Tamoxifen and bone metabolism in postmenopausal low-risk breast cancer patients: a randomized study.

PURPOSE This trial was undertaken to evaluate the effect of adjuvant tamoxifen on bone metabolism in postmenopausal women undergoing surgery for low-risk breast cancer. PATIENTS AND METHODS In an open trial, 25 women were randomized to receive tamoxifen 30 mg/d for 2 years, and 25 women constituted the control group. Twenty women treated with tamoxifen and 23 women in the control group provided data for the analysis. Inclusion criteria were operation for low-risk breast cancer and cessation of menstruations for more than 1 year. Exclusion criteria were presence of metastases, disorders of bone metabolism, contraindications against tamoxifen, use of drugs with influence on bone metabolism, ailments that made bone mineral measurements impossible, and age greater than 65 years. Repeated measurements of bone mineral density and content at the lumbar spine and forearms, serum alkaline phosphatase, phosphate, and ionized calcium were performed in all patients. RESULTS Lumbar spine bone mineral density increased during the first year in women treated with tamoxifen and then stabilized, compared with decreased bone mineral density in the control group (P = .00074). Bone mineral content at the forearms remained almost stable in tamoxifen-treated women compared with a decrease in the control group (P = .024). Serum alkaline phosphatase, phosphate, and ionized calcium decreased in the tamoxifen group (P < .00001, P = .002, and P = .002, respectively). CONCLUSION Tamoxifen has estrogen-like effects on bone metabolism that result in an increase and stabilization of bone mineral density in the axial skeleton and a stabilization of bone mineral content in the appendicular skeleton.

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Effects of One-Year Adjuvant Treatment with Tamoxifen on Bone Mineral Density in Postmenopausal Breast Cancer Women

Tumori Journal ◽

10.1177/030089169608200114 ◽

1996 ◽

Vol 82 (1) ◽

pp. 65-67 ◽

Cited By ~ 10

Author(s):

Sandro Barni ◽

Paolo Lissoni ◽

Gabriele Tancini ◽

Antonio Ardizzoia ◽

Marina Cazzaniga

Keyword(s):

Breast Cancer ◽

Bone Mineral Density ◽

Alkaline Phosphatase ◽

Bone Mineral Content ◽

Bone Mineral ◽

Adjuvant Treatment ◽

Mineral Content ◽

Postmenopausal Breast Cancer ◽

Mineral Density ◽

One Year

In this study, the authors have analyzed the possible effects of one-year adjuvant treatment with tamoxifen on bone mineral density in postmenopausal breast cancer women. Bone mineral content was studied by photon absorptiometry (I-125), whereas bone balance was analyzed indirectly by serum PTH, osteocalcin, calcitonin, calcium and alkaline phosphatase levels. Bone mineral content and serum bone-related substances were measured before starting treatment and after one year. Results were analyzed using Student's t test for paired data. No difference was found between the two measurements for bone mineral content, PTH, calcitonin, calcium and alkaline phosphatase levels. Measurements at entry and after one year of treatment showed a statistically significant difference ( P < 0.001) only for osteocalcin. In accordance with other authors, we can conclude that treatment with tamoxifen does not cause an increase in menopausal bone resorption. The finding that osteocalcin levels decreased after one year of therapy with tamoxifen is interesting, but further studies are necessary to clarify the role of such levels in predicting a turnover of bone balance towards osteoblastic activity.

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Abstract P615: Stress-Induced Changes in Total Bone Mineral Content and Total Bone Mineral Density due to Activation of the Renin-Angiotensin-Aldosterone System in Adolescent Females

Hypertension ◽

10.1161/hyp.68.suppl_1.p615 ◽

2016 ◽

Vol 68 (suppl_1) ◽

Author(s):

Vishwajeeth Pasham ◽

Deborah Stewart ◽

Laura Carbone ◽

Gregory A Harshfield

Keyword(s):

Bone Mineral Density ◽

Bone Mineral Content ◽

Bone Metabolism ◽

Bone Mineral ◽

Mineral Content ◽

Mineral Density ◽

Renin Angiotensin Aldosterone System ◽

Total Bone Mineral Density ◽

Total Bone Mineral Content ◽

The Relationship

Background: Previous literature has shown a strong negative effect of angiotensin II (ANGII) on bone metabolism within mouse models. Additionally, psychological stress has been associated with activation of the renin-angiotensin-aldosterone system (RAAS). Stress has also been related to lower total bone mineral density (TBMD). However, there is controversy in the literature examining the relationship between the RAAS and bone metabolism within humans and stress has not been considered as a direct link between these systems. Purpose: We aimed to examine the relationship between stress-induced RAAS activation and TBMD and total bone mineral content (TBMC). Methods: Participants were placed on a sodium controlled diet for three days. Participants then underwent two hours rest, one hour mental stressor, and two hours recovery with hourly collections of blood/urine samples. Renin, ANGII, aldosterone, TBMD and TBMC were measured. Results: This study recruited 586 adolescents (mean age 16±1.116) with 51% women and 62% African-American and 38% Caucasian. Overall, relationships were observed between ANGII and aldosterone, and TBMC and TBMD controlling for age, race, and BMI. During stress, aldosterone was related to TBMD (r=-.150, p<0.05) and ANGII was related to TBMC (r=-.156, p<0.05) and TBMD (r=-.139, p<0.05). When comparing males and females, only females demonstrated a relationship between TBMC and ANGII in response to stress (stress: r=-.229, p<0.05; post-stress: r=-.277, p<0.01) and between aldosterone and TBMC (stress: r=-.199, p<0.05) and TBMD (stress: r=-.250, p<0.01). Renin was not significantly correlated with TBMD nor TBMC in any population. Conclusion/Interpretations: These data suggest that stress-induced RAAS activation may be associated with lower TBMD and TBMC in girls. Despite small correlations, consistency across multiple measures of RAAS activation being apparent in adolescents is significant. This observation may indicate that stress activation of RAAS contributes to bone remodeling in early life.

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309 Effects of dietary supplying icariin on the bone metabolism and the laying performance in caged laying hens

Journal of Animal Science ◽

10.1093/jas/skz258.020 ◽

2019 ◽

Vol 97 (Supplement_3) ◽

pp. 11-11

Author(s):

Jie Huang ◽

Lei Zhang ◽

Zhongxin Zhou

Keyword(s):

Bone Mineral Density ◽

Bone Metabolism ◽

Bone Mineral ◽

Laying Hens ◽

Egg Quality ◽

Control Group ◽

Tartrate Resistant Acid Phosphatase ◽

Mineral Density ◽

Laying Performance ◽

Serum Biochemical

Abstract Icariin, a flavonol glycoside, is one of major active ingredients of the traditional Chinese medicine Herba epimedii. Icariin has been reported to successfully treat the osteoporosis of the rat. However, effects of icariin on the osteoporosis in caged laying hens are still unkown. This study present the effects of dietary icariin supplementation on the laying performance, the egg quality and the bone metabolism in caged laying hens. A total of 216 Lohmann pink-shell laying hens of 54-week-old from a commercial farm in the Hubei province of China were randomly assigned to 3 treatment groups with 6 replications per group and 12 birds per replication. The control group was fed a corn-soybean meal basal diet, and the experimental groups were fed basal diets supplemented with 500 and 2000 mg/kg icariin for 90 d. Layer performance responses, egg quality parameters, the bone mineral density and serum biochemical indicators were measured at the end of the experiment. Results showed that feed/egg ratio decreased as the supplied icariin level increased. The laying rate and the average egg weight were increased compared to the control group. However, no significant effect was observed on the egg quality. The bone mineral density of the tibia was measured by the dual-energy X-ray absorptiometry, indicating that icariin can increase the bone mineral density. Serum biochemical analysis showed that icariin decreased the level of alkaline phosphatase, tartrate-resistant acid phosphatase, osteocalcin and calcitonin. Our observations provided evidences that dietary supplementation of icariin increased the bone mineral density and improved the laying performance, and icariin can be used for the prevention of the osteoporosis in caged laying hens.

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Комплексная оценка минерально-костных нарушений у женщин с оксалатной нефропатией в постменопаузе

Dalʹnevostočnyj medicinskij žurnal ◽

10.35177/1994-5191-2020-2-5-10 ◽

2020 ◽

pp. 5-10

Keyword(s):

Bone Mineral Density ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Bone Metabolism ◽

Bone Mineral ◽

Calcium Metabolism ◽

Control Group ◽

Mineral Density ◽

High Level ◽

Oxalate Nephropathy

A study was made of phosphorus-calcium metabolism, markers of bone metabolism, bone mineral density in 142 women in the early postmenopausal period, the patients with oxalate nephropathy at stage 2 of chronic kidney disease. It is proved that patients have signs of secondary hyperparathyroidism (hypocalcemia, hypercalciuria, increased parathyroid hormone) and a deﬁciency of 25 (OH) D3. Violation of bone metabolism is conﬁrmed by a high level of β-Cross Laps and a decrease in bone mineral density. The probability of a 10-year risk of developing osteoporetic fractures in patients using the FRAX calculator is two times higher than in the control group. The conclusion was made that patients with oxalate nephropathy have a high risk of developing osteoporosis already in the early stages of chronic kidney disease.

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Effect of regular resistance exercise, vitamin D, and calcium supplements on the bone mineral content and density in postmenopausal model of rats: An experimental study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v19i1.8181 ◽

2021 ◽

Author(s):

Homa Hajisadeghi ◽

Mohammad Ali Azarbayjani ◽

Mohammadreza Vafaeenasab ◽

Maghsoud Peeri ◽

Mohamad Mahdi Modares Mosala

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Resistance Exercise ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Control Group ◽

Bone Thickness ◽

Mineral Density ◽

Calcium Supplements

Background: Postmenopausal osteoporosis progressively occurs due to alteration in the estrogen level during the menopause period, and subsequently elevates the risk of fractures. Objective: To evaluate the effect of regular resistance exercise, vitamin D, and calcium supplements on bone mineral content and density, postmenopausal rats used. Materials and Methods: In this experimental study, 72 female Sprague-Dawley rats (8-10 wk: 250 ± 15 gr) were ovariectomized and randomly divided into nine groups (n = 8/each): control, placebo, exercise (EX), exercise with vitamin D supplement (EX + D), exercise with calcium (EX + Ca), exercise with calcium and vitamin D (EX + Ca + D), vitamin D administration (D), calcium administration (Ca), and calcium and vitamin D (Ca + D) groups. Finally, the tail, hip, and lumbar bone mineral content, bone mineral density, bone thickness, and bone cells were evaluated in each group. Results: The tail, hip, and lumbar bone mineral density was increased significantly in the EX + Vit D group compared to the control group (p = 0.004, p = 0.007, p = 0.003, respectively). However, there were no significant changes in the bone mineral content of the hips and lumbar among the groups. Besides, bone thickness in the Ex + Vit D group was more than the other groups (p = 0.02). The number of osteoclast cells decreased in the Ca + Vit D, Ex + Ca, Ex + Vit D, and Ex + Vit D + Ca groups compared to the control group. Osteocyte numbers were increased only in the Ex + Vit D group. Conclusion: Resistance exercise in combination with vitamin D and calcium have a positive effect on the bone mineral density and bone mineral content and might be able to prevent or delay the osteoporosis among elderly women. However, additional researches are needed to assess the molecular pathways of this process. Key words: Menopause, Vitamin D, Exercise, Calcium, Bone mineral density.

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Assessment of Low Bone Mineral Density in Untreated Patients with Takayasu’s Arteritis

BioMed Research International ◽

10.1155/2021/6489631 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Lingfei Mo ◽

Jing Wang ◽

BoMiao Ju ◽

Yanhua Wang ◽

Jing Luo ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Loss ◽

Bone Metabolism ◽

Bone Mineral ◽

Takayasu’S Arteritis ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Control Group ◽

Mineral Density ◽

Low Bone Mineral Density

Chronic inflammation affects bone metabolism and accelerates bone loss. This study is aimed at analyzing the prevalence of low bone mineral density (LBMD) in patients with untreated Takayasu’s arteritis (TA) and risk factors. Forty untreated TA patients were enrolled, including 38 premenopausal women and 2 men before 50 years old. The control group included 60 age- and gender-matched healthy persons. Bone mineral density (BMD) of lumbar vertebrae and hip in patients with TA and the control group was measured by the dual-energy X-ray method. Serum 25OHD and β-CTX were also measured. The lumbar BMD of TA patients ( 0.89 ± 0.11 g/cm2) was significantly lower than that of the healthy control ( 0.97 ± 0.11 g/cm2). The prevalence of LBMD at the lumbar spine (17.50%) was significantly higher than that of the control group (3.33%). However, there was no significant difference at the hip. The 25OHD of TA patients was lower than that of healthy controls, while the level of β-CTX was higher. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in patients with LBMD were higher than those in patients with normal BMD. According to univariate correlation analysis, there was a significant negative correlation between LDL-C and lumbar BMD. Binary logistic regression analysis showed that LDL-C was an important factor affecting the occurrence of LBMD in patients with TA ( OR = 25.269 , P = 0.02 ). Our result reveals bone loss in TA patients, which hints the relationship among inflammation, lipid metabolism, and bone metabolism.

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Effect of hypercortisolism on bone mineral density and bone metabolism: A potential protective effect of adrenocorticotropic hormone in patients with Cushing’s disease

Journal of International Medical Research ◽

10.1177/0300060517725660 ◽

2017 ◽

Vol 46 (1) ◽

pp. 492-503 ◽

Cited By ~ 9

Author(s):

Weihong Guo ◽

Fengao Li ◽

Chonggui Zhu ◽

Baoping Wang ◽

Kunling Wang ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Turnover ◽

Bone Metabolism ◽

Bone Mineral ◽

Bone Turnover Markers ◽

Adrenocorticotropic Hormone ◽

Cushing's Disease ◽

Control Group ◽

Mineral Density ◽

Turnover Markers

Objective To investigate the effects of Cushing’s disease (CD) and adrenal-dependent Cushing’s syndrome (ACS) on bone mineral density (BMD) and bone metabolism. Methods Data were retrospectively collected for 55 patients with hypercortisolism (CD, n = 34; ACS n = 21) from January 1997 to June 2014. BMD was examined in all patients, and bone turnover markers were tested in some patients. Healthy controls (n = 18) were also recruited. Results The lumbar spine and femoral neck BMD were significantly lower in the ACS and CD groups than in the control group. Lumbar BMD was significantly lower in the ACS than CD group. The collagen breakdown product (CTX) concentrations were significantly higher while the osteocalcin and procollagen type I N-terminal propeptide (PINP) concentrations were significantly lower in the ACS and CD groups than in the control group. The PINP concentration was significantly lower while the CTX concentration was significantly higher in the ACS than CD group. In the CD group only, lumbar BMD and serum adrenocorticotropic hormone had a significant positive correlation. Conclusions Bone turnover markers indicated suppressed osteoblast and enhanced osteoclast activities. PINP and CTX changes might indicate bone mass deterioration. Adrenocorticotropic hormone might be protective for lumbar BMD in patients with CD.

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Bone mineral density in patients with juvenile idiopathic arthritis

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0908396s ◽

2009 ◽

Vol 137 (7-8) ◽

pp. 396-401 ◽

Cited By ~ 1

Author(s):

Gordana Susic ◽

Nada Pilipovic ◽

Roksanda Stojanovic

Keyword(s):

Bone Mineral Density ◽

Juvenile Idiopathic Arthritis ◽

Standard Deviation ◽

Bone Metabolism ◽

Bone Mineral ◽

Control Group ◽

Z Score ◽

Mineral Density ◽

Radiological Stage ◽

Systemic Onset

Introduction. It is well known that juvenile idiopathic arthritis (JIA) as a chronic inflammatory disease with onset during the childhood, beside other complication, can lead to bone metabolism disturbance and osteoporosis. Objective. To assess bone mineral density (BMD) in children with JIA and to identify factors playing role in bone mineral disturbance. Methods. Seventy-five patients (26 male and 49 female) average disease duration 7.2 (2.4-16.8) years, and 73 age matched healthy control subjects (29 male and 44 female) participated in the study. Mean age of the groups was about 14.5 years. BMD was determined by dual x-ray absorptiometry (DEXA) of the lumbar spine (L2-L4). For further analysis we used the absolute value of BMD, expressed as g/cm2, Z score expressed as SD (relative value as standard deviation decline of normal BMD values of referent Italian population with identical age and gender), bone mineral content (BMC) as g/cm, and corrected BMD - BMDv as g/cm3. Results. Z score in the group of patients was significantly lower (-1.02?1.6) in comparison to the control group (-0.09?1.4; p<0.001). BMD, BMDv and BMC were also statistically lower in patients with JIA. The lowest Z score was found in patients with systemic onset (-2.63 SD). Z score showed a statistically significant positive correlation with arthritis course (polyarticular course had lower Z score), body mass index and standard deviation score for height and weight. Statistically significant negative correlation was detected in regard to Z score and glucocorticoid (GC) treatment duration, GC cumulative dose, number of joints with limited range of motion, radiological stage and functional class. Conclusion. The results showed a decreased BMD in patients with JIA in comparison to the control group. Systemic onset, polyarthritis, longer treatment with GC and higher cumulative dosage, as well as higher damage level (functional status and radiological stage) are factors playing negative role in bone metabolism in children with JIA.

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