Analysis of prognostic factors with cervical squamous cell carcinoma after neoadjuvant chemotherapy

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 15060-15060
Author(s):  
S. Hayashi ◽  
T. Fujii ◽  
M. Nakamura ◽  
N. Hirao ◽  
H. Nakagawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Ct Scan ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Cervical Squamous Cell Carcinoma ◽  
Disease Recurrence ◽  
Node Metastasis

15060 Background: The purpose of the study was to evaluate retrospectively the clinical effects of neoadjuvant chemotherapy (NAC) given to women with cervical squamous cell carcinoma using the response rates, prognostic parameters, and diagnostic imaging data (CT scan or MRI). Methods: Patients included in the study were 32 women with a mean age of 48.8 ± 10.6 who had stage Ib-IIIb cervical squamous cell carcinoma and was treated initially with platinum-based NAC prior to surgical intervention at our institution between 1994 and 2003. The response rates in these patients were assessed, and a statistical analysis was performed to evaluate the effects of NACT on survival rates and disease recurrence using the following 9 parameters: 1. clinical stage of cancer, 2. lymph node metastasis, 3. blood vessel invasion, 4. parametrial involvement, 5. depth of stromal invasion, 6. tumor diameter, 7. pre- and post-treatment serum levels of the squamous cell carcinoma antigen, 8. age, and 9. rates of response to NAC. CT scan or MRI obtained prior to and after NAC were compared and evaluated for any evidence of lymph node metastasis. Results: Five and 18 patients achieved complete response (CR) and partial response (PR), respectively, with a response rate of 71.8% for these CR and PR patients. A multivariate analysis revealed that lymph node metastasis was the only independent prognostic parameter for survival rates and disease recurrence. In 13 patients in whom lymph node metastasis was found by the was found by the CT scan or MRI prior to NAC, 8 (61.5%) still showed the evidence of metastasis after treatment. Among these, 7 (87.5%) actually had metastatic lymph nodes. In addition, the occurrence of lymph node metastasis was unrelated to rates of response to NAC. Conclusions: The rates of response to NAC dose not predict prognosis in patients with cervical squamous cell carcinoma. The occurrence of lymph node metastasis is unrelated to rates of response to NAC. If metastatic lymph nodes are suspected after NAC, appropriate treatment approaches should be well considered in such patients. No significant financial relationships to disclose.

scholarly journals Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 122 ◽  
Author(s):  
Yueh-Min Lin ◽  
Chiao-Wen Lin ◽  
Jeng-Wei Lu ◽  
Kun-Tu Yeh ◽  
Shu-Hui Lin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Clinicopathological Features ◽  
Cytoplasmic Expression ◽  
Node Metastasis

A disintegrin and metalloproteinase with thrombospondin motif 14 (ADAMTS14) is a member of the zinc-dependent protease family that is implicated in the occurrence and progression of tumors. Oral cancer (OC) is a common cancer worldwide, but it is particularly prevalent in Taiwan. However, whether the expression of ADAMTS14 is correlated with the carcinogenesis and progression of oral squamous cell carcinoma (OSCC) has not yet been investigated. In this study, we used immunohistochemistry (IHC) to examine 250 OSCC specimens in order to identify correlations between the cytoplasmic expression of ADAMTS14 and (1) clinicopathological features of OSCC as well as (2) clinical outcomes of OSCC. Our results indicate that cytoplasmic expression of ADAMTS14 was lower in OSCC tissues than in normal tissues. In analyzing correlations between ADAMTS14 expression and clinicopathological features, we found that negative cytoplasmic expression of ADAMTS14 was significantly associated with higher frequencies of lymph node metastasis and more advanced AJCC stages (III/IV). Kaplan–Meier survival analysis revealed that negative cytoplasmic expression of ADAMTS14 was also associated with significantly worse OSCC survival. Univariate and multivariate analyses confirmed that cytoplasmic expression of ADAMTS14 was associated with lymph node metastasis, tumor stage, and tumor grade and also indicated that cytoplasmic ADAMTS14 expression may be an independent prognostic factor for OSCC. This is the first study to report that the cytoplasmic expression level of ADAMTS14 is associated with OSCC prognosis and tumor progression. Our data indicate that ADAMTS14 can serve as a prognostic marker and a potential therapeutic target for OSCC.

scholarly journals Impact of Histological and Molecular Parameters on Prognosis of Oral Squamous Cell Carcinoma: Analysis of 290 Cases

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
B. S. M. S. Siriwardena ◽  
H. D. N. U. Karunathilaka ◽  
P. V. R. Kumarasiri ◽  
W. M. Tilakaratne
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumour Size ◽  
Survival Rates ◽  
Node Metastasis ◽  
The Impact

Background. Nodal metastasis is a critical factor in predicting the prognosis of oral squamous cell carcinoma (OSCC). When patients present with a clinically positive neck, the treatment of choice is radical neck dissection. However, management of a clinically negative neck is still a subject of significant controversy. Aim. This study was carried out in order to propose a model to predict regional lymph node metastasis of OSCC using histological parameters such as tumour stage, tumour size, pattern of invasion (POI), differentiation of tumour, and host immune response, together with the expression levels of six biomarkers (periostin, HIF-1α, MMP-9, β-catenin, VEGF-C, and EGFR), and, furthermore, to compare the impact of all these parameters on recurrence and 3 yr and 5 yr survival rates. Materials and Method. Histological materials collected from the archives were used to evaluate histological parameters and immunohistochemical profiles. Standard methods were used for immunohistochemistry and for evaluation of results. Data related to recurrence and survival (3 and 5 years) was also recorded. Clinical data was collected from patients’ records. Results. Male to female ratio was 3 : 1. The commonest site of OSCC was the buccal mucosa, and majority of them were T3 or T4 tumours presented at stage 4. 62.5% of the tumours were well differentiated. Three-year and 5-year survival rates were significantly associated with lymph node metastasis and recurrence. POI was significantly correlated with tumour size, stage, 3-year survival, EGFR, HIF-1α, periostin, and MMP-9 ( p < 0.05 ). Expression of EGFR showed a direct association with metastasis ( p < 0.05 ). Conclusion. POI, level of differentiation, and expression of EGFR are independent prognostic markers for lymph node metastasis. Therefore, these parameters may help in treatment planning of a clinically negative neck.

scholarly journals Analysis of Clinicopathological Factors Affecting the Prognosis of Advanced Cervical Squamous Cell Carcinoma Treated With Chemoradiotherapy

2020 ◽  
Author(s):  
Zhenhua Zhang ◽  
Qian Dai ◽  
Yueshui Zhao ◽  
Shixin Xiang ◽  
Mintao Xiao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervical Squamous Cell Carcinoma ◽  
Factors Affecting ◽  
Node Metastasis ◽  
Resistant Group

Abstract ObjectiveThe clinical data of more than 900 patients with locally advanced cervical squamous cell carcinoma diagnosed for the first time and treated with radical chemoradiotherapy in recent 9 years were analyzed to find important prognostic factors in advanced cervical squamous cell carcinoma, and provide statistics for future research. MethodThe patients were divided into two groups: chemoradiotherapy resistant group and chemoradiotherapy sensitive group. The survival rate and prognostic factors were analyzed using R language. ResultThere was considerable difference in overall survival (OS) and progression free survival (PFS) between the two groups, of which the chemoradiotherapy sensitive group is about 10 months longer than the resistant group. In the chemoradiotherapy resistant group, there were more patients with higher staging, higher NLR(neutrophil to lymphocyte ratio), lymph node metastasis, and a total radiotherapy time of more than 8 weeks. For the factors affecting chemoradiotherapy sensitivity, radiotherapy alone rather than simultaneous chemoradiotherapy, late tumor stage, lymph node metastasis and a total time of radiotherapy more than 8 weeks predicts lower sensitivity. ConclusionThe main clinical factors affecting chemoradiotherapy sensitivity were tumor stage, lymph node metastasis and the total time of radiotherapy. Chemoradiotherapy sensitivity, tumor diameter, NLR, PLR (platelet to lymphocyte ratio) and total time of radiotherapy were independent prognostic factors for OS and PFS.

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