scholarly journals Periostin + cancer‐associated fibroblasts promote lymph node metastasis by impairing the lymphatic endothelial barriers in cervical squamous cell carcinoma

2020 ◽  
Vol 15 (1) ◽  
pp. 210-227
Author(s):  
Wen‐Fei Wei ◽  
Xiao‐Jing Chen ◽  
Luo‐Jiao Liang ◽  
Lan Yu ◽  
Xiang‐Guang Wu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervical Squamous Cell Carcinoma ◽  
Cancer Associated Fibroblasts ◽  
Node Metastasis ◽  
Endothelial Barriers

Analysis of prognostic factors with cervical squamous cell carcinoma after neoadjuvant chemotherapy

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 15060-15060
Author(s):  
S. Hayashi ◽  
T. Fujii ◽  
M. Nakamura ◽  
N. Hirao ◽  
H. Nakagawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Ct Scan ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Cervical Squamous Cell Carcinoma ◽  
Disease Recurrence ◽  
Node Metastasis

15060 Background: The purpose of the study was to evaluate retrospectively the clinical effects of neoadjuvant chemotherapy (NAC) given to women with cervical squamous cell carcinoma using the response rates, prognostic parameters, and diagnostic imaging data (CT scan or MRI). Methods: Patients included in the study were 32 women with a mean age of 48.8 ± 10.6 who had stage Ib-IIIb cervical squamous cell carcinoma and was treated initially with platinum-based NAC prior to surgical intervention at our institution between 1994 and 2003. The response rates in these patients were assessed, and a statistical analysis was performed to evaluate the effects of NACT on survival rates and disease recurrence using the following 9 parameters: 1. clinical stage of cancer, 2. lymph node metastasis, 3. blood vessel invasion, 4. parametrial involvement, 5. depth of stromal invasion, 6. tumor diameter, 7. pre- and post-treatment serum levels of the squamous cell carcinoma antigen, 8. age, and 9. rates of response to NAC. CT scan or MRI obtained prior to and after NAC were compared and evaluated for any evidence of lymph node metastasis. Results: Five and 18 patients achieved complete response (CR) and partial response (PR), respectively, with a response rate of 71.8% for these CR and PR patients. A multivariate analysis revealed that lymph node metastasis was the only independent prognostic parameter for survival rates and disease recurrence. In 13 patients in whom lymph node metastasis was found by the was found by the CT scan or MRI prior to NAC, 8 (61.5%) still showed the evidence of metastasis after treatment. Among these, 7 (87.5%) actually had metastatic lymph nodes. In addition, the occurrence of lymph node metastasis was unrelated to rates of response to NAC. Conclusions: The rates of response to NAC dose not predict prognosis in patients with cervical squamous cell carcinoma. The occurrence of lymph node metastasis is unrelated to rates of response to NAC. If metastatic lymph nodes are suspected after NAC, appropriate treatment approaches should be well considered in such patients. No significant financial relationships to disclose.

scholarly journals Analysis of Clinicopathological Factors Affecting the Prognosis of Advanced Cervical Squamous Cell Carcinoma Treated With Chemoradiotherapy

2020 ◽  
Author(s):  
Zhenhua Zhang ◽  
Qian Dai ◽  
Yueshui Zhao ◽  
Shixin Xiang ◽  
Mintao Xiao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervical Squamous Cell Carcinoma ◽  
Factors Affecting ◽  
Node Metastasis ◽  
Resistant Group

Abstract ObjectiveThe clinical data of more than 900 patients with locally advanced cervical squamous cell carcinoma diagnosed for the first time and treated with radical chemoradiotherapy in recent 9 years were analyzed to find important prognostic factors in advanced cervical squamous cell carcinoma, and provide statistics for future research. MethodThe patients were divided into two groups: chemoradiotherapy resistant group and chemoradiotherapy sensitive group. The survival rate and prognostic factors were analyzed using R language. ResultThere was considerable difference in overall survival (OS) and progression free survival (PFS) between the two groups, of which the chemoradiotherapy sensitive group is about 10 months longer than the resistant group. In the chemoradiotherapy resistant group, there were more patients with higher staging, higher NLR(neutrophil to lymphocyte ratio), lymph node metastasis, and a total radiotherapy time of more than 8 weeks. For the factors affecting chemoradiotherapy sensitivity, radiotherapy alone rather than simultaneous chemoradiotherapy, late tumor stage, lymph node metastasis and a total time of radiotherapy more than 8 weeks predicts lower sensitivity. ConclusionThe main clinical factors affecting chemoradiotherapy sensitivity were tumor stage, lymph node metastasis and the total time of radiotherapy. Chemoradiotherapy sensitivity, tumor diameter, NLR, PLR (platelet to lymphocyte ratio) and total time of radiotherapy were independent prognostic factors for OS and PFS.

scholarly journals Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma

2020 ◽  
Author(s):  
Jiaqi Zhu ◽  
Ruixue Zhao ◽  
Wei Xu ◽  
Jing Ma ◽  
Xin Ning ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Endoplasmic Reticulum ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Binding Protein ◽  
Cervical Squamous Cell Carcinoma ◽  
Expression Levels ◽  
Node Metastasis

Abstract Purpose: The aim of this study was to investigate the relationship between endoplasmic reticulum ribosomal binding protein 1 (RRBP1) expression in cervical squamous cell carcinoma tissues and its poor prognosis. RRBP1 is a nascent transporter on the rough endoplasmic reticulum. Its function is to regulate the transport and secretion of proteins in cells, and to relieve endoplasmic reticulum (ER) stress, thereby promoting tumor cell proliferation.Methods: The expression levels of RRBP1 in 96 cervical squamous cell carcinoma tissues were detected by immunohistochemistry. Western blot and qRT-PCR were used to compare the expression levels of RRBP1 in cervical squamous cell carcinoma tissues and normal cervical tissues. Then the chi-square test was used to analyze the results of immunohistochemistry. Finally, the Kaplan-Meier method was used to analyze the results by log-rank test and Cox regression (proportional risk model).Result: The overexpression of RRBP1 in cervical squamous cell carcinoma tissues was related to FIGO stage (P=0.030), tissue differentiation (P=0.047), lymph node metastasis (P=0.031), and was not related to the patient age (P=0.667). Univariate survival analysis showed that the prognosis was associated to the expression level of RRBP1 (P=0.045) and lymph node metastasis (P=0.001). Analysis of multi-factor survival cox model proved that RRBP1 was an independent prognostic factor. Conclusion: RRBP1 was overexpressed in cervical squamous cell carcinoma tissues, indicating that RRBP1 may be a new tumor marker for early diagnosis, treatment and prognosis of cervical squamous cell carcinoma, and it will provide help for individualized treatment and prognosis of cervical squamous cell carcinoma in the future.

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