Various terms such as sexual addiction and hypersexuality have been used to describe a problematic and destructive pattern of excessive sexual behavior that persists despite negative consequences. Proposed diagnostic criteria are presented and several typologies are described in terms of their clinical presentation and associated consequences. Pornography addiction is discussed in terms of its typical course and observed impact on sexual arousal, sexual functioning, and the romantic partnership. Interpersonal neurobiology is used to conceptualize sex addiction from the three interacting theoretical perspectives of dysfunctional neural reward circuitry, maladaptive affect regulation, and disordered intimacy (or insecure attachment). A set of standard multimodal, multidisciplinary treatment recommendations are presented in the context of the three dimensions of interpersonal neurobiology that draw upon interventions that can be integrated into a unique, client-specific treatment plan. Complimentary, alternative, and integrative methodologies are explored to form a more comprehensive approach to treatment.