Implementation of HPV vaccination pilot project in Kazakhstan: Successes and challenges.

e13056 Background: Cervical cancer (CC) is the second most frequent cancer of women after breast cancer. Prophylactic vaccines for human papillomavirus (HPV) are being introduced in many countries more than 10 years ago. The standardized incidence of СС in Kazakhstan (KZ) in 2017 was 17.1 per 100,000 women. From 2013 to 2016, there was a pilot project of school-based HPV vaccination of adolescent girls in four districts of KZ. Vaccination was carried out with two vaccines (Gardasil and Cervarix) on the choice of parents in a three-dose regimen. Due to the high rejection of vaccination, this program was completed in 2016. Aim of study was to analyze the results of HPV vaccination in KZ. Methods: The results of vaccination of adolescent girls from 9 to 15 years old were evaluated. We analyzed database registry of Kazakhstani vaccinated girls to evaluate vaccine coverage in four district of KZ. Results: A total 11,648 adolescent girls were fully vaccinated during the pilot program for 2013-2016. The average age of the vaccinated is 12.67 ± 1.04. In 2013, immunization was performed for 1,816 girls aged 11–13 years. In 2014, the age range of the target group was expanded to 15 years. The number of vaccinated girls increased to 5,699 adolescent girls. 7,136 girls were fully vaccinated in 2015. 10,004 girls have not received full doses of vaccine. Overall coverage rates of fully vaccinated were 14.8%. The majority of coverage results was stastically similar except for Almaty, where coverage was higher than the average coverage (17.9% vs. 14.8%, p < 0.05). Conclusions: Pilot project of vaccination in Kazakhstan was declared unsuccessful. This situation is associated with a lack of information campaigns on vaccination. This findings highlights the need for phased implementation of vaccination through an educational campaign of parents.

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Impact of a Brief School Based Educational Intervention to Increase the Knowledge about HPV Vaccination among Adolescent Girls

International Journal of Healthcare Education & Medical Informatics ◽

10.24321/2455.9199.201811 ◽

2018 ◽

Vol 05 (03) ◽

pp. 6-10

Author(s):

Latha M Sneha ◽

Keyword(s):

Adolescent Girls ◽

Educational Intervention ◽

Hpv Vaccination ◽

School Based

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Random network models to predict the long term impact of HPV vaccination on genital warts

10.20944/preprints201707.0083.v1 ◽

2017 ◽

Author(s):

Javier Díez-Domingo ◽

Víctor Sánchez-Alonso ◽

Rafael-J. Villanueva ◽

Luis Acedo ◽

José-Antonio Moraño ◽

...

Keyword(s):

Vaccine Coverage ◽

Random Network ◽

Hpv Vaccination ◽

Herd Immunity ◽

Network Models ◽

Dose Schedule ◽

Genital Warts ◽

Contact Network ◽

Long Term Impact ◽

Coverage Rates

HPV vaccine induces a herd immunity effect in genital warts when a large number of the population is vaccinated. That aspect should be taken into account when devising new vaccine strategies, like vaccination at older ages or male vaccination. Therefore it is important to develop mathematical models with good predictive capacities. We devised a sexual contact network that was calibrated to simulate the Spanish epidemiology of different HPV genotypes. Through this model we simulated the scenario that occurred in Australia in 2007, where 12-13 year-old girls where vaccinated with a three-dose schedule of a vaccine containing genotypes 6 and 11, that protect against genital warts, and also a catch-up program in women up to 26 years of age. Vaccine coverage were 73 % in girls with three doses and with coverage rates decreasing with age until 52 % for 20-26 year-olds. A fast 59 % reduction in the genital warts diagnoses occurred in the model in the first years after the start of the program, similar to what was described in the literature.

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Introduction of human papillomavirus (HPV) vaccination in Belgium, 2007-2008

Eurosurveillance ◽

10.2807/ese.14.46.19407-en ◽

2009 ◽

Vol 14 (46) ◽

Author(s):

C Simoens ◽

M Sabbe ◽

P Van Damme ◽

P Beutels ◽

M Arbyn

Keyword(s):

Human Papillomavirus ◽

Secondary School ◽

Hpv Vaccine ◽

Vaccine Coverage ◽

Hpv Vaccination ◽

Target Population ◽

Hepatitis B Vaccination ◽

First Year ◽

Vaccine Introduction ◽

School Based

This paper documents the progress of human papillomavirus (HPV) vaccine introduction in Belgium. Information on vaccine use is based on sales statistics and reimbursement claims. From November 2007 to November 2008, the National Institute for Health and Disability Insurance reimbursed the HPV vaccine for girls aged between 12-15 years. In December 2008, the age limit was extended to include girls up to the age of 18. In November 2008, the total number of HPV vaccines sold exceeded 530,000 doses. The number of vaccines reimbursed in Belgium, for the period November 2007-November 2008, corresponds to the amount required to fully vaccinate 44% of all girls aged between 12-15 years. However, the trend was decreasing over the last 10 months. By the current reimbursement policy, we can expect that maximum half of the target population can be reached. In Flanders (one of the three Communities in Belgium), the intention is to start, from September 2010, with a free school-based HPV immunisation for girls in the first year of secondary school (12 years of age), complemented with vaccination by a physician of choice. This strategy ensures a higher HPV vaccine coverage which is expected to be as high as the current coverage in the hepatitis B vaccination programme (approximately 80%) offered to boys and girls in the same age group and under the same circumstances.

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Evolution of Public Health Human Papillomavirus Immunization Programs in Canada

Current Oncology ◽

10.3390/curroncol28010097 ◽

2021 ◽

Vol 28 (1) ◽

pp. 991-1007

Author(s):

Alexandra Goyette ◽

Glorian P. Yen ◽

Voica Racovitan ◽

Parambir Bhangu ◽

Smita Kothari ◽

...

Keyword(s):

Public Health ◽

Human Papillomavirus ◽

Vaccination Coverage ◽

Prince Edward Island ◽

Hpv Vaccination ◽

Hpv Infection ◽

After School ◽

Vaccination Programs ◽

School Based ◽

Coverage Rates

Background: Since 2007, all Canadian provinces and territories have had a publicly funded program for vaccination against human papillomavirus (HPV) infection. The objective of this study was to describe the evolution of these vaccination programs. Methods: This was a targeted literature review of public HPV vaccination programs and vaccination coverage rates, based on information provided by jurisdictional public health authorities. Results: HPV vaccination of schoolgirls began in school years 2007/08 to 2010/11 with three doses of the quadrivalent HPV vaccine in all provinces except Quebec, which started with two doses. By 2018/19, all jurisdictions were vaccinating with two doses of the nonavalent vaccine in both girls and boys, except Quebec, which used a mixed vaccination schedule with one dose of the nonavalent and one dose of the bivalent vaccines. Public HPV vaccination programs in most provinces include after-school catch-up vaccination. Immunocompromised or other high-risk individuals are eligible for the HPV public vaccination program in most provinces, but policies vary by jurisdiction. In 2017/18, vaccination coverage rates in provincial HPV school-based programs varied from 62% in Ontario to 86% in Prince Edward Island in girls and from 58% in Ontario to 86% in Prince Edward Island in boys. Conclusions: Since their introduction, Canadian school-based HPV public vaccination programs have evolved from a three-dose to a two-dose schedule, from a quadrivalent to a nonavalent vaccine, and from a girls-only to a gender-neutral policy. Vaccination coverage rates have varied markedly and only Prince Edward Island and Newfoundland/Labrador have maintained rates exceeding 80%.

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Human papillomavirus vaccination and respect for children’s developing autonomy: Results from a European Union wide study

Journal of Child Health Care ◽

10.1177/1367493519852476 ◽

2019 ◽

Vol 23 (3) ◽

pp. 343-357 ◽

Cited By ~ 2

Author(s):

Kyriakos Martakis ◽

Denise Alexander ◽

Tamara Schloemer ◽

Mitch Blair ◽

Michael Rigby ◽

...

Keyword(s):

European Union ◽

Human Papillomavirus ◽

Vaccine Coverage ◽

Hpv Vaccination ◽

European Economic Area ◽

Paradigm Change ◽

Human Papillomavirus Vaccination ◽

Vaccination Programs ◽

Coverage Rates ◽

Sex Equity

Children’s rights to autonomy of choice are differently expressed throughout Europe. We explored differences regarding expressions of respect for children’s autonomy throughout Europe, using the procedure of human papillomavirus (HPV) vaccination offer as indicator. We used a mixed methods approach, utilizing an expert survey within the frame of “Models of Child Health Appraised” (MOCHA), among all 30 European Union (EU) and European Economic Area states. A questionnaire was designed using vignettes regarding the vaccine provision. Thirty MOCHA country agents were invited to respond from June 2017 to April 2018. In total, 28 country agents responded. We studied the following themes: (i) provision of informed consent, (ii) parental and medical paternalism, (iii) relevance of the child’s chronological age or maturity, and (iv) vaccination programs targeting boys. These are being handled differently across the region. We explored associations of these implemented practices with the national vaccine coverage rate across Europe. We used the processes of HPV vaccination to study child’s autonomy, the paradigm change toward libertarian paternalism and issues of sex-equity. Interestingly, greater respect for children’s autonomy tends to be associated with medium or high vaccination coverage rates and lower respect with lower rates. Respect and empowerment seem to have practical as well as moral benefits. Identifying and transferring the most suitable ethical approaches is crucial and should be strengthened.

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“I just signed”: Factors influencing decision-making for school-based HPV vaccination of adolescent girls.

Health Psychology ◽

10.1037/a0021449 ◽

2010 ◽

Vol 29 (6) ◽

pp. 618-625 ◽

Cited By ~ 35

Author(s):

Spring Chenoa Cooper Robbins ◽

Diana Bernard ◽

Kirsten McCaffery ◽

Julia M. L. Brotherton ◽

S. Rachel Skinner

Keyword(s):

Decision Making ◽

Adolescent Girls ◽

Hpv Vaccination ◽

School Based ◽

Factors Influencing

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Success of community approach to HPV vaccination in school-based and non-school-based settings in Haiti

PLoS ONE ◽

10.1371/journal.pone.0252310 ◽

2021 ◽

Vol 16 (6) ◽

pp. e0252310

Author(s):

Cynthia Riviere ◽

Tatiana Bell ◽

Yonie Cadot ◽

Christian Perodin ◽

Benedict Charles ◽

...

Keyword(s):

Adolescent Girls ◽

Vaccination Campaign ◽

Hpv Vaccination ◽

School Program ◽

Logistic Regression Models ◽

School Based ◽

Community Approach ◽

Series Completion ◽

Vaccination Campaigns ◽

Vaccination Completion

Objectives To assess the success of a human papillomavirus (HPV) vaccination program among adolescent girls aged 9–14 years in Haiti and to understand predictors of completion of a two-dose HPV vaccination series. Methods Data collection was conducted during HPV vaccination campaigns in Port-au-Prince between August 2016 and April 2017. Descriptive statistics and logistic regression models were used to examine characteristics associated with vaccination series completion of school based and non-school based vaccination delivery modalities. Results Of the 2,445 adolescent girls who participated in the awareness program, 1,994 participants (1,307 in non-school program, 687 in school program) received the first dose of the vaccine; 1,199 (92%) in the non-school program and 673 (98%) in the school program also received the second dose. Menarche (OR: 1.87; 95% CI, 1.11–3.14), if the participant was a prior patient at the GHESKIO clinics (OR: 2.17; 95% CI, 1.32–3.58), and participating in the school-based program (OR: 4.17; 95% CI, 2.14–8.12) were significantly associated with vaccination completion. Conclusions Vaccination in school- and non-school-based settings was successful, suggesting that a nationwide HPV vaccination campaign using either approach would be successful using either approach.

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Kesediaan Vaksinasi HPV pada Remaja Putri Ditinjau dari Faktor Orang Tua

Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) ◽

10.26699/jnk.v7i2.art.p213-222 ◽

2020 ◽

Vol 7 (2) ◽

pp. 213-222

Author(s):

Nonik Ayu Wantini ◽

Novi Indrayani

Keyword(s):

Adolescent Girls ◽

Emotional Support ◽

Parental Support ◽

Hpv Vaccination ◽

Information Support ◽

Bivariate Analysis ◽

P Value ◽

Fisher Exact Test ◽

Chi Square ◽

Cross Sectional

Infeksi HPV dan pre kanker serviks (sel-sel abnormal pada leher rahim yang dapat menyebabkan kanker) telah menurun secara signifikan sejak vaksin HPV digunakan.Cakupan vaksinasi HPV masih rendah di Indonesia.Orang tua adalah pemegang tanggung jawab dan kewajiban utama di dalam penjaminan pemenuhan hak dasar anak untuk mendapatkan vaksinasi. Tujuan penelitian adalah untuk mengetahui faktor yang berhubungan (sikap, kepercayaan, dukungan orang tua) dengan kesediaan vaksinasi pada remaja putri. Jenis penelitian adalah survey analitik dengan pendekatan cross sectional. Penelitian dilaksanakan di SD Muhammadiyah Macanan, Ngemplak dan SMPN 1 Berbah, Sleman pada Mei-Juli 2019. Jumlah sampel 127 remaja putri beserta orang tuanya dipilih dengan accidental sampling. Instrumen kuesioner dan telah dilakukan uji validitas. Analisis bivariat dengan uji chi square (dukungan instrumen, emosional, kepercayaan orang tua) dan uji fisher exact (dukungan informasi dan sikap). Hasil penelitian menunjukkan 92,9% orang tua tidak memberikan dukungan informasi, 85% tidak memberikan dukungan instrumen, 75,6% memberikan dukungan emosional kepada putrinya terkait vaksinasi. Faktor yang berhubungan dengan kesediaan vaksinasi adalah dukungan instrumen (p-value = 0,048). Faktor yang menjadi pertimbangan terbanyak orang tua untuk mengijinkan anaknya di vaksinasi adalah keamanan vaksin (81,1%). Kesimpulan: Ada hubungan dukungan instrumen orang tua dengan kesediaan vaksinasi HPV pada remaja putri. HPV infections and cervical precancers (abnormal cells on the cervix that can lead to cancer) have dropped significantly since HPV vaccine has been in use. HPV vaccination coverage is still low in Indonesia. Parents are the main responsibility and obligation in guaranteeing the fulfillment of the child's basic rights to get a vaccination. The purpose of this study was to determine the related factors (attitudes, beliefs, parental support) with the willingness to participate in HPV vaccination among adolescent girls. This type of the study was analytic survey with cross sectional approach. The study was conducted at SD Muhammadiyah Macanan, Ngemplak and SMPN 1 Berbah, Sleman in May-July 2019. The sample was 127 adolescent girl and their parents selected by accidental sampling. The instrument used questionnaire and already undergone validity test. The bivariate analysis used chi square test (instrument and emotional support, parental trust) and fisher exact test (information support and attitude). The results showed 92.9% of parents did not provide information support, 85% did not provide instrument support, 75.6% provided emotional support to their daughters related to vaccination. Factors related to the willingness of vaccinations were instrument support (p-value = 0.048). The factor that was considered by most parents to allow their children to be vaccinated was vaccine safety (81.1%). Conclusion: There was a correlation between parental instrument support and HPV vaccination willingness of adolescent girls.

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