scholarly journals Sclerostin Is Positively Associated With Bone Mineral Density in Men and Women and Negatively Associated With Carotid Calcified Atherosclerotic Plaque in Men From the African American-Diabetes Heart Study

2014 ◽  
Vol 99 (1) ◽  
pp. 315-321 ◽  
Author(s):  
Thomas C. Register ◽  
Keith A. Hruska ◽  
Jasmin Divers ◽  
Donald W. Bowden ◽  
Nicholette D. Palmer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
African American ◽  
Bone Mineral ◽  
Atherosclerotic Plaque ◽  
Mineral Density ◽  
Men And Women ◽  
Negatively Associated ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals Genome-wide association study of vitamin D concentrations and bone mineral density in the African American-Diabetes Heart Study

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251423
Author(s):  
Nicholette D. Palmer ◽  
Lingyi Lu ◽  
Thomas C. Register ◽  
Leon Lenchik ◽  
J. Jeffrey Carr ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
African American ◽  
African Americans ◽  
Bone Mineral ◽  
Vitamin D Binding Protein ◽  
Mineral Density ◽  
Vitamin D Metabolism ◽  
Heart Study ◽  
Diabetes Heart Study

Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher 1,25-dihydroxyvitamin D (1,25(OH)2D3) concentrations and bone mineral density (BMD), and paradoxically reduced burdens of calcified atherosclerotic plaque (subclinical atherosclerosis). To identify genetic factors contributing to vitamin D and BMD measures, association analysis of >14M variants was conducted in a maximum of 697 African American-Diabetes Heart Study participants with type 2 diabetes (T2D). The most significant association signals were detected for VDBP on chromosome 4; variants rs7041 (β = 0.44, SE = 0.019, P = 9.4x10-86) and rs4588 (β = 0.17, SE = 0.021, P = 3.5x10-08) in the group-specific component (vitamin D binding protein) gene (GC). These variants were found to be independently associated. In addition, rs7041 was also associated with bioavailable vitamin D (BAVD; β = 0.16, SE = 0.02, P = 3.3x10-19). Six rare variants were significantly associated with 25OHD, including a non-synonymous variant in HSPG2 (rs116788687; β = -1.07, SE = 0.17, P = 2.2x10-10) and an intronic variant in TNIK (rs143555701; β = -1.01, SE = 0.18, P = 9.0x10-10), both biologically related to bone development. Variants associated with 25OHD failed to replicate in African Americans from the Insulin Resistance Atherosclerosis Family Study (IRASFS). Evaluation of vitamin D metabolism and bone mineral density phenotypes in an African American population enriched for T2D could provide insight into ethnic specific differences in vitamin D metabolism and bone mineral density.

scholarly journals Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: The diabetes heart study

Bone ◽  
2008 ◽  
Vol 42 (1) ◽  
pp. 43-52 ◽  
Author(s):  
J. Jeffrey Carr ◽  
Thomas C. Register ◽  
Fang-Chi Hsu ◽  
Kurt Lohman ◽  
Leon Lenchik ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Mineral ◽  
Atherosclerotic Plaque ◽  
Mineral Density ◽  
Heart Study ◽  
Diabetes Heart Study

Muscle mass and fat mass in relation to bone mineral density in very old men and women: the Framingham Heart Study

1998 ◽  
Vol 49 (5-6) ◽  
pp. 745-747 ◽  
Author(s):  
M. Visser ◽  
D.P. Kiel ◽  
J. Langlois ◽  
M.T. Hannan ◽  
D.T. Felson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Muscle Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Framingham Heart Study ◽  
Mineral Density ◽  
Men And Women ◽  
Very Old ◽  
Heart Study ◽  
Old Men

Heritability of Spinal Trabecular Volumetric Bone Mineral Density Measured by QCT in the Diabetes Heart Study

2004 ◽  
Vol 75 (4) ◽  
pp. 305-312 ◽  
Author(s):  
L. Lenchik ◽  
F.-C. Hsu ◽  
T. C. Register ◽  
K. K. Lohman ◽  
B. I. Freedman ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Heart Study ◽  
Diabetes Heart Study

scholarly journals Bone Mineral Density of the Radius Predicts All-Cause Mortality in Patients With Type 2 Diabetes: Diabetes Heart Study

2018 ◽  
Vol 21 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Leon Lenchik ◽  
Thomas C. Register ◽  
Fang-Chi Hsu ◽  
Jianzhao Xu ◽  
S. Carrie Smith ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Mineral ◽  
Mineral Density ◽  
Heart Study ◽  
All Cause Mortality ◽  
Diabetes Heart Study

scholarly journals The Association of Lumbar Disc Herniation with Lumbar Volumetric Bone Mineral Density in a Cross-Sectional Chinese Study

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 938
Author(s):  
Jian Geng ◽  
Ling Wang ◽  
Qing Li ◽  
Pengju Huang ◽  
Yandong Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Magnetic Resonance Images ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Men And Women ◽  
The Relationship

Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

scholarly journals Blood lead and cadmium levels are negatively associated with bone mineral density in young female adults

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Jianfeng Lu ◽  
Ji Lan ◽  
Xiao’e Li ◽  
Zhongxin Zhu
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mineral ◽  
Subgroup Analysis ◽  
Blood Lead ◽  
Negative Association ◽  
Skewed Distribution ◽  
Mineral Density ◽  
Negatively Associated ◽  
Lead And Cadmium

Abstract Background The organ toxicities of lead and cadmium have been extensively studied; however, studies of their toxic effects on bone remain limited, especially in young adults. The objective of this study was to examine the associations of blood lead levels (BLL) and blood cadmium levels (BCL) with bone mineral density (BMD) among young adults. Methods We performed a cross-sectional study using the National Health and Nutrition Examination Survey 2011–2018 database. Because of the skewed distribution, BLL and BCL were Ln-transformed for analysis. Weighted multivariate regressions were performed to evaluate the associations between LnBLL and LnBCL and lumbar BMD. Subgroup analyses were further performed. Results A total of 3234 participants aged 20–35 years were included in this study. No significant association between LnBLL and lumbar BMD was found (β = − 5.6, 95%CI: − 13.5–2.3). However, in the subgroup analysis stratified by sex, this association became negative in women (β = − 18.2, 95%CI: − 29.9– − 6.4). Moreover, this negative association was more prominent in female blacks (β = − 35.5, 95%CI: − 63.4– − 7.6). On the other hand, a negative association between LnBCL and lumbar BMD was found (β = − 7.4, 95%CI: − 14.0– − 0.8). In the subgroup analysis stratified by sex, this negative association only existed in women (β = − 18.7, 95%CI: − 28.0– − 9.5). Moreover, this negative association was more prominent in female whites (β = − 31.1, 95%CI: − 46.2– − 16.1). Conclusions Our finding showed that both BLL and BCL were independently and negatively associated with lumbar BMD among young females, but not among young males.

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