Delta-Selective Ligands Related to Naltrindole

2003 ◽  
pp. 157-176
Keyword(s):  
Selective Ligands

ChemInform Abstract: Discovery of μ-Opioid Selective Ligands Derived from 1-Aminotetralin Scaffolds Made via Metal-Catalyzed Ring-Opening Reactions.

ChemInform ◽  
2009 ◽  
Vol 40 (29) ◽  
Author(s):  
Chris Dockendorff ◽  
Shujuan Jin ◽  
Madeline Olsen ◽  
Mark Lautens ◽  
Martin Coupal ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Reactions ◽  
Selective Ligands ◽  
Metal Catalyzed

scholarly journals Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

2020 ◽  
Vol 63 (6) ◽  
pp. 3090-3103 ◽  
Author(s):  
Jussara Amato ◽  
Giulia Miglietta ◽  
Rita Morigi ◽  
Nunzia Iaccarino ◽  
Alessandra Locatelli ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cancer Cells ◽  
Genome Instability ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
G Quadruplex ◽  
Selective Ligands

scholarly journals A Computational-Based Approach to Identify Estrogen Receptor α/β Heterodimer Selective Ligands

2018 ◽  
Vol 93 (3) ◽  
pp. 197-207 ◽  
Author(s):  
Carlos G. Coriano ◽  
Fabao Liu ◽  
Chelsie K. Sievers ◽  
Muxuan Liang ◽  
Yidan Wang ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Selective Ligands

Synthesis of Unnatural Morphinan Compounds to Induce Itch-like Behaviors in Mice: Towards the Development of MRGPRX2 Selective Ligands

2021 ◽  
pp. 128485
Author(s):  
Keita Iio ◽  
Noriki Kutsumura ◽  
Yasuyuki Nagumo ◽  
Tsuyoshi Saitoh ◽  
Akihisa Tokuda ◽  
...  
Keyword(s):  
Selective Ligands

Design and synthesis of carborane-containing estrogen receptor-beta (ERβ)-selective ligands

2015 ◽  
Vol 25 (19) ◽  
pp. 4174-4178 ◽  
Author(s):  
Kiminori Ohta ◽  
Takumi Ogawa ◽  
Akifumi Oda ◽  
Asako Kaise ◽  
Yasuyuki Endo
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Beta ◽  
Design And Synthesis ◽  
Selective Ligands ◽  
Receptor Beta

Serotonin Receptor Subtypes: Implications for Psychopharmacology

1991 ◽  
Vol 159 (S12) ◽  
pp. 7-14 ◽  
Author(s):  
P. J. Cowen
Keyword(s):  
Cognitive Processes ◽  
Serotonin Receptor ◽  
Antidepressant Treatment ◽  
Receptor Subtypes ◽  
Therapeutic Effects ◽  
Controlled Clinical Trials ◽  
Wide Range ◽  
Selective Ligands ◽  
Coupling Mechanisms ◽  
Therapeutic Possibilities

Serotonin (5-HT) interacts with multiple brain 5-HT receptor subtypes to influence a wide range of behaviours. Three main families of 5-HT receptors (5-HT1, 5-HT2 and 5-HT3) have been described which differ in their binding affinity for selective ligands, their receptor-effector coupling mechanisms, and the behavioural processes they regulate. Nevertheless, manipulation of several different 5-HT receptor subtypes (5-HT1A, 5-HT1c, 5-HT2 and 5-HT3) may produce anxiolytic effects; 5-HT1A and 5-HT2 receptors may be involved in the aetiology of major depression and the therapeutic effects of antidepressant treatment; and 5-HT3 receptors have been linked to reward mechanisms and cognitive processes. These advances offer therapeutic possibilities, the value of which can only be satisfactorily assessed by controlled clinical trials.

Retinoic Acid Receptor β,γ-Selective Ligands: Synthesis and Biological Activity of 6-Substituted 2-Naphthoic Acid Retinoids

1996 ◽  
Vol 39 (12) ◽  
pp. 2411-2421 ◽  
Author(s):  
Kuo-Long Yu ◽  
Patrick Spinazze ◽  
Jacek Ostrowski ◽  
Stephen J. Currier ◽  
Edward J. Pack ◽  
...  
Keyword(s):  
Biological Activity ◽  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Naphthoic Acid ◽  
Selective Ligands
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