scholarly journals Immunolocalization of Nuclear Transcription Factors, DAX-1 and COUP-TF II, in the Normal Human Ovary: Correlation with Adrenal 4 Binding Protein/ Steroidogenic Factor-1 Immunolocalization during the Menstrual Cycle

2003 ◽  
Vol 88 (7) ◽  
pp. 3415-3420 ◽  
Author(s):  
Yoko Sato ◽  
Takashi Suzuki ◽  
Kumiko Hidaka ◽  
Hiroshi Sato ◽  
Kiyoshi Ito ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Menstrual Cycle ◽  
Binding Protein ◽  
Human Ovary ◽  
Steroidogenic Factor 1 ◽  
Normal Human

Immunohistochemical localization of 17α-hydroxylase/C17–20 lyase and aromatase cytochrome P-450 in the human ovary during the menstrual cycle

1992 ◽  
Vol 135 (3) ◽  
pp. 589-NP ◽  
Author(s):  
T. Tamura ◽  
J. Kitawaki ◽  
T. Yamamoto ◽  
Y. Osawa ◽  
S. Kominami ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Corpus Luteum ◽  
Granulosa Cells ◽  
Polyclonal Antibodies ◽  
Immunohistochemical Localization ◽  
Corpora Lutea ◽  
Human Ovary ◽  
Normal Human ◽  
Theca Interna ◽  
Cytochrome P 450

ABSTRACT Immunohistochemical localization of 17α-hydroxylase/C17–20 lyase (P-45017α,lyase) and aromatase cytochrome P-450 (P-450arom) in normal human ovaries during the menstrual cycle was studied using specific polyclonal antibodies which were raised against corresponding enzymes. In the follicular phase of matured follicles, P-45017α,lyase was localized in theca interna cells and P-450arom in granulosa cells. P-45017α,lyase was expressed in theca interna cells before P-450arom was expressed in granulosa cells. The corpus luteum showed immunoreactivity to both enzymes and, after menstruation, immunoreactivity decreased gradually until it could not be detected in the corpus albicans. In corpus luteum graviditatis the immunoreactivity continued to be expressed strongly. In some atretic follicles, P-45017α,lyase and/or P-450arom continued to be expressed. In the stromal layer, P-45017α,lyase was detected in secondary interstitial cells, which originated from the theca interna of atretic follicles, and P-450arom was detected in hilar cells. Immunoreactivity to both enzymes was also detected in oocytes of developing follicles. These results are consistent with the two cell theory in the human ovary. They also suggest that androgens and oestrogens are produced not only by follicles and corpora lutea but also by stroma and oocytes. Journal of Endocrinology (1992) 135, 589–595

PATTERN OF STEROIDOGENESIS OF ANDROGENS IN THE NORMAL HUMAN OVARY SSOCIATED WITH RHYTHMIC PROCESSES OF THE MENSTRUAL CYCLE

1965 ◽  
Vol 20 (4) ◽  
pp. 628-631
Author(s):  
Gregory S. Duboff ◽  
Jan Behrman ◽  
Hasmukh Saraiya ◽  
James Catchick
Keyword(s):  
Menstrual Cycle ◽  
Human Ovary ◽  
Normal Human

Pattern of Steroidogenesis of Androgens in the Normal Human Ovary Associated with Rhythmic Processes of the Menstrual Cycle

1964 ◽  
Vol 15 (6) ◽  
pp. 661-674 ◽  
Author(s):  
Gregory S. Duboff ◽  
S. Jan Behrman ◽  
Hasmukh Saraiya ◽  
James Catchick
Keyword(s):  
Menstrual Cycle ◽  
Human Ovary ◽  
Normal Human

scholarly journals METHYL-CpG-BINDING PROTEIN 2 IS LOCALIZED IN THE POSTSYNAPTIC COMPARTMENT: AN IMMUNOCHEMICAL STUDY OF SUBCELLULAR FRACTIONS

2018 ◽  
Author(s):  
Mohammed H Jarrar
Keyword(s):  
Transcription Factors ◽  
Cognitive Impairment ◽  
Subcellular Localization ◽  
Neuronal Differentiation ◽  
Binding Protein ◽  
Limited Data ◽  
Coding Region ◽  
Immunochemical Study ◽  
Normal Human ◽  
Neuronal Distribution

Rett syndrome (RS) is a developmental neurologic disordercharacterized by severe cognitive impairment, autisticbehavior, stereotypic movements, and frequently also seizures(Naidu, 1997). The disorder is associated in a majorityof cases with mutations of the coding region of thegene for methyl-CpG-binding protein 2 (MeCP2) (Shahbazianand Zoghbi, 2001; Hoffbuhr et al., 2001). More recently,other neurologic syndromes different from RS havebeen reported as associated with MeCP2 mutations (Imessaoudeneet al., 2001; Watson et al., 2001; Dotti et al.,2002). Only limited data are available about the expressionof MeCP2 in the CNS. These immunochemical studiesdescribe a predominant neuronal compartmentalization(LaSalle et al., 2001; Shahbazian et al., 2002), and apattern of expression that parallels neuronal differentiation(Akbarian et al., 2001; Shahbazian et al., 2002). Despitethis information, and considering that MeCP2 has widetissue distribution (LaSalle et al., 2001; Shahbazian et al.,2002), it is still unclear why abnormal MeCP2 expression ismainly associated with neurologic dysfunction. Moreover,recent data show that several transcription factors, withexpression in the CNS and other organs, may have aunique neuronal distribution characterized by both nuclearand synaptic localizations (Paratcha et al., 2000; Eberwineet al., 2001). For these reasons, we examined MeCP2expression in normal human neocortex with special emphasison its subcellular localization.

Plasma Components which Interfere with Ristocetin-induced Platelet Aggregation

1975 ◽  
Vol 33 (03) ◽  
pp. 540-546 ◽  
Author(s):  
Robert F Baugh ◽  
James E Brown ◽  
Cecil Hougie
Keyword(s):  
Platelet Aggregation ◽  
Human Plasma ◽  
Plasma Proteins ◽  
Binding Protein ◽  
Plasma Heating ◽  
Protein S ◽  
Fold Increase ◽  
Normal Human Plasma ◽  
Preliminary Examination ◽  
Normal Human

SummaryNormal human plasma contains a component or components which interfere with ristocetin-induced platelet aggregation. Preliminary examination suggests a protein (or proteins) which binds ristocetin and competes more effectively for ristocetin than do the proteins involved in ristocetin-induced platelet aggregation. The presence of this protein in normal human plasma also prevents ristocetin-induced precipitation of plasma proteins at levels of ristocetin necessary to produce platelet aggregation (0.5–2.0 mg/ml). Serum contains an apparent two-fold increase of this component when compared with plasma. Heating serum at 56° for one hour results in an additional 2 to 4 fold increase. The presence of a ristocetin-binding protein in normal human plasma requires that this protein be saturated with ristocetin before ristocetin-induced platelet aggregation will occur. Variations in the ristocetin-binding protein(s) will cause apparent discrepancies in ristocetin-induced platelet aggregation in normal human plasmas.

scholarly journals The Impact of Anthocyanins and Iridoids on Transcription Factors Crucial for Lipid and Cholesterol Homeostasis

2021 ◽  
Vol 22 (11) ◽  
pp. 6074
Author(s):  
Maciej Danielewski ◽  
Agnieszka Matuszewska ◽  
Adam Szeląg ◽  
Tomasz Sozański
Keyword(s):  
Transcription Factors ◽  
Cholesterol Metabolism ◽  
Binding Protein ◽  
Regulatory Element ◽  
Cholesterol Homeostasis ◽  
Lipid Lowering ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cell Functions ◽  
The Impact

Nutrition determines our health, both directly and indirectly. Consumed foods affect the functioning of individual organs as well as entire systems, e.g., the cardiovascular system. There are many different diets, but universal guidelines for proper nutrition are provided in the WHO healthy eating pyramid. According to the latest version, plant products should form the basis of our diet. Many groups of plant compounds with a beneficial effect on human health have been described. Such groups include anthocyanins and iridoids, for which it has been proven that their consumption may lead to, inter alia, antioxidant, cholesterol and lipid-lowering, anti-obesity and anti-diabetic effects. Transcription factors directly affect a number of parameters of cell functions and cellular metabolism. In the context of lipid and cholesterol metabolism, five particularly important transcription factors can be distinguished: liver X receptor (LXR), peroxisome proliferator-activated receptor-α (PPAR-α), peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT/enhancer binding protein α (C/EBPα) and sterol regulatory element-binding protein 1c (SREBP-1c). Both anthocyanins and iridoids may alter the expression of these transcription factors. The aim of this review is to collect and systematize knowledge about the impact of anthocyanins and iridoids on transcription factors crucial for lipid and cholesterol homeostasis.

The novel antimicrobial peptide derived from insulin-like growth factor-binding protein 5 (AMP-IBP5) activates normal human keratinocytes

2016 ◽  
Vol 84 (1) ◽  
pp. e164
Author(s):  
Panjit Chieosilapatham ◽  
François Niyonsaba ◽  
Chanisa Kiatsurayanon ◽  
Ko Okumura ◽  
Shigaku Ikeda ◽  
...  
Keyword(s):  
Growth Factor ◽  
Antimicrobial Peptide ◽  
Binding Protein ◽  
Human Keratinocytes ◽  
Insulin Like Growth Factor ◽  
The Novel ◽  
Factor Binding ◽  
Normal Human Keratinocytes ◽  
Normal Human
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