Exercise and adipose tissue production of cytokines

2001 ◽  
pp. 79-100
Author(s):  
Richard Israel ◽  
Matthew Hickey
Keyword(s):  
Adipose Tissue ◽  
Tissue Production

scholarly journals Obesity and infection. Another comorbidity?

2019 ◽  
Vol 16 (2) ◽  
pp. 3-8
Author(s):  
Leonid I. Dvoretskii
Keyword(s):  
Adipose Tissue ◽  
Literature Review ◽  
Antibiotic Therapy ◽  
Humoral Immunity ◽  
Preoperative Preparation ◽  
Immunomodulating Effect ◽  
Pathogenetic Mechanisms ◽  
Cellular And Humoral Immunity ◽  
Mechanisms Of Development ◽  
Tissue Production

A literature review is devoted to the problem of comorbidity of obesity (Ob) and infections. At present, extensive material has been accumulated about the increased propensity of patients with Ob to various infections (respiratory, urinary, viral, nosocomial, postoperative). One of the pathogenetic mechanisms of infection development in patients with Ob is dysfunction of cellular and humoral immunity, induced by adipose tissue production of cytokines (adipokines), which have an immunomodulating effect in various directions. Further research is needed in the field of epidemiology, mechanisms of development and course of infections in patients with Ob, as well as developing tactics for conducting this category of patients (diagnosis, antibiotic therapy, preoperative preparation, etc.).

scholarly journals The adipose tissue production of adiponectin is increased in end-stage renal disease

2013 ◽  
Vol 83 (3) ◽  
pp. 487-494 ◽  
Author(s):  
Maria P Martinez Cantarin ◽  
Scott A Waldman ◽  
Cataldo Doria ◽  
Adam M Frank ◽  
Warren R Maley ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage ◽  
Tissue Production

Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo

1999 ◽  
Vol 277 (6) ◽  
pp. E971-E975 ◽  
Author(s):  
Vidya Mohamed-Ali ◽  
Steven Goodrick ◽  
Karen Bulmer ◽  
Jeffrey M. P. Holly ◽  
John S. Yudkin ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Body Fat ◽  
Subcutaneous Adipose Tissue ◽  
Tnf Receptor ◽  
Soluble Receptor ◽  
Tnf Α ◽  
Subcutaneous Adipose ◽  
Tissue Production ◽  
Necrosis Factor

To investigate in vivo adipose tissue production of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and their soluble receptors: TNF receptor type I (sTNFR-I), TNF receptor type II (sTNFR-II), and IL-6 receptor (sIL-6R), we determined arteriovenous differences in their levels across abdominal subcutaneous adipose tissue in obese subjects. Subjects had a median (interquartile range) age of 44.5 (27–51.3) yr, body mass index (BMI) of 32.9 (26.0–46.6) kg/m2, and %body fat of 42.5 (28.5–51.2) %. Although there was not a significant difference in the arteriovenous concentrations of TNF-α ( P = 0.073) or sTNFR-II ( P = 0.18), the levels of sTNFR-I ( P = 0.002) were higher in the vein compared with artery, suggesting adipose tissue production of this soluble receptor. There was a significant arteriovenous difference in IL-6 ( P < 0.001) but not in its soluble receptor ( P = 0.18). There was no relationship between TNF-α levels and adiposity indexes ( r s = 0.12–0.22, P = not significant); however, levels of both its soluble receptor isomers correlated significantly with BMI and %body fat (sTNFR-I r s = 0.42–0.72, P < 0.001; sTNFR-II r s = 0.36–0.65, P < 0.05- <0.001). IL-6 levels correlated significantly with both BMI and %body fat ( r s = 0.51, P = 0.004, and r s = 0.63, P < 0.001), but sIL-6R did not. In conclusion, 1) soluble TNFR-I is produced by adipose tissue, and concentrations of both soluble isoforms correlate with the degree of adiposity, and 2) IL-6, but not its soluble receptor, is produced by adipose tissue and relates to adiposity.

scholarly journals OXIDATIVE STRESS: ITS ROLE IN INSULIN SECRETION, HORMONE RECEPTION BY ADIPOCYTES AND LIPOLYSIS IN ADIPOSE TISSUE

2014 ◽  
Vol 13 (3) ◽  
pp. 32-39
Author(s):  
V. V. Ivanov ◽  
Ye. V. Shakhristova ◽  
Ye. A. Stepovaya ◽  
O. L. Nosareva ◽  
T. S. Fyodorova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Insulin Secretion ◽  
Type I Diabetes ◽  
The Body ◽  
Type I ◽  
The Metabolic Syndrome ◽  
Antioxidant Protection System ◽  
Tissue Production

Oxidative stress is one of the pathogenetic components of many diseases during which generation of reactive oxigen species increases and the capacity of the antioxidant protection system diminishes. In the research of the last decades special attention has been given to adipose tissue, production of adipokines by it and their role in development of immunoresistance associated with formation of the metabolic syndrome and diabetes.Search for methods of therapeutic correction of adipokine secretion disorders, their influence on metabolism of separate cells and the organism on the whole as well as development of new approaches to correction of disorders in cell sensitivity to insulin are extremely topical nowadays. Systematization and consolidation of accumulated data allow to determine the strategies of further research more accurately; as a result, we have attempted to summarize and analyze the accumulated data on the role of adipose tissue in oxidative stress development.On the basis of literature data and the results of the personal investigations, the role of adipose tissue in forming oxidative stress in diabetes has been analyzed in the article. Brief description of adipose tissue was given as a secretory organ regulating metabolic processes in adipocytes and influencing functions of various organs and systems of the body. Mechanisms of disorder in insulin secretion as well as development of insulin sesistance in type I diabetes were described along with the contribution of lipolysis in adipose tissue to these processes.

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