Trends in lung cancer mortality between 2001 and 2017: An observational study in USA and EU.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e19277-e19277
Author(s):  
Chinmay Jani ◽  
Dominic C Marshall ◽  
Harpreet Singh ◽  
Joseph Shalhoub ◽  
Justin Salciccioli
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
World Health ◽  
Mortality Data ◽  
Male Mortality ◽  
Standard Population ◽  
The World ◽  
Males And Females ◽  
The Eu

e19277 Background: The lung is the commonest site of cancer and has the highest worldwide cancer-related mortality. Past two decades has seen advancements in screening technologies and guidelines, as well as new modalities for treatment. Few studies have reported on lung cancer trends in the 21st century. Our study reports and compares trends in lung cancer mortality in the USA and European Union (EU). Methods: We utilized the World Health Organization (WHO) Mortality Database and Center for Disease Control (CDC) Wonder database. We extracted Lung Cancer mortality data from 2001 to 2017 based on ICD 10 system. Crude mortality rates were dichotomized by sex and reported by year. We computed Age Standardized Death Rates (ASDRs) per 100,000 population using the World Standard Population and USA Standard Population. Lung cancer mortality trends were compared using Joinpoint regression analysis. Results: We analyzed a data from a total of 26 EU countries and USA, of which 6 countries had data till 2017, 12 till 2016, 7 till 2015 and 2 till 2014. We observed that mortality in men was down-trending in all countries except Cyprus and Portugal. In females, there was an increase in mortality in 22 countries. Amongst EU nations, most recently (2017) Hungary had the highest ASDRs for both males and females (64.5/100,000 and 31.0/100,000), whereas the lowest mortality was in Sweden for males (17.3/100,000) and Lithuania for the females (7.58/100,000). Latvia had the highest Estimated Annual Percentage Change (EAPC) in male mortality (-9.6%). Based on recent most data, we saw that there was a significantly lower mortality in males amongst European nations that joined the EU pre-2004 as compared to those that joined the EU post-2004 (p = 0.006). In USA, ASDRs in males and females were 44.3/100,000 and 30.6/100,000, respectively, with EAPC of -5.1% and -4.2% in males and females, respectively. Conclusions: For the study period, we observed expected decrease in lung cancer mortality in males. In contrast, there was a gradual rising trend in lung cancer mortality amongst females. In addition, there was substantial variation between nations. USA has shown consistent downtrend since 2001 where as there have been fluctuations in trends in other EU nations.

scholarly journals CANCER MORTALITY IN NORTH CYPRUS 1995-2007

2016 ◽  
Vol 68 (1) ◽  
pp. 31 ◽  
Author(s):  
Evren Hinçal
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Breast Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Mortality Data ◽  
The North ◽  
North Cyprus ◽  
Total Cancer ◽  
Recent Trends ◽  
The Eu

<p><strong>BACKGROUND:</strong> From 1995 to 2007, age‑standardized total cancer mortality rates in the North Cyprus (NC) fell by around 9% in both sexes. Available cancer mortality data in Europe up to 2002 allow a first check of the forecast of further declines in cancer mortality. <strong>MATERIALS AND METHODS:</strong> We considered trends in age‑standardized mortality from major cancer sites in the NC during the period 1995-2007. <strong>RESULTS:</strong> In women, total cancer mortality declined by 23% from 92/100 000 to 75/100 000 between the years 1995‑2007. Corresponding figures for men were 85/100 000 to 66/100 000, corresponding to falls of 23% from 1995 to 2007. Lung cancer in men declined from 20/100 000 around 1995 to 16 around 2007 (−20%). In women, lung cancer mortality was 2/100 000 and there were no changes between the years 1995 and 2007. Bladder cancer declined by 25% for both men and women from 1995 to 2007. Breast cancer mortality declined from 18/100 000 around 1995 to 15/100 000 (−16%) in 2007. Prostate cancer was approximately stable until 2000, but declined from 8 to 6 (−25%) in 2007. <strong>CONCLUSIONS:</strong> Despite the persisting rises in female lung cancer in the EU, the recent trends in cancer mortality in the NC are encouraging and indicate that a 9% reduction in total cancer mortality from 1995 to 2007 is realistic and possible.</p>

scholarly journals Trends of HIV-Related Cancer Mortality between 2001 and 2018: An Observational Analysis

2021 ◽  
Vol 6 (4) ◽  
pp. 213
Author(s):  
Chinmay Jani ◽  
Omar Al Omari ◽  
Harpreet Singh ◽  
Alexander Walker ◽  
Kripa Patel ◽  
...  
Keyword(s):  
Cancer Mortality ◽  
Population Data ◽  
Developed Countries ◽  
World Health ◽  
Mortality Data ◽  
Female Mortality ◽  
Mortality Trends ◽  
Male Mortality ◽  
The World ◽  
Health Organization

The burden of AIDS-defining cancers has remained relatively steady for the past two decades, whilst the burden of non-AIDS-defining cancer has increased. Here, we conduct a study to describe mortality trends attributed to HIV-associated cancers in 31 countries. We extracted HIV-related cancer mortality data from 2001 to 2018 from the World Health Organization Mortality Database. We computed age-standardized death rates (ASDRs) per 100,000 population using the World Standard Population. Data were visualized using Locally Weighted Scatterplot Smoothing (LOWESS). Data for females were available for 25 countries. Overall, there has been a decrease in mortality attributed to HIV-associated cancers among most of the countries. In total, 18 out of 31 countries (58.0%) and 14 out of 25 countries (56.0%) showed decreases in male and female mortality, respectively. An increasing mortality trend was observed in many developing countries, such as Malaysia and Thailand, and some developed countries, such as the United Kingdom. Malaysia had the greatest increase in male mortality (+495.0%), and Canada had the greatest decrease (−88.5%). Thailand had the greatest increase in female mortality (+540.0%), and Germany had the greatest decrease (−86.0%). At the endpoint year, South Africa had the highest ASDRs for both males (16.8/100,000) and females (19.2/100,000). The lowest was in Japan for males (0.07/100,000) and Egypt for females (0.028/100,000).

scholarly journals Trends of HIV Mortality between 2001 and 2018: An Observational Analysis

2021 ◽  
Vol 6 (4) ◽  
pp. 173
Author(s):  
Chinmay Jani ◽  
Kripa Patel ◽  
Alexander Walker ◽  
Harpreet Singh ◽  
Omar Al Omari ◽  
...  
Keyword(s):  
South Africa ◽  
World Health ◽  
Mortality Data ◽  
Observational Analysis ◽  
Standard Population ◽  
Hiv Mortality ◽  
The World ◽  
World Standard ◽  
Males And Females ◽  
Health Organization

Since the beginning of the epidemic in the early 1980s, HIV-related illnesses have led to the deaths of over 32.7 million individuals. The objective of this study was to describe current mortality rates for HIV through an observational analysis of HIV mortality data from 2001 to 2018 from the World Health Organization (WHO) Mortality Database. We computed age-standardized death rates (ASDRs) per 100,000 people using the World Standard Population. We plotted trends using locally weighted scatterplot smoothing (LOWESS). Data for females were available for 42 countries. In total, 31/48 (64.60%) and 25/42 (59.52%) countries showed decreases in mortality in males and females, respectively. South Africa had the highest ASDRs for both males (467.7/100,000) and females (391.1/100,000). The lowest mortalities were noted in Egypt for males (0.2/100,000) and in Japan for females (0.01/100,000). Kyrgyzstan had the greatest increase in mortality for males (+6998.6%). Estonia had the greatest increase in mortality for females (+5877.56%). The disparity between Egypt (the lowest) and South Africa (the highest) was 3042-fold for males. Between Japan and South Africa, the disparity was 43,454-fold for females. Although there was a decrease in mortality attributed to HIV among most of the countries studied, a rising trend remained in a number of developing countries.

scholarly journals Ambient Air Pollution and Cigarette Smoking: Co-Drivers of Increased Burden of Lung Cancer in Europe

2020 ◽  
Author(s):  
Maybin Kalubula ◽  
Heqing Shen ◽  
Longjian Liu
Keyword(s):  
Lung Cancer ◽  
Air Pollution ◽  
Particulate Matter ◽  
Mortality Rate ◽  
Cigarette Smoking ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Small Cell ◽  
World Health ◽  
Adeno Carcinoma

Background: Lung cancer is one of the leading causes of morbidity and mortality worldwide with 25% of deaths due to lung cancer occurring in Europe. This study therefore sought to assess the burden of lung cancer by country and to evaluate the magnitude of fine Particulate Matter (PM2.5) and cigarette smoking by country in Europe. Methods: An ecological study nested on the World Health Organization air pollution database 2016 was conducted. We sampled 30 European Countries, with a total of 1625 mean annual samples of Particulate Matter (PM2.5) collected from 1625 designated sites (n = 1625). We further used the &lsquo;World Health Disease Rankings&rsquo; database to extract Lung Cancer Morbidity and Mortality Rate by country. We used SAS version 9.4 to indicate the distribution of PM2.5 and Lung Cancer Mortality Rate. Results: Lung cancer Relative Risk (RR) was 1.0 in all never- smokers. RR for Ex-smokers for Adeno carcinoma was 3.5 in males and 1.1 in females, small cell carcinoma was 16.2 in males and 3.8 in females. RR for current smokers for Adeno carcinoma was 8.0 in males and 4.1 in females, small cell carcinoma was 57.9 in males and 18.2 in females. Mean annual PM2.5 by country ranged from 6.01 to 37.28&micro;g/m3 whereas lung cancer mortality rate by country ranged from 19.67 to 54.26 deaths per 100,000 population. Conclusion: Cigarette smoking and exposure to both second hand smoke and high concentration of PM2.5 resulted into increased burden of lung cancer in Europe. Countries should re-strategize to reduce the burden of lung cancer in Europe.

scholarly journals Lung cancer mortality in Europe and the United States between 2000 and 2017: an observational analysis

2021 ◽  
pp. 00311-2021
Author(s):  
Chinmay Jani ◽  
Dominic C Marshall ◽  
Harpreet Singh ◽  
Richard Goodall ◽  
Joseph Shalhoub ◽  
...  
Keyword(s):  
United States ◽  
Lung Cancer ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
The United States ◽  
Mortality Rates ◽  
World Health ◽  
Female Mortality ◽  
The Us ◽  
Male To Female

BackgroundThe lung is the most common site for cancer and has the highest worldwide cancer-related mortality. Our study reports and compares trends in lung cancer mortality in the United States (US) and 26 European countries.Study design and methodsLung cancer mortality data were extracted for males and females for each of the years 2000–2017 from the World Health Organization (WHO) Mortality and the Centers for Disease Control and Prevention (CDC) WONDER databases. Lung cancer mortality trends were compared using Joinpoint regression analysis, and male-to-female mortality ratios were calculated.ResultsDown-trending lung cancer mortality rates were observed in males in all countries except Cyprus and Portugal between 2000 and 2017. In females, increasing mortality rates were observed in 22 of the 27 countries analyzed. Latvia had the highest estimated annual percentage change (EAPC) in male mortality (−9.6%) between 2013–2015. In the US, EAPCs were −5.1% for males and −4.2% for females between 2014–2017. All countries had an overall decrease in the ratio of male-to-female lung cancer mortality. The most recent observation of median male-to-female mortality was 2.26 (IQR 1.92–4.05). The countries with the greatest current sex disparity in lung cancer mortality were Lithuania (5.51) and Latvia (5.00).ConclusionBetween 2000 and 2017, lung cancer mortality rates were decreasing for males in Europe and the US, whereas increasing lung cancer mortality rates were generally observed in females. There is a persistent but decreasing sex-mortality gap, with men having persistently greater lung cancer mortality but with rates decreasing faster than women.

Validity of Lung Cancer Mortality Data

JAMA ◽  
1967 ◽  
Vol 199 (9) ◽  
pp. 674
Author(s):  
Milton B. Rosenblatt
Keyword(s):  
Lung Cancer ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Mortality Data
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