Quality-of-life index: Implications for prognosis in colorectal cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 16032-16032
Author(s):  
R. Neelam ◽  
C. G. Lis ◽  
D. L. Citrin ◽  
S. Williams ◽  
P. G. Vashi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Patient Satisfaction ◽  
Case Series ◽  
Well Being ◽  
Rank Test ◽  
Life Index ◽  
Quality Of Life Index ◽  
The Impact

16032 Background: Quality of Life (QoL) assessment is important to evaluate the impact of disease and treatment in patients with advanced cancer. Recently, it has been hypothesized that patient satisfaction with their QoL may have a prognostic role in cancer, however, there is little evidence in the literature to support this view. The Ferrans and Powers Quality of Life Index (QLI) is one such instrument. QLI defines QoL as a person’s sense of well-being that stems from satisfaction or dissatisfaction with the areas of life that are important to him/her. The purpose of this study was to determine whether baseline QLI would predict length of survival in patients with colorectal cancer undergoing care in a non-clinical trial setting. Methods: We examined a case series of 177 colorectal cancer patients treated at Cancer Treatment Centers of America between 04/01 and 11/04. QLI measures global QoL and QoL in four major subscales: health and physical, social and economic, psychological and spiritual, and family. All scores range from 0 to 30 with higher scores indicating better QoL. QLI subscales were dichotomized at the median to split the patient population into 2 distinct groups. Kaplan Meier method with Log Rank test was used to calculate survival. Results: Of 177 patients, 46 were newly diagnosed and 131 had prior treatment history. The median age was 53 years (range 25– 85 years). 8 patients had stage I disease, 16 stage II, 51 stage III, and 77 stage IV. Table 1 describes the median survival for all QLI subscales. Conclusions: Baseline levels of patient satisfaction with their health and physical functioning provided useful prognostic information in colorectal cancer. Interestingly, the other subscales that evaluate various existential and economic issues did not provide statistically significant differences in survival. These findings need to be evaluated further to ascertain which subscales of QLI have a role in predicting patients’ prognosis. [Table: see text] No significant financial relationships to disclose.

Prognostic significance of quality of life index in breast cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 6135-6135
Author(s):  
D. Gupta ◽  
J. F. Grutsch ◽  
J. Granick ◽  
R. Neelam ◽  
P. G. Vashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Patient Satisfaction ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Breast Cancer Patients ◽  
Prognostic Information ◽  
Life Index ◽  
Quality Of Life Index

6135 Background: Quality of Life (QoL) is a multidimensional construct. There is extensive data showing that QoL tools measuring the activities of daily life provide prognostic information in cancer. However, similar information on QoL tools measuring patient satisfaction with their life is sparse. The Ferrans and Powers Quality of Life Index (QLI) is one such instrument. The goal of this study was to evaluate the statistical strength of association between QLI and survival in breast cancer patients undergoing care in a non-clinical trial setting. Methods: We examined a case series of 251 breast cancer patients treated at Cancer Treatment Centers of America between 04/01 and 11/04. QLI defines QoL in terms of satisfaction with the aspects of life that are important to the patient. QLI measures overall QoL and QoL in four major subscales: health and physical, social and economic, psychological and spiritual, and family. All scores range from 0 to 30 with higher scores indicating better QoL. Study patients were dichotomized into 2 groups based on median scores for all QoL subscales. Kaplan Meier method was used to calculate survival. Log-Rank test was used to study the equality of survival distributions. Results: Of 251 patients, 74 were newly diagnosed and 177 had prior treatment history. The median age was 48 years (range 25 - 74 years). 45 patients had stage I disease, 105 stage II, 38 stage III, and 32 stage IV. The table describes the median survival for all QLI subscales. Health and physical functioning subscale and QLI subtotal subscale were significantly associated with survival. Conclusions: This study shows that baseline levels of patient satisfaction with their QoL provide useful prognostic information in breast cancer. While these findings need to be evaluated further to ascertain which subscales of QoL have a role in predicting patients’ prognosis, they have important implications for patient stratification in clinical trials and may aid decision-making in clinical practice. [Table: see text] No significant financial relationships to disclose.

Association of the quality of psychosocial support and quality of life in patients with chronic oncological pain.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e23113-e23113
Author(s):  
Juan Francisco Gonzalez-Guerrero ◽  
Antonia Gloria Alcorta-Garza ◽  
Fernando Alcorta-Nuñez ◽  
Emma María Melgoza-Alcorta ◽  
Melany Gonzalez-Rodriguez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Chronic Diseases ◽  
Psychosocial Support ◽  
Metastatic Cancer ◽  
Life Index ◽  
Quality Of Life Index ◽  
The University ◽  
The Impact

e23113 Background: Most studies report that tumor related pain occurs between 46% and 92%. The prevalence of pain by clinical stage is 15% in initial stages, 30% in middle stages, 74% in metastatic cancer and, 87% in terminal disease. In the face of chronic diseases such as cancer, patient's relationships with their social networks are affected; among them the interpersonal relationships between the patient and his networks and these towards the patient. With this, the patient’s quality of life is affected. Most of the recent studies on health-related quality of life come from pharmaceutical groups, so it is necessary for other groups to be vigorously involved in the study of the effect of medical interventions on the quality of life, as well as on the impact on health and on the social support of patients with chronic diseases. Methods: In order to obtain the data, validated questionnaires were used as instruments to evaluate the quality of life, measuring psychosocial and health variables, as well as for the detection of the type and quality of psychosocial support perceived by the subjects. The instruments were applied to 207 patients of the Oncology Service of the University Center Against Cancer of the University Hospital “Dr. Jose Eleuterio Gonzalez” in Nuevo Leon, Mexico, during a session of 25 to 30 minutes. Results: Data were collected from 207 patients with chronic oncological pain. The satisfaction index with psychosocial support had a high linear correlation ( r = .640) with the quality of life index. On the other hand, the number of caregivers was not correlated with this last index. Fatigue was the symptom most frequently associated with a decrease in the quality of life index. In addition, pain correlated with all variables except the cognitive index. Conclusions: Satisfaction with the perceived social support is a factor associated with the quality of life in patients with chronic oncological pain; however, the number of caregivers is not. There was no relationship between the size of the network and satisfaction with it. Also, the symptoms associated with chronic oncological pain affect quality of life, identity and social functionality and roles, which in turn impact on the quality of life perceived by patients.

scholarly journals Validation study of the Multicultural Quality of Life Index (MQLI) in a Peruvian sample

2006 ◽  
Vol 28 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Kurt I Schwartz ◽  
María I Zapata-Vega ◽  
Juan E Mezzich ◽  
Guido Mazzotti
Keyword(s):  
Quality Of Life ◽  
Internal Structure ◽  
Discriminant Validity ◽  
High Reliability ◽  
Well Being ◽  
Average Score ◽  
Life Index ◽  
Significant Difference ◽  
Quality Of Life Index

OBJETIVE: The Multicultural Quality of Life Index is a concise instrument for comprehensive, culture-informed, and self-rated assessment of health-related quality of life. It is composed of 10 items (from physical well-being to global perception of quality of life). Each item is rated on a 10-point scale. The objective was to evaluate the reliability (test-retest), internal structure, discriminant validity, and feasibility of the Multicultural Quality of Life Index in Lima, Peru. METHOD: The reliability was studied in general medical patients (n = 30) hospitalized in a general medical ward. The Multicultural Quality of Life Index was administered in two occasions and the correlation coefficients ("r") between both interviews were calculated. Its discriminant validity was studied statistically comparing the average score in a group of patients with AIDS (with presumed lower quality of life, n = 50) and the average score in a group of dentistry students and professionals (with presumed higher quality of life, n = 50). Data on its applicability and internal structure were compiled from the 130 subjects. RESULTS: A high reliability correlation coefficient (r = 0.94) was found for the total score. The discriminant validity study found a significant difference between mean total score in the samples of presumed higher (7.66) and lower (5.32) quality of life. The average time to complete the Multicultural Quality of Life Index was less than 4 minutes and was reported by the majority of subjects as easily applicable. A high Cronbach's a (0.88) was also documented. CONCLUSIONS: The results reported that the Multicultural Quality of Life Index is reliable, has a high internal consistency, is capable of discriminating groups of presumed different quality of life levels, is quite efficient, and easy to use.

Quality of life assessment among children with psoriasis

2021 ◽  
pp. 41-48
Author(s):  
Yulia V. Agafonova ◽  
Daria L. Simonova ◽  
Sergey N. Simonov
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Complete Recovery ◽  
Skin Lesions ◽  
Life Assessment ◽  
Life Index ◽  
Scalp Psoriasis ◽  
Quality Of Life Index ◽  
The Impact

An increase of psoriasis in childhood, a more severe course of this disease, the presence of a cosmetic defect, which causes a negative impact on the quality of life of such patients, determine the relevance of this problem of modern dermatology. Psoriasis is characterized by a psoriatic rash, which is based on hyperkeratosis caused by uncontrollable mitosis of keratinocytes. Despite the recent studies of a large number of various mechanisms that can contribute to the psoriasis development, there is still no clear answer which of them is the main one, and this makes it impossible to achieve in most cases the desired clinical result of treatment, in particular, ensuring stable clinical remission or complete recovery of patients. The purpose of our study was to assess the impact of psoriatic manifestations on the quality of life among children. The object of observation was 106 children aged 4 to 17 years suffering from psoriasis. The average age of the children was 13 years. The measurement was carried out using the “Dermatological Quality of Life Index” (DLQI) (age 16–17 years), and the “Pediatric Dermatological Quality of Life Index” (CDLQI) (age 4–15 years). In addition, we analyze the severity indices of psoriasis in children: BSA, PASI and PGA. As a result of the study, the following was found: in general, psoriasis has a small impact on the quality of life in children – DLQI in children with psoriasis is 5 points; the value of the DLQI index is statistically significantly higher in girls than in boys, and with age the effect on the quality of life in children with psoriasis increases; skin lesions with psoriatic plaques of open areas in children has a significant impact on the quality of life: with scalp psoriasis, the DLQI level is the highest; statistically significant relationships between DLQI and psoriasis severity indices are established: between DLQI and BSA (r = 0.378; p < 0.001), between PASI and DLQI (r = 0.38; p < 0.001). With an increase in the intensity of manifestations of the pathological process assessed by the PGA index, the influence of psoriasis on the quality of life among children also increases (p = 0.011). According to the results of the study, methodological recommendations on medical and social support for children with psoriasis were drawn up and provided to specialized medical organizations.

scholarly journals Surgical treatment for colorectal cancer: analysis of the influence of an enhanced recovery programme on long-term oncological outcomes—a study protocol for a prospective, multicentre, observational cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e040316
Author(s):  
Jose-M Ramirez-Rodriguez ◽  
Javier Martinez-Ubieto ◽  
Jose-L Muñoz-Rodes ◽  
Jose-R Rodriguez-Fraile ◽  
Jose-A Garcia-Erce ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cohort Study ◽  
Enhanced Recovery ◽  
Intervention Group ◽  
Rank Test ◽  
Control Group ◽  
The Impact

IntroductionThe evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life.Methods and analysisA multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant.Ethics and disseminationEthical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings.Trial registration numberNCT04305314.

scholarly journals Predictive model estimating the decrease of postoperative gastrointestinal quality of life index (GIQLI) in patients after elective laparoscopic sigmoid resection for diverticular disease

2021 ◽  
Author(s):  
Alberto Posabella ◽  
Daniel Christian Steinemann ◽  
Raoul André Droeser ◽  
Nadshathra Varathan ◽  
Selin Göksu Ayçiçek ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Disease ◽  
Predictive Model ◽  
Diverticular Disease ◽  
Well Being ◽  
Related Factors ◽  
Life Index ◽  
Quality Of Life Index ◽  
Gastrointestinal Quality Of Life

Abstract Background Growing consideration in quality of life (QoL) has changed the therapeutic strategy in patients suffering from diverticular disease. Patients’ well-being plays a crucial role in the decision-making process. However, there is a paucity of studies investigating patients’ or surgery-related factors influencing the postoperative gastrointestinal function. The aim of this study was to investigate in a predictive model patients or surgical variables that allow better estimation of the postoperative gastrointestinal QoL. Methods This observational study retrospectively analyzed patients undergoing elective laparoscopic sigmoidectomy for diverticulitis between 2004 and 2017. The one-time postoperative QoL was assessed with the gastrointestinal quality of life index (GIQLI) in 2019. A linear regression model with stepwise selection has been applied to all patients and surgery-related variables. Results Two hundred seventy-two patients with a mean age of 62.30 ± 9.74 years showed a mean GIQLI of 116.39±18.25 at a mean follow-up time of 90.4±33.65 months. Women (n=168) reported a lower GIQLI compared to male (n=104; 112.85±18.79 vs 122.11±15.81, p<0.001). Patients with pre-operative cardiovascular disease (n=17) had a worse GIQLI (106.65 ±22.58 vs 117.08±17.66, p=0.010). Finally, patients operated less than 5 years ago (n=63) showed a worse GIQLI compared to patients operated more than 5 years ago (n=209; 111.98±19.65 vs 117.71±17.63, p=0.014). Conclusions Female gender and the presence of pre-operative cardiovascular disease are predictive for a decreased postoperative gastrointestinal QoL. Furthermore, patients’ estimation of gastrointestinal functioning seems to improve up to 5 years after surgery. Graphical abstract

scholarly journals The impact of herbal remedies on adverse effects and quality of life in HIV-infected individuals on antiretroviral therapy

2010 ◽  
Vol 5 (01) ◽  
pp. 048-053 ◽  
Author(s):  
Nyashadzashe Bepe ◽  
Nathan Madanhi ◽  
Tinashe Mudzviti ◽  
Samuel Gavi ◽  
Charles C Maponga ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Antiretroviral Therapy ◽  
Herbal Remedy ◽  
Antiretroviral Drugs ◽  
Herbal Remedies ◽  
P Value ◽  
Life Index ◽  
Quality Of Life Index ◽  
The Impact

Introduction: Use of herbal remedies among HIV-infected individuals in Africa increased in the past decade, mainly due to traditional beliefs and at times inconsistent access to antiretroviral drugs.  In Zimbabwe, accessibility and availability of antiretroviral drugs has increased in recent years; however, the use of herbal remedies remains high.   This study was conducted to determine the impact of concomitant use of herbal remedies with antiretroviral drugs on adverse events and on quality of life. Methodology: A convenient sample of HIV positive patients at Parirenyatwa group of hospitals' Family Care Clinic (Harare, Zimbabwe) was enrolled. A questionnaire was used to collect data on the adverse event experiences of the patients using herbal remedies for their HIV, as well as the types of herbal remedy used. Quality of life index was measured using an HIV/AIDS targeted quality of life (HAT-QOL) tool developed by the World Health Organization. Results:  Abdominal pain (odds ratio = 2.7, p-value = 0.01) and rash (odds ratio = 2.5, p-value = 0.02) had significant associations with using herbal remedies during antiretroviral therapy. Improved quality of life index was not significantly associated with herbal remedy use during antiretroviral therapy. Conclusions:  There is evidence to suggest that some traditional herbal remedies used in Zimbabwe may increase incidence of certain types of adverse events when used in combination with antiretroviral drugs.  Use of herbal drugs in combination with antiretroviral therapy does not significantly improve quality of life index in comparison to antiretroviral drug use only.

scholarly journals Life quality as an indicator of sustainable development: international statistical research

2021 ◽  
Vol 30 (4) ◽  
pp. 772-780
Author(s):  
Iryna M. Trunina ◽  
Inna V. Khovrak ◽  
Kateryna A. Pryakhina ◽  
Olga P. Usanova
Keyword(s):  
Quality Of Life ◽  
Sustainable Development ◽  
Life Quality ◽  
Basic Knowledge ◽  
Statistical Research ◽  
Life Index ◽  
Depth Analysis ◽  
Quality Of Life Index ◽  
The Impact

The purpose of the article is to substantiate the methodology for determining the European quality of life index. The theoretical and methodological basis of research is the ideas of the interdependence of life quality and sustainable development. To achieve the desired goal, the following research methods were used: analysis and synthesis (for determining theoretical and practical aspects of ensuring the life quality); statistical (for determining standardized indicators and a European Quality of Life Index for Sweden and Ukraine); abstract-logical (for theoretical summarization and conclusion). As a result, the authors created the European Quality of Life Index based on the comparison of the characteristics of international life quality assessment systems (calculation principle, number and composition of indicators, number of countries covered for calculation), as well as systematization of research by Ukrainian and foreign authors. Therefore, the authors selected twelve main indicators. The indicators are divided into two groups: stimulants (prosperity index, basic human needs index, welfare bases, availability of nutrition and basic health care, GDP per capita, population, global competitiveness index, personal security, access to basic knowledge, ecosystem status) and disincentive (government debt, unemployment). To determine the “European life quality index”, the authors used the formula for calculating the arithmetic mean, as all selected indicators can be considered equivalent as a result of standardization by the method of “minimum- maximum”. In addition, for in-depth analysis, the authors calculated the growth rates of indicators, as well as coefficients of variation. The authors made calculations based on data of 2013–2019 for two countries, namely Sweden and Ukraine. Sweden occupies a much better position in achieving the Sustainable Development Goals, so studying the impact of life quality on sustainable development in this country will suggest ways to achieve the chosen strategic priorities for Ukraine.

Sign in / Sign up

Export Citation Format

Share Document