Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst–Like Morphology

2017 ◽  
Vol 25 (4) ◽  
pp. 374-378 ◽  
Author(s):  
Carole Van Haverbeke ◽  
Jo Van Dorpe ◽  
Evelyne Lecoutere ◽  
Uta Flucke ◽  
Liesbeth Ferdinande ◽  
...  
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Bone Cyst ◽  
Dedifferentiated Liposarcoma ◽  
Resected Specimen ◽  
Retroperitoneal Mass ◽  
Mdm2 Gene ◽  
History Of ◽  
Mdm2 Overexpression

A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst–like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst–like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst–like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma.

Primary telangiectatic osteosarcoma of the cervical spine

2012 ◽  
Vol 16 (4) ◽  
pp. 373-378 ◽  
Author(s):  
Mazda K. Turel ◽  
Vivek Joseph ◽  
Vandita Singh ◽  
Vinu Moses ◽  
Vedantam Rajshekhar
Keyword(s):  
Cervical Spine ◽  
Aneurysmal Bone Cyst ◽  
Histopathological Examination ◽  
Bone Cyst ◽  
Biological Behavior ◽  
Adjuvant Radiation ◽  
Diagnostic Challenge ◽  
Telangiectatic Osteosarcoma ◽  
History Of ◽  
Glue Embolization

Telangiectatic osteosarcoma (TOS) is one of the 8 subtypes of osteosarcoma that infrequently affects the spine. The radiopathological features of TOS overlap with those of more benign entities, most commonly the aneurysmal bone cyst), and therefore is a significant diagnostic challenge. It is a rare but well-described entity in the thoracolumbar and sacral spine, and to the authors' knowledge has not been previously reported in the cervical spine. The authors report the case of a 15-year-old boy who presented with a 6-month history of neck pain and torticollis. He underwent preoperative glue embolization followed by a staged subtotal C-5 spondylectomy and posterior fusion for a C-5 vertebral body lytic expansile lesion. Histopathological examination showed the lesion to be TOS. The surgery was followed by adjuvant radiation and chemotherapy with a favorable outcome at the 1-year follow-up. This report reiterates that TOS is an important differential diagnosis for aneurysmal bone cyst and giant-cell tumor of the spine, as its biological behavior and clinical outcome differ from those of these more benign lesions, which it mimics.

Retroperitoneal lipo-leiomyomata in a woman with history of breast cancer and antiestrogen therapy.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e22542-e22542
Author(s):  
Jung Joo Moon ◽  
Daniel D Mais
Keyword(s):  
Breast Cancer ◽  
Histopathological Examination ◽  
Pelvic Mass ◽  
University Hospital ◽  
Retroperitoneal Mass ◽  
Diagnostic Challenge ◽  
Mdm2 Gene ◽  
Multiple Variable ◽  
History Of ◽  
Antiestrogen Therapy

e22542 Background: Retroperitoneal lipo-leiomyomata are extremely rare. The usual-type retroperitoneal leiomyoma is itself a rare tumor that is mistaken preoperatively for malignant retroperitoneal tumors or thought of as an exophytic subserosal leiomyoma of the uterus. Lipo-leiomyoma is a variant of leiomyoma with an incidence in uterus ranging between 0.03% - 0.2%, but its presentation as a retroperitoneal mass has not been documented in literature yet. We present a unique case of retroperitoneal lipo-leiomyoma that presented as a diagnostic challenge due to its unique location and unusual histologic appearance. Methods: A 68-year-old female patient with a history of breast cancer diagnosed 4 years ago, currently on antiestrogen therapy (Fulvestrant) and Herceptin, presented to our university hospital with symptomatic left pelvic mass. An abdominal CT showed a heterogeneous low-density pelvic mass with foci of internal calcification and fat with surrounding intermixed intermediate and high density fluid in the expected location of the uterus. Results: A debulking surgery including radical hysterectomy was planned. Intraoperatively, a normal sized uterus was found, the myometrium of which contained multiple variable-sized intramural leiomyomata. In addition, a huge left retroperitoneal mass was found that had no connection to the uterus. Histopathological examination revealed abenign lipoleiomyomatous tumor, composed of an encapsulated proliferation of benign adipocytes and myoid cells intimately admixed. Immunohistochemistry confirmed myoid differentiation, with negative reactions for HMB45 and CKIT, and . MDM2 gene amplification by fluorescence in situ hybridization (FISH) was negative. Conclusions: Some unusually located extra-uterine leiomyomata have been reported; retroperitoneal leiomyoma being among them. Such a tumor with the added feature of lipomatous differentiation presents a differential diagnosis that includes leiomyosarcoma, liposarcoma, angiomyolipoma, and gastrointestinal stromal tumor. The association of an uncommonly located leiomyoma with subsequent lipomatous change withantiestrogen therapy is an unexplored issue that merits further investigation.

scholarly journals Giant Endometrial Polyp in a Postmenopausal Woman without Hormone/Drug Use and Vaginal Bleeding

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Betül Ünal ◽  
Selen Doğan ◽  
Fatma Şeyda Karaveli ◽  
Tayup Şimşek ◽  
Gülgün Erdoğan ◽  
...  
Keyword(s):  
Postmenopausal Woman ◽  
Drug Use ◽  
Vaginal Bleeding ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Uterine Cavity ◽  
Endometrial Polyp ◽  
Lower Back ◽  
History Of

The objective of this study is to determine and discuss the causes of a giant endometrial polyp in a postmenopausal woman without hormone/drug use and to submit interesting clinical presentation. Here we report a seventy-year-old female patient who was admitted to our hospital with lower back pain. There were no other complaints from her. Physical examination was normal. For further examination, computed tomography was performed and a heterogeneous mass, with a diameter of 10×9 centimeters, was detected in the uterine cavity. Hysterectomy because of suspected endometrial cancer was performed. Histopathological examination showed us a giant endometrial polyp with edematous and focal fibrotic stroma, large thick walled blood vessels between normal sized and cystically dilated endometrial glands. To the best of our knowledge, this is the first report of a giant endometrial polyp which is unrelated to use of drugs such as tamoxifen and raloxifene; however, based on the history of the patient it may be associated with long-term consumption of thyme, which is a kind of phytoestrogen.

Aneurysmal bone cyst of the spine

2005 ◽  
Vol 119 (6) ◽  
pp. 495-497 ◽  
Author(s):  
C E B Giddings ◽  
D Bray ◽  
S Stapleton ◽  
H Daya
Keyword(s):  
Differential Diagnosis ◽  
Aneurysmal Bone Cyst ◽  
Osteolytic Lesion ◽  
Bone Cyst ◽  
Treatment Modalities ◽  
Open Resection ◽  
Cervical Trauma ◽  
Radiographic Appearance ◽  
Posterior Triangle ◽  
History Of

The authors present the case of an 11-year-old boy with a painful, rapidly expanding lesion in the posterior triangle of the neck. There was no history of cervical trauma. Computerized tomography of the neck revealed a unicameral (single-chambered) aneurysmal bone cyst involving the C3 vertebra. Treatment was by open resection and curettage; no recurrence was seen at six months. We discuss the natural history, differential diagnosis, radiographic appearance and treatment modalities for this unusual, benign, expanding, osteolytic lesion containing blood-filled cystic cavities.

scholarly journals Localized Pigmented Villonodular Synovitis of the Hip: Sudden-Onset Pain Caused by Torsion of the Tumor Pedicle

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Kiyokazu Fukui ◽  
Ayumi Kaneuji ◽  
Eriko Kinoshita ◽  
Yuhei Numata ◽  
Takayuki Nojima ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Giant Cells ◽  
Pigmented Villonodular Synovitis ◽  
Sudden Onset ◽  
Resected Specimen ◽  
Villonodular Synovitis ◽  
Surgical Dislocation ◽  
Localized Pigmented Villonodular Synovitis ◽  
Pigmented Villonodular

Pigmented villonodular synovitis is a rare, benign, but potentially locally aggressive disease that should be considered in younger patients who present with monoarticular joint symptoms and pathology. We present the case of a 33-year-old woman with a mass arising from her right hip joint that was examined using a multimodal radiological approach. Because her clinical presentation mimicked that of synovial osteochondromatosis of the hip, surgical dislocation was performed. Histopathological examination of the resected specimen confirmed the diagnosis of localized pigmented villonodular synovitis, with the mass consisting of proliferation of fibrohistiocytic cells, abundant hemosiderin, foamy histiocytes, and occasional giant cells. Because of the presence of tumor necrosis, we hypothesize that torsion of the tumor pedicle was the cause of acute presentation.

scholarly journals Cecal Lipoma Presenting as Acute Intestinal Obstruction in an Elderly Woman: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Miltiades Kastanakis ◽  
Dimitrios Anyfantakis ◽  
Emmanouil K. Symvoulakis ◽  
Nikolaos Katsougris ◽  
Alexandros Papadomichelakis ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Intestinal Obstruction ◽  
Elderly Woman ◽  
Acute Abdominal Pain ◽  
Histopathological Examination ◽  
Right Hemicolectomy ◽  
Resected Specimen ◽  
Appetite Loss ◽  
Risk Of Malignancy ◽  
History Of

Colonic lipomas are rare nonepithelial tumors that are usually detected incidentally during surgery or colonoscopy. Although lipomas generally remain asymptomatic, when they exceed 2 cm of diameter they may cause abdominal pain, obstruction, or intussusception. Here we present a case of an elderly woman referred by her general practitioner to a general hospital of Crete because of acute abdominal pain along with signs of intestinal obstruction and a positive history of appetite loss. Abdominal computed tomography was performed. To marginalise the risk of malignancy, a right hemicolectomy was performed. Histopathological examination of the resected specimen confirmed the diagnosis of cecal lipoma.

scholarly journals The transformation of aneurysmal bone cyst into telangiectatic osteosarcoma: the development of a second tumour or a wrong initial diagnosis?

2020 ◽  
Vol 19 (4) ◽  
pp. 150-157
Author(s):  
N. V. Zhukov ◽  
L. L. Kazakova
Keyword(s):  
Differential Diagnosis ◽  
Aneurysmal Bone Cyst ◽  
Clinical Case ◽  
Clinical Presentation ◽  
Bone Cyst ◽  
Initial Diagnosis ◽  
Modern Concept ◽  
Morphological Pattern ◽  
Treatment Approaches ◽  
Telangiectatic Osteosarcoma

Aneurysmal bone cyst (ABC) and telangiectatic osteosarcoma (TOS) share a lot of similarities in terms of the initial clinical presentation, the radiological semiotics and even the morphological pattern, however, they are completely different nosological entities requiring absolutely different treatment approaches. This article reports a clinical case of TOS of the femur which developed 1.5 years after the treatment of ABC of the same location and presents an analysis of literature on the differential diagnosis of these diseases, the modern concept of the pathogenesis of ABC and the possibility of the transformation of ABC into TOS. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.

Classic Adamantinoma with Osteofibrous Dysplasia-like Foci and Secondary Aneurysmal Bone Cyst

2003 ◽  
Vol 6 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Angelica Putnam ◽  
Suzanne Yandow ◽  
Cheryl M. Coffin
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Unusual Case ◽  
Bone Cyst ◽  
Bone Lesion ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Osteofibrous Dysplasia ◽  
Pathologic Features ◽  
History Of ◽  
Secondary Aneurysmal Bone Cyst

Adamantinoma, a rare bone lesion of the tibia and fibula, has two distinct variants, classic adamantinoma and osteofibrous dysplasia-like adamantinoma. Composite lesions have not been described. Aneurysmal bone cyst is a benign cystic lesion which may also occur in the tibia and fibula. We report an unusual case of classic adamantinoma with osteofibrous dysplasia-like areas and foci of secondary aneurysmal bone cyst with prominent giant cells. A lesion was diagnosed in a 17-year-old girl with a 14-year history of a slowly enlarging left tibial mass and increasing deformity. Pathologically, the predominant pattern was classic adamantinoma, with minor foci of osteofibrous dysplasia-like adamantinoma and areas of secondary aneurysmal bone cyst with abundant multinucleated giant cells. We report the clinical, radiologic, and pathologic features of this case, and summarize lesions associated with secondary aneurysmal bone cyst. To our knowledge, the association of adamantinoma with secondary aneurysmal bone cyst has not been previously reported.

Role of Radiotherapy in a Recurrent Aneurysmal Bone Cyst of the Temporal Bone: Case Report

Neurosurgery ◽  
2006 ◽  
Vol 58 (3) ◽  
pp. E584-E584 ◽  
Author(s):  
Piyush Kumar ◽  
Shalini Singh ◽  
Rajendra V. Phadke ◽  
Himanshu Diwakar ◽  
Tanu Agarawal ◽  
...  
Keyword(s):  
Case Report ◽  
Temporal Bone ◽  
Aneurysmal Bone Cyst ◽  
Rare Case ◽  
Clinical Presentation ◽  
Bone Cyst ◽  
Temporal Region ◽  
Radiological Images

Abstract OBJECTIVE AND IMPORTANCE: A rare case of aneurysmal bone cyst (ABC) of the temporal bone is presented which, following recurrence after surgery, was successfully treated with radiotherapy. The role of radiotherapy in such cases is reviewed. CLINICAL PRESENTATION: A 30-year-old man presented with a recurrent swelling and pain in right temporal region following surgery for ABC at that site. INTERVENTION: Local radiotherapy to a dose of 31.5 Gy in 18 fractions over 3.5 weeks was delivered to the site of recurrence. The patient had a near total regression of the ABC as evident clinically and on radiological images. CONCLUSION: To the best of our knowledge, radiation for the recurrent ABC at the temporal bone has not been described in the literature. However, in view of the response evident in this patient, radiotherapy seems to be effective for recurrent cases of ABC at the temporal bone and a dose of around 30 to 36 Gy could be effectively delivered with satisfactory results.

Synchronous Renal Dedifferentiated Liposarcoma and Retroperitoneal Well-Differentiated Liposarcoma: A Case Report With Literature Review

2020 ◽  
pp. 106689692098168
Author(s):  
Ling Nie ◽  
Xueqin Chen ◽  
Jing Gong ◽  
Mengni Zhang ◽  
Miao Xu ◽  
...  
Keyword(s):  
Left Kidney ◽  
Final Diagnosis ◽  
Dedifferentiated Liposarcoma ◽  
Pathological Examination ◽  
Retroperitoneal Mass ◽  
Mdm2 Gene ◽  
Contrast Enhanced ◽  
High Grade Sarcoma ◽  
Well Differentiated ◽  
Enhanced Computed Tomography

Liposarcoma is the most common soft tissue malignancy and usually occurs in the retroperitoneum or the extremities but rarely in the kidney. In this article, we report a case of a 71-year-old female patient who presented with abdominal lump and left flank pain for 1 month. An abdominal contrast-enhanced computed tomography scan demonstrated a 12 cm × 7 cm solid mass arising from the upper pole of left kidney and another 8 cm × 6 cm low-density retroperitoneal mass with fat density. Radical nephrectomy of the left kidney and resection of the retroperitoneal mass were performed. Surprisingly, pathological examination revealed a high-grade sarcoma (with minor lipomatous component) in the left kidney and a retroperitoneal well-differentiated liposarcoma. MDM2 gene amplification was identified by fluorescence in situ hybridization in both tumors, supporting final diagnosis of dedifferentiated liposarcoma of the kidney and well-differentiated liposarcoma of the retroperitoneum.

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