Coexpression of Functionally Active Receptors for Thyrotropin and Platelet-Derived Growth Factor in Human Thyroid Carcinoma Cells*

Endocrinology ◽  
1991 ◽  
Vol 129 (4) ◽  
pp. 2187-2193 ◽  
Author(s):  
NILS-ERIK HELDIN ◽  
DUBRAVKA CVEJIĆ ◽  
STAFFAN SMEDS ◽  
BENGT WESTERMARK
Keyword(s):  
Growth Factor ◽  
Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Platelet Derived Growth Factor ◽  
Human Thyroid

scholarly journals Knockdown of Latent Transforming Growth Factor-β (TGF-β)-Binding Protein 2 (LTBP2) Inhibits Invasion and Tumorigenesis in Thyroid Carcinoma Cells

2017 ◽  
Vol 25 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Fuqiang Wan ◽  
Li Peng ◽  
ChaoYu Zhu ◽  
XinFa Zhang ◽  
FangWen Chen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Thyroid Carcinoma ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Binding Protein ◽  
Transforming Growth Factor Β ◽  
Vital Role ◽  
Carcinoma Cells ◽  
Human Thyroid

Latent transforming growth factor-β (TGF-β)-binding protein 2 (LTBP2) is one of four proteins in the LTBP family of proteins (LTBP1‐4) and was shown to play a vital role in tumorigenesis. However, little is known regarding the functional role of LTBP2 in thyroid carcinoma. Therefore, the current study aimed to evaluate the effect of LTBP2 expression on the proliferation, invasion, and tumorigenesis in thyroid carcinoma cells and to explore the molecular mechanism of LTBP2 in tumor progression. Our results showed that the expression of LTBP2 is upregulated in human thyroid carcinoma and cell lines. Knockdown of LTBP2 inhibits the proliferation, invasion, and EMT phenotype in thyroid carcinoma cells. Furthermore, knockdown of LTBP2 attenuates thyroid carcinoma growth in nude mice. Finally, knockdown of LTBP2 inhibits activation of the PI3K/Akt pathway in thyroid carcinoma cells. In summary, the present study has provided further evidence that knockdown of LTBP2 inhibits invasion and tumorigenesis in thyroid carcinoma cells. Our findings may help to further elucidate the molecular mechanisms underlying thyroid carcinoma progression and provide candidate targets for the prevention and treatment of thyroid carcinoma.

Anticancer activity of all- trans retinoic acid-loaded liposomes on human thyroid carcinoma cells

2017 ◽  
Vol 150 ◽  
pp. 408-416 ◽  
Author(s):  
Maria Chiara Cristiano ◽  
Donato Cosco ◽  
Christian Celia ◽  
Andra Tudose ◽  
Rosario Mare ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Thyroid Carcinoma ◽  
Anticancer Activity ◽  
Carcinoma Cells ◽  
Human Thyroid ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid
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