scholarly journals High Molecular Weight, Rather than Total, Adiponectin Levels Better Reflect Metabolic Abnormalities Associated with Childhood Obesity

2006 ◽  
Vol 91 (12) ◽  
pp. 5113-5116 ◽  
Author(s):  
Shunsuke Araki ◽  
Kazushige Dobashi ◽  
Kazuyasu Kubo ◽  
Kohtaro Asayama ◽  
Akira Shirahata
Keyword(s):  
Metabolic Syndrome ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
University Hospital ◽  
Metabolic Abnormalities ◽  
Obese Children ◽  
High Molecular Weight Adiponectin ◽  
Visceral Fat Area ◽  
Metabolic Derangement ◽  
Total Adiponectin

Abstract Context: Japanese are prone to obesity-induced metabolic derangement, which is linked to serum adipocytokine profile even in children. Objective: The objective of the study was to determine whether high molecular-weight adiponectin (H-Adn) more specifically relates to metabolic derangement in obese children than total adiponectin (T-Adn). Design and Setting: A case (n = 59) control (n = 28) study was performed at the pediatric clinic of a university hospital. Patients: Japanese obese children (38 boys and 21 girls) were consecutively enrolled. The ages ranged from 5 to 15 (10.3 ± 0.3; mean ± sem) yr. Nonobese children (15 boys and 13 girls) were assigned as age-matched controls. Main Outcome Measures: Serum adiponectin multimeric complexes were assayed by an ELISA kit. The relationship of adiponectin to metabolic abnormalities was evaluated. Results: T-Adn (5.1 ± 0.2 vs. 8.8 ± 0.4 μg/ml), H-Adn (1.3 ± 0.1 vs. 4.8 ± 0.4 μg/ml), and medium molecular weight-Adn were significantly lower in obese than in control children. After adjustment for age and sex, both T- and H-Adn were inversely correlated with insulin and homeostasis model of assessment-insulin resistance, whereas H-Adn (but not T-Adn) inversely correlated with visceral fat area, as determined by computed tomography. Seven obese children were estimated to have metabolic syndrome and showed selective decrease in H-Adn and H/T-Adn. Conclusion: H-Adn reflects metabolic abnormalities due to obesity better than T-Adn in children. H-Adn is associated with the development of metabolic syndrome, even in childhood.

scholarly journals Linoleic Acid–Rich Oil Supplementation Increases Total and High-Molecular-Weight Adiponectin and Alters Plasma Oxylipins in Postmenopausal Women with Metabolic Syndrome

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Rachel M Cole ◽  
Sarah Puchala ◽  
Jia-Yu Ke ◽  
Mahmoud Abdel-Rasoul ◽  
Kristin Harlow ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Molecular Weight ◽  
Linoleic Acid ◽  
High Molecular Weight ◽  
Oil Consumption ◽  
Open Label ◽  
High Molecular Weight Adiponectin ◽  
Markers Of Inflammation ◽  
Hmw Adiponectin ◽  
Total Adiponectin

ABSTRACT Background The onset of menopause increases the risk of metabolic syndrome (MetS). Adiponectin is an adipokine associated with insulin sensitivity that is lower in people with MetS. Supplementing diets with linoleic acid (LA)-rich oil increased adiponectin concentrations and improved glucose control in women with type 2 diabetes. The effect of LA on adipokines, especially total and the bioactive form of adiponectin, high-molecular-weight (HMW) adiponectin, in women with MetS is unknown. Objectives The aim of this study was to explore the effect of supplementation of the diet with an oil rich in LA on adipokines in women with MetS. The effect of the LA-rich oil (LA-oil) on oxylipins, key metabolites that may influence inflammation and metabolism, was also explored. Methods In this open-label single-arm pilot study, 18 postmenopausal nondiabetic women with MetS enrolled in a 2-phase study were instructed to consume LA-rich vegetable oil (10 mL/d) as part of their habitual diets. Women consumed an oleic acid–rich oil (OA-oil) for 4 wk followed by an LA-oil for 16 wk. Fasting concentrations of adipokines, fatty acids, oxylipins, and markers of glycemia and inflammation were measured. Results After 4 wk of OA-oil consumption, fasting glucose and total adiponectin concentrations decreased whereas fasting C-reactive protein increased. After 16 wk of LA-oil supplementation total and HMW adiponectin and plasma oxylipins increased. Markers of inflammation and glycemia were unchanged after LA-oil consumption. Conclusions Supplementation with LA-oil increased total and HMW adiponectin concentrations and altered plasma oxylipin profiles. Larger studies are needed to elucidate the links between these changes and MetS. This trial was registered at clinicaltrials.gov as NCT02063165.

scholarly journals Interaction of high-molecular-weight adiponectin concentration in blood serum with the risk of metabolic syndrome in women

2021 ◽  
Vol 28 (1) ◽  
pp. 32-39
Author(s):  
O. D. Belyaeva ◽  
D. L. Brovin ◽  
O. A. Berkovich ◽  
T. L. Karonova ◽  
N. A. Korelskaya
Keyword(s):  
Metabolic Syndrome ◽  
Molecular Weight ◽  
Blood Serum ◽  
High Molecular Weight ◽  
Abdominal Obesity ◽  
High Molecular Weight Adiponectin ◽  
Total Adiponectin ◽  
Increased Risk ◽  
Significant Factors

Introduction. The development of metabolic syndrome (MS) in patients with abdominal obesity (AO) may be associated with a low level of the adiponectin (AN) - protective adipocytokine. AN circulates in the blood in various molecular forms.The high molecular weight AN is assumed to have greater metabolic activity. It is currently not clear what level of high molecular weight adiponectin (HMWA) in women with AO is associated with MS and its components.The objective was to study the role of high molecular weight adiponectin in the development of metabolic syndrome in women with abdominal obesity.Methods and materials. 302 women with AO and 161 women without AO were examined. MS was diagnosed in 62.3 % of patients.Results. The concentration of total adiponectin (TAN) and HMAN in the blood serum in women with MS was lower than in patients without MS (p<0.05). According to logistic regression analysis, the most significant factors influencing the risk of MS were low concentration of HMAN in the blood, age, and body mass index (p <0.05).Conclusions. It was found that women with AO and HMAN concentration of less than 1.96 μg/ml in the blood had an increased risk of metabolic syndrome.

A NovelADIPOQMutation (p.M40K) Results in Impaired High-Molecular-Weight Adiponectin and Associates with Obesity and Early-Onset Metabolic Syndrome

2011 ◽  
pp. OR38-4-OR38-4
Author(s):  
Ana Carolina Bueno ◽  
Margaret Castro ◽  
Jorge Elias Junior ◽  
Viviane Cunha Cardoso ◽  
Marco Antonio Barbieri ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Early Onset ◽  
High Molecular Weight Adiponectin

scholarly journals Reduced circulating oxytocin and High-Molecular-Weight adiponectin are risk factors for metabolic syndrome

2016 ◽  
Vol 63 (7) ◽  
pp. 655-662 ◽  
Author(s):  
Guoyue Yuan ◽  
Weiyun Qian ◽  
Ruirong Pan ◽  
Jue Jia ◽  
Dan Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
High Molecular Weight Adiponectin

Measurement of high-molecular-weight adiponectin is not useful in assessing coronary stenosis

2012 ◽  
Vol 50 (4) ◽  
Author(s):  
Takuya Imatoh ◽  
Motonobu Miyazaki ◽  
Ken Kadowaki ◽  
Shinichi Tanihara ◽  
Chinami Akashi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Coronary Stenosis ◽  
Active Form ◽  
Surrogate Marker ◽  
Area Under The Curve ◽  
High Molecular Weight Adiponectin ◽  
Cross Sectional ◽  
Hmw Adiponectin ◽  
Total Adiponectin

AbstractIn many studies, high-molecular-weight (HMW) adiponectin has been considered the active form of adiponectin. However, whether HMW adiponectin is a good surrogate marker for coronary artery disease still needs to be elucidated.We conducted a hospital-based cross-sectional study to examine the relationship between total, HMW or non-HMW adiponectin concentrations and coronary stenosis in 83 male patients and 138 male controls.Patients with coronary stenosis had significantly lower total adiponectin concentrations compared with controls. Non-HMW adiponectin concentrations in cases were significantly lower than the controls. However, there were no significant differences between cases and controls in HMW adiponectin concentrations. From the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for total and non-HMW adiponectin was significantly larger than that for HMW adiponectin concentrations. Of the three models, that for non-HMW adiponectin showed the largest AUC (total adiponectin 0.74, HMW adiponectin 0.54, and non-HMW adiponectin 0.79).Despite associations between total adiponectin levels and coronary stenosis, our data go against any apparent association between HMW adiponectin concentrations and coronary stenosis.

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