Blood lead and cadmium levels are negatively associated with bone mineral density in young female adults

Abstract Background The organ toxicities of lead and cadmium have been extensively studied; however, studies of their toxic effects on bone remain limited, especially in young adults. The objective of this study was to examine the associations of blood lead levels (BLL) and blood cadmium levels (BCL) with bone mineral density (BMD) among young adults. Methods We performed a cross-sectional study using the National Health and Nutrition Examination Survey 2011–2018 database. Because of the skewed distribution, BLL and BCL were Ln-transformed for analysis. Weighted multivariate regressions were performed to evaluate the associations between LnBLL and LnBCL and lumbar BMD. Subgroup analyses were further performed. Results A total of 3234 participants aged 20–35 years were included in this study. No significant association between LnBLL and lumbar BMD was found (β = − 5.6, 95%CI: − 13.5–2.3). However, in the subgroup analysis stratified by sex, this association became negative in women (β = − 18.2, 95%CI: − 29.9– − 6.4). Moreover, this negative association was more prominent in female blacks (β = − 35.5, 95%CI: − 63.4– − 7.6). On the other hand, a negative association between LnBCL and lumbar BMD was found (β = − 7.4, 95%CI: − 14.0– − 0.8). In the subgroup analysis stratified by sex, this negative association only existed in women (β = − 18.7, 95%CI: − 28.0– − 9.5). Moreover, this negative association was more prominent in female whites (β = − 31.1, 95%CI: − 46.2– − 16.1). Conclusions Our finding showed that both BLL and BCL were independently and negatively associated with lumbar BMD among young females, but not among young males.

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The Oslo Health Study: A Dietary Index Estimating Frequent Intake of Soft Drinks and Rare Intake of Fruit and Vegetables Is Negatively Associated with Bone Mineral Density

Journal of Osteoporosis ◽

10.4061/2011/102686 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Arne Torbjørn Høstmark ◽

Anne Johanne Søgaard ◽

Kari Alvær ◽

Haakon E. Meyer

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Fruits And Vegetables ◽

Soft Drinks ◽

Negative Association ◽

Health Study ◽

Distal Forearm ◽

Mineral Density ◽

Negatively Associated ◽

Dietary Index

Background. Since nutritional factors may affect bone mineral density (BMD), we have investigated whether BMD is associated with an index estimating the intake of soft drinks, fruits, and vegetables.Methods. BMD was measured in distal forearm in a subsample of the population-based Oslo Health Study. 2126 subjects had both valid BMD measurements and answered all the questions required for calculating aDietary Index= the sum of intake estimates of colas and non-cola beverages divided by the sum of intake estimates of fruits and vegetables. We did linear regression analyses to study whether the Dietary Index and the single food items included in the index were associated with BMD.Results. There was a consistent negative association between the Dietary Index and forearm BMD. Among the single index components, colas and non-cola soft drinks were negatively associated with BMD. The negative association between the Dietary Index and BMD prevailed after adjusting for gender, age, and body mass index, length of education, smoking, alcohol intake, and physical activity.Conclusion. An index reflecting frequent intake of soft drinks and rare intake of fruit and vegetables was inversely related to distal forearm bone mineral density.

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Starting age of oestrogen‐progestin therapy is negatively associated with bone mineral density in young adults with Turner syndrome independent of age and body mass index

Clinical Endocrinology ◽

10.1111/cen.14484 ◽

2021 ◽

Author(s):

Satsuki Nishigaki ◽

Tomoyo Itonaga ◽

Yukihiro Hasegawa ◽

Masanobu Kawai

Keyword(s):

Bone Mineral Density ◽

Body Mass Index ◽

Young Adults ◽

Turner Syndrome ◽

Body Mass ◽

Bone Mineral ◽

Mineral Density ◽

Negatively Associated ◽

Progestin Therapy

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Author response for "Bone Mineral Density in Antiretroviral Therapy‐Naïve HIV‐1‐Infected Young Adults using Depot Medroxyprogesterone Acetate or Non‐Hormonal Contraceptives in Uganda"

10.1002/jbm4.10446/v2/response1 ◽

2020 ◽

Author(s):

Flavia Kiweewa Matovu ◽

Martin Nabwana ◽

Noah Kiwanuka ◽

Delia Scholes ◽

Esther Isingel ◽

...

Keyword(s):

Bone Mineral Density ◽

Young Adults ◽

Bone Mineral ◽

Medroxyprogesterone Acetate ◽

Author Response ◽

Mineral Density ◽

Depot Medroxyprogesterone Acetate ◽

Hiv 1

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The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18063321 ◽

2021 ◽

Vol 18 (6) ◽

pp. 3321

Author(s):

Hsin-Hua Chou ◽

Sao-Lun Lu ◽

Sen-Te Wang ◽

Ting-Hsuan Huang ◽

Sam Li-Sheng Chen

Keyword(s):

Bone Mineral Density ◽

Young Adults ◽

Bone Mass ◽

Periodontal Disease ◽

Bone Mineral ◽

Intervention Program ◽

Past History ◽

Low Bone Mass ◽

Mineral Density ◽

Periodontal Index

The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density (BMD) were collected for the diagnostic criteria of osteopenia and osteoporosis. The Community Periodontal Index (CPI) was measured for defining PD. A multiple logistic regression model was used to assess the effect of low bone mass on the risk of PD. Of 7298 enrollees, 31% had periodontal pockets >3 mm, 36.2% had osteopenia, and 2.1% had osteoporosis. The 39.8% of PD prevalence was high in adults with osteoporosis, followed by 33.3% in osteopenia. A negative association was found between BMD and CPI value (p < 0.0001). Low bone mass was associated with the risk of PD (adjusted OR: 1.13; 95% CI:1.02–1.26) after adjusting the confounding factors, including age, gender, education level, overweight, smoking status, past history of osteoporosis, and diabetes mellitus. An association between BMD and PD among young adults was found. An intervention program for the prevention of PD and osteoporosis could be considered starting in young adults.

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