The impact of chemotherapy on sleep quality in women undergoing cytotoxic treatment for breast, ovarian, and endometrial cancer.

e23077 Background: To determine changes in sleep quality among women with breast, ovarian, and endometrial cancer during chemotherapy and to assess the impact of sleep quality on quality of life (QOL). Methods: A prospective cohort study was performed at The Program in Women’s Oncology among chemotherapy naïve women diagnosed with breast, ovarian, or endometrial cancer scheduled to begin treatment. Ovarian and endometrial patients were combined into one group (Gyn) for analysis. Two validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI) and the Functional Assessment of Cancer Therapy (FACT), which measure sleep quality and QOL, respectively, were administered prior to-, halfway through-, completion of-, and 6 months after chemotherapy completion. Descriptive statistics were used to summarize baseline characteristics. Categorical variables were compared by Chi-square (χ2) test and continuous variables by T-test. The PSQI and FACT scores were analyzed by linear or logistic regression with GEEs. Results: Of the 99 women enrolled, 27 had ovarian, 23 had endometrial, and 49 had breast cancer. 97 were included in the analysis. The breast cohort was younger than their Gyn counterparts: 50 vs. 62, (p < .001), and more likely to identify as Hispanic (p = .012). 56% of women endorsed poor sleep quality at baseline. By mid-treatment, both cohorts reported a significant reduction in sleep quality (p = .008) and QOL (p = .0003) that did not persist at end of- or 6 months post-treatment. Increased need for sleep medications (p = .012) and reduction in sleep efficiency (p = .002) were identified mid-treatment. No significant changes in PSQI or FACT-G were seen by end of treatment. At 6 months post treatment, less Gyn patients reported poor sleep quality when compared to baseline (46 vs 53%) while experiencing a significant improvement in QOL (p = .03). Poor sleep quality was correlated with worse QOL at all time points (p < .001). Conclusions: There is a sparsity of research on sleep disturbances in gynecologic malignancies. In this study, three quarters of all women reported poor sleep quality by mid-treatment with concomitant decrease in QOL. Poor sleep was reported by nearly 50% of women at all other time points. Larger studies need to be done to further define the problem and identify areas suitable for interventions.

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Poor sleep quality is associated with perinatal depression. A systematic review of last decade scientific literature and meta-analysis

Journal of Perinatal Medicine ◽

10.1515/jpm-2019-0214 ◽

2019 ◽

Vol 47 (7) ◽

pp. 689-703 ◽

Cited By ~ 6

Author(s):

Ernesto González-Mesa ◽

Celia Cuenca-Marín ◽

María Suarez-Arana ◽

Beatriz Tripiana-Serrano ◽

Nadia Ibrahim-Díez ◽

...

Keyword(s):

Systematic Review ◽

Sleep Quality ◽

Sleep Disturbances ◽

Perinatal Depression ◽

Meta Analysis ◽

Well Being ◽

Mental States ◽

Poor Sleep ◽

Poor Sleep Quality ◽

The Impact

Abstract Background Although pregnancy is frequently associated with mental states of happiness, hope and well-being, some physical and psychological changes can contribute to increased sleep disturbances and worsened sleep quality. Sleep quality has been linked to negative emotions, anxiety and depression. The main objective of this paper was to systematically review the impact of sleep during pregnancy on maternal mood, studying the association between objective and subjective measures of sleep quality and perinatal depression. Methods We performed a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, which included studies published between January 2008 and April 2019, and met the following criteria: (i) studies on pregnant women assessing the effects of sleep quality variables on perinatal mood disorders, (ii) studies published in English and (iii) full paper published in a peer-reviewed scientific journal with full-text format available. Results A total of 36 studies published in the last decade met the inclusion criteria for qualitative review and eight of them were suitable for meta-analysis. Both confirmed the negative effects of poor sleep on perinatal mood. However, qualitative analysis showed that unrepresentative samples and low participation rates falling below 80% biased some of the studies. The standard random-effects meta-analysis showed a pooled size effect [ln odds ratio (OR) 1.49 (95% confidence interval [CI] 1.19, 1.79)] for perinatal depression in cases of poor prenatal sleep quality, although heterogeneity was moderate to high [Q 16.05, P ≤ 0.025, H2 2.45 (95% CI 1.01, 13.70)]. Conclusion Poor sleep quality was associated with perinatal mood disturbances. The assessment of sleep quality along the pregnancy could be advisable with a view to offering preventative or therapeutic interventions when necessary.

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Short sleep duration and poor sleep quality among migraineurs: A population-based study

Cephalalgia ◽

10.1177/0333102417716936 ◽

2017 ◽

Vol 38 (5) ◽

pp. 855-864 ◽

Cited By ~ 15

Author(s):

Tae-Jin Song ◽

Chang-Ho Yun ◽

Soo-Jin Cho ◽

Won-Joo Kim ◽

Kwang Ik Yang ◽

...

Keyword(s):

Sleep Quality ◽

Sleep Duration ◽

Sleep Disturbances ◽

Population Based ◽

Poor Sleep ◽

Headache Frequency ◽

Poor Sleep Quality ◽

Short Sleep Duration ◽

Short Sleep ◽

The Impact

Background Sleep disturbances are closely related to migraine. Nevertheless, information regarding the impact of short sleep duration and poor sleep quality on the clinical presentation of migraine at population level is limited. Methods This study was a nationwide population-based survey on adults aged 19–69 years. Headache frequency (attacks/month) and intensity (visual analogue scale, 0–10) were documented. Short sleep duration and poor sleep quality were defined as average sleep duration <6 h/day and Pittsburgh Sleep Quality Index score >5, respectively. The association of sleep parameters with headache frequency and intensity was analysed among migraineurs. Results Of 2695 participants, 143 (5.3%) had migraine. Headache frequency was significantly higher among migraineurs with short sleep duration (2.0 [1.0–12.0] vs. 1.0 [0.3–4.0], p = 0.048) and poor sleep quality (2.0 [0.6–4.7] vs. 1.0 [0.2–3.0], p = 0.009) than among those without. However, headache intensity was similar between migraineurs with short sleep duration and poor sleep quality. Multiple linear regression analyses revealed that short sleep duration was a significant contributing factor for headache frequency (β = 0.210, p = 0.015). Conclusions Self-reported short sleep duration (<6 h per day) is associated with an increased headache frequency among migraineurs in a population-based setting.

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Left superior temporal sulcus morphometry mediates the impact of anxiety and depressive symptoms on sleep quality in healthy adults

Social Cognitive and Affective Neuroscience ◽

10.1093/scan/nsab012 ◽

2021 ◽

Author(s):

Yanlin Wang ◽

Ping Jiang ◽

Shi Tang ◽

Lu Lu ◽

Xuan Bu ◽

...

Keyword(s):

Depressive Symptoms ◽

Sleep Quality ◽

Sleep Problems ◽

Superior Temporal Sulcus ◽

Healthy Adults ◽

Poor Sleep ◽

Emotional Symptoms ◽

Neural Basis ◽

Poor Sleep Quality ◽

The Impact

Abstract Anxiety and depressive symptoms may predispose individuals to sleep disturbance. Understanding how these emotional symptoms affect sleep quality, especially the underlying neural basis, could support the development of effective treatment. The aims of the present study were therefore to investigate potential changes in brain morphometry associated with poor sleep quality and whether this structure played a mediating role between the emotional symptoms and sleep quality. One hundred and forty-one healthy adults (69 women, mean age = 26.06 years, SD = 6.36 years) were recruited. A structural magnetic resonance imaging investigation was performed, and self-reported measures of anxiety, depressive symptoms and sleep quality were obtained for each participant. Whole-brain regression analysis revealed that worse sleep quality was associated with thinner cortex in left superior temporal sulcus (STS). Furthermore, the thickness of left STS mediated the association between the emotional symptoms and sleep quality. A subsequent commonality analysis showed that physiological component of the depressive symptoms had the greatest influence on sleep quality. In conclusion, thinner cortex in left STS may represent a neural substrate for the association between anxiety and depressive symptoms and poor sleep quality and may thus serve as a potential target for neuromodulatory treatment of sleep problems.

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Association between depression and sleep quality in patients with systemic lupus erythematosus: a systematic review and meta-analysis

Sleep And Breathing ◽

10.1007/s11325-021-02405-0 ◽

2021 ◽

Author(s):

Rulan Yin ◽

Lin Li ◽

Lan Xu ◽

Wenjie Sui ◽

Mei’e Niu ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Sleep Quality ◽

Lupus Erythematosus ◽

Sleep Disturbances ◽

Cochrane Library ◽

Poor Sleep ◽

Moderate Correlation ◽

Systemic Lupus ◽

Poor Sleep Quality ◽

Subjective Sleep Quality

Abstract Background Currently, there is no consistent understanding of the relationship between depression and sleep quality in patients with systemic lupus erythematosus (SLE). This study aimed to explore the correlation between depression and sleep quality in SLE patients. Methods Five English (PubMed, Web of Science, EMBASE, Cochrane Library, and CINAHL) databases were systematically searched from inception to January 12, 2021. Two authors independently screened publications and extracted data according to set inclusion and exclusion criteria. Statistical analyses were performed with STATA 16.0. Data were pooled using a random-effects model. Results A total of 9 identified studies matched the inclusion criteria, reporting on 514 patients with SLE in the analysis. A moderate correlation of depression with sleep quality was found (pooled r = 0.580 [0.473, 0.670]). Compared to good sleepers, patients with SLE and poor sleep quality had higher levels of depression (standardized mean difference = − 1.28 [− 1.87, − 0.69]). Depression was associated with subjective sleep quality (r = 0.332 [0.009, 0.592]), sleep latency (r = 0.412 [0.101, 0.649]), sleep disturbances (r = 0.405 [0.094, 0.645]), daytime dysfunction (r = 0.503 [0.214, 0.711]), the four dimensions of Pittsburgh Sleep Quality Index (PSQI), while no significant correlation was found in the other three PSQI dimensions. Conclusion Depression had a moderate correlation with sleep quality in patients with SLE. Patients with poor sleep quality tended to have higher level of depression than that of good sleepers. Awareness of the correlation may help rheumatology physicians and nurses to assess and prevent depression and improve sleep quality in patients with SLE.

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1142 Comprehensive Phenotyping Of Ambulatory Sleep Patterns In Multiple Sclerosis

SLEEP ◽

10.1093/sleep/zsaa056.1136 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A435-A435

Author(s):

T J Braley ◽

A L Kratz ◽

D Whibley ◽

C Goldstein

Keyword(s):

Multiple Sclerosis ◽

Sleep Quality ◽

Extreme Values ◽

Sleep Onset ◽

External Support ◽

Poor Sleep ◽

Sleep Patterns ◽

Poor Sleep Quality ◽

Historical Cohort ◽

The Impact

Abstract Introduction The majority of sleep research in persons with multiple sclerosis (PwMS) has been siloed, restricted to evaluation of one or a few sleep measures in isolation. To fully characterize the impact of sleep disturbances in MS, multifaceted phenotyping of sleep is required. The objective of this study was to more comprehensively quantify sleep in PwMS, using a recently developed multi-domain framework of duration, continuity, regularity, sleepiness/alertness, and quality. Methods Data were derived from a parent study that examined associations between actigraphy and polysomnography-based measures of sleep and cognitive function in MS. Actigraphy was recorded in n=55 PwMS for 7-12 days (Actiwatch2®, Philips Respironics). Sleep metrics included: duration=mean total sleep time (TST, minutes); continuity=mean wake time after sleep onset (minutes), and regularity=stddev wake-up time (hours). ‘Extreme’ values for continuity/regularity were defined as the most extreme third of the distributions. ‘Extreme’ TST values were defined as the lowest or highest sixth of the distributions. Sleepiness (Epworth Sleepiness Scale score) and sleep quality [Pittsburgh Sleep Quality Index (PSQI) sleep quality item] were dichotomized by accepted cutoffs (>10 and >1, respectively). Results Sleep was recorded for a mean of 8.2 days (stddev=0.95). Median (1st, 3rd quartile) values were as follows: duration 459.79 (430.75, 490.60), continuity 37.00 (23.44, 52.57), regularity 1.02 (0.75, 1.32), sleepiness/alertness 8 (4, 12), and sleep quality 1.00 (1.00, 2.00). Extreme values based on data distributions were: short sleep <=426.25 minutes (18%), long sleep >515.5 minutes (16%), poor sleep continuity ≥45 minutes (33%), and poor sleep regularity ≥1.17 hours (33%). Sleepiness and poor sleep quality were present in 36% and 40% respectively. For comparison, in a historical cohort of non-MS patients, the extreme third of sleep regularity was a stddev of 0.75 hours, 13% had ESS of >10, and 16% had poor sleep quality. Conclusion In this study of ambulatory sleep patterns in PwMS, we found greater irregularity of sleep-wake timing, and higher prevalence of sleepiness and poor sleep quality than published normative data. Efforts should be made to include these measures in the assessment of sleep-related contributions to MS outcomes. Support The authors received no external support for this work.

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Perception of Sleep Disturbances due to Bedtime Use of Blue Light-Emitting Devices and Its Impact on Habits and Sleep Quality among Young Medical Students

BioMed Research International ◽

10.1155/2019/7012350 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8

Author(s):

Asmaa Jniene ◽

Leila Errguig ◽

Abdelkader Jalil El Hangouche ◽

Hanan Rkain ◽

Souad Aboudrar ◽

...

Keyword(s):

Medical Students ◽

Sleep Quality ◽

Blue Light ◽

Sleep Disturbances ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Light Emitting ◽

Light Emitting Devices ◽

The Mean ◽

Perception Of Sleep

Introduction. The use of blue light-emitting devices (smartphones, tablets, and laptops) at bedtime has negative effects on sleep due to light stimulation and/or problematic excessive use. We aimed to evaluate, among young medical students, if the perception of sleep disturbances due to bedtime use of these devices is consistent with healthier habits and a better sleep quality. Materials and methods. 294 medical students in medicine and pharmacy from the Faculty of Medicine and Pharmacy of Rabat, Morocco, took part in this anonymous and voluntary cross-sectional study and answered an electronic questionnaire. Student and Mann–Whitney U tests were used to compare variables between 2 groups based on their perception of sleep disturbances. The level of significance was p≤0.05. Results. 286 students (97.3%) used a blue light-emitting smart device at bedtime before sleep, and sleep quality was poor (Pittsburgh Sleep Quality Index, PSQI > 5) in 101 students (35.3%). The perception of sleep disturbances due to this night usage was reported by 188 of them (65.7%). In this group, 154 (81.9%) used their device with all the lights turned off in the room (p=0.02), 34 (18.1%) put devices under pillows (p=0.04), 114 (60.6%) interrupted sleep to check messages (p<0.001), and the mean duration use of these technologies at bedtime was 2 h ± 23 min per night (p=0.02). Also, the mean sleep duration was 6.3 hours ± 1.25 (p=0.04), 119 (63.3%) presented fatigue on waking more than one time per week (p=0.04), and 76 (40.4%) presented poor sleep quality (75.2% of the students with PSQI > 5) (p=0.005). Conclusions. Despite the perception of sleep disturbances due to bedtime use of blue light-emitting devices, unhealthy sleep habits tend to be frequent in young medical students and worrying because it is associated to significant poor sleep quality.

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The Effect of Shift Fluctuations on Sleep Quality among Nurses Working in the Emergency Room in Amman, Jordan

International Journal of Occupational Safety and Health ◽

10.3126/ijosh.v10i1.29877 ◽

2020 ◽

Vol 10 (1) ◽

pp. 11-17

Author(s):

Khaled Suleiman ◽

Tarek Al-Khaleeb ◽

Mahmoud Al-Kaladeh ◽

Loai Abu Sharour

Keyword(s):

Sleep Quality ◽

Emergency Room ◽

Work Performance ◽

Poor Sleep ◽

Emergency Rooms ◽

Poor Sleep Quality ◽

Cross Sectional ◽

Public And Private ◽

Work Related ◽

The Impact

Introduction: Sleep Quality disturbances are common among nurses especially those working in stressful situations such as emergency room. Additionally, sleep quality disturbances were found to interfere with nurses’ quality of life and work performance. No studies have found the effect of fluctuated shifts on sleep quality among nurses. Objectives: To examine the impact of shift fluctuations on sleep quality among nurses working in the emergency room. Methods: A cross-sectional, descriptive design was employed. Five emergency rooms were selected from public and private hospitals located in Amman, Jordan. The selected hospitals were also referral sites with capacity of more than 200 beds. A convenient sample of nurses who had a minimum of six months experience in the emergency room and working on rotating shifts were eligible for participation. Nurses with known chronic respiratory problems and sleep apnea were excluded. A self-administered questionnaire including a demographic and work-related questions, and the Arabic version of the Pittsburgh Sleep Quality Index were provided. Shift fluctuations were clustered based on interchanging between morning, evening and night shifts. Results: A total of 179 emergency nurses working in rotating shifts participated in the study. The majority of the nurses were poor sleepers. The study found no significant differences between different shifts interchange and sleep quality. However, interchange between morning and evening shift reported the highest sleep disturbance. Sleep quality was positively correlated with the length of experience, while negatively correlated with the age and the number of monthly shifts. Nurses who declared higher satisfaction and ability to work under pressure revealed better sleep quality. Conclusion: Emergency room nurses showed poor sleep quality. While there was no specific shift interchange cluster inducing poor sleep quality, some demographical and work-related characteristics indicated their influence on sleep quality.

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Poor sleep quality in systemic lupus erythematosus: does it depend on depressive symptoms?

Lupus ◽

10.1177/0961203314540762 ◽

2014 ◽

Vol 23 (13) ◽

pp. 1350-1357 ◽

Cited By ~ 22

Author(s):

L Palagini ◽

C Tani ◽

R M Bruno ◽

A Gemignani ◽

M Mauri ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Depressive Symptoms ◽

Sleep Quality ◽

Lupus Erythematosus ◽

Sleep Disturbances ◽

Control Group ◽

Poor Sleep ◽

Systemic Lupus ◽

Poor Sleep Quality ◽

Obstructive Sleep

Objectives Sleep disturbances are frequently observed in rheumatic diseases including systemic lupus erythematosus (SLE). This study aimed at evaluating the prevalence of insomnia, poor sleep quality and their determinants in a cohort of SLE patients. Methods Eighty-one consecutive SLE female patients were evaluated in a cross-sectional study. The Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Beck Depression Inventory (BDI) and the Self-rating Anxiety Scale (SAS) were administered. Patients with previous diagnosis of obstructive sleep apnea or restless legs syndrome were excluded. Fifty-three women with hypertension (without SLE) were enrolled as control group (H). Results In the SLE cohort poor sleep quality (65.4% vs 39.6%, p < 0.01) and difficulty in maintaining sleep and/or early morning awakening (65.4% vs 22.6%, p < 0.001), but not insomnia (33.3% vs 22.6%, p = ns), were more prevalent than in H. Depressive symptoms were present in 34.6% of SLE vs 13.2% H patients ( p < 0.001) while state anxiety was more common in H patients (H 35.8% vs SLE 17.3%, p < 0.005). SLE was associated with a 2.5-times higher probability of presenting poor sleep quality in comparison to H (OR 2.5 [CI 1.21–5.16]). After adjusting for confounders, both depressive symptoms (OR 4.4, [1.4–14.3]) and use of immunosuppressive drugs (OR 4.3 [CI 1.3–14.8]) were significantly associated with poor sleep quality in SLE patients. Furthermore, poor sleep quality was not associated either with disease duration or activity. Conclusions In a cohort of SLE women, insomnia and poor sleep quality, especially difficulties in maintaining sleep, were common. Depressive symptoms might be responsible for the higher prevalence of poor sleep quality in SLE.

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Factors associated with poor sleep quality in women with cancer

Revista Latino-Americana de Enfermagem ◽

10.1590/1518-8345.1478.2858 ◽

2017 ◽

Vol 25 (0) ◽

Cited By ~ 4

Author(s):

Thalyta Cristina Mansano-Schlosser ◽

Maria Filomena Ceolim

Keyword(s):

Sleep Quality ◽

Quality Index ◽

Sleep Disturbances ◽

Pittsburgh Sleep Quality Index ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Factors Associated ◽

Scale Data

ABSTRACT Objectives: to analyze the factors associated with poor sleep quality, its characteristics and components in women with breast cancer prior to surgery for removing the tumor and throughout the follow-up. Method: longitudinal study in a teaching hospital, with a sample of 102 women. The following were used: a questionnaire for sociodemographic and clinical characterization, the Pittsburgh Sleep Quality Index; the Beck Depression Inventory; and the Herth Hope Scale. Data collection covered from prior to the surgery for removal of the tumor (T0) to T1, on average 3.2 months; T2, on average 6.1 months; and T3, on average 12.4 months. Descriptive statistics and the Generalized Estimating Equations model were used. Results: depression and pain contributed to the increase in the score of the Pittsburgh Sleep Quality Index, and hope, to the reduction of the score - independently - throughout follow-up. Sleep disturbances were the component with the highest score throughout follow-up. Conclusion: the presence of depression and pain, prior to the surgery, contributed to the increase in the global score of the Pittsburgh Sleep Quality Index, which indicates worse quality of sleep throughout follow-up; greater hope, in its turn, influenced the reduction of the score of the Pittsburgh Sleep Quality Index.

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