scholarly journals Is There Any Association Between Processed Meat Consumption and Colorectal Cancer Risk in Morocco?

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 194s-194s
Author(s):  
M. Mint Sidi Deoula ◽  
K. El Kinany ◽  
H.A. Boudouaya ◽  
Z. Hatime ◽  
I. Huybrechts ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Conditional Logistic Regression ◽  
Large Body ◽  
Meat Consumption ◽  
Bivariate Analysis ◽  
Processed Meat ◽  
Meat Intake ◽  
Study Support ◽  
Processed Meat Consumption ◽  
Research Show

Background: Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related deaths worldwide. A large body of epidemiologic research show that countries where people eat more red meat and processed meat are also countries where the risk of CRC is high. The processed meat intake was described as a convincing risk factor for CRC according to the recent report of the World Cancer Research Fund published in 2017. In Morocco the incidence of CRC is increased significantly during the last years according to the Cancer Registry of the Greater Casablanca region. In addition to the imported of modern processed meat; this country is characterized also by the presence of their traditional processed meat as: quaddid (obtained by salting and sun-drying of meat) and khlii (obtained from salted-dried meat, which is cooked and conditioned in fat). In contrast, no studies have been conducted previously to evaluate the association between processed meat and CRC risk. Aim: This study aimed to evaluate the association between processed meat intake and CRC risk in Morocco. Methods: A case-control study was conducted in 5 major public health hospitals in Morocco. Each case was matched with a control by age (±5 years), sex and center. Dietary data were collected by a validated Food Frequency Questionnaire including traditional processed meat (quaddid and khlii) and modern processed meat (delicatessen meat). Conditional logistic regression was done to predict the association between processed meat consumption and CRC risk. Results: Among 500 cases and 500 controls matched by age; sex and center, 50.9% were male and 49.1% were female. The mean age was 55.53 ± 14.53 years. Among the cases, 44.5% was diagnosed with colon cancer, and 55.5% with rectum cancer. Most participants live in the urban area; never attend school and are poor. The bivariate analysis was used to evaluate the association between processed meat intake and CRC. We found no statistical significant between the occurrence of CRC and consumption of traditional processed meat (OR = 1.04; 95% CI, 0.74-1.48; P = 0.43). While, this study found strong significant association between modern processed meat and CRC risk (OR = 9.23; 95% CI, 3.91-21.77; P = 0.00). Conclusion: This study support that high consumption of modern processed meat such delicatessen meat increased the risk of CRC. In contrast, this study did not provide evidence that traditional processed meat is related to CRC risk in Morocco. We could explain this association by the low consumption of traditional processed meat in this study sample. In addition, the increases in the urbanization could also reduce the consumption of these types of traditional processed meat. Further studies are needed to evaluate the association between meat consumption and CRC risk in the context Moroccan.

scholarly journals Association Between Red and Processed Meat Intake and Mortality Among Colorectal Cancer Survivors

2013 ◽  
Vol 31 (22) ◽  
pp. 2773-2782 ◽  
Author(s):  
Marjorie L. McCullough ◽  
Susan M. Gapstur ◽  
Roma Shah ◽  
Eric J. Jacobs ◽  
Peter T. Campbell
Keyword(s):  
Colorectal Cancer ◽  
Meat Consumption ◽  
Cox Proportional Hazards ◽  
Processed Meat ◽  
Meat Intake ◽  
Risk Of Death ◽  
Specific Mortality ◽  
Before And After ◽  
Processed Meat Consumption ◽  
Red And Processed Meat

Purpose Red and processed meat intake is convincingly associated with colorectal cancer (CRC) incidence, but its impact on prognosis after CRC diagnosis is unknown. We examined associations of red and processed meat consumption, self-reported before and after cancer diagnosis, with all-cause and cause-specific mortality among men and women with invasive, nonmetastatic CRC. Patients and Methods Participants in the Cancer Prevention Study II Nutrition Cohort reported information on diet and other factors at baseline in 1992-1993, 1999, and 2003. Participants with a verified CRC diagnosis after baseline and up to June 30, 2009, were observed for mortality through December 31, 2010. Results Among 2,315 participants diagnosed with CRC, 966 died during follow-up (413 from CRC and 176 from cardiovascular disease [CVD]). In multivariable-adjusted Cox proportional hazards regression models, red and processed meat intake before CRC diagnosis was associated with higher risks of death as a result of all causes (top v bottom quartile, relative risk [RR], 1.29; 95% CI, 1.05 to 1.59; Ptrend = .03) and from CVD (RR, 1.63; 95% CI, 1.00 to 2.67; Ptrend = .08) but not CRC (RR, 1.09; 95% CI, 0.79 to 1.51; Ptrend = 0.54). Although red and processed meat consumption after CRC diagnosis was not associated with mortality, survivors with consistently high (median or higher) intakes before and after diagnosis had a higher risk of CRC-specific mortality (RR, 1.79; 95% CI, 1.11 to 2.89) compared with those with consistently low intakes. Conclusion This study suggests that greater red and processed meat intake before diagnosis is associated with higher risk of death among patients with nonmetastatic CRC.

scholarly journals Red and processed meat consumption and colorectal cancer risk: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (47) ◽  
pp. 83306-83314 ◽  
Author(s):  
Zhanwei Zhao ◽  
Quanxin Feng ◽  
Zifang Yin ◽  
Jianbo Shuang ◽  
Bin Bai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Meat Consumption ◽  
Colorectal Cancer Risk ◽  
Processed Meat ◽  
Processed Meat Consumption ◽  
Red And Processed Meat

scholarly journals A Prospective Analysis of Red and Processed Meat Consumption and Risk of Colorectal Cancer in Women

2019 ◽  
Vol 29 (1) ◽  
pp. 141-150 ◽  
Author(s):  
Suril S. Mehta ◽  
Whitney D. Arroyave ◽  
Ruth M. Lunn ◽  
Yong-Moon Mark Park ◽  
Windy A. Boyd ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Meat Consumption ◽  
Processed Meat ◽  
Prospective Analysis ◽  
Processed Meat Consumption ◽  
Red And Processed Meat

scholarly journals Meat intake and cancer risk: prospective analyses in UK Biobank

2019 ◽  
Author(s):  
Anika Knuppel ◽  
Keren Papier ◽  
Georgina K. Fensom ◽  
Paul N. Appleby ◽  
Julie A. Schmidt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Colorectal Cancer ◽  
Cancer Risk ◽  
Meat Consumption ◽  
Red Meat ◽  
Processed Meat ◽  
Uk Biobank ◽  
Meat Intake ◽  
Incidence Trends ◽  
Red And Processed Meat

AbstractBackgroundRed and processed meat has been consistently associated with risk for colorectal cancer, but evidence for other cancer sites is limited and few studies have examined the association between poultry intake and cancer risk. We examined associations between total meat, red meat, processed meat and poultry intake and incidence for 20 common cancer sites.Methods and FindingsWe analysed data from 475,023 participants (54% women) in UK Biobank. Participants were aged 37-73 years and cancer free at baseline. Information on meat consumption was based on a touchscreen questionnaire completed at baseline covering type and frequency of meat intake. Diet intake was re-measured a minimum of three times in a subsample (15%) using a web-based 24h dietary recall questionnaire. Multivariable-adjusted Cox proportional hazards models were used to determine the association between baseline meat intake and cancer incidence. Trends in risk across baseline meat intake categories were calculated by assigning a mean value to each category using estimates from the re-measured meat intakes. During a mean follow-up of 6.9 years, 28,955 participants were diagnosed with a malignant cancer. Total, red and processed meat intakes were each positively associated with risk of colorectal cancer (e.g. hazard ratio (HR) per 70 g/day higher intake of red and processed meat combined 1.31, 95%-confidence interval (CI) 1.14-1.52).Red meat intake was positively associated with breast cancer (HR per 50 g/day higher intake 1.12, 1.01-1.24) and prostate cancer (1.15, 1.03-1.29). Poultry intake was positively associated with risk for cancers of the lymphatic and hematopoietic tissues (HR per 30g/day higher intake 1.16, 1.03-1.32). Only the associations with colorectal cancer were robust to Bonferroni correction for multiple comparisons. Study limitations include unrepresentativeness of the study sample for the UK population, low case numbers for less common cancers and the possibility of residual confounding.ConclusionsHigher intakes of red and processed meat were associated with a higher risk of colorectal cancer. The observed positive associations of red meat consumption with breast and prostate cancer, and poultry intake with cancers of the lymphatic and hematopoietic tissues, require further investigation.

scholarly journals Estimated Global, Regional, and National Cardiometabolic Disease Burdens Related to Red and Processed Meat Consumption: An Analysis from the Global Dietary Database (P10-073-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Dimitra Karageorgou ◽  
Victoria Miller ◽  
Frederick Cudhea ◽  
Jianyi Zhang ◽  
Peilin Shi ◽  
...  
Keyword(s):  
Meat Consumption ◽  
Assessment Model ◽  
Attributable Mortality ◽  
Cardiometabolic Disease ◽  
Processed Meat ◽  
Meat Intake ◽  
Diabetes Mortality ◽  
The Impact ◽  
Processed Meat Consumption ◽  
Red And Processed Meat

Abstract Objectives Red and processed meats are associated with cardiometabolic disease (CMD) risk; yet, corresponding global burdens are not well established. We aimed to quantify the impact of meat intake on coronary heart disease (CHD) and type 2 diabetes mortality by nation (n = 187), super-region (n = 9), age (20 + y), and sex using the largest standardized Global Dietary Database (GDD) available. Methods A comparative risk assessment model estimated the absolute and % CHD and diabetes mortality attributable to suboptimal unprocessed red and processed meat consumption, incorporating data and corresponding uncertainty on: intakes from the GDD, estimated by a Bayesian hierarchical imputation model using national and sub-national surveys worldwide (266 surveys; 1630,069 individuals; 113/187 countries; 82% of the world's population); etiologic effects of meat intake on CHD and diabetes mortality from meta-analyses of prospective cohorts; optimal population meat intakes based on observed intakes associated with lowest risk; and disease-specific deaths from the Global Burden of Diseases. Results In 2010, suboptimal red meat intake was associated with 43,987 (95% uncertainty interval: 42,243–45,635) diabetes deaths, accounting for 3.5% (3.4–3.6%) of global diabetes mortality. Highest proportional mortality was estimated in Central African Republic, United Arab Emirates, and Gabon (Figure 1). Similar attributable mortality was seen in men (4%) vs women (3%), and higher in younger (25–54 y; 5–7%) vs older (55–85 y; 1–4%) adults. Processed meat intake was linked to 510,214 (482,092–541,175) CHD and 86,923 (83,832–90,488) diabetes deaths, accounting for 7.3% (6.9–7.8%) of global CHD and 6.9% (6.7–7.2%) of diabetes mortality. CHD mortality was highest in Panama, Costa Rica, and Colombia, and diabetes mortality in Panama, Belarus, and El Salvador (Figure 2). Attributable mortality was higher in men vs women (CHD: 9 vs 6%; diabetes: 8 vs 6%), and in younger vs older adults (14–15% vs 4–11%; 12–15% vs 3–9%). Meat-related CMD burdens in 1990 and 2015 will be presented at the meeting. Conclusions Suboptimal processed meat intake contributed to substantial CMD mortality, greatly exceeding burdens attributed to unprocessed red meats. Such data highlight the need for strategies to reduce meat, particularly processed meat, consumption. Funding Sources Gates Foundation. Supporting Tables, Images and/or Graphs

scholarly journals Association between total, processed, red and white meat consumption and all-cause, CVD and IHD mortality: a meta-analysis of cohort studies

2014 ◽  
Vol 112 (5) ◽  
pp. 762-775 ◽  
Author(s):  
Itziar Abete ◽  
Dora Romaguera ◽  
Ana Rita Vieira ◽  
Adolfo Lopez de Munain ◽  
Teresa Norat
Keyword(s):  
Cohort Studies ◽  
Meta Analysis ◽  
Meat Consumption ◽  
Red Meat ◽  
Processed Meat ◽  
White Meat ◽  
Meat Intake ◽  
Risk Of Mortality ◽  
Processed Meat Consumption ◽  
Cvd Mortality

An association between processed and red meat consumption and total mortality has been reported by epidemiological studies; however, there are many controversial reports regarding the association between meat consumption and CVD and IHD mortality. The present meta-analysis was carried out to summarise the evidence from prospective cohort studies on the association between consumption of meat (total, red, white and processed) and all-cause, CVD and IHD mortality. Cohort studies were identified by searching the PubMed and ISI Web of Knowledge databases. Risk estimates for the highest v. the lowest consumption category and dose–response meta-analysis were calculated using a random-effects model. Heterogeneity among the studies was also evaluated. A total of thirteen cohort studies were identified (1 674 272 individuals). Subjects in the highest category of processed meat consumption had 22 and 18 % higher risk of mortality from any cause and CVD, respectively. Red meat consumption was found to be associated with a 16 % higher risk of CVD mortality, while no association was found for total and white meat consumption. In the dose–response meta-analysis, an increase of 50 g/d in processed meat intake was found to be positively associated with all-cause and CVD mortality, while an increase of 100 g/d in red meat intake was found to be positively associated with CVD mortality. No significant associations were observed between consumption of any type of meat and IHD mortality. The results of the present meta-analysis indicate that processed meat consumption could increase the risk of mortality from any cause and CVD, while red meat consumption is positively but weakly associated with CVD mortality. These results should be interpreted with caution due to the high heterogeneity observed in most of the analyses as well as the possibility of residual confounding.

scholarly journals Values and Preferences Related to Cancer Risk among Red and Processed Meat Eaters: A Pilot Cross-Sectional Study with Semi-Structured Interviews

Foods ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2182
Author(s):  
Victoria Howatt ◽  
Anna Prokop-Dorner ◽  
Claudia Valli ◽  
Joanna Zajac ◽  
Malgorzata Bala ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Meat Consumption ◽  
Cross Sectional Study ◽  
Red Meat ◽  
Processed Meat ◽  
Sectional Study ◽  
Cross Sectional ◽  
Meat Intake ◽  
Processed Meat Consumption ◽  
Red And Processed Meat

Introduction: Over the last decade, the possible impact of meat intake on overall cancer incidence and mortality has received considerable attention, and authorities have recommended decreasing consumption; however, the benefits of reducing meat consumption are small and uncertain. As such, individual decisions to reduce consumption are value- and preference-sensitive. Consequently, we undertook a pilot cross-sectional study to explore people’s values and preferences towards meat consumption in the face of cancer risk. Methods and analysis: The mixed-method pilot study included a quantitative questionnaire followed by qualitative evaluation to explore the dietary habits of 32 meat eaters, their reasons for eating meat, and willingness to change their meat consumption when faced with a potential risk reduction of cancer over a lifetime based on a systematic review and dose–response meta-analysis. We recruited a convenience sample of participants from two Canadian provinces: Nova Scotia and Prince Edward Island. This project was approved by the Research Ethics Board for Health Sciences research at Dalhousie University, Canada. Results: The average weekly consumption of red meat was 3.4 servings and the average weekly consumption of processed meat was 3 servings. The determinants that influenced meat intake were similar for both red and processed meat. Taste, cost, and family preferences were the three most commonly cited factors impacting red meat intake. Taste, cost, and (lack of) cooking time were the three most commonly cited factors impacting processed meat intake. None of the participants were willing to eliminate red or processed meat from their diet. About half of participants were willing to potentially reduce their meat consumption, with one third definitely willing to reduce their consumption. Strengths and limitations: This study is the first that we are aware of to share data with participants on the association of red meat and processed meat consumption and the risk of cancer mortality and cancer incidence, including the certainty of evidence for the risk reduction. The limitations of this study include its small sample size and its limited geographic sampling. Conclusions: When presented explicit information about the small uncertain cancer risk associated with red and processed meat consumption, study participants were unwilling to eliminate meat, while about one-third were willing to reduce their meat intake.

scholarly journals Red Meat and Processed Meat Consumption and Risk of Colorectal Cancer

2019 ◽  
Author(s):  
Natalia Vladimirovna Ozhiganova ◽  
Svetlana Vladimirovna Mustafina
Keyword(s):  
Colorectal Cancer ◽  
Colon Carcinogenesis ◽  
Meat Consumption ◽  
Red Meat ◽  
Processed Meat ◽  
Scientific Discussion ◽  
Long Time ◽  
The Subject ◽  
Colorectal Cancer Incidence ◽  
Processed Meat Consumption

The potential connection between consumption of red meat and development of colorectal cancer has been the subject of scientific discussion for a long time. However, uncertainty persists to this day. Consumption of processed meat and red meat may play a role in colon carcinogenesis, among other risk factors. An analysis of the updated data demonstrates an ever-smaller connection between red meat consumption and colorectal cancer incidence.

scholarly journals A Review of the In Vivo Evidence Investigating the Role of Nitrite Exposure from Processed Meat Consumption in the Development of Colorectal Cancer

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2673 ◽  
Author(s):  
William Crowe ◽  
Christopher T. Elliott ◽  
Brian D. Green
Keyword(s):  
Colorectal Cancer ◽  
Sodium Nitrite ◽  
Meat Consumption ◽  
Nitroso Compounds ◽  
Processed Meat ◽  
Processed Meats ◽  
Unique Approach ◽  
Media Reports ◽  
Processed Meat Consumption

The World Cancer Research Fund (WCRF) 2007 stated that the consumption of processed meat is a convincing cause of colorectal cancer (CRC), and therefore, the public should avoid it entirely. Sodium nitrite has emerged as a putative candidate responsible for the CRC-inducing effects of processed meats. Sodium nitrite is purported to prevent the growth of Clostridium botulinum and other food-spoiling bacteria, but recent, contradictory peer-reviewed evidence has emerged, leading to media reports questioning the necessity of nitrite addition. To date, eleven preclinical studies have investigated the effect of consuming nitrite/nitrite-containing meat on the development of CRC, but the results do not provide an overall consensus. A sizable number of human clinical studies have investigated the relationship between processed meat consumption and CRC risk with widely varying results. The unique approach of the present literature review was to include analysis that limited the human studies to those involving only nitrite-containing meat. The majority of these studies reported that nitrite-containing processed meat was associated with increased CRC risk. Nitrite consumption can lead to the formation of N-nitroso compounds (NOC), some of which are carcinogenic. Therefore, this focused perspective based on the current body of evidence links the consumption of meat containing nitrites and CRC risk.

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