A Recht ◽  
B S Danoff ◽  
L J Solin ◽  
S Schnitt ◽  
J Connolly ◽  
...  
Keyword(s):  
Nipple Discharge ◽  
Distant Metastases ◽  
Excisional Biopsy ◽  
Intraductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Palpable Mass ◽  
Results Of Treatment ◽  
Number Of Patients ◽  
Boost Dose

Between 1976 and 1983, 40 women with intraductal carcinoma of the breast without invasion underwent excisional biopsy and irradiation as an alternative to mastectomy. The median age was 53 years (range, 28 to 77 years) and the median follow-up time since initiation of radiation was 44 months (range, 14 to 97 months). Twenty-seven patients presented with a palpable mass; in 13 patients the tumor was detected only by mammography. A limited axillary dissection was performed in 13 patients, and all lymph nodes removed were negative. Treatment was administered to the breast and adjacent chest wall to a dose of 4,600 to 5,000 rad, with 26 patients also receiving a boost dose of 1,000 to 2,000 rad to the site of the primary. Four patients have developed a recurrence in the treated breast, at 17, 19, 35, and 63 months after the beginning of radiation therapy. The 5-year actuarial rate of local recurrence is 10%. Three of the recurrences were in those four patients who presented with a nipple discharge and a central primary. In two cases, the recurrence consisted of only intraductal carcinoma; in the other two, both intraductal and invasive cancer were found. All four patients with recurrence underwent mastectomy and are well without evidence of distant metastases at 1, 12, 15, and 15 months since mastectomy. Cosmetic results were excellent. No patient has developed distant metastases. Since the number of patients treated is small and the period of follow-up is short, one must be cautious in the interpretation of these results. Nonetheless, the treatment of intraductal carcinoma of the breast by excision and irradiation appears to give acceptable local control and excellent survival when suitable precautions of patient selection and evaluation are taken.

Intraductal carcinoma of the breast: Results of treatment with excisional biopsy and irradiation

1984 ◽  
Vol 10 ◽  
pp. 139-140
Author(s):  
Robert L. Goodman ◽  
Barbara F. Danoff ◽  
Abram Recht ◽  
Itzhak D. Goldberg ◽  
Leslie Botnick ◽  
...  
Keyword(s):  
Excisional Biopsy ◽  
Intraductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Results Of Treatment

scholarly journals LAPAROSCOPIC ADRENALECTOMY IN SURGICAL TREATMENT OF ADRENANOCORTICAL CARCINOMA

2019 ◽  
Vol 21 (1) ◽  
pp. 75-78
Author(s):  
A V Krivosheev ◽  
T A Britvin ◽  
M E Beloshitsky
Keyword(s):  
Surgical Treatment ◽  
Laparoscopic Adrenalectomy ◽  
Distant Metastases ◽  
Long Term Results ◽  
R0 Resection ◽  
Morphological Examination ◽  
Number Of Patients ◽  
Immunohistochemical Studies

Relevance of research: аdrenalectomy remains the only method of potentially radical treatment of adrenocortical carcinoma (AСС), and the complete resection is considered one of the leading factors in the prognosis of disease. The question of the possibility and feasibility of using video- endoscopic technologies in the treatment of patients with ACC is still being discussed. Objective: the purpose of our study was to evaluate the effectiveness of laparoscopic adrenalectomy in the treatment of ACC patients. Material and methods: the study is based on the analysis of the results of diagnostics and surgical treatment of 12 patients who underwent laparoscopic adrenalectomy and verified ACC during histological and immunohistochemical studies. Results: stage I were verified (according to the ENSAT) in 4 cases, in 4 - II stage, and in 4 - III stage. The median of tumor size was 4.9 cm. Intraoperative and postoperative complications did not occur. In all cases, the R0-resection was confirmed by morphological examination. The median patient follow-up was 71 months (1; 141), during this period 11 patients were alive, 1 patient, who had surgery in stage III died of disease progression (distant metastases) 49 months after surgery. During the follow-up period tumor recurrence did not occur. Overall 5-year survival was 75% (95% CI; 30-95%). Conclusion: despite the small number of patients included in this study, satisfactory immediate results (absence of complications, R0-resection) and long-term results allow us to consider video- endoscopic surgery as an effective treatment for patients with ACC.

Breast cancer in male veterans: A retrospective chart review.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e12531-e12531
Author(s):  
Anita Aggarwal ◽  
Min-Ling L Liu ◽  
Nihar Kiritkumar Patel ◽  
Rebecca Evangelista ◽  
Steven Krasnow
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Nipple Discharge ◽  
Agent Orange ◽  
Clinicopathologic Characteristics ◽  
Palpable Mass ◽  
Bloody Nipple Discharge ◽  
Male Veterans ◽  
Male Patients

e12531 Background: Male breast cancer (BCA) is rare and makes up < 1% of all of breast cancer cases. Treatment is mainly based on what is known from female BCA and survival is similar between genders. Objectives: To investigate the clinicopathologic characteristics of BCA and overall survival in male veterans. Methods: Medical records of male patients diagnosed with breast cancer at the Veterans Affairs Medical Centers of Washington DC, Baltimore and Martinsburg from 1992-2012 were reviewed after Institutional Review Board approval. Results: From 1995-2012, 51 male patients with BCA were identified from cancer registry. 29/51(57%) were African American (AA), 41% Caucasian (WM), and 2% other race. Median age was 70 years (44-86years). Palpable mass was presenting symptom in 41/51(80%) and 8(16%) had gynecomastia or bloody nipple discharge. Family history of breast cancer was positive in 11 patients without mention of BRCA genes except pt #24 who was BRCA2+. 3 patients were exposed to Agent Orange. ER/PR was positive in 36(71%), ER+/PR- in 1(2%), ER+/PR+/HER2+ in 2(4%), ER-/PR-/HER- in 2(4%). 41% & 57% had right and left BCA, respectively. 40 (80%) underwent mastectomy. 18(36%) had lymph node involvement (1-13 LN). 90% had invasive ductal carcinoma (IDC), 8% DCIS, and 2% sarcoma. Cancer in 26% was stage I, 38% stage II, 18% stage III and 8% stage IV. 12(24%) received combination chemotherapy. 33(66%) were given tamoxifen. 4(8%) patients had relapsed/recurrent disease in 1-5 years of their diagnosis and died within 2-12 years after the relapse. At median follow up of 174m (4m-19years), 28(56%) patients died (cause of death not known in all), 21(42%) alive and 3(6%) lost to follow up. Conclusions: Median age at diagnosis of BCA seems to be higher in males (70 years) as compared to historical female age (60 years). IDC is the main pathology and 73% tumors were ER +. Survival rate is approximately 40% at >10years of follow up. Survival by stage revealed no difference.

scholarly journals Alveolar soft part sarcoma of the orbit, a case report of a rare tumor

2017 ◽  
Vol 9 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Ángel Nava-Castañeda ◽  
José Luis Tovilla-Canales ◽  
Francisca Zuazo ◽  
Lourdes Rodríguez-Cabrera ◽  
Lilia Garnica-Hayashi
Keyword(s):  
Malignant Tumor ◽  
Soft Part ◽  
Extended Period ◽  
Distant Metastases ◽  
Excisional Biopsy ◽  
Lower Eyelid ◽  
Soft Tissue Tumors ◽  
Alveolar Soft Part Sarcoma ◽  
The Right

Background: Alveolar Soft Part Sarcoma is a rare malignant tumor of uncertain histogenesis, representing 0.5-1% of all soft tissue tumors. It occurs predominantly in head and neck regions, especially the orbit and the tongue, in infants, causing no specific symptoms for an extended period of time. Case: A four year old girl was brought to consultation because of persistent swelling of her left upper and lower eyelid for the past six months. A 4 mm proptosis was noted on her left eye with significant upwards displacement of the globe. A firm, not pulsating and non tender mass was palpated, and motility examination revealed deficient abduction and infraduction. Visual acuity was 20/40 and 1/200 in the right and left eye, respectively. The computed tomography revealed an extraconal mass on the inferotemporal aspect of the left orbit, with no bony erosion or globe invasion. An excisional biopsy was made, finding a tumor with nests of clusters of large polygonal cells, separated by fibrous septa and a sinusoidal vascular channel. An Alveolar Soft Part Sarcoma was diagnosed. Our patient had a favorable post-operative follow up, and oncologic evaluations have not shown metastasis or local recurrences. Observations and Conclusions: Alveolar Soft Part Sarcoma is a rare malignant tumor of indolent course, but with propensity to distant metastases, making early diagnose and long term follow up necessary. 

scholarly journals Conjunctival Leiomyosarcoma, a Rare Neoplasm Always Originating at the Limbus? Report of a New Case and Review of 11 Published Cases

2019 ◽  
Vol 5 (5) ◽  
pp. 333-339 ◽  
Author(s):  
V. De Groot ◽  
E. Verhelst ◽  
P.C.W. Hogendoorn ◽  
R.J.W. de Keizer
Keyword(s):  
Adjuvant Radiotherapy ◽  
Myogenic Differentiation ◽  
Distant Metastases ◽  
Excisional Biopsy ◽  
Complete Resection ◽  
Favorable Prognosis ◽  
Strontium 90 ◽  
Malignant Mesenchymal Tumor ◽  
Histopathological Investigation

Purpose of the Study: To describe the differential diagnosis and management of a rare conjunctival malignancy. Procedures: A 79-year-old man presented with a conjunctival mass at the limbus. Excisional biopsy revealed a malignant mesenchymal tumor with myogenic differentiation. Six months later, three suspect lesions developed at the border of the previous excision. Pathological diagnosis pointed to a leiomyosarcoma. Adjuvant radiotherapy with strontium-90 brachytherapy was applied. After 3 years, there was neither recurrence nor distant metastases. A literature review revealed 11 cases of conjunctival leiomyosarcoma. Results: All 12 cases seemed to originate at the limbal conjunctiva. Scleral invasion was found only in one patient with multiple previous resections. Corneal invasion was reported in two patients. Four patients had a globe-sparing resection. In two of them, margins were not tumor free and additional brachytherapy gave a tumor-free follow-up of 1 and 3 years. Four cases underwent an exenteration. Conclusion and Message: Primary conjunctival leiomyosarcoma is a rare tumor with a favorable prognosis due to early detection and consequently limited size. Diagnosis involves histopathological investigation including immunohistochemistry. If possible, complete resection has the best prognosis. Adjunctive radiotherapy can be effective when the margins are not free and should be considered.

Pseudoangiomatous Stromal Hyperplasia on Core Needle Biopsy Does Not Require Surgical Excision

2016 ◽  
Vol 82 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Adam Protos ◽  
Kim T. Nguyen ◽  
Jamie L. Caughran ◽  
Michael Naski ◽  
Jessica L. Keto
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Group Versus ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Data Set ◽  
Palpable Mass ◽  
Core Needle ◽  
Pseudoangiomatous Stromal Hyperplasia

Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon, benign localized fibrotic lesion. Historically, PASH has been difficult to differentiate from angiosarcoma. This difficulty has led to recommendations of surgical excision. We sought to identify the incidence of upgraded pathology to atypia or malignancy on surgical excisional biopsy after identification of PASH on core needle biopsy (CNB). A 5-year retrospective review at a single institution was conducted including all cases of PASH confirmed on CNB. The data set was divided into patients who underwent excisional biopsy and those followed only by imaging. Primary end points included the incidence of subsequent malignancy or high-risk pathology on histologic analysis or the presentation of suspicious imaging. Thirty-seven patients were reviewed, 19 (51.4%) underwent surgical excision and 18 (48.6%) were followed with imaging alone. A palpable mass was noted in 36.8 per cent of patients in the excisional group versus 5.6 per cent in the imaging group ( P = 0.02). The median follow-up for the excisional and imaging groups were 43 and 35 months, respectively ( P = 0.85). The 95 per cent confidence interval for the presence of malignancy was 0 to 9.4 per cent. Although further characterization of PASH is needed, our data support using CNB with follow-up imaging as a safe alternative to excisional biopsy in the absence of symptoms or other clinical factors. However, further research in this area is needed.

scholarly journals Experience in creation of database (registry) of patients with posttraumatic cicatrical biliary strictures. First results

2021 ◽  
Vol 26 (4) ◽  
pp. 105-113
Author(s):  
Yu. V. Kulezneva ◽  
L. I. Kurmanseitova ◽  
I. V. Patrushev ◽  
M. G. Efanov ◽  
V. V. Tsvirkun ◽  
...  
Keyword(s):  
Long Term Results ◽  
Biliary Strictures ◽  
Results Of Treatment ◽  
Number Of Patients ◽  
Treatment Data ◽  
First Results ◽  
Post Traumatic ◽  
Cis Countries

Aim. To demonstrate the first results of the work on database created to assess long-term results of treatment of patients with posttraumatic biliary strictures and to develop a unified approach to the management of these patients.Materials and methods. “The register of patients with post-traumatic strictures of the bile ducts in Russia and the CIS countries” was created in 2016. It is a software for a computer that provides the opportunity for detailed registration and data analysis of a large number of patients.Results. From 2016 to 2021, the data of 132 patients were entered into the register. Long-term results were traced in 49 (60.5%) patients with the minimum and maximum follow-up periods of 3 and 44 months.Conclusion. The first registry results demonstrate its capabilities in generalization and analysis of treatment data for the patients with cicatrical posttraumatic biliary strictures. It also showed the necessity for wider participation of different specialists in work of database.

scholarly journals Clinical and laboratory characteristics and results of treatment of patients with ACTH-producing neuroendocrine tumors of various localization

2021 ◽  
Vol 93 (10) ◽  
pp. 1171-1178
Author(s):  
Olga O. Golounina ◽  
Zhanna E. Belaya ◽  
Liudmila Ya. Rozhinskaya ◽  
Evgeniya I. Marova ◽  
Michail Yu. Pikunov ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Fatal Outcome ◽  
Distant Metastases ◽  
Multiple Organ ◽  
Ectopic Acth Syndrome ◽  
Ectopic Acth ◽  
Results Of Treatment ◽  
Single Center Study ◽  
Pancreatic Net

Aim. To study the clinical, biochemical characteristics, treatment results and follow-up of patients with ectopic ACTH syndrome EAS (ACTH adrenocorticotropic hormone ). Materials and methods. A retrospective, observational, single-center study of 130 patients with EAS. Demographic information of patients, medical history, results of laboratory and instrumental investigations at the pre- and postoperative stages and follow-up of EAS were analyzed. Results. The mean age at the diagnosis ranged from 12 to 74 years (Me 40 years [28; 54]). The duration of the disease from the onset of symptoms to the verification of the diagnosis varied from 2 to 168 months (Me 17.5 months [7; 46]). Eighty-one (62,3%) patients had bronchopulmonary NET, 9 thymic carcinoid, 7 pancreatic NET, 5 pheochromocytoma, 1 cecum NET, 1 appendix carcinoid tumor, 1 medullary thyroid cancer and 25 (19.2%) had an occult source of ACTH. The median follow-up period of patients was 27 months [9.75; 61.0] with a maximum follow-up of 372 months. Currently, primary tumor was removed in 82 (63.1%) patients, bilateral adrenalectomy was performed in 23 (18%) patients, in 16 of them there was an occult source of ACTH-producing NET and in 7 patients in order to control hypercortisolism after non-successful surgical treatment. Regional and distant metastases were revealed in 25 (19.2%) patients. At the time of the last observation 59 (72%) patients were exhibited a full recovery, 12 (14.6%) had relapse of the disease and 26 (20%) died from multiple organ failure (n=18), pulmonary embolism (n=4), surgical complications (n=2), disseminated intravascular coagulation syndrome (n=1) or COVID-19 (n=1). Conclusion. In our cohort of patients bronchopulmonary NET are the most frequent cause of EAS (62.3%). Surgical treatment leads to remission of hypercortisolism in 72% cases; the proportion of relapse (14.6%) and fatal outcome (20%) remains frequent in EAS.

scholarly journals Quantitative detection of peripheral thyroglobulin mRNA has limited clinical value in the follow-up of thyroid cancer patients

2003 ◽  
Vol 40 (1) ◽  
pp. 94-99 ◽  
Author(s):  
P.N. Span ◽  
M.J.M. Sleegers ◽  
W.J. van den Broek ◽  
H.A. Ross ◽  
W-A. Nieuwlaat ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Distant Metastases ◽  
Whole Body ◽  
Quantitative Detection ◽  
Rt Pcr ◽  
Clinical Value ◽  
Serum Thyroglobulin ◽  
Number Of Patients ◽  
Periodic Monitoring

Background: As recurrences after treatment for differentiated thyroid cancer can occur many years after thyroidectomy, periodic monitoring of serum thyroglobulin (Tg) levels is performed in these patients. However, autoantibodies that can interfere with Tg immunoassays occur in the blood of approximately 25% of these patients. Several earlier reports suggest that measuring Tg mRNA by reverse-transcriptase polymerase chain reaction (RT-PCR) could be of value, especially in patients with Tg autoantibodies. Methods: Using an earlier described, real-time quantitative Taqman RT-PCR assay, Tg mRNA concentrations were assessed in peripheral blood taken from 58 patients treated for thyroid cancer and from two healthy controls. Results: In all tested samples Tg mRNA could be found. No correlation between serum Tg protein and Tg mRNA could be found. Tg mRNA concentrations did not differ between serum Tg-negative and Tg-positive patients. No differences in the number of patients with high or low Tg/ β-actin ratios were found between the groups of patients without, 131I uptake on whole-body scan, or patients with thyroid bed uptake, uptake elsewhere in the neck, or distant metastases with or without regional uptake ( P = 0·871). Conclusions: We were not able to confirm earlier positive reports on the clinical value of Tg mRNA measurement for the monitoring of patients treated for thyroid cancer.

scholarly journals Intraductal carcinoma of the breast: Follow-up after biopsy only

Cancer ◽  
1982 ◽  
Vol 49 (4) ◽  
pp. 751-758 ◽  
Author(s):  
David L. Page ◽  
William D. Dupont ◽  
Lowell W. Rogers ◽  
Marie Landenberger
Keyword(s):  
Intraductal Carcinoma ◽  
Carcinoma Of The Breast
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