Antibodies in the Serum of Patients with Autoimmune Thyroid Disorders React with a Recombinant 98 Amino Acid Fragment of a Full Length 64 KDA Eye Muscle Membrane Protein which is also Expressed in the Thyroid

Autoimmunity ◽  
1992 ◽  
Vol 13 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Z-G. Zhang ◽  
Q. Dong ◽  
P. Rodien ◽  
L. Alcalde ◽  
N. Bernard ◽  
...  
Keyword(s):  
Amino Acid ◽  
Membrane Protein ◽  
Full Length ◽  
Muscle Membrane ◽  
Thyroid Disorders ◽  
Eye Muscle ◽  
Autoimmune Thyroid ◽  
Amino Acid Fragment ◽  
Acid Fragment

scholarly journals Two Overlapping Domains of a Lyssavirus Matrix Protein That Acts on Different Cell Death Pathways

2010 ◽  
Vol 84 (19) ◽  
pp. 9897-9906 ◽  
Author(s):  
Florence Larrous ◽  
Alireza Gholami ◽  
Shahul Mouhamad ◽  
Jérôme Estaquier ◽  
Hervé Bourhy
Keyword(s):  
Cell Death ◽  
Amino Acid ◽  
Matrix Protein ◽  
Full Length ◽  
M Protein ◽  
Genotype 3 ◽  
Cell Death Pathways ◽  
Acid Fragment ◽  
M Proteins ◽  
Cellular Apoptosis

ABSTRACT The lyssavirus matrix (M) protein induces apoptosis. The regions of the M protein that are essential for triggering cell death pathways are not yet clearly defined. We therefore compared the M proteins from two viruses that have contrasting characteristics in terms of cellular apoptosis: a genotype 3 lyssavirus, Mokola virus (MOK), and a genotype 1 rabies virus isolated from a dog from Thailand (THA). We identified a 20-amino-acid fragment (corresponding to positions 67 to 86) that retained the cell death activities of the full-length M protein from MOK via both the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and inhibition of cytochrome c oxidase (CcO) activity. We found that the amino acids at positions 77 and 81 have an essential role in triggering these two cell death pathways. Directed mutagenesis demonstrated that the amino acid at position 77 affects CcO activity, whereas the amino acid at position 81 affects TRAIL-dependent apoptosis. Mutations in the full-length M protein that compromised induction of either of these two pathways resulted in delayed apoptosis compared with the time to apoptosis for the nonmutated control.

OC9 ALPHASTATIN, A 24-AMINO ACID FRAGMENT OF FIBRINOGEN IS A NOVEL ANTI-ANGIOGENIC AND ANTI-VASCULAR AGENT

2004 ◽  
Vol 11 (6) ◽  
pp. 531-532
Author(s):  
C. A. Staton ◽  
N. J. Brown ◽  
G. Rodgers ◽  
K. P. Corke ◽  
S. Tazzyman ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Fragment ◽  
Acid Fragment

scholarly journals A 35 amino acid fragment of leptin inhibits feeding in the rat.

Endocrinology ◽  
1996 ◽  
Vol 137 (11) ◽  
pp. 5182-5185 ◽  
Author(s):  
W K Samson ◽  
T C Murphy ◽  
D Robison ◽  
T Vargas ◽  
E Tau ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Fragment ◽  
Acid Fragment

Chiral β3-isocyanopropionates for multicomponent synthesis of peptides and depsipeptides containing a β-amino acid fragment

2018 ◽  
Vol 16 (33) ◽  
pp. 5987-5998 ◽  
Author(s):  
Danil P. Zarezin ◽  
Olga I. Shmatova ◽  
Valentine G. Nenajdenko
Keyword(s):  
Amino Acid ◽  
Multicomponent Reactions ◽  
Short Peptides ◽  
Multicomponent Synthesis ◽  
Acid Moiety ◽  
Amino Acid Fragment ◽  
Acid Fragment ◽  
Amino Acid Moiety ◽  
New Type

Chiral β3-isocyanopropionic acids derivatives is a new type of isocyanides for multicomponent reactions. The use of these isocyanides in Ugi and Passerini reactions allows to prepare short peptides and depsipeptides with β-amino acid moiety in the structure.

scholarly journals Antimicrobial activity of pleurocidin is retained in Plc-2, a C-terminal 12-amino acid fragment

Peptides ◽  
2013 ◽  
Vol 45 ◽  
pp. 78-84 ◽  
Author(s):  
Andre L.A. Souza ◽  
Paola Díaz-Dellavalle ◽  
Andrea Cabrera ◽  
Patricia Larrañaga ◽  
Marco Dalla-Rizza ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Amino Acid Fragment ◽  
Acid Fragment
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