The Relationship between Serum Vitamin D and Hemoglobin A1c Levels in Adolescents with Type 1 and Type 2 Diabetes

Background: Type-2 diabetes mellitus (T2DM) is a progressive and chronic disease characterized by both β-cell dysfunction and increased insulin resistance. Diabetes mellitus is now considered a giant killer disease of the 21st century with its vicious prongs in the South-East Asian countries, specially India, which is rightly said to be the ''Diabetes Capital'' of the world. Vitamin D has important effects on insulin action, and may impact on a number of pathways which may be of importance in the development of type 2 diabetes mellitus. Materials & Methods: In this study 62 Type-2 diabetic patients, 62 healthy controls were enrolled. Biochemical analytes measured were Serum glucose (Fasting Blood Sugar & Post Prandial Blood Sugar), Glycosylated Haemoglobin, Serum Vitamin-D. Results: The mean Serum Vitamin-D in Type-2 diabetic subjects were (16.3 ±3.0) while in healthy subjects(controls) the values were (39.3±5.2) respectively. These values were found to be statistically highly signicant(p<0.001). Conclusion: Serum Vitamin-D levels were decreased in Type 2 diabetic subjects as compared to the values in healthy subjects(controls).

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Association of serum Vitamin D level with Glycemic Status in Patients of Type 2 Diabetes Mellitus

Endocrinology & Metabolic Syndrome ◽

10.4172/2161-1017.1000268 ◽

2017 ◽

Vol 06 (03) ◽

Author(s):

Arindam Sur ◽

Gnana Priya

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Serum Vitamin ◽

Glycemic Status ◽

Serum Vitamin D

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Interactions between Serum Vitamin D Levels and Vitamin D Receptor Gene FokI Polymorphisms for Renal Function in Patients with Type 2 Diabetes

PLoS ONE ◽

10.1371/journal.pone.0051171 ◽

2012 ◽

Vol 7 (12) ◽

pp. e51171 ◽

Cited By ~ 12

Author(s):

Keitaro Yokoyama ◽

Akio Nakashima ◽

Mitsuyoshi Urashima ◽

Hiroaki Suga ◽

Takeshi Mimura ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Renal Function ◽

Vitamin D Receptor ◽

Receptor Gene ◽

Serum Vitamin ◽

Vitamin D Receptor Gene ◽

Serum Vitamin D ◽

Vitamin D Levels

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A Study for Evaluation of Serum Vitamin D Levels in Patients with type 2 Diabetes Mellitus with or without Complications

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v6i9.115 ◽

2018 ◽

Vol 6 (9) ◽

Author(s):

Dr Pankaj Kumar ◽

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels

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Assessment of vitamin D status and its association with insulin resistance among type 2 diabetic subjects

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20184877 ◽

2018 ◽

Vol 6 (12) ◽

pp. 3825

Author(s):

Jaitra Bhattacharya

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Type 2 Diabetic

Background: The 21st century has seen the rise of diabetes mellitus as one of the major metabolic issues as is vitamin D deficiency which has been found to be pandemic worldwide. The present study is an endeavor to study the status of serum vitamin D levels in relation to the glycemic and insulin resistance status in type 2 diabetes mellitus patients.Methods: The present is a cross-sectional study with a sample size of 100 type 2 diabetic subjects in the age group of 30-60 years. Serum vitamin D and Insulin levels were estimated using the ELISA technique. HbA1c levels were measured using immunoturbidimetric assays and plasma glucose levels were determined using glucose oxidase- peroxidase method.Results: The fasting plasma glucose, HbA1c and serum insulin levels were found to be significantly higher in those with vitamin D levels below the normal cut-off value of less than 30ng/ml (p value <0.01). Also, the insulin resistance calculated using HOMA-IR was found to be higher in those subjects having vitamin D deficiency or insufficiency.Conclusions: Hence, the study suggests that vitamin D deficiency contributes to further insulin resistance and poorer long-term diabetic control in type 2 diabetes mellitus subjects.

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COMBINATORIAL EFFECT OF LEPTIN, TUMOR NECROSIS FACTOR-ΑLPHA, AND VITAMIN D IN PROGRESSION OF TYPE 2 DIABETES IN KASHMIRI POPULATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i10.28097 ◽

2018 ◽

Vol 11 (10) ◽

pp. 477 ◽

Cited By ~ 1

Author(s):

Sabhiya Majid ◽

Fouzia Rashid ◽

Ishrat Hussain ◽

Rakesh K Koul ◽

Jasiya Qadir ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Tumor Necrosis ◽

Serum Vitamin ◽

Healthy Controls ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Tnf Α ◽

Necrosis Factor

Objectives: Type 2 diabetes mellitus (T2DM) is a metabolic disorder usually characterized by hyperglycemia. Adipose tissue secretes bioactive substances known as adipocytokines including leptin, tumor necrosis factor-alpha (TNF-α), and adiponectin. These are considered as a bridge connecting obesity and insulin resistance. There is considerable epidemiological evidence to suggest a role of Vitamin D deficiency in the etiology of T2DM. This study was performed to evaluate and compare serum Vitamin D and adipocytokine levels in T2DM patients and healthy controls of Jammu and Kashmir region of India.Methods: A total of 200 T2DM patients and normal 200 healthy controls were considered for the study. Enzyme-linked immunosorbent assay was used to measure serum leptin and TNF-α levels. The Vitamin D levels were measured by chemiluminescent microparticle immunoassay method. Biochemical parameters were measured by the enzymatic method.Results: Our results concluded that basic metabolic parameters, TNF-α and leptin levels were significantly higher in cases than controls. The serum Vitamin D levels were found significantly lower among T2DM patients. No correlation of Vitamin D with leptin was observed in cases and controls. However, a positive correlation between leptin and TNF-α was noted in T2DM subjects as well as in controls with statistical significance being higher in females (r=0.500; p=0.001) as compared to males (r=0.298; p=0.036) in T2DM subjects as well as in controls (r=0.659; p=0.001; r=0.621; p=001).Conclusion: These results concluded that lowering of Vitamin D levels and upregulation of leptin and TNF-α altogether play an important role in the development of T2DM, and from correlation analysis, it could be predicted that leptin and TNF-α act in a synergistic manner toward the development of T2DM.

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