scholarly journals Tie-2 Is Overexpressed by Monocytes in Autoimmune Thyroid Disorders and Participates in Their Recruitment to the Thyroid Gland

2009 ◽  
Vol 94 (7) ◽  
pp. 2626-2633 ◽  
Author(s):  
Nicté Figueroa-Vega ◽  
Manuel Alfonso-Pérez ◽  
Carlos Cuesta-Mateos ◽  
Francisco Sánchez-Madrid ◽  
Ricardo Moreno-Otero ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid

scholarly journals Thyroid Disorders and COVID-19

Doctor Ru ◽  
2021 ◽  
Vol 20 (2) ◽  
pp. 6-10
Author(s):  
N.A. Petunina ◽  
◽  
Ya.A. Al Taravi ◽  
A.Yu. Surkova ◽  
N.S. Martirosyan ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Pulmonary Complications ◽  
Target Cells ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid ◽  
Direct Invasion ◽  
Global Pandemic ◽  
Novel Coronavirus ◽  
Available Information ◽  
The Impact

Objective of the Review: To present the available information on the SARS-CoV-2 impact on thyroid gland (TG), impact from a thyroid pathology over COVID-19 morbidity and course, and management of patients with various thyroid pathologies and the novel coronavirus infection. Key Points. SARS-CoV-2 virus demonstrates exponential spread all over the globe and has caused a global pandemic of COVID-19 infection. Currently, the mechanism of non-pulmonary complications of SARS-CoV-2 and endocrine involvement is yet not clear. The impact from SARS-CoV-2 on TG can be a result of direct invasion of target cells by the virus or activation of immunise and inflammatory response.Changes in the pituitary-hypothalamic thyroid system can be caused by developing euthyroid pathology syndrome, glucocorticosteroid therapy, destructive thyroiditis. Manifestation of autoimmune thyroid disorders associated with COVID-19 cannot be ruled out. Conclusion. Currently there is no information on direct thyroid invasion by SARS-CoV-2; however the available results from trials and clinical observations demonstrate possible impact from coronavirus infections, in particular from SARS-CoV and SARS-CoV-2, on the pituitaryhypothalamic-thyroid system with development of various pathologies or a number of changes in thyroid hormone levels. Taking into account possible associations between thyroid dysfunction and prolonged hospitalisation, risk of deaths in hospital, and the association between thyrotoxicosis and atrial fibrillation and hypercoagulation, it is advisable to screen patients with severe COVID-19. Keywords: SARS-CoV-2, COVID-19, thyroid gland, nonsuppurative granulematous thyroiditis.

scholarly journals Prevalence and risk factors of thyroid dysfunction in young age

2020 ◽  
Vol 210 ◽  
pp. 17022
Author(s):  
Yuliya Molokanova ◽  
Vladimir Saprykin ◽  
Irina Lyalina
Keyword(s):  
Risk Factors ◽  
Thyroid Gland ◽  
Young People ◽  
Laboratory Test ◽  
Thyroid Dysfunction ◽  
Structural Changes ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid ◽  
Laboratory Test Results ◽  
Study Participants

We examined people aged from 17 to 22 on the state of the thyroid gland. Analyzed results of the ultrasonography, laboratory test data, health assessment questionnaires and food records of the 300 study participants. Risk factors of thyroid dysfunction development for young people were analyzed. Signs of structural changes of the thyroid gland were detected amongst 57 % of study participants. The laboratory test results confirmed 44 % of the primary outcome received after palpation and ultrasonography. As a result 67 % of the examined volunteers from the in need of treatment group and 35 % intact volunteers were transferred into the group of dynamic follow-up thyroid gland monitoring. Discovered a less number of cases of the structural and/or functional thyroid disorders amongst people who have lived for 5 years in ecologically clean regions. All study participants had chronic alimentary iodine insufficiency which didn’t allow us to confirm the fundamental role of the iodine deficiency in the thyroid gland dysfunction development amongst young people. Laboratory confirmed diagnoses autoimmune thyroid disorders were found only amongst volunteers that consumed less than ¼ of the daily dose of iodine and lived in ecologically unsafe districts.

scholarly journals Prevalence of KIR2DL2/DS2 and KIR2DL3 and Presence of B19V in Patients with Thyroid Disorders

2021 ◽  
Vol 75 (1) ◽  
pp. 16-19
Author(s):  
Sabīne Grāvelsiņa ◽  
Elisabetta Caselli ◽  
Zaiga Nora-Krūkle ◽  
Simons Svirskis ◽  
Anda Vilmane ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Killer Cell ◽  
Thyroid Tissue ◽  
Control Group ◽  
Thyroid Disorders ◽  
Antigen Receptors ◽  
Tissue Samples ◽  
Variable Regions ◽  
Autoimmune Thyroid ◽  
Human Natural Killer Cells

AbstractThe functions of human natural killer cells are controlled by diverse families of antigen receptors. Prominent among these are the killer cell immunoglobulin-like receptors (KIR), controlled by a family of genes clustered in one of the most variable regions of the human genome — on chromosome 19q13.4. This study aimed to investigate the possible interplay between KIR allotype, B19 infection, and thyroid disorders. Thyroid gland tissue of 30 patients with autoimmune thyroid gland diseases (AITD), 30 patients with non-autoimmune thyroid gland diseases (non-AITD) and 30 deceased subjects whose histories did not show any of autoimmune or thyroid diseases (control group) were enrolled in the study. The presence of B19V, KIR2DL2/DS2, and KIR2DL3 was detected using PCRs (nPCR, PCR). The results showed that 28% of samples of thyroid tissue from patients with AITD and 67% with non-AITD were positive for the presence of B19V, in contrast only 5% control tissue samples harbored B19V DNA. B19V-positive AITD patients had higher frequency of KIR2DL2/DS2 homozygosity and lower frequency of homozygous KIR2DL3 genotype compared to B19V negative cases (33% vs 21% and 17% vs 46%, respectively). Although our data showed that B19V positive patients with AITD had a higher frequency of homozygosity for KIR2DL2/DS2, further studies with larger groups of patients are necessary to confirm the relationship between KIR, B19V and susceptibility to thyroid disease.

scholarly journals Thyroid autoimmunity in patients with malignant and benign breast diseases before surgery

2006 ◽  
Vol 154 (5) ◽  
pp. 645-649 ◽  
Author(s):  
E Giustarini ◽  
A Pinchera ◽  
P Fierabracci ◽  
M Roncella ◽  
L Fustaino ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Autoimmunity ◽  
Breast Disease ◽  
Stressful Events ◽  
Thyroid Disorders ◽  
Serum Free ◽  
Autoimmune Thyroid ◽  
Autoimmune Hypothyroidism ◽  
Ultrasound Evaluation ◽  
High Prevalence

Background: Previous studies have demonstrated a high prevalence of thyroperoxidase antibodies (TPOAb) and autoimmune hypothyroidism in breast cancer (BC). These studies have been performed in BC patients generally 20–30 days after mastectomy. It is known that stress may have an influence on the immune system and a relation between stressful events and the onset or worsening of autoimmune thyroid disorders has been reported by several authors. The aim of the study was to evaluate the prevalence of autoimmune thyroid disease in patients with nodular breast disease selected for surgery before any treatment. Our hypothesis was that the high prevalence of thyroid autoimmune disorders in BC is independent of stressful events represented by surgery and/or anaesthetic procedures. Methods: Our series included 61 consecutive women aged 52.8 ± 10.2 yrs (mean age ± s.d.) with nodular breast disease selected for breast surgery: 36 out of 61 of them (59%) had BC and 25 out of 61 had benign breast disease (BBD). Controls included 100 healthy age-matched women. All patients and control subjects were submitted to clinical, ultrasound thyroid evaluation and serum-free thyroxine (FT4), serum-free tri-iodothyronine (FT3), TSH, TPOAb and thyroglobulin antibodies (TgAb) determination. Results: Mean FT3, FT4 and TSH concentration showed no differences between BC patients, BBD patients and controls. The prevalence of TPOAb in BC patients (12/36: 33.33%) was significantly higher than in BBD patients (5/25: 20%) (P < 0.01) and in controls (8/100: 8%) (P < 0.01). Similarly, the prevalence of TgAb in BC patients was 12 out of 36 (33.33%) significantly higher than that detected in BBD patients (4/25: 16%) (P < 0.01) and in controls (12/100: 12%) (P < 0.01). Of the 36 BC patients, 20 showed a diffuse hypoechogenicity of the thyroid gland to ultrasound evaluation, significantly higher than in BBD (7/25: 28%) (P = 0.03). Of the 20 BC patients who showed a hypoechogenic pattern of thyroid gland, 10 (50%) were associated with antithyroid antibodies positivity (TAb). This finding was present in two of seven BBD (28.57%) (P < 0.0001). Only two controls showed focal hypoechogenicity of the thyroid gland. Generally, 24 out of 36 (66.7%) of BC and 9 out of 25 (36%) of BBD (P = 0.02) had signs of thyroid autoimmunity consistent with the hypoechogenic pattern of thyroid gland associated or not with TAb; 2 out of 36 (5.55%) of BC and 1 out of 25 (4%) of BBD patients had autoimmune hypothyroidism and no hypothyroidism was found in controls. Conclusions: The results of this study confirm the strong relation between thyroid autoimmunity and BC. This finding is independent of stressful events represented by surgery or anaesthetic procedures. The present data call attention to the usefulness of screening for autoimmune thyroid disorders in patients with nodular breast disease selected for surgery.

Ultrasonography of the thyroid gland in pregnancies complicated by autoimmune thyroid disease

1993 ◽  
Vol 21 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Peter Zimmermann ◽  
Teuvo Takala ◽  
Lauri Pöyhönen ◽  
Reijo Punnonen
Keyword(s):  
Thyroid Gland ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

scholarly journals Drug utilization in treatment of thyroid disorders during pregnancy in Serbia

2016 ◽  
Vol 69 (1-2) ◽  
pp. 11-15
Author(s):  
Olga Horvat ◽  
Zdenko Tomic ◽  
Vesna Mijatovic ◽  
Ana Sabo
Keyword(s):  
Pregnant Woman ◽  
Thyroid Gland ◽  
Drug Utilization ◽  
Thyroid Dysfunction ◽  
Hashimoto Thyroiditis ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
Study Results ◽  
Novi Sad

Introduction. Depleted uranium radiation and pollution with polychlorinated biphenyls resulting from bombings the territories of Serbia as well as the additional long-term stress may have affected the function of thyroid gland. The objective of this study was to determine the trend of drug utilization in the treatment of thyroid dysfunction during pregnancy in Novi Sad. Material and Methods. Women who had given birth at the Department of Gynecology in 1989, 1999, 2007 and 2011 were interviewed during a one-month period about thyroid diseases in the pregnancy as well as the drugs they had taken. Results. Not a single pregnant woman was reported to have a thyroid disorder in 1989 and 1999, while in 2007 four women were reported to have a thyroid dysfunction. In 2011, fourteen out of 18 women with thyroid dysfunction were using levothyroxine and in most cases hypothyroidism was diagnosed as autoimmune Hashimoto thyroiditis. Conclusion. The study results suggest the necessity of performing more detailed analyses of the correlation between the frequency of the thyroid gland dysfunction and the effects of environmental pollution in Serbia.

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