Corrigendum to: “Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity”

Abstract Context Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity. Objective To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies. Design We performed a genome-wide meta-analysis for beta-cell glucose sensitivity in subjects with type 2 diabetes and nondiabetic subjects from 6 independent cohorts (n = 5706). Beta-cell glucose sensitivity was calculated from mixed meal and oral glucose tolerance tests, and its associations between known glycemia-related single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) SNPs were estimated using linear regression models. Results Beta-cell glucose sensitivity was moderately heritable (h2 ranged from 34% to 55%) using SNP and family-based analyses. GWAS meta-analysis identified multiple correlated SNPs in the CDKAL1 gene and GIPR-QPCTL gene loci that reached genome-wide significance, with SNP rs2238691 in GIPR-QPCTL (P value = 2.64 × 10−9) and rs9368219 in the CDKAL1 (P value = 3.15 × 10−9) showing the strongest association with beta-cell glucose sensitivity. These loci surpassed genome-wide significance when the GWAS meta-analysis was repeated after exclusion of the diabetic subjects. After correction for multiple testing, glycemia-associated SNPs in or near the HHEX and IGF2B2 loci were also associated with beta-cell glucose sensitivity. Conclusion We show that, variation at the GIPR-QPCTL and CDKAL1 loci are key determinants of pancreatic beta-cell glucose sensitivity.

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Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11)

Journal of Endocrinological Investigation ◽

10.1007/s40618-020-01483-3 ◽

2021 ◽

Author(s):

C. Zusi ◽

E. Rinaldi ◽

S. Bonetti ◽

M. L. Boselli ◽

E. Trabetti ◽

...

Keyword(s):

Type 2 Diabetes ◽

Beta Cell ◽

Pancreatic Beta Cell ◽

Newly Diagnosed ◽

Beta Cell Glucose Sensitivity ◽

Glucose Sensitivity ◽

Cell Glucose

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1827-P: Higher Glucagon-Like Peptide-1 Response and Lower Beta-Cell Glucose Sensitivity Are Associated with Increased Glycemic Variability among Individuals with Prediabetes

Diabetes ◽

10.2337/db19-1827-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 1827-P

Author(s):

ELAINE CHOW ◽

ANDREA LUK ◽

JAMES LING ◽

ALICE P. KONG ◽

RONALD C. MA ◽

...

Keyword(s):

Beta Cell ◽

Glycemic Variability ◽

Beta Cell Glucose Sensitivity ◽

Glucose Sensitivity ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1 ◽

Cell Glucose

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Faculty Opinions recommendation of Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1083881.536824 ◽

2007 ◽

Cited By ~ 1

Author(s):

Terri Beaty

Keyword(s):

Type 2 Diabetes ◽

Association Analysis ◽

Genome Wide Association ◽

Genome Wide Association Analysis ◽

Genome Wide

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Faculty Opinions recommendation of Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1157877.619129 ◽

2009 ◽

Author(s):

Francine Kauffmann ◽

Lidwien Smit

Keyword(s):

Association Analysis ◽

Toluene Diisocyanate ◽

Genome Wide Association ◽

Risk Variant ◽

Genome Wide Association Analysis ◽

Genome Wide

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A Caution in Association of ABO Blood Group with COVID-19

Global Clinical and Translational Research ◽

10.36316/02.0031 ◽

2020 ◽

Cited By ~ 2

Keyword(s):

Gene Cluster ◽

Clinical Outcomes ◽

Blood Group ◽

Association Analysis ◽

Blood Type ◽

Genome Wide Association ◽

Chromosome 3 ◽

Abo Blood Group ◽

Genome Wide Association Analysis ◽

Genome Wide

A comment on Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, et al. Association of ABO blood group and Covid19 susceptability. medRxiv [PREPRINT]. 2020; https://doi.org/10.1101/2020.03.11.20031096. Zeng X, Fan H, Lu D, Huang F, Meng X, Li Z, et al. Association between ABO blood group and clinical outcomes of Covid19. medRxiv[PREPRINT].2020; https://doi.org/10.1101/2020.04.15.20063107. Zietz M, Tatonetti N. Testing the association between blood type and COVID-19 infection, intubation, and death medRxiv [PREPRINT]. 2020; https://doi.org/10.1101/2020.04.08.20058073. Ellinghaus D, Degenhardt F, Bujanda L, al. e. The ABO blood group and a chromosome 3 gene cluster associate with SRAS-CoV2 respitarory failure in an Italy-Spain genome-wide association analysis. medRxiv. 2020; https://doi.org/10.1101/2020.05.31.20114991.

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