Assessment of pulmonary function test abnormalities in adult survivors of childhood cancer.

117 Background: As childhood cancer survival approaches 85%, it is increasingly recognized that childhood cancer survivors (CCS) are at risk for long-term therapy-related complications. Data suggest that pulmonary function test (PFT) abnormalities occur in as many as 84.1% of CCS. Our aim was to assess the prevalence and nature of respiratory abnormalities in adult CCS and to correlate these abnormalities with therapeutic exposures and health behaviors. Methods: Patients who received pulmonary toxic therapy routinely undergo PFTs at their first visit to the POGO AfterCare clinic in Ottawa, Canada. We conducted a retrospective review of all patients seen in clinic from August 2015 until December 2016. PFT results, treatment exposures and health habits were documented. We used NHANES-III prediction equations for PFT interpretation, with expiratory flows and lung volumes of ≥80% predicted as cutoffs for normal. Results: Of a total of 200 patients, 48 received pulmonary toxic therapy and 38 underwent PFTs. Mean age at the time of PFT was 28.8 years (18.5-57.5 years) and the mean time from diagnosis was 17.4 years (3.4-47.5 years). Although no patients reported respiratory symptoms, 42% (16/38) demonstrated a mild restrictive ventilatory defect, 11% (4/38) had mild airflow obstruction, 18% (7/38) had an isolated reduction in diffusion capacity and 1 patient had a moderate mixed obstructive/restrictive abnormality. Only 26% (10/38) had normal lung function. Of those with restrictive defects, all received radiation and 50% were also exposed to pulmonary toxic chemotherapy. All patients with obstructive defects received radiation therapy in combination with bleomycin. Tobacco or marijuana use was reported in 26% (10/38) of the cohort, and in 29% (8/28) of those with PFT abnormalities. Conclusions: PFT abnormalities are common among adult CCS who received pulmonary toxic therapy. Studies evaluating the change in pulmonary function abnormalities over time and their correlation to cardiopulmonary exercise testing and lung imaging are required to inform the health impact on these survivors.

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CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary function test results

Jornal Brasileiro de Pneumologia ◽

10.1590/s1806-37132013000600009 ◽

2013 ◽

Vol 39 (6) ◽

pp. 701-710 ◽

Cited By ~ 3

Author(s):

Helena Mocelin ◽

Gilberto Bueno ◽

Klaus Irion ◽

Edson Marchiori ◽

Edgar Sarria ◽

...

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Test ◽

Clinical Score ◽

Obliterative Bronchiolitis ◽

Normal Lung ◽

Test Results ◽

Air Trapping ◽

Clinical Scores ◽

Function Test ◽

Minute Walk

OBJECTIVE: To determine whether air trapping (expressed as the percentage of air trapping relative to total lung volume [AT%]) correlates with clinical and functional parameters in children with obliterative bronchiolitis (OB).METHODS: CT scans of 19 children with OB were post-processed for AT% quantification with the use of a fixed threshold of −950 HU (AT%950) and of thresholds selected with the aid of density masks (AT%DM). Patients were divided into three groups by AT% severity. We examined AT% correlations with oxygen saturation (SO2) at rest, six-minute walk distance (6MWD), minimum SO2 during the six-minute walk test (6MWT_SO2), FVC, FEV1, FEV1/FVC, and clinical parameters.RESULTS: The 6MWD was longer in the patients with larger normal lung volumes (r = 0.53). We found that AT%950 showed significant correlations (before and after the exclusion of outliers, respectively) with the clinical score (r = 0.72; 0.80), FVC (r = 0.24; 0.59), FEV1 (r = −0.58; −0.67), and FEV1/FVC (r = −0.53; r = −0.62), as did AT%DM with the clinical score (r = 0.58; r = 0.63), SO2 at rest (r = −0.40; r = −0.61), 6MWT_SO2 (r = −0.24; r = −0.55), FVC (r = −0.44; r = −0.80), FEV1 (r = −0.65; r = −0.71), and FEV1/FVC (r = −0.41; r = −0.52).CONCLUSIONS: Our results show that AT% correlates significantly with clinical scores and pulmonary function test results in children with OB.

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Medium-Term Pulmonary Function Test After Thoracoscopic Lobectomy and Segmentectomy for Congenital Lung Malformation: A Comparative Study With Normal Control

Frontiers in Pediatrics ◽

10.3389/fped.2021.755328 ◽

2021 ◽

Vol 9 ◽

Author(s):

Jin-Xi Huang ◽

Song-Ming Hong ◽

Jun-Jie Hong ◽

Qiang Chen ◽

Hua Cao

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Test ◽

Small Airway ◽

Normal Lung ◽

Control Group ◽

Medium Term ◽

Thoracoscopic Lobectomy ◽

Congenital Lung Malformation ◽

Significant Difference ◽

Function Test

Purpose: This study aimed to compare the outcomes and pulmonary function test (PFT) of thoracoscopic segmentectomy and lobectomy in infants with congenital lung malformation and study the result of PFT on a medium-term basis.Methods: The clinical data of 19 infants with congenital lung malformation who underwent thoracoscopic surgery in our hospital from January 2018 to March 2019 were retrospectively studied; these infants were paired with another 19 infants who underwent thoracoscopic lobectomy during the same period using propensity score matching. Age-matched healthy individuals with similar body sizes were recruited for PFT as the control group. Patient characteristics, postoperative PFT, and outcomes were extracted for statistical analysis.Results: The average length of hospital stay did not significantly differ between segmentectomy and lobectomy groups. The segmentectomy group had more chest tube drainage than the lobectomy group. PFT 1 month after the operation showed that the tidal volume of the lobectomy group was lower than that of the segmentectomy group. Time to peak expiratory flow/time of expiration and peak flow/terminal airway velocity (V25%) indicated small airway dysfunction in the lobectomy group, and no obvious abnormalities were found in “time of inspiratory/time of expiration” in either group. Reexamination of pulmonary function 2 years after the operation showed that the small airway function of the segmentectomy group returned to normal, and no significant difference in pulmonary function was noted among the three groups.Conclusion: The short-term pulmonary function recovery was better after segmentectomy than after lobectomy. Patients who underwent thoracoscopic lobectomy and segmentectomy have normal lung function 2 years after the operation.

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High-Resolution CT in Patients with Chronic Airflow Obstruction: Correlation with Clinical Diagnosis and Pulmonary Function Test

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2000.42.6.939 ◽

2000 ◽

Vol 42 (6) ◽

pp. 939

Author(s):

Ki Taek Hong ◽

Eun Young Kang ◽

Ji Yong Rhee ◽

Jin Hyung Kim ◽

Jung Ah Choi ◽

...

Keyword(s):

High Resolution ◽

Pulmonary Function ◽

Clinical Diagnosis ◽

Pulmonary Function Test ◽

Airflow Obstruction ◽

High Resolution Ct ◽

Function Test

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The role of the pulmonary function test and the exercise test for assessing impairment/disability in patients with chronic airflow obstruction

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.1996.43.3.377 ◽

1996 ◽

Vol 43 (3) ◽

pp. 377 ◽

Cited By ~ 1

Author(s):

Seon Hee Cheon

Keyword(s):

Pulmonary Function ◽

Exercise Test ◽

Pulmonary Function Test ◽

Airflow Obstruction ◽

Function Test

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Significance of frequent spirometry test in treated pulmonary tuberculosis patients in tertiary care teaching hospital

IP Indian Journal of Immunology and Respiratory Medicine ◽

10.18231/j.ijirm.2021.017 ◽

2021 ◽

Vol 6 (2) ◽

pp. 75-79

Author(s):

Jaykumari Choudhary ◽

Suprova Chakraborty ◽

Prasanta Kumar De

Keyword(s):

Pulmonary Tuberculosis ◽

Pulmonary Function ◽

Pulmonary Function Test ◽

Communicable Disease ◽

Tertiary Care ◽

Normal Lung ◽

Test Results ◽

Duration Of Symptoms ◽

Function Test ◽

Restrictive Pattern

Tuberculosis is one of the most important communicable disease, which poses a global public health threat and remains the leading cause of death among infectious diseases, especially in undeveloped and developing countries.It was a prospective, observational, hospital based study conducted in the department of Respiratory Medicine, IPGMER SSKM Hospital, Kolkata from January 2020 to December 2020. Atotal of 80 cases, with history of adequately treated one episode of pulmonary tuberculosis, were included in this study.According to pulmonary function test results, 30(37.5%) patients had obstructive pattern and 11(13.8%) had restrictive pattern, in spirometry. Another 15(18.8%) patients had, mixed obstructive/restrictive pattern, while in rest 24 (30%) patients, spirometry test results were normal. The distribution of various pulmonary function test results among patients with obstructive pattern (N=30), ATT completion history was 7.57 ± 2.77 years back in average. Whereas average duration of symptoms in them was found to be 4.03 ± 1.96 years. For patients with restrictive pattern (N=11), these durations were 10.91 ± 2.51years and 7.59 ± 2.35 years respectively. Patients with mixed pattern (N=15), both durations were 11.33 ± 3.50 years and 7.33 ± 2.94 years respectively. Whereas among patients with normal lung function (N=24), ATT completion duration was 2.83 ± 2.21 years and symptom onset duration was 0.63 ± 0.34 years.There was emphatically found thatduration of anti-tubercular treatment, duration of symptoms and pulmonary function abnormalities. Hence clinical suspicion, early diagnosis and early treatment strategy are required to prevent further deterioration of pulmonary function in treated Pulmonary tuberculosis (PTB) patients. So, frequent or annual spirometry is required in these patients.

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