scholarly journals 309 Effects of dietary supplying icariin on the bone metabolism and the laying performance in caged laying hens

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 11-11
Author(s):  
Jie Huang ◽  
Lei Zhang ◽  
Zhongxin Zhou
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Laying Hens ◽  
Egg Quality ◽  
Control Group ◽  
Tartrate Resistant Acid Phosphatase ◽  
Mineral Density ◽  
Laying Performance ◽  
Serum Biochemical

Abstract Icariin, a flavonol glycoside, is one of major active ingredients of the traditional Chinese medicine Herba epimedii. Icariin has been reported to successfully treat the osteoporosis of the rat. However, effects of icariin on the osteoporosis in caged laying hens are still unkown. This study present the effects of dietary icariin supplementation on the laying performance, the egg quality and the bone metabolism in caged laying hens. A total of 216 Lohmann pink-shell laying hens of 54-week-old from a commercial farm in the Hubei province of China were randomly assigned to 3 treatment groups with 6 replications per group and 12 birds per replication. The control group was fed a corn-soybean meal basal diet, and the experimental groups were fed basal diets supplemented with 500 and 2000 mg/kg icariin for 90 d. Layer performance responses, egg quality parameters, the bone mineral density and serum biochemical indicators were measured at the end of the experiment. Results showed that feed/egg ratio decreased as the supplied icariin level increased. The laying rate and the average egg weight were increased compared to the control group. However, no significant effect was observed on the egg quality. The bone mineral density of the tibia was measured by the dual-energy X-ray absorptiometry, indicating that icariin can increase the bone mineral density. Serum biochemical analysis showed that icariin decreased the level of alkaline phosphatase, tartrate-resistant acid phosphatase, osteocalcin and calcitonin. Our observations provided evidences that dietary supplementation of icariin increased the bone mineral density and improved the laying performance, and icariin can be used for the prevention of the osteoporosis in caged laying hens.

Комплексная оценка минерально-костных нарушений у женщин с оксалатной нефропатией в постменопаузе

2020 ◽  
pp. 5-10
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Calcium Metabolism ◽  
Control Group ◽  
Mineral Density ◽  
High Level ◽  
Oxalate Nephropathy

A study was made of phosphorus-calcium metabolism, markers of bone metabolism, bone mineral density in 142 women in the early postmenopausal period, the patients with oxalate nephropathy at stage 2 of chronic kidney disease. It is proved that patients have signs of secondary hyperparathyroidism (hypocalcemia, hypercalciuria, increased parathyroid hormone) and a deficiency of 25 (OH) D3. Violation of bone metabolism is confirmed by a high level of β-Cross Laps and a decrease in bone mineral density. The probability of a 10-year risk of developing osteoporetic fractures in patients using the FRAX calculator is two times higher than in the control group. The conclusion was made that patients with oxalate nephropathy have a high risk of developing osteoporosis already in the early stages of chronic kidney disease.

scholarly journals Keel Bone Damage in Laying Hens—Its Relation to Bone Mineral Density, Body Growth Rate and Laying Performance

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1546
Author(s):  
Christin Habig ◽  
Martina Henning ◽  
Ulrich Baulain ◽  
Simon Jansen ◽  
Armin Manfred Scholz ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Rate ◽  
Bone Mineral ◽  
Laying Hens ◽  
Bone Fractures ◽  
Body Growth ◽  
Mineral Density ◽  
High Performing ◽  
Laying Performance ◽  
Bone Damage

Keel bone damage is an important animal welfare problem in laying hens. Two generations of four layer lines, differing in phylogenetic background and performance level and kept in single cages or floor pens were weighed and scored for keel bone deformities (KBD) during the laying period. KBD, keel bone fractures (KBF) and the bone mineral density (BMD) of the keels were assessed post mortem. For BMD, relationships to laying performance and body growth were estimated. Caged hens showed more deformities, but fewer fractures and a lower BMD of the keel bone than floor-housed hens. White-egg layers had a lower BMD (0.140–0.165 g/cm2) and more KBD than brown-egg layers (0.179–0.184 g/cm2). KBF occurred more often in the high-performing lines than the moderate-performing ones. However, in the high-performing lines, BMD was positively related to total egg number from 18 to 29 weeks of age. The adult body weight derived from fitted growth curves (Gompertz function) had a significant effect (p < 0.001) on keels’ BMD. The study contributes to the understanding of predisposing factors for keel bone damage in laying hens. It showed that the growth rate has a rather subordinate effect on keels’ BMD, while the BMD itself greatly affects KBD.

Tamoxifen and bone metabolism in postmenopausal low-risk breast cancer patients: a randomized study.

1994 ◽  
Vol 12 (5) ◽  
pp. 992-997 ◽  
Author(s):  
B Kristensen ◽  
B Ejlertsen ◽  
P Dalgaard ◽  
L Larsen ◽  
S N Holmegaard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Mineral Content ◽  
Serum Alkaline Phosphatase ◽  
Low Risk ◽  
Control Group ◽  
Mineral Density ◽  
Risk Breast Cancer

PURPOSE This trial was undertaken to evaluate the effect of adjuvant tamoxifen on bone metabolism in postmenopausal women undergoing surgery for low-risk breast cancer. PATIENTS AND METHODS In an open trial, 25 women were randomized to receive tamoxifen 30 mg/d for 2 years, and 25 women constituted the control group. Twenty women treated with tamoxifen and 23 women in the control group provided data for the analysis. Inclusion criteria were operation for low-risk breast cancer and cessation of menstruations for more than 1 year. Exclusion criteria were presence of metastases, disorders of bone metabolism, contraindications against tamoxifen, use of drugs with influence on bone metabolism, ailments that made bone mineral measurements impossible, and age greater than 65 years. Repeated measurements of bone mineral density and content at the lumbar spine and forearms, serum alkaline phosphatase, phosphate, and ionized calcium were performed in all patients. RESULTS Lumbar spine bone mineral density increased during the first year in women treated with tamoxifen and then stabilized, compared with decreased bone mineral density in the control group (P = .00074). Bone mineral content at the forearms remained almost stable in tamoxifen-treated women compared with a decrease in the control group (P = .024). Serum alkaline phosphatase, phosphate, and ionized calcium decreased in the tamoxifen group (P < .00001, P = .002, and P = .002, respectively). CONCLUSION Tamoxifen has estrogen-like effects on bone metabolism that result in an increase and stabilization of bone mineral density in the axial skeleton and a stabilization of bone mineral content in the appendicular skeleton.

scholarly journals Assessment of Low Bone Mineral Density in Untreated Patients with Takayasu’s Arteritis

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Lingfei Mo ◽  
Jing Wang ◽  
BoMiao Ju ◽  
Yanhua Wang ◽  
Jing Luo ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Takayasu’S Arteritis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Mineral Density ◽  
Low Bone Mineral Density

Chronic inflammation affects bone metabolism and accelerates bone loss. This study is aimed at analyzing the prevalence of low bone mineral density (LBMD) in patients with untreated Takayasu’s arteritis (TA) and risk factors. Forty untreated TA patients were enrolled, including 38 premenopausal women and 2 men before 50 years old. The control group included 60 age- and gender-matched healthy persons. Bone mineral density (BMD) of lumbar vertebrae and hip in patients with TA and the control group was measured by the dual-energy X-ray method. Serum 25OHD and β-CTX were also measured. The lumbar BMD of TA patients ( 0.89 ± 0.11  g/cm2) was significantly lower than that of the healthy control ( 0.97 ± 0.11  g/cm2). The prevalence of LBMD at the lumbar spine (17.50%) was significantly higher than that of the control group (3.33%). However, there was no significant difference at the hip. The 25OHD of TA patients was lower than that of healthy controls, while the level of β-CTX was higher. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in patients with LBMD were higher than those in patients with normal BMD. According to univariate correlation analysis, there was a significant negative correlation between LDL-C and lumbar BMD. Binary logistic regression analysis showed that LDL-C was an important factor affecting the occurrence of LBMD in patients with TA ( OR = 25.269 , P = 0.02 ). Our result reveals bone loss in TA patients, which hints the relationship among inflammation, lipid metabolism, and bone metabolism.

scholarly journals Effect of hypercortisolism on bone mineral density and bone metabolism: A potential protective effect of adrenocorticotropic hormone in patients with Cushing’s disease

2017 ◽  
Vol 46 (1) ◽  
pp. 492-503 ◽  
Author(s):  
Weihong Guo ◽  
Fengao Li ◽  
Chonggui Zhu ◽  
Baoping Wang ◽  
Kunling Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Adrenocorticotropic Hormone ◽  
Cushing's Disease ◽  
Control Group ◽  
Mineral Density ◽  
Turnover Markers

Objective To investigate the effects of Cushing’s disease (CD) and adrenal-dependent Cushing’s syndrome (ACS) on bone mineral density (BMD) and bone metabolism. Methods Data were retrospectively collected for 55 patients with hypercortisolism (CD, n = 34; ACS n = 21) from January 1997 to June 2014. BMD was examined in all patients, and bone turnover markers were tested in some patients. Healthy controls (n = 18) were also recruited. Results The lumbar spine and femoral neck BMD were significantly lower in the ACS and CD groups than in the control group. Lumbar BMD was significantly lower in the ACS than CD group. The collagen breakdown product (CTX) concentrations were significantly higher while the osteocalcin and procollagen type I N-terminal propeptide (PINP) concentrations were significantly lower in the ACS and CD groups than in the control group. The PINP concentration was significantly lower while the CTX concentration was significantly higher in the ACS than CD group. In the CD group only, lumbar BMD and serum adrenocorticotropic hormone had a significant positive correlation. Conclusions Bone turnover markers indicated suppressed osteoblast and enhanced osteoclast activities. PINP and CTX changes might indicate bone mass deterioration. Adrenocorticotropic hormone might be protective for lumbar BMD in patients with CD.

scholarly journals Effects of B-Wave Ultraviolet Supplementation Using Light-Emitting Diodes on Caged Laying Hens during the Later Phase of the Laying Cycle

Animals ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 15 ◽  
Author(s):  
Yongxiang Wei ◽  
Weichao Zheng ◽  
Baoming Li ◽  
Qin Tong ◽  
Haipeng Shi ◽  
...  
Keyword(s):  
Egg Production ◽  
Light Emitting Diodes ◽  
Laying Hens ◽  
Egg Quality ◽  
Control Group ◽  
Vitamin D Metabolites ◽  
Mineral Density ◽  
Light Emitting ◽  
Laying Performance ◽  
Later Phase

Caged laying hens are prone to calcium deficiencies, resulting in osteoporosis and egg quality deterioration during the later phase of the laying cycle. Fluorescent light and light-emitting diodes (LEDs), which are widely used in poultry houses now, are both deficient in ultraviolet (UV) light, the lack of which is detrimental to chickens’ welfare and health. This study was conducted to investigate the effects of UVB light supplementation using LEDs on the bone traits, blood parameters, laying performance, and egg quality for caged laying hens at 68–75 weeks. In total, 120 Jingfen laying hens were randomly assigned to four different groups, with three replicates in each group (10 hens in each cage as a replicate). UVB-LED lamps installed under the feed troughs were used to provide UVB light (296–316 nm) for the birds in the three treatment groups (1 h, 2 h, and 3 h UVB supplementation per day, respectively), while the control group was not exposed to UVB-LED light. Bone traits, egg quality, and amounts of calcium (Ca), phosphorus (P), 25-hydroxyvitamin D3 (25(OH)D3), 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and 7-dehydrocholesterol (7-DHC) in both the serum and egg yolks were tested during the experiment. The results demonstrated that UVB-LED exposure significantly increased the bone mineral density (BMD), egg production, and yolk 1,25(OH)2D3 concentrations (p < 0.05), and reduced the content of serum 7-DHC (p < 0.05), especially in the 2 h/day group; however, it did not improve egg quality, vitamin D metabolites, or photoproducts in the serum and yolk 25(OH)2D3 concentrations (p > 0.05). This study concluded that UVB supplementation using LEDs had a positive effect on caged laying hens during the later phase of the laying cycle.

scholarly journals Bone mineral density in patients with juvenile idiopathic arthritis

2009 ◽  
Vol 137 (7-8) ◽  
pp. 396-401 ◽  
Author(s):  
Gordana Susic ◽  
Nada Pilipovic ◽  
Roksanda Stojanovic
Keyword(s):  
Bone Mineral Density ◽  
Juvenile Idiopathic Arthritis ◽  
Standard Deviation ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Control Group ◽  
Z Score ◽  
Mineral Density ◽  
Radiological Stage ◽  
Systemic Onset

Introduction. It is well known that juvenile idiopathic arthritis (JIA) as a chronic inflammatory disease with onset during the childhood, beside other complication, can lead to bone metabolism disturbance and osteoporosis. Objective. To assess bone mineral density (BMD) in children with JIA and to identify factors playing role in bone mineral disturbance. Methods. Seventy-five patients (26 male and 49 female) average disease duration 7.2 (2.4-16.8) years, and 73 age matched healthy control subjects (29 male and 44 female) participated in the study. Mean age of the groups was about 14.5 years. BMD was determined by dual x-ray absorptiometry (DEXA) of the lumbar spine (L2-L4). For further analysis we used the absolute value of BMD, expressed as g/cm2, Z score expressed as SD (relative value as standard deviation decline of normal BMD values of referent Italian population with identical age and gender), bone mineral content (BMC) as g/cm, and corrected BMD - BMDv as g/cm3. Results. Z score in the group of patients was significantly lower (-1.02?1.6) in comparison to the control group (-0.09?1.4; p<0.001). BMD, BMDv and BMC were also statistically lower in patients with JIA. The lowest Z score was found in patients with systemic onset (-2.63 SD). Z score showed a statistically significant positive correlation with arthritis course (polyarticular course had lower Z score), body mass index and standard deviation score for height and weight. Statistically significant negative correlation was detected in regard to Z score and glucocorticoid (GC) treatment duration, GC cumulative dose, number of joints with limited range of motion, radiological stage and functional class. Conclusion. The results showed a decreased BMD in patients with JIA in comparison to the control group. Systemic onset, polyarthritis, longer treatment with GC and higher cumulative dosage, as well as higher damage level (functional status and radiological stage) are factors playing negative role in bone metabolism in children with JIA.

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