Retroperitoneal lipo-leiomyomata in a woman with history of breast cancer and antiestrogen therapy.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e22542-e22542
Author(s):  
Jung Joo Moon ◽  
Daniel D Mais
Keyword(s):  
Breast Cancer ◽  
Histopathological Examination ◽  
Pelvic Mass ◽  
University Hospital ◽  
Retroperitoneal Mass ◽  
Diagnostic Challenge ◽  
Mdm2 Gene ◽  
Multiple Variable ◽  
History Of ◽  
Antiestrogen Therapy

e22542 Background: Retroperitoneal lipo-leiomyomata are extremely rare. The usual-type retroperitoneal leiomyoma is itself a rare tumor that is mistaken preoperatively for malignant retroperitoneal tumors or thought of as an exophytic subserosal leiomyoma of the uterus. Lipo-leiomyoma is a variant of leiomyoma with an incidence in uterus ranging between 0.03% - 0.2%, but its presentation as a retroperitoneal mass has not been documented in literature yet. We present a unique case of retroperitoneal lipo-leiomyoma that presented as a diagnostic challenge due to its unique location and unusual histologic appearance. Methods: A 68-year-old female patient with a history of breast cancer diagnosed 4 years ago, currently on antiestrogen therapy (Fulvestrant) and Herceptin, presented to our university hospital with symptomatic left pelvic mass. An abdominal CT showed a heterogeneous low-density pelvic mass with foci of internal calcification and fat with surrounding intermixed intermediate and high density fluid in the expected location of the uterus. Results: A debulking surgery including radical hysterectomy was planned. Intraoperatively, a normal sized uterus was found, the myometrium of which contained multiple variable-sized intramural leiomyomata. In addition, a huge left retroperitoneal mass was found that had no connection to the uterus. Histopathological examination revealed abenign lipoleiomyomatous tumor, composed of an encapsulated proliferation of benign adipocytes and myoid cells intimately admixed. Immunohistochemistry confirmed myoid differentiation, with negative reactions for HMB45 and CKIT, and . MDM2 gene amplification by fluorescence in situ hybridization (FISH) was negative. Conclusions: Some unusually located extra-uterine leiomyomata have been reported; retroperitoneal leiomyoma being among them. Such a tumor with the added feature of lipomatous differentiation presents a differential diagnosis that includes leiomyosarcoma, liposarcoma, angiomyolipoma, and gastrointestinal stromal tumor. The association of an uncommonly located leiomyoma with subsequent lipomatous change withantiestrogen therapy is an unexplored issue that merits further investigation.

Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst–Like Morphology

2017 ◽  
Vol 25 (4) ◽  
pp. 374-378 ◽  
Author(s):  
Carole Van Haverbeke ◽  
Jo Van Dorpe ◽  
Evelyne Lecoutere ◽  
Uta Flucke ◽  
Liesbeth Ferdinande ◽  
...  
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Bone Cyst ◽  
Dedifferentiated Liposarcoma ◽  
Resected Specimen ◽  
Retroperitoneal Mass ◽  
Mdm2 Gene ◽  
History Of ◽  
Mdm2 Overexpression

A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst–like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst–like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst–like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma.

scholarly journals CELIAC DISEASE

2015 ◽  
Vol 22 (01) ◽  
pp. 072-075
Author(s):  
Sana Zulfiqar ◽  
Amin Fahim ◽  
Aneela Qureshi ◽  
Sadia Adnan ◽  
Shomail Saeed Siddiqui ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Histopathological Examination ◽  
Duodenal Mucosa ◽  
Cross Sectional Study ◽  
University Hospital ◽  
P Value ◽  
Cross Sectional ◽  
Marsh Type ◽  
History Of ◽  
And Gender

Objective: To find out the Modified Marsh type of celiac disease (CD)patients on histopathological examination of duodenal (D2) biopsies and to correlate it withtissue transglutaminase IgA levels. Study Design: Cross sectional study. Place of Study:Histopathology laboratory (Department of Pathology), Isra University Hospital and AsianInstitute of Medical Sciences (AIMS), Hyderabad. Duration of Study: July 2013 to December2013. Materials and Methods: 96 patients with a history of malabsorption or atypical symptomswith clinical suspicion of CD were subjected to endoscopy. Endoscopic duodenal (D2) biopsieswere taken regardless of age and gender. D2 biopsies were processed for histopathologicalexamination under light microscopy. Results: Out of 96 patients, 45 (46.9%) patients hadmoderate type of lamina propria inflammation along with highly significant p-value (0.0001).CDtype 3a was observed in 34 patients (35.4%). In this study the comparison of serological level oftissue Transglutaminase IgA (tTGA) and histological severity revealed significant correlation. AllModified Marsh types of CD with tTGA level seen in our study were highly significant (p-value0.001). Conclusion: In this study strong correlation was observed between the serologicaltTGA level and histological findings by Modified Marsh classification along with lamina propriainflammation of duodenal mucosa in CD patients.

scholarly journals Imaging finding in diabetic mastopathy: A case report

2018 ◽  
Vol 5 (2) ◽  
pp. 19
Author(s):  
Lynda Nadine Gui Bile ◽  
Hanane Antoun ◽  
Judicael Ahoury ◽  
Raissa Kabas ◽  
Estelle Valerie Ohui-Acko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Type I Diabetes ◽  
Imaging Finding ◽  
Breast Disease ◽  
Type I ◽  
Diagnostic Challenge ◽  
Diabetic Mastopathy ◽  
Biopsy Confirmation ◽  
History Of

Diabetic mastopathy is an uncommon immunologic breast disease occurring usually in patients under long-term insulin treatment. It can pose a question of differential diagnosis with breast cancer especially in case of family history of breast cancer. We report the radiological diagnostic approach of a case of diabetic mastopathy with family history of breast cancer. The mammogram was nonspecific. Ultrasound showed two suspicious masses of right breast without suspicious enhancement on MRI. Diabetic mastopathy was confirmed on histology without cancer cells. Diabetic mastopathy is a diagnostic challenge and needs to be suspected in all patients with type I diabetes. Image-guided biopsy confirmation remains mandatory. The literature is briefly reviewed.

scholarly journals Abdominal-Pelvic Actinomycosis Mimicking Malignant Neoplasm

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Teresa Pusiol ◽  
Doriana Morichetti ◽  
Corrado Pedrazzani ◽  
Francesco Ricci
Keyword(s):  
Intrauterine Device ◽  
Periodic Acid ◽  
Malignant Neoplasm ◽  
Pelvic Mass ◽  
Psoas Muscle ◽  
Distal Ileum ◽  
Retroperitoneal Mass ◽  
Diagnostic Challenge ◽  
Periodic Acid Schiff ◽  
Pelvic Actinomycosis

Abdominal-pelvic actinomycosis is often mistaken for other conditions, presenting a preoperative diagnostic challenge. In a 46-year-old female, computed tomography showed an abdominal-pelvic retroperitoneal mass extending from the lower pole of the right kidney to the lower pelvis. The patient had a 3-year history of intrauterine device. The mass appeared to involve the ascending colon, cecum, distal ileum, right Fallopian tube and ovary, and ureter anteriorly and the psoas muscle posteriorly. The resection of retroperitoneal mass, distal ileum appendicectomy, right hemicolectomy, and right salpingo-oophorectomy was performed. The postoperative period was uneventful. Penicillin therapy was given for six months without any complication. The retroperitoneal mass measured 4.5 × 3.5 × 3 cm, surrounded adjacent organs and histologically showed inflammatory granulomatous tissue, agglomeration of filaments, and sulfur granules ofActinomyces, with positive reaction with periodic acid Schiff. Right tubo-ovarian abscess was present. Abdominalpelvic actinomycosis should always be considered in patients with a pelvic mass especially in ones using intrauterine device.

scholarly journals Identification of BRCA1/2 p.Ser1613Gly, p.Pro871Leu, p.Lys1183Arg, p.Glu1038Gly, p.Ser1140Gly, p.Ala2466Val, p.His2440Arg variants in women under 45 years old with breast nodules suspected of having breast cancer in Burkina Faso

2019 ◽  
Vol 10 (1) ◽  
pp. 120-127
Author(s):  
Tani Sagna ◽  
Elena Bonora ◽  
Marie Nabonswindé Lamoussa Ouedraogo ◽  
Daniela Fusco ◽  
Abdou Azaque Zoure ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Burkina Faso ◽  
Genomic Dna ◽  
Direct Sequencing ◽  
Dna Amplification ◽  
University Hospital ◽  
Benign Tumors ◽  
Increased Risk ◽  
Pcr Products ◽  
History Of

AbstractBreast cancer is the top cause of cancer mortality among women in the world and the second in Africa. The aims of this study were to: i) identify women with breast nodules suspected of having breast cancer ii) sequence the BRCA1 and BRCA2 genes and iii) screen mutations. From 2015 to 2016, 112 women aged from 35 to 44 years, who had come for consultation in the gynecology/obstetrics and the oncology department of the University Hospital Yalgado Ouedraogo, voluntarily agreed to participate to this study. Whole blood was collected from those with mammary nodules. The genomic DNA was extracted using Qiagen kit. FAST KAPA was used for genomic DNA amplification and the purified PCR products were analyzed by direct sequencing using Big Dye v1.1 and ABI 3730 automated sequencer. Nucleotides substitutions were determined. We identified BRCA1 SNPs rs1799966, rs799917, rs16942, rs16941, rs2227945, and BRCA2 SNPs rs169547, rs4986860. These identified variants are found mostly in cases of benign tumors of breast or ovarian cancer with familial history of breast cancer. This study in Burkina-Faso, is the basis for improved and more specific genetic testing, and suggests that additional genes contributing to an increased risk of breast cancer should be analyzed.

Rapid Response of Breast Cancer Cutaneous Metastasis to Single-Agent Palbociclib: A Case Report

Chemotherapy ◽  
2021 ◽  
pp. 1-3
Author(s):  
Sami Droubi ◽  
Anum Aqsa ◽  
Maryam Rehan ◽  
Meekoo Dhar
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Histopathological Examination ◽  
Single Agent ◽  
Metastatic Breast ◽  
Radical Mastectomy ◽  
Cutaneous Metastasis ◽  
Breast Adenocarcinoma ◽  
Prior History ◽  
History Of

Palbociclib is a cyclin-dependent kinase (CDK) 4/6 inhibitor. Palbociclib combined with endocrine therapy has shown promising results in hormone-receptor-positive (HR+) and human epidermal growth factor receptor-negative (HER-2−) breast cancer progression. We present a case of a woman with a history of infiltrating lobular cancer of the left breast, status post modified radical mastectomy 6 years prior, presenting with nodular erythematous lesions on the left arm and back. Histopathological examination confirmed the diagnosis of recurrent metastatic breast adenocarcinoma. She had complete resolution of cutaneous metastasis with 1 cycle of Palbociclib. We believe our case is unique as the resolution of cutaneous metastasis with 1 cycle of single-agent Palbociclib is rare. Furthermore, it highlights the importance of considering cutaneous metastasis as a possibility in patients with prior history of primary internal malignancy.

scholarly journals Attitude, Awareness and Experience of Women towards the Breast Self-examination in Saudi Arabia

2019 ◽  
pp. 1-6
Author(s):  
Nisar Haider Zaidi ◽  
Fatma K. Althoubaity
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Breast Biopsy ◽  
Cultural Beliefs ◽  
Breast Cancer Incidence ◽  
University Hospital ◽  
Cancer Awareness ◽  
Breast Self Examination ◽  
History Of ◽  
Self Examination

Objective: To evaluate the attitude, awareness and experience of Women towards the breast self-examination. Methods: This is population-based study with the total number of the participants were 349 between 25-70 yrs of age, between December 2017 to February 2018 at King Abdulaziz University Hospital, Jeddah. A questionnaire was given to females attending the clinic or attending a lecture for breast cancer awareness. Results: A total of 349 patients were studied. Saudi was 76.5% and non-Saudi was 23.5%. Patients less than 25 years were 26.4% and above 25 years were 73.6%. The majority were between 25 to 45 years of age which was 66.4%. The majority were married 64.5%, single 30.4%, widow 2.9% and divorced were 2.3%. 65% had children and 59.3% did lactate their kids. Use of contraceptive pills was 50.4%. Family history of breast cancer was in 18.1% and sister had breast cancer in 3.46%, aunt 3.7%, stepdaughter in 6%, grandmother in 3.2% and mother in 2% of cases. Smokers were 10.6%. Family history of other malignancy was in 9.7% with colon cancer in 6.3% and uterus in 3.4%. History of taking herbs was in 14.6% of cases of which soya in 3.4%, baboon 2.6%, green tea 2.3%, ginger 2.3% and weight lowering herbs 1.7%. 12.3% of patient had breast biopsy and 12% had another tumour like thyroid, uterus, colon etc. 22.1% admitted that they did self- breast examination. Their source of knowledge about breast self-examination was Television in 13.5%, hospital 5.7% and doctor in 2.9%. Routine clinical examination was done in 82.2% and the reason for it was not known to the majority of them. Examination by doctors was done in 25.5% of cases. Mammography was done by 16.9%, ultrasound in 16.9%. 12.3% preferred mammography. Regarding the belief that biopsy will lead to spreading of the tumour, 16.3% said that they believe it. 3.4% believed that cancer is infective disease and 86.2% believed that breastfeeding decreases breast cancer incidence. Conclusions: Breast self-examination is an effective tool to detect early breast cancer especially in poor and underdeveloped countries which lack resources for proper screening of breast cancer. Cultural beliefs and ritual practices may affect early detection of breast cancer.

Image-guided biopsy of non-palpable breast lesions: Experience of a university hospital in Mexico City.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e11098-e11098
Author(s):  
Daniela Morales-Espinosa ◽  
Lilian Monica Navarro-Garcia ◽  
Dan Green ◽  
Daniel Motola ◽  
Gabriela Alvarado-luna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Mexico City ◽  
Medical Records ◽  
University Hospital ◽  
Past Medical History ◽  
Image Guided ◽  
History Of ◽  
Advanced Stages ◽  
Palpable Breast

e11098 Background: Breast cancer is the most common cancer in women in Mexico. It is mostly diagnosed at advanced stages. Objective: To describe the experience of image-guided biopsies of non-palpable breast tumors in a University Hospital in Mexico City. Methods: Medical records from the Radiology and Oncology Department (January 2007 - April 2011) were reviewed. Patients with incomplete medical records as well as those lacking imaging control and pathology report were excluded. Results: A total of 123 medical records were obtained,12 were excluded. The median age was 50 years (rank 21-88). Most patients were asymptomatic. Medical indications leading to biopsy: see table below. Of the studied population, 56% had a family history of any type of cancer; 40% had a family history of breast cancer. Nine patients had a past medical history positive for breast cancer, 8 patients had a past medical history of any type of cancer. 26 patients were nulligravid and 60 post-menopausal; of which 27 had received hormone replacement therapy. 24 patients had positive contraceptive use. Most patients were catalogued as BIRADs 4A. From all the imaged-marked lesions, only 18 were malignant; 72% of which were carcinoma in situ. Most procedures were ambulatory; only 15 patients had to be admitted. The complications rate was very low (6%), 1 procedure-related infection, 3 seromas and 3 hematomas. Conclusions: Imaging-guided biopsies are a safe, with very low morbidity, accessible procedure. It helps to prompt effective treatment; especially in patients with non-palpable lesions who would otherwise not be diagnosed until advanced stages. [Table: see text]

scholarly journals Clinical and mammographic profile of patients with breast cancer surgically treated

2015 ◽  
Vol 61 (3) ◽  
pp. 220-226
Author(s):  
Raquel Rodrigues Muradas ◽  
Maria Teresa Aquino de Campos Velho ◽  
Itamar dos Santos Riesgo ◽  
Alexandre Duarte Brum ◽  
Raquel Montagner Rossi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Histopathological Examination ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Research Committee ◽  
Cross Sectional ◽  
Palpable Mass ◽  
Santa Maria

Summary Objective: to analyze the epidemiological, clinical and mammographic profile of women with breast cancer who were treated at the mastology clinic of the University Hospital of Santa Maria and who underwent breast surgery between January 2007 and December 2012. Methods: this was a cross-sectional study, approved by the Ethics in Research Committee. A review of the patients' medical records was performed. The data were then exported to a software program for statistical analysis, namely Minitab 14.1. Results: the patients' profile indicated that they were mostly born and raised in Santa Maria (respectively 11.1%, n=16, and 26.3%, n=68). They were about 55.6 years old (SD±12.3), white (90.2%, n=213), had already given birth and breastfed their children, were nonsmokers, but also overweight (average BMI of 27kg/m2). On physical examination of the first medical consultation, these patients, as described in the records: had a palpable mass (81.1%, n=184) measuring over three centimeters, located in the left breast, precisely in the upper outer quadrant (41.4%, n=81). Mammography (39%, n=109) showed that this lump was classified as BIRADS ® 5 (40%, n=81). On histopathological examination, the lump was diagnosed as an invasive ductal cancer (71.1%, n=191). Surgery was generally a radical mastectomy (84.7%, n=236) with axillary dissection (92.5%, n=222). Conclusion: some of the epidemiological, clinical and mammographic features mentioned above resembled those found in the literature reviewed. However, these patients had advanced disease and underwent non conservative surgical procedures.

scholarly journals Male Breast Cancer in Togo: Imaging and Clinicopathological Findings

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Tchin Darre ◽  
Mazamaesso Tchaou ◽  
Toukilnan Djiwa ◽  
Panakinao Simgban ◽  
Ayi Kossi Amavi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rare Condition ◽  
University Hospital ◽  
Luminal B ◽  
Clinicopathological Findings ◽  
History Of ◽  
Annual Frequency ◽  
Grade Ii ◽  
The University ◽  
Breast Cancer In Men

Background. Breast cancer in men is a rare condition, often diagnosed late. The purpose of this study was to describe its epidemiological, histopathological, and radiographic aspects in Togo. Materials and Methods. This was a descriptive retrospective study on cases of breast cancer in humans diagnosed histologically at the Laboratory of Anatomy Pathological and Imagery of the University Hospital in Lomé, over a period of 25 years (1995 to 2019). The parameters studied were epidemiological, anatomopathological, and imaging. Results. Eighty-two (82) cases were diagnosed, an annual frequency of 3.28 cases. The mean age was 45±2.5 years; the range was 27-63 years. The family history of 47 patients (57.32%) was known. Carcinomas represented the predominant histological group with predominantly nonspecific invasive carcinoma (87.5%). These cancers were diagnosed at late stages (75.71% grade II). They were mainly of luminal B profile (38.75%) and associated with mutations of the BRCA2 and BRCA1 genes in 14.63% of the cases. The lesions were classified ACR 5 in 61.5% (11/18). Two cases of breast angiosarcoma were diagnosed by the identification of CD31 markers and factor VIII in immunohistochemistry. Hormone therapy such as tamoxifen was prescribed in all luminal patients (43 patients). Radiotherapy was administered to 15 patients (18.3%), with acute toxicity in 20% of the cases. After a median follow-up of 36 months, the evolution was complete remission in 27 patients (32.93%). Conclusion. Breast cancer in men is rare, often diagnosed late with a poor prognosis.

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