scholarly journals C-Type Natriuretic Peptide Forms in Pregnancy: Maternal Plasma Profiles during Ovine Gestation Correlate with Placental and Fetal Maturation

Endocrinology ◽  
2009 ◽  
Vol 150 (10) ◽  
pp. 4777-4783 ◽  
Author(s):  
Bryony A. McNeill ◽  
Graham K. Barrell ◽  
Martin Wellby ◽  
Timothy C. R. Prickett ◽  
Timothy G. Yandle ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Maternal Plasma ◽  
Late Gestation ◽  
Amino Terminal ◽  
Elevated Protein ◽  
Strong Relation ◽  
Firm Basis ◽  
Circulating Levels ◽  
Amino Terminal Fragment

Abstract Circulating concentrations of C-type natriuretic peptide (CNP) and a related amino terminal fragment (NTproCNP) were measured at weekly intervals from preconception to 3 wk postpartum in ewes with twins (n = 8) and nonpregnant ewes (n = 8). In contrast to low and stable values in nonpregnant ewes (CNP, 0.75 ± 0.08; NTproCNP, 22 ± 2 pmol/liter), CNP forms increased abruptly at 40–50 d of gestation and rose to peak values (CNP, 31 ± 5, NTproCNP, 270 ± 16 pmol/liter) at about d 120. Approximately 7 d prepartum, the concentration of both CNP forms fell precipitously to preconception values immediately postpartum. In separate studies, circulating maternal CNP forms were positively related to fetal number at d 120. Consistent with a major contribution from the placenta to circulating levels, the concentrations of CNP forms were elevated in the placentome (cotyledon: CNP, 18 ± 4, NTproCNP, 52 ± 10 pmol/g; caruncle: CNP, 13 ± 3, NTproCNP, 31 ± 6 pmol/g) and much higher than those of intercaruncular uterine tissue (CNP, 0.19 ± 0.05, NTproCNP, 0.98 ± 0.2 pmol/g) in late-gestation ewes (P < 0.001, n = 4). These distinctive patterns of maternal plasma CNP forms, positive relation with fetal number, and greatly elevated protein concentrations in the placentome demonstrate the hormone’s strong relation to placental and fetal maturation. The findings provide a firm basis for future studies of the functional role of CNP in fetal-maternal welfare.

scholarly journals Evolution of the hedgehog Gene Family

Genetics ◽  
1996 ◽  
Vol 142 (3) ◽  
pp. 965-972 ◽  
Author(s):  
Sudhir Kumar ◽  
Kristi A Balczarek ◽  
Zhi-Chun Lai
Keyword(s):  
Intercellular Communication ◽  
Short Range ◽  
Gene Duplications ◽  
Future Directions ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Carboxyl Terminal ◽  
Multicellular Organisms ◽  
Amino Terminal Fragment

Abstract Effective intercellular communication is an important feature in the development of multicellular organisms. Secreted hedgehog (hh) protein is essential for both long- and short-range cellular signaling required for body pattern formation in animals. In a molecular evolutionary study, we find that the vertebrate homologs of the Drosophila hh gene arose by two gene duplications: the first gave rise to Desert hh, whereas the second produced the Indian and Sonic hh genes. Both duplications occurred before the emergence of vertebrates and probably before the evolution of chordates. The amino-terminal fragment of the hh precursor, crucial in long- and short-range intercellular communication, evolves two to four times slower than the carboxyl-terminal fragment in both Drosophila hh and its vertebrate homologues, suggesting conservation of mechanism of hh action in animals. A majority of amino acid substitutions in the amino- and carboxyl-terminal fragments are conservative, but the carboxyl-terminal domain has undergone extensive insertion-deletion events while maintaining its autocleavage protease activity. Our results point to similarity of evolutionary constraints among sites of Drosophila and vertebrate hh homologs and suggest some future directions for understanding the role of hh genes in the evolution of developmental complexity in animals.

Circulating levels of GH-releasing hormone and GH during human pregnancy

1990 ◽  
Vol 125 (1) ◽  
pp. 161-167 ◽  
Author(s):  
M. Mazlan ◽  
C. Spence-Jones ◽  
T. Chard ◽  
J. Landon ◽  
C. McLean
Keyword(s):  
Cord Blood ◽  
Potential Role ◽  
Maternal Plasma ◽  
Placental Lactogen ◽  
Immunoradiometric Assay ◽  
Plasma Samples ◽  
Releasing Hormone ◽  
Significant Difference ◽  
Circulating Levels

ABSTRACT To study the potential role of GH-releasing hormone (GHRH) in maintaining circulating levels of GH during pregnancy, 302 maternal plasma samples were collected from non-fasted subjects at various stages of pregnancy and assayed for GHRH using a 'two-site' immunoradiometric assay. The GH and placental lactogen levels were also determined. In addition, maternal plasma samples taken during labour, amniotic fluid and cord blood were also assayed for these hormones. Maternal plasma GHRH levels were similar to non-pregnant levels throughout gestation despite fluctuations in GH values which were always higher than non-pregnant levels. There was no significant difference between GHRH levels in maternal plasma and cord blood although high GH levels were observed in the latter. These findings suggest that peripheral GHRH levels do not play an important role in maintaining circulating GH levels during pregnancy. Journal of Endocrinology (1990) 125, 161–167

scholarly journals Amino-terminal fragment of the prohormone brain-type natriuretic peptide in rheumatoid arthritis

2008 ◽  
Vol 58 (9) ◽  
pp. 2662-2669 ◽  
Author(s):  
Joseph Solus ◽  
Cecilia P. Chung ◽  
Annette Oeser ◽  
Ingrid Avalos ◽  
Tebeb Gebretsadik ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Natriuretic Peptide ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment

scholarly journals The diagnostic and prognostic role of amino-terminal pro-brain type natriuretic peptides in pediatric cardiac diseases and pulmonary hypertension

2021 ◽  
Vol 5 (Volume 1) ◽  
pp. 21
Author(s):  
Kayirnisa Tilemanbetova ◽  
Taalaibek Kudaiberdiev ◽  
Jalil Sheishenov ◽  
Damirbek Abibillaev
Keyword(s):  
Congenital Heart Disease ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Natriuretic Peptide ◽  
Congenital Heart ◽  
Pediatric Patients ◽  
Heart Diseases ◽  
Congenital Heart Diseases ◽  
Amino Terminal

Objective: Several studies showed that N-terminal pro-brain type natriuretic peptide (NT-pro-BNP) as the reliable marker both in diagnostic and prognostic workup of pediatric patients with congenital heart disease complicated by pulmonary hypertension. Furthermore, it has well assisted both in therapeutic and surgical management of children with congenital heart diseases. In this review, we aimed to analyze recent studies concerning the role of the NT-pro-BNP in pediatric cardiac patients with pulmonary hypertension. Methods: PubMed, Cochrane, Science Direct and Google Scholar databases were used with the searching of the following words: “amino terminal pro brain type natriuretic peptide”, “pediatric pulmonary hypertension”, “congenital heart diseases”, emphasizing on original research articles published within recent 15 years and in English language. We critically analyzed and summarized the retrieved studies. Conclusion: NT-pro-BNP remains as the reliable diagnostic and prognostic marker of pulmonary hypertension and congenital heart diseases in pediatric patients. NT-pro-BNP and BNP remain as the universal marker of cardiovascular pathology in pediatric population. Improvement of their effectiveness in diagnostic workup in patients with CHD and PH undergoing surgery needs further clarification. Key words: pediatric pulmonary hypertension, N-terminal pro brain type natriuretic peptide, congenital heart disease

scholarly journals The Amino-Terminal Fragment of Pro-Brain Natriuretic Peptide in Plasma as a Biological Marker for Predicting Mortality in Community-Acquired Pneumonia: A Cohort Study

2016 ◽  
Vol 15 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Manuel Antonio Tazón Varela ◽  
Pedro Muñoz Cacho ◽  
Héctor Alonso Valle ◽  
Jaime Gallo Terán ◽  
Luis Angel Pérez Mier ◽  
...  
Keyword(s):  
Cohort Study ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Biological Marker ◽  
Community Acquired Pneumonia ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment

The Role of the Circulation in Processing pro-Brain Natriuretic Peptide (proBNP) to Amino-Terminal BNP and BNP-32

Peptides ◽  
1997 ◽  
Vol 18 (10) ◽  
pp. 1475-1481 ◽  
Author(s):  
P.J Hunt ◽  
E.A Espiner ◽  
M.G Nicholls ◽  
A.M Richards ◽  
T.G Yandle
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Amino Terminal

Amino-terminal Fragment of C-type Natriuretic Peptide Precursor and C-type Natriuretic Peptide Do Not Correlate in Patients With Chagas Disease: Role For Neutral Endopeptidase

2010 ◽  
Vol 55 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Yong Wang ◽  
Maria da Consolação V Moreira ◽  
Silvia Heringer-Walther ◽  
Heinz-Peter Schultheiss ◽  
Wolf-Eberhard Siems ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Chagas Disease ◽  
Neutral Endopeptidase ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Peptide Precursor ◽  
Amino Terminal Fragment

Caloric restriction, but not caloric loading, affects circulating fetal and maternal C-type natriuretic peptide concentrations in late ovine gestation

2012 ◽  
Vol 24 (8) ◽  
pp. 1063 ◽  
Author(s):  
B. A. McNeill ◽  
G. K. Barrell ◽  
M. J. Ridgway ◽  
M. P. Wellby ◽  
T. C. R. Prickett ◽  
...  
Keyword(s):  
Growth Factor ◽  
Caloric Restriction ◽  
Natriuretic Peptide ◽  
Nutrient Status ◽  
Maternal Plasma ◽  
Nutrient Supply ◽  
Late Gestation ◽  
Short Term ◽  
Fetal Plasma ◽  
In Pregnancy

The factors regulating the greatly elevated concentrations of maternal plasma C-type natriuretic peptide (CNP) forms in ruminant pregnancy are largely unknown, but nutrient status is likely to be important. Previous work has shown that increases in maternal plasma CNP, sourced from the placenta, occur in response to caloric restriction in late gestation. Whether oversupply of nutrients also regulates CNP secretion in pregnancy has not been studied. Hypothesising that CNP in fetal and maternal tissues will be responsive to both deficiency and excess, we studied changes in CNP and a cosecreted fragment, namely N-terminal pro-CNP (NTproCNP), during short-term periods of caloric restriction (CR) and loading (CL). Twin-bearing ewes received CR (fasted Days 121–124), CL (Days 110–124) or control maintenance diets. During CR, fetal plasma CNP forms, insulin-like growth factor (IGF)-1 and liveweight all fell, and maternal plasma NTproCNP increased. During CL, fetal IGF-1 increased, whereas CNP forms and liveweight were unchanged, as were maternal concentrations of CNP forms. The high abundance of CNP peptides in placental tissues was unaffected by these short-term changes in nutrient supply. We conclude that CNP in the fetal–maternal unit is acutely responsive to undernutrition, but is unaffected by oversupply in late gestation.

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