scholarly journals Evolving therapeutic strategies for premature ejaculation: The search for on-demand treatment – topical versus systemic

2012 ◽  
Vol 6 (5) ◽  
Author(s):  
Alvaro Morales
Keyword(s):  
Clinical Trials ◽  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Premature Ejaculation ◽  
Therapeutic Strategies ◽  
Phase 3 ◽  
On Demand ◽  
Sexual Dissatisfaction ◽  
Ejaculatory Control

Premature ejaculation (PE) is a common sexual dysfunction affecting20% to 30% of men worldwide. Definitions of PE vary, but itis typically characterized by short intravaginal ejaculatory latencytime (IELT) with concomitant sexual dissatisfaction and distress.PE may be lifelong or acquired, but its etiology remains unclear.Treatment of PE typically involves pharmacotherapy, particularlywhen lifelong. Although there are numerous reports on the offlabeluse of selective serotonin reuptake inhibitors (SSRIs) andother compounds, only 2 treatments have been evaluated in randomizedcontrolled phase 3 clinical trials: PSD502 and dapoxetine(SSRI). Both significantly improved IELT and patient-reportedoutcome domains of ejaculatory control, sexual satisfaction, anddistress as measured by the index of premature ejaculation (IPE),compared with placebo. They constitute the focus of this review.Evidence demonstrated that PSD502, dapoxetine and other SSRIsall significantly improve the symptoms of PE. Systemic use of SSRIspresents risks associated with the known pharmacology of thisclass. PSD502 allows for topical on-demand treatment appliedapplied immediately before intercourse, and is not associated withsystemic adverse events.

scholarly journals The comparison of on-demand caffeine consumption with squeezing technique on treating patients with premature ejaculation; a randomized clinical trial

2021 ◽  
Vol 15 (6) ◽  
pp. 2005-2010
Author(s):  
Seyyed Hassan Saadat ◽  
Khodabakhsh Ahmadi
Keyword(s):  
Sexual Satisfaction ◽  
Premature Ejaculation ◽  
Post Treatment ◽  
Common Disease ◽  
Latency Time ◽  
Caffeine Consumption ◽  
On Demand ◽  
Ejaculation Latency ◽  
Significant Difference ◽  
Pre Treatment

Background: The present study was aimed at evaluating the effect of on-demand caffeine consumption on treating patients with premature ejaculation (PE compared to squeezing technique. Methods: In this non-blind RCT, 42 otherwise healthy individuals with PE were divided into 2 groups of caffeine and squeezing technique group. The former received 100 mg of encapsulated caffeine for 3 weeks, 2 hours prior to each intercourse. Intra-vaginal ejaculation latency time and index of sexual satisfaction were calculated before and after treatment in both groups. Results: Mean age of the participants was 39.48±7.62 years. Despite the fact that there was no significant difference between pre-treatment and post-treatment values of both IELT and ISS between our 2 groups, significant difference was seen in both groups between pre-treatment and post-treatment values. Furthermore, no strong correlation was seen in pre-treatment IELT and ISS; however, statistically significant correlation was found in post-treatment values. Conclusion: Regarding the fact that caffeine is a well-known and widely-used drug in common disease, the use of this compound is highly unlikely to bear any stigma. Our study demonstrates that 100 mg of on-demand caffeine can equally increase both IELT and ISS significantly as squeezing technique. Further investigations are needed. Keywords: caffeine, premature ejaculation, squeezing technique, intra-vaginal ejaculation latency time, index of sexual satisfaction,

Pharmacologic Treatment Strategies for Sexual Dysfunction in Patients with Epilepsy and Depression

CNS Spectrums ◽  
2006 ◽  
Vol 11 (S9) ◽  
pp. 31-37 ◽  
Author(s):  
Glen L. Stimmel ◽  
Mary A. Gutierrez
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Sexual Desire ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Premature Ejaculation ◽  
Sexual Disorders ◽  
Comorbid Condition ◽  
Phosphodiesterase Type 5 Inhibitor ◽  
Female Orgasmic Disorder ◽  
Patients With Epilepsy

AbstractSexual dysfunction is a frequently encountered comorbid condition in patients with many medical and psychiatric conditions, such as epilepsy and depression. Most depressed patients experience some type of sexual dysfunction, decreased sexual desire being the most common. The association of sexual dysfunction with epilepsy is less clear. Changes in sex hormone levels are common in patients with epilepsy and may be attributable to the disease or to antiepileptic drugs (AEDs). Sexual dysfunction associated with depression or epilepsy is generally treated according to standard guidelines for the management of sexual disorders, since data from special populations are not available. The most common forms of female sexual dysfunction are lack of sexual desire and difficulty achieving orgasm. There are no approved pharmacotherapies for female hypoactive sexual desire disorder or female orgasmic disorder. Female sexual arousal disorder is treated with estrogen replacement therapy when indicated or vaginal lubricants. The most common male sexual dysfunction disorders are premature ejaculation and erectile dysfunction.  Phosphodiesterase type-5 inhibitor drugs are now the first-line treatment for erectile dysfunction, and selective serotonin reuptake inhibitors and topical anesthetic creams are nonapproved but effective treatments for premature ejaculation. Testosterone and aromatase inhibitors have been used investigationally to treat sexual dysfunction in men taking AEDs. Patient education and follow-up appointments are essential to ensure optimal outcomes of pharmacologic treatments for sexual dysfunction.

scholarly journals Observational study on the effects of a topical formulation in patients with premature ejaculation

2020 ◽  
Vol 92 (4) ◽  
Author(s):  
Giuseppe Quarto ◽  
Luigi Castaldo ◽  
Giovanni Grimaldi ◽  
Alessandro Izzo ◽  
Raffaele Muscariello ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Observational Study ◽  
Sexual Satisfaction ◽  
Premature Ejaculation ◽  
Clinical History ◽  
Diagnostic Approach ◽  
Latency Time ◽  
Topical Formulation ◽  
Ejaculatory Latency

Premature ejaculation (PE) has been defined as the inability to control or delay ejaculation, resulting in dissatisfaction or distress of the patient. Although PE is the most frequent sexual dysfunction, it is still underdiagnosed. An accurate clinical history is the best diagnostic approach that, in the majority of cases, is enough to differentiate between primary and acquired PE. Nowadays, treatment is not curative but is effective in increasing the intravaginal ejaculatory latency time (IELT), improving the sexual satisfaction of the couple [...].

Prevalence and predictors of sexual dysfunction in long-term survivors of marrow transplantation.

1998 ◽  
Vol 16 (9) ◽  
pp. 3148-3157 ◽  
Author(s):  
K L Syrjala ◽  
S L Roth-Roemer ◽  
J R Abrams ◽  
J M Scanlan ◽  
M K Chapko ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Repeated Measures ◽  
Marrow Transplantation ◽  
Hormone Replacement ◽  
Sexual Problem ◽  
Men And Women ◽  
Sexual Quality Of Life ◽  
Sexual Dissatisfaction ◽  
Receive Hormone Replacement Therapy

PURPOSE To describe the prevalence of sexual difficulties in men and women after marrow transplantation (MT), and to define medical, demographic, sexual, and psychologic predictors of sexual dysfunction 3 years after MT. PATIENTS AND METHODS Four hundred seven adult MT patients were assessed pretransplantation. Survivors repeated measures of psychologic and sexual functioning at 1 and 3 years posttransplantation. RESULTS Data were analyzed from 102 event-free 3-year survivors who defined themselves as sexually active. Men and women did not differ in sexual satisfaction pretransplantation. At 1 and 3 years posttransplantation, women reported significantly more sexual dysfunction than men. Eighty percent of women and 29% of men reported at least one sexual problem by 3 years after MT. No pretransplantation variables were significant predictors of 3-year sexual satisfaction for women. For men, pretransplantation variables of older age, poorer psychologic function, not being married, and lower sexual satisfaction predicted sexual dissatisfaction at 3 years (R2=.28; P < .001). Women who were more dissatisfied 3 years after MT did not receive hormone replacement therapy (HRT) at 1 -year posttransplantation and were less satisfied at 1 year, but not pretransplantation (R2=.35; P < .001). CONCLUSION Sexual problems are significant in the lives of MT survivors, particularly for women. Although HRT before 1 year posttransplantation improves sexual function, it does not ensure sexual quality of life. Intervention for women is needed to apply hormonal, mechanical, and behavioral methods to prevent sexual difficulties as early after transplantation as possible.

Sexual Dysfunction in Early-Onset Parkinson’s Disease: A Cross-Sectional, Multicenter Study

2020 ◽  
Vol 10 (4) ◽  
pp. 1621-1629
Author(s):  
Lydia Vela-Desojo ◽  
Daniele Urso ◽  
Monica Kurtis-Urra ◽  
Pedro J. García-Ruiz ◽  
Elia Pérez-Fernández ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Sexual Satisfaction ◽  
Multicenter Study ◽  
Early Onset ◽  
Urinary Dysfunction ◽  
Cross Sectional ◽  
Sexual Dissatisfaction

Background: Sexual dysfunction (SD) is one of the least studied non-motor symptoms in Parkinson’s disease (PD). Objectives: To assess sexual function in a cohort of patients with early-onset PD (EOPD) and compare it to a group of healthy controls. Methods: In this cross-sectional multicenter study, SD was assessed with gender-specific multi-dimensional self-reported questionnaires: The Brief Male Sexual Function Inventory (BSFI-M) and the Female Sexual Function Index (FSFI). Scores between patients and controls were compared and associations between SD and demographical and clinical variables were studied. Results: One hundred and five patients (mean age 47.35±7.8, disease duration 6 (3–11) years, UPDRS part III 17 (10–23) and 90 controls were recruited. The BSFI-M total score was lower in EOPD men than in controls, and specific items were also significantly lower, such as drive, erections, ejaculation, and satisfaction. EOPD women had lower scores than controls in total FSFI, and certain domains such as lubrication and pain. SD was present in 70.2% of patients and 52.5% of controls. Sexual satisfaction in 35.2% of patients and 81.2% of controls. By gender, male and female patients had more SD than controls but only male patients had more dissatisfaction than controls. Gender, higher depression scores and urinary dysfunction were associated with SD in multivariate analysis; and gender, UPDRS and urinary dysfunction with sexual satisfaction Conclusion: In this Spanish cohort, SD and sexual dissatisfaction was more prevalent in EOPD patients than in the general population. Gender and urinary disfunction were associated with SD and sexual dissatisfaction.

scholarly journals Fisioterapia pélvica no tratamento da ejaculação precoce: uma revisão integrativa / Pelvic physiotherapy in the treatment of premature ejaculation: an integrative review

2017 ◽  
Vol 7 (3) ◽  
pp. 25-27
Author(s):  
Fernanda Santos Fontana ◽  
Kelfany De Melo ◽  
Lorrany Vieira Ferreira ◽  
Erica Feio Carneiro Nunes ◽  
Gustavo Fernando Sutter Latorre
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Electrical Stimulation ◽  
Physical Therapy ◽  
Sexual Dysfunction ◽  
Pelvic Floor ◽  
Premature Ejaculation ◽  
Cure Rate ◽  
Different Types ◽  
And Training

A ejaculação precoce (EP) é prevalente, apresentando diversos tipos de tratamento, evidenciando a falta de uma modalidade definitiva. A fisioterapia pélvica emerge como modalidade terapêutica e necessita de maior esclarecimento. Assim, buscou-se descrever a eficácia das técnicas de fisioterapia utilizadas no tratamento da EP. Para tanto, foi realizada uma revisão integrativa de ensaios clínicos nas bases de dados PubMed, LILACS e SciELO. Os resultados retornaram ensaios passíveis de inclusão, num total de cinco artigos utilizados. A fisioterapia pélvica mostrou sucesso de 54% a 83% de cura. O treino da musculatura do assoalho pélvico, auxiliado ou não por eletroestimulação e biofeedback, foi a técnica descrita. Conclui-se que a fisioterapia pélvica é eficaz na cura da maior parte das vítimas de EP. No entanto, mais estudos se fazem necessário nesta área, particularmente ensaios clínicos testando as diferentes técnicas.Palavras-Chave: Ejaculação precoce; Fisioterapia; SexualidadeABSTRACTPremature ejaculation (PE) is the most prevalent sexual dysfunction in men, and today there are several different types of treatment, indicating the lack of a definite mode for that. Physiotherapy emerges as a therapeutic, but needs further clarification. To describe the physiotherapy techniques currently used in the treatment of PE, discussing their effectiveness. Having this in mind, we performed a systematic review on PubMed, LILACS and SciELO, including clinical trials of physiotherapy techniques treating PE. Two databases returned files amenable to inclusion so, a total of five articles was used. Pelvic physiotherapy showed 54% to 83% cure rate and training of the pelvic floor muscles, aided or not by electrical stimulation and biofeedback, was the most frequent modality. Pelvic physiotherapy is effective in curing the majority of victims of PE, but further study in this area is a necessity, mainly clinical trials which test different techniques.Keywords: Premature ejaculation; Physical therapy specialty; Sexuality

scholarly journals Premature Ejaculation – From Physiology to Treatment

2019 ◽  
Author(s):  
Mário Pereira-Lourenço ◽  
Duarte Vieira e Brito ◽  
Bruno Jorge Pereira
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Literature Search ◽  
Diagnostic Method ◽  
Premature Ejaculation ◽  
Clinical History ◽  
Latency Time ◽  
Ejaculatory Latency

Objective: To review in literature about the concept of premature ejaculation from physiology to treatment. Materials and methods: A literature search conducted with Pubmed and Cochrane. Results: An accurate clinical history is the best diagnostic method, and in the majority of the cases it is enough to differentiate between primary and acquired premature ejaculation. Nowadays the treatment is not curative but is effective in increasing the Intravaginal Ejaculatory Latency Time, improving the couple’s sexual satisfaction. Conclusion: Although PE is the most frequent sexual dysfunction, it is still sub-diagnosed. Combining behavioural techniques with pharmacotherapy is the best way of treatment.

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