Relevance of real-time teletransmission of physical activity, sleep, and circadian rhythms from gastrointestinal cancer (GIC) patients (pts) during daily routine (IDEAs, IRAS 233972).

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 801-801
Author(s):  
Francis Levi ◽  
Sandra Komarzynski ◽  
Qi Huang ◽  
Teresa Young ◽  
Yeng Ang ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Surface Temperature ◽  
Real Time ◽  
Markov Models ◽  
Activity Rhythm ◽  
Performance Status ◽  
Specific Treatment ◽  
Poor Sleep ◽  
Daily Routine ◽  
Rest Activity

801 Background: The relative amount of activity and rest over the 24-hours, as measured by the dichotomy index I < O from actimetry records, is an independent predictor of overall survival and quality of life, and an early warning signal for emergency hospitalisation. The IDEAs study aimed to determine the sleep, physical and circadian pathologies in pts during their daily routine at home, which could lower I < O and be modifiable through personalised interventions. Methods: The rest-activity and surface temperature patterns were monitored in real time using a tele-transmitting chest sensor and a GPRS-platform for one week in 25 pts, with a WHO performance status of 0-1 and metastatic GIC (colorectal, 56%). Each pt completed questionnaires including Chronotype, HADS, and Pittsburgh Sleep Index, filled a precise diary of daily activities, meals and sleep times, and the MD Anderson Symptoms Inventory daily. I < O counts the In-bed activity bouts per min that are below the median activity Out-of-bed. Other pt-specific circadian parameters were estimated with spectral analyses and Hidden Markov models (HMM). I < O predictors were identified through correlation and regression analyses. Results: A poor I < O was found for 13 pts (52%). Self-reported scores for sleep quality or physical fitness showed no significant differences according to I < O. Yet HMM-modelled rest-activity revealed that pts with poor I < O had lower activity out-of-bed (median activity counts per minute, 110 vs 52, p = 0.001) and fractionated sleep (probability of remaining at rest when asleep, 94% vs 90%, p = 0.01). Poor I < O was significantly associated with an abnormal circadian rhythm in chest surface temperature, that was either wrongly timed or suppressed, for 83% of the pts as compared to 25% of those with a good I < O (p = 0.012). Conclusions: Nearly half of the pts displayed altered circadian rest-activity rhythm, with poor sleep and low daytime activity. In most of them, the circadian rhythm in body temperature, which critically regulates sleep, was abnormal. Exploration and specific treatment of sleep and circadian disorders are warranted for improving outcomes in cancer pts. Clinical trial information: 233972.

Effects of Sleep Loss on the Rest–Activity Circadian Rhythm of Helpers Participating in Continuous Dogsled Races

2013 ◽  
Vol 16 (2) ◽  
pp. 123-133 ◽  
Author(s):  
Giovanna Calogiuri ◽  
Andi Weydahl
Keyword(s):  
Circadian Rhythm ◽  
Sleep Quality ◽  
Activity Rhythm ◽  
Activity Cycle ◽  
Negative Influence ◽  
Sleep Loss ◽  
Poor Sleep ◽  
Sporting Events ◽  
Long Distance ◽  
Rest Activity

Objective:The Finnmarksløpet dogsled race lasts up to 7 days. Helpers, who keep time, coach, and transport equipment, have to be alert though they have little and fragmented sleep. This study investigated disruptions of the rest–activity rhythm among helpers.Methods:10 helpers were monitored by actigraph a week before, during, and after the race. Sleep logs, sleepiness rate, and self-reported quality of sleep were collected.Results:Nonparametric circadian rhythm analysis showed significant differences between the pre- and postrace interdaily stability and amplitude of rhythm. Compared to prerace, sleepiness at bedtime was increased and number of nocturnal awakenings was reduced postrace, although the actigraphic outputs showed no improvement in sleep quality. Helpers who were engaged in the race for a longer span (5–6 days) had more difficulty recovering from the sleep loss accumulated during the race than those engaged for a shorter time (2–3 days).Conclusion:Poor sleep combined with prolonged and demanding mental focus for 2 days or more has a negative influence upon the rest–activity cycle, though complete restoration of the cycle occurs over 1 week or more. Being in such a condition for ≥ 5 days leads to disruptions of the circadian component of the sleep–wake cycle that hampers the sleep recovery process. Disrupted sleep and demanding mental requirements are common in long-distance sporting events as well as among shift workers. Follow-up intervention should be made in such cases to ensure the return of a healthy rest–activity rhythm and sleep quality.

scholarly journals Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ryo Imai ◽  
Hiroshi Makino ◽  
Takasumi Katoh ◽  
Tetsuro Kimura ◽  
Tadayoshi Kurita ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Phase Shift ◽  
Clock Genes ◽  
Activity Rhythm ◽  
Time Of Day ◽  
Prevention And Treatment ◽  
The Relationship ◽  
Relative Mrna Expression ◽  
Master Clock ◽  
Rest Activity

Abstract Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane. In the present study, we examined the rest/activity rhythm of mice by counting the number of running wheel rotations, and we found that desflurane anesthesia caused a phase shift in the circadian rhythm that was dependent on the time of day of anesthesia. We also found that desflurane anesthesia altered the relative mRNA expression of four major clock genes (Per2, Bmal, Clock, and Cry1) in the suprachiasmatic nucleus (SCN). These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.

Effects of Sleep Loss and Strenuous Physical Activity on the Rest–Activity Circadian Rhythm

2010 ◽  
Vol 13 (4) ◽  
pp. 409-418 ◽  
Author(s):  
Giovanna Calogiuri ◽  
Andi Weydahl ◽  
Eliana Roveda
Keyword(s):  
Circadian Rhythm ◽  
Sleep Disturbances ◽  
Activity Rhythm ◽  
Sleep Loss ◽  
Physically Active ◽  
Before And After ◽  
Strenuous Physical Activity ◽  
Prolonged Fatigue ◽  
Neurobehavioral Deficits ◽  
Rest Activity

Objective. Rest–activity circadian rhythm is strongly linked to an organism’s entrainment. Sleep loss and prolonged fatigue could affect the circadian system, inducing neurobehavioral deficits. The Finnmarksløpet is Europe’s longest dogsled race. In this competition, lasting up to 7 days, participants (mushers) are physically active most of the time, having little and fragmented rest. Therefore, the race provides an opportunity to investigate the effects of prolonged fatigue and sleep loss. Methods. Ten mushers, participating in the 500 km and 1,000 km categories, underwent continuous actigraph monitoring (5 days) before and after the race. During the competition, heart rate (HR) was recorded by an HR monitor. Results. There was a reduction in the average activity values during the 24-hr cycle after the race. Although there were signs of a forward phase shift, these were weak and unstable. Nonparametric circadian rhythm analysis (NPCRA) showed reductions in interdaily stability (IS) and relative amplitude (RA). 1,000 km mushers also showed sleep disturbances. Conclusion. A period of 3 days of little and fragmented sleep (3–4 hr of total rest per day), in which subjects were engaged in a prolonged physical effort, was enough to significantly affect the rest–activity rhythm. A longer period (5 days) in such a condition induced even more accentuated alterations, with a disturbance in nocturnal sleep. Disrupted sleep is common among hospitalized patients and those working long shifts. This study demonstrates changes in the structure of the rest–activity circadian rhythm that can result and may suggest opportunities for intervention.

Circadian robustness as an independent predictor of prolonged progression-free survival (PFS) and overall survival (OS) in 436 patients with metastatic colorectal cancer (mCRC).

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 464-464 ◽  
Author(s):  
Francis Levi ◽  
Arti Parganiha ◽  
Abdoulaye Karaboué ◽  
Pasquale F. Innominato ◽  
Sylvie Giacchetti ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Independent Predictor ◽  
Activity Rhythm ◽  
Performance Status ◽  
Accurate Determination ◽  
Biological Significance ◽  
Progression Free Survival ◽  
Experimental Models ◽  
Wrist Actigraphy ◽  
Rest Activity

464 Background: The rest-activity rhythm is a biomarker of the circadian timing system (CTS), whose disruption accelerates cancer progression in experimental models. Prior studies in cancer pts identified a reliable measure of CTS function in cancer pts based on non invasive wrist actigraphy monitoring. Methods: The prognostic value of I<O, the ratio between activity counts in-bed vs out-of-bed, was explored for PFS and OS in mCRC. The rest-activity rhythm was recorded for >48 h in 436 mCRC pts from 3 international cohorts. Data were stratified per cohort, and analyzed with Kruskall-Wallis ANOVA, log rank tests, and multivariate Cox analyses. Results: Median age was 59.2 y. Pts were mainly men (62.6%); had good performance status (PS = 0, 58.2%; 1, 33%); > 2 metastatic sites (51.6%); metastases in liver (79%) or lung (38.8%); were chemotherapy-naïve (54.6%). After baseline actigraphy recording, pts received a median of 8 courses of oxaliplatin- or irinotecan-based chemotherapy, including chronomodulated schedules (chrono; 81.4%). Despite a strong correlation with PS (p< 0.0001), I<O independently influenced both PFS and OS. Thus, both median PFS and OS nearly doubled in the pts with I<O above 97.5% (upper two quartiles) as compared to those with I<O below 93.2% (lowest quartile). Median PFS ranged from 4.8 to 10.6 months (log rank, p<0.001) and median OS from 10.1 to 20.6 months (p<0.001). In multivariate analyses, I<O ranked as the second best independent predictor of PFS, after metastases surgery, with a hazard ratio (HR) of 0.967 [95% C.L., 0.95-0.98] (p<0.001). I<O ranked as first independent predictor of OS, with a HR of 0.95 [0.94-0.97] (p<0.001). Forrest plots revealed consistent HR of I<O for PFS and OS in each cohort. Conclusions: The circadian biomarker indicator I<O is a robust, consistent and independent quantitative predictor of both PFS and OS in mCRC pts. Rest-activity rhythm monitoring deserves further testing for helping accurate determination of mCRC prognosis. The biological significance of I<O implies that specific treatments of circadian disruption could enhance survival in cancer pts.

Circadian rest-activity rhythm as a predictor of survival in metastatic colorectal cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14006-e14006 ◽  
Author(s):  
David Spiegel ◽  
Pierre-Antoine Dugué ◽  
Pasquale F. Innominato ◽  
Abdoulaye Karaboué ◽  
Garance Dispersyn ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Progression ◽  
Activity Rhythm ◽  
Performance Status ◽  
Progression Free Survival ◽  
Adjusted Relative Risk ◽  
Circadian Timing System ◽  
Metastatic Sites ◽  
Rest Activity

e14006 Background: Experimental disruption of the Circadian Timing System (CTS) accelerates cancer progression. The relative amount of activity in-bed versus out-of-bed (I<O) was identified as a quantitative CTS estimate that predicted survival in two cohorts of patients with metastatic colorectal cancer (CI, CII). Methods: The independent prognostic value of I<O was investigated for Overall Survival (OS) and Progression-Free Survival (PFS) 1) in a new cohort of 142 patients (CIII) receiving circadian-based salvage treatment for metastatic colorectal cancer, and 2) in a pooled population of 436 patients from cohorts I-III. All patients had two-day rest-activity rhythm monitoring and then received a new treatment. Cohort-adjusted data were analyzed with log rank and multivariate Cox analyses. Results: Patients in CIII had poor prognosis disease compared to CI and CII, as assessed by prior chemotherapy (CIII, 69%; CI, 59.5%; CII, none), prior oxaliplatin (CIII, 55%; CII, none; CI, 2%) and/or irinotecan (CIII, 39.4%; CII, none; CI, 7%). The 273 male and 163 female patients in the pooled population had generally good performance status 0 (60.7%) or 1 (33.1%) and 51% had two or more metastatic sites. Following rest-activity rhythm determination, patients received a median of 8 chemotherapy courses. Median OS was 21.6 months [95% Confidence Limits, 17.8 to 25.5] in the patients with I<O above the cutoff median value of 97.5% as compared to 11.9 months [10.4 to 13.3] in those with a lower I<O (p from Log rank < 0.001). The adjusted relative risk related to I<O above cutoff was 0.587 [0.477 to 0.722] for earlier death (p<0.001) and 0.661 [0.542 to 0.807] for earlier progression (p <0.001). Conclusions: The circadian biomarker indicator I<O is a robust and independent quantitative long-term predictor of both OS and PFS in patients with metastatic colorectal cancer. Cancer patients with low I<O could potentially benefit from specific treatments for circadian disruption in order to enhance survival.

Effects of Melatonin in Two Individuals with Alzheimer's Disease

1998 ◽  
Vol 87 (1) ◽  
pp. 331-339 ◽  
Author(s):  
Girardin Jean-Louis ◽  
Ferdinand Zizi ◽  
Hans Von Gizycki ◽  
Harvey Taub
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Circadian Rhythm ◽  
Aging Process ◽  
Activity Rhythm ◽  
The Other ◽  
Beneficial Effects ◽  
Melatonin Administration ◽  
Activity Cycles ◽  
Rest Activity

Dementia has been associated with circadian rhythm disturbances expressed in several dimensions including body temperature, hormonal concentrations, sleep and wakefulness patterns, and rest-activity cycles. These disturbances may be the result of a dampening in the amplitude of the circadian rhythm. One of the symptoms associated with the aging process has been a decline in the amplitude of the melatonin rhythm. Here, the results of melatonin administration to two patients with Alzheimer's disease are presented. Melatonin administration enhanced and stabilized the circadian rest-activity rhythm in one of the patients along with some reduction of daytime sleepiness and an improvement in mood. The other patient, who was characterized by less cognitive impairment, showed no significant changes associated with melatonin ingestion. Interestingly, the acrophase of rest-activity was delayed for about one hour in both patients. These results suggest that melatonin may have beneficial effects in some patients with Alzheimer's disease

Initial proof of concept that a consumer wearable can be used for real-time rest-activity rhythm monitoring

SLEEP ◽  
2021 ◽  
Author(s):  
Stephen F Smagula ◽  
Sarah T Stahl ◽  
Robert T Krafty ◽  
Daniel J Buysse
Keyword(s):  
Real Time ◽  
Activity Rhythm ◽  
Proof Of Concept ◽  
Rhythm Monitoring ◽  
Rest Activity

scholarly journals 0380 Association of Day-to-Day Variability in Rest-Activity Circadian Rhythm with Sleep Quality Among Law Enforcement Officers

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A146-A146
Author(s):  
D Fekedulegn ◽  
S Service ◽  
C Ma ◽  
J Gu ◽  
J Violanti ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Sleep Quality ◽  
Goodness Of Fit ◽  
Daily Variation ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Occupational Factors ◽  
Mean Values ◽  
The Impact ◽  
Rest Activity

Abstract Introduction Poor sleep quality may be attributed to several occupational factors and has been linked to adverse health outcomes, including cardiovascular disease. Recent epidemiologic studies suggest rest-activity circadian rhythm (RAR) as a possible determinant of poor sleep quality. The focus of these studies has been on the magnitude of the parameters of RAR with little attention to the impact of their day-to-day fluctuation. We examined association of daily variation in parameters of RAR with sleep quality. Methods Participants (n=280) were officers from the Buffalo Cardio-metabolic Occupational Police Stress Study (2004-2009). Sleep quality was determined using the Pittsburgh Sleep Quality Index (PSQI). Participants wore wrist actigraph for a minimum of seven days. A cosine curve was fit to measure goodness of fit and estimate the mean values of the three parameters of RAR: Mesor, Amplitude, and Acrophase. Day-to-day variability of the parameters were assessed by fitting the cosine function separately for each day and computing the sample standard deviation across the days. Poisson regression models were conducted adjusting for demographic, lifestyle, and occupational factors. Results The prevalence of poor sleep quality was 50.3%. Poor sleep quality was 56% higher in officers with the largest day-to-day variability in Mesor (PR=1.56, 95%CI:1.11 - 2.19) compared to those with the lowest daily variation. Similar estimates were found for Amplitude (PR=1.42, 1.03 - 1.95), Acrophase (PR=1.86, 1.29 - 2.67), and measure of goodness of fit (PR=1.54, 1.13 - 2.11). On the other hand, mean values of RAR parameters were not significantly associated with poor sleep quality. Conclusion Results suggest larger daily variation in parameters of RAR is associated with a decrease in sleep quality. Given that day-to-day variation in RAR may increase the odds of poor sleep quality, future studies ought to address risk factors for higher daily fluctuations in RAR which could aid in developing intervention measures. Support CDC/NIOSH grant 1R01OH009640-01A1

Robustness of circadian rest-activity rhythm for predicting efficacy of intravenous cetuximab (Cet) and hepatic artery infusion (HAI) of chronomodulated irinotecan, 5-fluorouracil and oxaliplatin (Chrono-Optiliv) for liver metastases from colorectal cancer (LM-CRC) (Optiliv translational study, NCT00852228).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e20519-e20519
Author(s):  
Abdoulaye Karaboué ◽  
Pasquale F. Innominato ◽  
Mohamed Bouchahda ◽  
Magali Mocquery ◽  
Rachel Bossevot ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Tumor Response ◽  
Activity Rhythm ◽  
Performance Status ◽  
Experimental Models ◽  
Antitumor Efficacy ◽  
Hepatic Artery Infusion ◽  
Poor Overall Survival ◽  
Prior Chemotherapy ◽  
Rest Activity

e20519 Background: The rest-activity rhythm is a biomarker of the circadian timing system, whose disruption both accelerates cancer progression in experimental models (Filipski et al. JNCI 2002, 2005) and predicts for poor overall survival in cancer patients (pts) (Innominato et al. Cancer Res 2009; Int J Cancer 2012). Here we investigate the relevance of early signals of circadian disruption for the antitumor efficacy of intravenous Cet and chronomodulated triplet HAI in pts with unresectable and refractory LM-CRC. Methods: Rest-activity was monitored q1min using a wrist watch actigraph worn for three weeks, starting 1 week before HAI onset. A robust and validated parameter (I<O), the relative measure of activity In-bed vs Out-of-bed, was used to evaluate rest-activity patterns. Tumor response was evaluated using RECIST criteria. Results: 10M and 3F, aged 33-72 y (median, 60 y) had a good Performance Status (0, 10 pts; 1, 3 pts) and received one (7 pts), two or three (6 pts) prior chemotherapy lines. Pts displayed complete or partial response (1 CR, 6 PR), or stable disease (SD, 6 pts). Median I<0 was 95.4% (25-75% quartiles, 88.8-98.0) at baseline, 92.8% (89.4- 96.2) during the treatment week (p<0.001 vs “baseline”) and 95.0% (89.2- 97.6, NS) on the week after HAI. On this last week, I<O improved or recovered fully in 5 pts (38.5%), or partly in 3 pts (23.1%). Rest-activity rhythm disruption persisted in 5 pts (38.5%). An objective tumor response was achieved in 7/ 8 pts whose I<O improved or recovered (87.5%) while the poor I<O computed for 5 patients on the week after HAI predicted for SD only (p=0.003). This relation was independent of PS and prior chemotherapy lines (p=0.013). Conclusions: The robustness of the rest-activity rhythm during the first course of Chrono-Optiliv was an early signal that predicted subsequent antitumor activity. Further testing of this circadian biomarker is warranted as an early surrogate endpoint of antitumor efficacy of Chrono-Optiliv. Clinical trial information: NCT00852228.

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