Prevalence and predictors of sexual dysfunction in long-term survivors of marrow transplantation.

1998 ◽  
Vol 16 (9) ◽  
pp. 3148-3157 ◽  
Author(s):  
K L Syrjala ◽  
S L Roth-Roemer ◽  
J R Abrams ◽  
J M Scanlan ◽  
M K Chapko ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Repeated Measures ◽  
Marrow Transplantation ◽  
Hormone Replacement ◽  
Sexual Problem ◽  
Men And Women ◽  
Sexual Quality Of Life ◽  
Sexual Dissatisfaction ◽  
Receive Hormone Replacement Therapy

PURPOSE To describe the prevalence of sexual difficulties in men and women after marrow transplantation (MT), and to define medical, demographic, sexual, and psychologic predictors of sexual dysfunction 3 years after MT. PATIENTS AND METHODS Four hundred seven adult MT patients were assessed pretransplantation. Survivors repeated measures of psychologic and sexual functioning at 1 and 3 years posttransplantation. RESULTS Data were analyzed from 102 event-free 3-year survivors who defined themselves as sexually active. Men and women did not differ in sexual satisfaction pretransplantation. At 1 and 3 years posttransplantation, women reported significantly more sexual dysfunction than men. Eighty percent of women and 29% of men reported at least one sexual problem by 3 years after MT. No pretransplantation variables were significant predictors of 3-year sexual satisfaction for women. For men, pretransplantation variables of older age, poorer psychologic function, not being married, and lower sexual satisfaction predicted sexual dissatisfaction at 3 years (R2=.28; P < .001). Women who were more dissatisfied 3 years after MT did not receive hormone replacement therapy (HRT) at 1 -year posttransplantation and were less satisfied at 1 year, but not pretransplantation (R2=.35; P < .001). CONCLUSION Sexual problems are significant in the lives of MT survivors, particularly for women. Although HRT before 1 year posttransplantation improves sexual function, it does not ensure sexual quality of life. Intervention for women is needed to apply hormonal, mechanical, and behavioral methods to prevent sexual difficulties as early after transplantation as possible.

scholarly journals Evolving therapeutic strategies for premature ejaculation: The search for on-demand treatment – topical versus systemic

2012 ◽  
Vol 6 (5) ◽  
Author(s):  
Alvaro Morales
Keyword(s):  
Clinical Trials ◽  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Premature Ejaculation ◽  
Therapeutic Strategies ◽  
Phase 3 ◽  
On Demand ◽  
Sexual Dissatisfaction ◽  
Ejaculatory Control

Premature ejaculation (PE) is a common sexual dysfunction affecting20% to 30% of men worldwide. Definitions of PE vary, but itis typically characterized by short intravaginal ejaculatory latencytime (IELT) with concomitant sexual dissatisfaction and distress.PE may be lifelong or acquired, but its etiology remains unclear.Treatment of PE typically involves pharmacotherapy, particularlywhen lifelong. Although there are numerous reports on the offlabeluse of selective serotonin reuptake inhibitors (SSRIs) andother compounds, only 2 treatments have been evaluated in randomizedcontrolled phase 3 clinical trials: PSD502 and dapoxetine(SSRI). Both significantly improved IELT and patient-reportedoutcome domains of ejaculatory control, sexual satisfaction, anddistress as measured by the index of premature ejaculation (IPE),compared with placebo. They constitute the focus of this review.Evidence demonstrated that PSD502, dapoxetine and other SSRIsall significantly improve the symptoms of PE. Systemic use of SSRIspresents risks associated with the known pharmacology of thisclass. PSD502 allows for topical on-demand treatment appliedapplied immediately before intercourse, and is not associated withsystemic adverse events.

Effectiveness of Relationship Enrichment program (REP) on sexual dysfunction and Satisfaction of Females with Multiple Sclerosis-An Educational Study

2021 ◽  
Vol 17 ◽  
Author(s):  
Negin Sayari ◽  
Katayon Vakilian ◽  
Zohre Khalajinia ◽  
Seyyed Amir Hejazi ◽  
Mostafa Vahedian
Keyword(s):  
Multiple Sclerosis ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Satisfaction ◽  
Repeated Measures ◽  
Intervention Group ◽  
Sexual Life ◽  
Educational Design ◽  
Significant Difference ◽  
Enrichment Program

Aims: Improving sexual function in women with disability such as multiple sclerosis was aimed. Background: Sexual dysfunction and the consequent low satisfaction is very common in females with Multiple Sclerosis (MS). Objectives: This study aimed to investigate the effectiveness of Relationship Enhancement Therapy (REP) on sexual function and satisfaction of females with MS. Methods: the present study was an educational design with two groups, in which 44 females with MS participated and their spouses (N= 88) participated and randomly divided in two groups of intervention (N= 22 couples) and control (N= 22 couples). They signed written consent forms and were included in the project. The intervention group received the REP in six 90-minute sessions. The groups completed standard questionnaires of sexual dysfunction and sexual satisfaction in three stages of pretest-posttest and 3 months later. The Descriptive and inferential statistics (Two- way repeated measures ANOVA, chi-square, t-test and Mann-Whitney U test) were used to analyze data. Results: The results of analysis showed that there was a clinically significant difference between the scores of sexual dysfunction in different phases of the assessment between two groups (p <0.05). Also sexual satisfaction was higher in the intervention group vs. in the control (p <0.05). Conclusion: according to the findings, marital enrichment program was effective in improvement of sexual function and sexual satisfaction of females with multiple sclerosis. It is recommended to healthcare providers to use enrichment alongside medical services to improve patients' sexual life.

Decline in Sexual Functioning Over a 3-Year Period after Hematopoietic Cell Transplantation (HCT): Gender-Specific Impact of Total Body Irradiation (TBI) and Chronic Graft-Versus-Host Disease (cGvHD)

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 743-743
Author(s):  
F. Lennie Wong ◽  
Stephen J. Forman ◽  
Liton Francisco ◽  
Mitzi Gonzales ◽  
Melanie Sabado ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Psychosocial Factors ◽  
Sexual Satisfaction ◽  
Sexual Functioning ◽  
Physical Stress ◽  
Satisfaction Level ◽  
Men And Women ◽  
Time Points ◽  
Composite Scores ◽  
Gender Specific

Abstract Sexual dysfunction is a multidimensional problem caused by both physiologic and psychosocial factors. Yet little is known about the longitudinal trends of sexual functioning in HCT survivors, or the clinical or psychosocial factors associated with decline. Using a longitudinal study design, we administered the Derogatis Interview for Sexual Functioning (DISF-SR), the Global Sexual Satisfaction Index (GSSI), and the City of Hope-QOL instrument at 5 time points to a large cohort of patients undergoing HCT at City of Hope (COH): prior to HCT, at 6m, 1y-, 2y-, and 3y-post-HCT. DISF-SR assessed 5 domains of sexual functioning (Cognition/Fantasy, Arousal, Behavior/Experiences, Orgasm, and Drive/Relationship), and a Total score. GSSI elicited patients’ subjective appraisal of sexual satisfaction. The COH-QOL instrument was used to obtain self-reported levels of anxiety, distress, depression, pain, physical strength, and sleep changes, which were converted to composite scores of mental and physical stress. Long-term trends of sexual functions were estimated using the Generalized Estimating Equation. We examined the effects of sociodemographic factors, primary diagnosis, HCT conditioning regimens, disease status at HCT, presence of cGvHD, and composite mental and physical stress levels on the longitudinal trends of DISF-SR, the Total score, and GSSI. The cohort included 312 adults (median age at HCT 48y; 56% males) undergoing autologous (n=175) or allogeneic (n=137) HCT for hematologic malignancies or severe aplastic anemia; 144 patients completed the 3y sexual survey (participation rate at 3 years=75%). GSSI (general sexual satisfaction) declined significantly after HCT (p=0.001) for both men and women, and remained depressed over the 3-y study period, with 40% reporting poor or worse sexual satisfaction level at 3y. There were no significant differences between men and women in terms of general sexual satisfaction level. However, the degree of sexual dysfunction as measured by DISF-SR was worse in women than in men for all domains, and for Total score (p<.001) at all post-HCT time points (Fig. 1A). Furthermore, assessment of DISF-SR scores revealed that while men experienced a persistent decline in satisfaction with Orgasm and Drive/Relationship (p<0.05), women did not demonstrate a significant decline in sexual function in any of the domains post-HCT. Gender-specific multivariate analyses revealed certain subgroups that were more vulnerable to a decline in sexual functions after HCT. Notably, older age (≥40y) (Fig. 1B), being married, and TBI exposure in men (Fig. 1C), and older age (≥30y) (Fig. 1D), being overweight, and greater mental and/or physical stress in women were factors identified as significantly associated with decreased sexual functioning following HCT. Although cGvHD was not directly related to DISF-SR or GSSI, presence of cGvHD was accompanied by worse mental and physical composite scores (p<0.0001). Lower mental and/or physical composite scores in turn were significantly related to lower sexual functions for all domains of DISF-SR, the Total score (Fig. 1E) and GSSI in women (p<0.05). Thus, women may be vulnerable to the effects of cGvHD mediated through mental and/or physical stress, in turn resulting in compromised sexual functions and satisfaction after HCT. This study should inform healthcare providers that patients undergoing HCT require more attention to their sexual QOL within the first year after HCT. Routine inquiry of patients’ sexual health should be included in follow-up exams after HCT, especially for those at high risk (i.e. TBI-exposed men and those with cGvHD), with the ability to offer a multidisciplinary approach to managing this distressing complication. Figure Figure

Sexual Dysfunction in Early-Onset Parkinson’s Disease: A Cross-Sectional, Multicenter Study

2020 ◽  
Vol 10 (4) ◽  
pp. 1621-1629
Author(s):  
Lydia Vela-Desojo ◽  
Daniele Urso ◽  
Monica Kurtis-Urra ◽  
Pedro J. García-Ruiz ◽  
Elia Pérez-Fernández ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Satisfaction ◽  
Multicenter Study ◽  
Early Onset ◽  
Urinary Dysfunction ◽  
Cross Sectional ◽  
Sexual Dissatisfaction

Background: Sexual dysfunction (SD) is one of the least studied non-motor symptoms in Parkinson’s disease (PD). Objectives: To assess sexual function in a cohort of patients with early-onset PD (EOPD) and compare it to a group of healthy controls. Methods: In this cross-sectional multicenter study, SD was assessed with gender-specific multi-dimensional self-reported questionnaires: The Brief Male Sexual Function Inventory (BSFI-M) and the Female Sexual Function Index (FSFI). Scores between patients and controls were compared and associations between SD and demographical and clinical variables were studied. Results: One hundred and five patients (mean age 47.35±7.8, disease duration 6 (3–11) years, UPDRS part III 17 (10–23) and 90 controls were recruited. The BSFI-M total score was lower in EOPD men than in controls, and specific items were also significantly lower, such as drive, erections, ejaculation, and satisfaction. EOPD women had lower scores than controls in total FSFI, and certain domains such as lubrication and pain. SD was present in 70.2% of patients and 52.5% of controls. Sexual satisfaction in 35.2% of patients and 81.2% of controls. By gender, male and female patients had more SD than controls but only male patients had more dissatisfaction than controls. Gender, higher depression scores and urinary dysfunction were associated with SD in multivariate analysis; and gender, UPDRS and urinary dysfunction with sexual satisfaction Conclusion: In this Spanish cohort, SD and sexual dissatisfaction was more prevalent in EOPD patients than in the general population. Gender and urinary disfunction were associated with SD and sexual dissatisfaction.

Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis

2001 ◽  
Vol 7 (6) ◽  
pp. 417-421 ◽  
Author(s):  
Frederick W Foley ◽  
Nicholas G LaRocca ◽  
Audrey Sorgen Sanders ◽  
Vance Zemon
Keyword(s):  
Multiple Sclerosis ◽  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Repeated Measures ◽  
Treatment Team ◽  
Counseling Intervention ◽  
Repeated Measures Analysis ◽  
Quasi Experimental ◽  
Published Research ◽  
Prevalent Symptom

Sexual dysfunction is a highly prevalent symptom of multiple sclerosis (MS), with little published research on effective treatments. This pilot study tested the efficacy of a counseling intervention in nine couples utilizing a quasi-experimental research design. The intervention consisted of 12 counseling sessions, communication with the MS medical treatment team, education, and tailoring symptomatic treatments so they interfere less with sexual function. Repeated measures analysis of variance indicated significant improvements in affective and problem-solving communication, marital satisfaction, and sexual satisfaction during the treatment vs. the waiting list phase of the study (F=1.7, P5.001). MS patients and their spouses reported similar levels of improvement.

Pornography and Sexual Dissatisfaction: The Role of Pornographic Arousal, Upward Pornographic Comparisons, and Preference for Pornographic Masturbation

2021 ◽  
Vol 47 (2) ◽  
pp. 192-214
Author(s):  
Paul J Wright ◽  
Bryant Paul ◽  
Debby Herbenick ◽  
Robert S Tokunaga
Keyword(s):  
Conceptual Model ◽  
Sexual Satisfaction ◽  
Research Finding ◽  
Theoretical Development ◽  
Men And Women ◽  
Theoretical Perspectives ◽  
Sexual Dissatisfaction ◽  
Pornography Use ◽  
Path Analytic

Abstract Research finding that pornography use is associated with lower sexual satisfaction is common; evaluation of the mechanisms hypothesized as underlying the association is not. Informed by multiple theoretical perspectives, the present study tested a conceptual model positing that (a) regularly consuming pornography conditions the user’s arousal template to be particularly responsive to pornographic depictions, (b) this amplified arousal to pornography increases both (c) upward comparisons between one’s own sex life and sex as it is represented in pornography and (d) a preference for masturbation to pornography over partnered sex, which in turn (e) weaken perceptions of how satisfying it is to have sex with one’s partner, and ultimately (f) decreases perceptions of how satisfying one’s relationship is with one’s partner. Path-analytic results were supportive of the hypothesized linkages for both men and women. Discussion focuses on the implications of the present study’s findings for current debates in the literature and theoretical development.

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