Improvement in quality of life and symptom control with MYCOBACTERIUM W (CADI-05) in head and neck cancer

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 21186-21186
Author(s):  
R. I. Dave ◽  
U. B. Tripathi ◽  
B. J. Parikh ◽  
K. M. Patel ◽  
H. K. Shukla
Keyword(s):  
Quality Of Life ◽  
Neck Cancer ◽  
Side Effect ◽  
Symptom Control ◽  
Age Distribution ◽  
The Body ◽  
One Year ◽  
And Control ◽  
Mycobacterium W

21186 Background: Recurrent, radiated and chemotherapy given patients are having many unmanageable symptoms and problems. This condition is worsened by malnutrion, infection, pain and immuno suppression. Modifying immune mechanism of the body is the last and best weapon to fight against such diseases. Role of immunotherapy in the treatment of malignant diseases is on experimental level. Dr George Thyphrontis & Michael Kousilers have produced good results in carcinoma of urinary bladder, melanoma & lung cancer with Immunotherapy. At GCRI, we have tried vaccine, prepared from mycobacterium-W in 100 cases of Head & Neck Cancer. Methods: As a prospective nonrandomized study, to see beneficiary effect on quality of life and symptom control, we have done a trial during Jan. 2004 to Dec.2005. Informed consent and ethical clearance was obtained. Study was made to find out any side effect or adverse reactions of the vaccine. After fulfilling the criteria of inclusion and exclusion the case was selected for study and 0.1 ml vaccine (CADI-05) was injected intradermally with all aseptic precautions. Four injections, weekly and later on four injections monthly were given. Patient was followed up for 6 months. Results: Total No. of cases -100. M / F - 89/11. age distribution - Maximum No. were in 5th decade -(34%) followed by 6th decade (21%)Site of primary - Commonest site was Buccal mucosa (29%) followed by tongue (17%). There was no major side effect. Only 5% Patients developed constitutional symptoms and infection at injection site. 27% patients had pain relief. Symptom control was seen in 15% patients. Improvement in quality of life was observed in 82% of patients. 4% of patients had no effect. The beneficiary effect lasted for three month in 27% patients and more than six months in 13% patients. The effect was more marked in dysphagia, ulcer and fistula. Effect was insignificant in strider, change in voice and metastatic nodes. Four patients are living with Immuvac in spite of disease symptom free for more than one year. Conclusions: Immunotherapy with Mycobacteium W can safely be used to improve quality of life and control of symptom in terminally ill Head & Neck cancer. No significant financial relationships to disclose.

Impact on quality of life and sleep in head and neck cancer survivors one year after receiving radiotherapy

2021 ◽  
Author(s):  
Natalia Muñoz Vigueras ◽  
Vanessa Gabriela Jerviz Guia ◽  
Isabel Castillo Pérez ◽  
Paula Obeso Benitez ◽  
Javier Martín Núñez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Cancer Survivors ◽  
Head And Neck ◽  
Neck Cancer ◽  
One Year

Supportive Care Needs of Patients with Head and Neck Cancer Referred to Palliative Medicine

2020 ◽  
Vol 163 (2) ◽  
pp. 356-363
Author(s):  
Chen Lin ◽  
Stephen Y. Kang ◽  
Samantha Donermeyer ◽  
Theodoros N. Teknos ◽  
Sharla M. Wells-Di Gregorio
Keyword(s):  
Quality Of Life ◽  
Substance Use ◽  
Head And Neck Cancer ◽  
Supportive Care ◽  
Head And Neck ◽  
Neck Cancer ◽  
Palliative Medicine ◽  
Symptom Control ◽  
Case Series

Objective Patients with head and neck cancer (HNC) face a unique set of unmet needs. A subset of these patients experience symptom control challenges related to their disease burden and treatments. A multidisciplinary approach involving palliative medicine is underutilized but crucial to identify and address these concerns. There is limited information on palliative integration with head and neck oncology. Study Design Case series with planned data collection. Setting Academic quaternary care center. Subjects and Methods We provide descriptive analyses of patients with HNC, including psychodiagnostic assessment and validated quality-of-life screening, from patients’ first encounter at outpatient palliative medicine. Results HNC (N = 80) contributed the greatest number of palliative referrals (25%) between 2010 and 2012. This cohort was 74% male and 79% Caucasian with a mean age of 53 years (95% CI, 51.1-54.9) and with stage IV disease of the oral cavity (28%) or oropharynx (31%). Sixty-three percent of patients had no evidence of disease. Seventy-five percent had a psychological history based on DSM-IV criteria ( Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition), and 70% had a history of substance use disorder. The most distressing quality-of-life concerns were pain, housing and financial problems, and xerostomia. Conclusions Patients with HNC who were referred to palliative medicine are burdened by multiple physical, psychological, substance use, and social challenges. We recommend comprehensive cancer-specific screening, such as the James Supportive Care Screening, to triage patients to appropriate supportive care services. Palliative care is one of many services that these patients may need, and it should be utilized at any point of the disease trajectory rather than reserved for end-of-life care.

Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer

2015 ◽  
Vol 191 (6) ◽  
pp. 501-510 ◽  
Author(s):  
Silke Tribius ◽  
Marieclaire Raguse ◽  
Christian Voigt ◽  
Adrian Münscher ◽  
Alexander Gröbe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Advanced Head ◽  
Intensity Modulated ◽  
One Year

scholarly journals Functional fitness and quality of life of elderly Lian Gong, Tai Chi, and Qigong practitioners

2020 ◽  
Author(s):  
Márcia Regina Martinez Tedeschi ◽  
Tatiane Assone ◽  
Mauro Ferreira ◽  
Káren Mendes Jorge de Souza
Keyword(s):  
Quality Of Life ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
The Body ◽  
Control Group ◽  
Case Group ◽  
Functional Fitness ◽  
And Control ◽  
Body Practices

Abstract BACKGROUND Long-term regular physical activity, such as body practices of Traditional Chinese Medicine, seems to be an important habit for maintaining the functional fitness, independence and quality of life of elderly individuals. However, scientific knowledge production concerning assessment of such practices, specifically for the elderly population, focusing on functional fitness and quality of life, is still modest. Moreover, there is a lack of studies with long-term follow-up and control groups. Therefore, this study aims to compare the parameters of functional fitness and the dimensions of quality of life of elderly participants and non-participants in the body practices of Traditional Chinese Medicine. Longer adherence time, shorter adherence time and control group have been considered. METHODS This is an observational epidemiological case-control study carried out with 118 elderly individuals (≥ 60 years). The case group was represented by 59 elderly people practicing the body practices of Traditional Chinese Medicine, and they were subdivided into two groups, according to their median adherence time (< 24 months and ≥ 24 months). The control group was composed of 59 participants who were not participating in physical activity programs or guided body practices. Collection was carried out in four Traditional Medicine Specialized Units of the Municipal Health Office of the city of São Paulo. Sociodemographic and functional variables were collected. Quality of life was measured by Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). For data analysis, a univariate logistic regression and the Kruskal Wallis test have been performed. RESULTS When assessing quality of life, favorable results were found for the case group, with longer (≥ 24 months) adherence time in the domains of bodily pain (p = 0.003), vitality (p = 0.021), role emotional (p = 0.034), and mental health (p = 0.020). A better result was observed in the case group, with longer (≥ 24 months) adherence time in the functional 30-second chair stand test (p = 0.006). CONCLUSIONS The body practices of Traditional Chinese Medicine can contribute to quality of life, functional fitness, and lower limb strength.

scholarly journals Robotic surgery of head and neck cancers, a narrative review

2020 ◽  
Vol 30 (2) ◽  
pp. 297-303
Author(s):  
Farbood Kalantari ◽  
Shahin Rajaeih ◽  
Ali Daneshvar ◽  
Zahra Karbasi ◽  
Mohammad Mahdi Salem
Keyword(s):  
Quality Of Life ◽  
Robotic Surgery ◽  
Head And Neck ◽  
Neck Cancer ◽  
Transoral Robotic Surgery ◽  
The Body ◽  
Head And Neck Cancers ◽  
Organ Function ◽  
Advantages And Disadvantages

Head and neck cancers are the most common cancers in the body. Treatments are determined on the basis of the location and stage of the primary tumor. The goal of treatment is to eliminate the tumor, prevent recurrence or metastasis, and maintain the quality of life. There are several treatments available for the management of head and neck cancers, including surgery, radiation therapy, chemotherapy, new molecular agents, and a combination of them. Transoral robotic technique is a short-time operation using a type of robotic machine in which the patient undergoes anesthesia for a shorter time and the side effects of this operation and the time of hospitalization are less than open surgery. Due to the importance of speed and accuracy in head and neck cancer surgery and the importance of application of robotics in surgery, the present study was designed and implemented to review the application of robotics in the management of head and neck cancers. In this review study, the keywords: application, robotic, surgical, head cancer, transoral robotic surgery (TORS), and neck cancer, were searched in ISI, PubMed, Scopus, Google scholar databases. Related articles written domestically or abroad that have covered areas such as the background of transoral robotic surgery, maintaining organ function and approaches, the advantages and disadvantages of TORS, the affordability of TORS, the combination of TORS with other therapeutic approaches published from 2003 to 2019 were reviewed. The use of robotic surgery for precise operations such as head and neck cancers seems to be essential. More advanced robotic devices are expected to expand the surgery treatment for head and neck cancers as well as the results of using TORS for oncologic optimization and acceptability of results while maintaining organ function and patient's quality of life.

Quality of life in elderly patients with head and neck cancer one year after diagnosis

Head & Neck ◽  
2004 ◽  
Vol 26 (12) ◽  
pp. 1045-1052 ◽  
Author(s):  
Wynia Derks ◽  
Rob J. de Leeuw ◽  
Gerrit Jan Hordijk ◽  
Jacques A. Winnubst
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Elderly Patients ◽  
Head And Neck ◽  
Neck Cancer ◽  
One Year

Quality-of-life among head and neck cancer survivors at one year after treatment – A systematic review

2012 ◽  
Vol 48 (15) ◽  
pp. 2391-2408 ◽  
Author(s):  
W.K.W. So ◽  
R.J. Chan ◽  
D.N.S. Chan ◽  
B.G.M. Hughes ◽  
S.Y. Chair ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Head And Neck Cancer ◽  
Cancer Survivors ◽  
Head And Neck ◽  
Neck Cancer ◽  
One Year

scholarly journals Mapping Health-Related Quality of Life, Anxiety, and Depression in Patients with Head and Neck Cancer Diagnosed with Malnutrition Defined by GLIM

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1167
Author(s):  
Ylva Tiblom Ehrsson ◽  
Per Fransson ◽  
Sandra Einarsson
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Anxiety And Depression ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
One Year

Patients with cancer deal with problems related to physical, psychological, social, and emotional functions. The aim was to investigate malnutrition defined by the Global Leadership Initiative on Malnutrition (GLIM) criteria in relation to health-related quality of life, anxiety, and depression in patients with head and neck cancer. This was a prospective observational research study with 273 patients followed at the start of treatment, seven weeks, and one year. Data collection included nutritional status and support, and the questionnaires: European Organization for Research and Treatment of Cancer Head and neck cancer module (EORTC QLQ-H&N35) and the Hospital Anxiety and Depression Scale (HADS). Malnutrition was defined using the GLIM criteria. The study showed that patients with malnutrition had significantly greater deterioration in their health-related quality of life at seven weeks. On a group level, health-related quality of life was most severe at this time point and some scores still implied problems at one year. Significantly, more patients reported anxiety at the start of treatment whereas significantly more patients reported depression at seven weeks. Over the trajectory of care, the need for support often varies. Psychosocial support is imperative and at the end of treatment extra focus should be put on nutritional interventions and managing treatment-related symptoms to improve nutritional status and health-related quality of life. In the long-term, head and neck cancer survivors need help to find strategies to cope with the remaining sequel.

scholarly journals Does the Masticatory Function Interfere With the Nutritional Status and Quality of Life in Individuals After Treatment for Head and Neck Cancer?

2021 ◽  
Author(s):  
Renata Camilla Favarin Froes ◽  
Mariana Inri Carvalho² ◽  
Raquel Rosa Rodrigues³ ◽  
Paulo Sérgio dos Santos Silva ◽  
Giédre Berretin-Felix
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Oral Health ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Muscle Activity ◽  
The Body ◽  
Fat Percentage

Abstract Head and neck cancer damages the oral health and chewing performance, impairing the nutritional status and quality of life even after treatment completion. Objective: This study investigated the effect of treatment on the chewing function, the influence on oral health in chewing function and the relationships between chewing, nutritional status and quality of life in individuals after treatment of head and neck cancer. Methods: The study was conducted on twenty individuals who were evaluated by surface electromyography; nutritional status; evaluation of oral health and quality of life. Results: The results of electromyography showed an asymmetric pattern, with predominance of activity on the working side. The correlations evidenced that the greater the use of upper dentures and caries activity, the greater the asymmetry of muscle activity, while the greater need of lower denture led to more chewing cycles. The lower the body fat percentage, the greater the symmetry of muscle activity; and the lower the recruitment of temporalis muscles, the greater the physical limitation. Conclusions: It was concluded that, in individuals after treatment of head and neck cancer, there was relationship between the correlated variables.

scholarly journals Nutritional Deficiencies in Radiotherapy-Treated Head and Neck Cancer Patients

2021 ◽  
Vol 10 (4) ◽  
pp. 574
Author(s):  
Tomasz Powrózek ◽  
Joanna Dziwota ◽  
Teresa Małecka-Massalska
Keyword(s):  
Quality Of Life ◽  
Body Composition ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Clinical Problem ◽  
The Body ◽  
Nutritional Deficiencies

Nutritional deficiencies (malnutrition, cachexia, sarcopenia, and unfavorable changes in the body composition) developing as a side effect of radiotherapy (RT) currently represents a significant but still inaccurately studied clinical problem in cancer patients. The incidence of malnutrition observed in head and neck cancer (HNC) patients in oncological radiology departments can reach 80%. The presence of malnutrition, sarcopenia, and cachexia is associated with an unfavorable prognosis of the disease, higher mortality, and deterioration of the quality of life. Therefore, it is necessary to identify patients with a high risk of both metabolic syndromes. However, the number of studies investigating potential predictive markers for the mentioned purposes is still significantly limited. This literature review summarizes the incidence of nutritional deficiencies in HNC patients prior to therapy and after the commencement of RT, and presents recent perspectives for the prediction of unfavorable nutritional changes developing as a result of applied RT.

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