Transforming growth factor-beta inhibits progesterone-induced enkephalinase expression in human endometrial stromal cells

1996 ◽  
Vol 81 (11) ◽  
pp. 4022-4027 ◽  
Author(s):  
M. L. Casey
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Stromal Cells ◽  
Transforming Growth Factor ◽  
Endometrial Stromal Cells ◽  
Growth Factor Beta

Role of Transforming Growth Factor Beta in Human Cancer

2005 ◽  
Vol 23 (9) ◽  
pp. 2078-2093 ◽  
Author(s):  
Rebecca L. Elliott ◽  
Gerard C. Blobe
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Stromal Cells ◽  
Transforming Growth Factor ◽  
Human Cancer ◽  
Inhibition Of Proliferation ◽  
Human Cancers ◽  
Growth Factor Beta

Transforming growth factor beta (TGF-β) is a ubiquitous and essential regulator of cellular and physiologic processes including proliferation, differentiation, migration, cell survival, angiogenesis, and immunosurveillance. Alterations in the TGF-β signaling pathway, including mutation or deletion of members of the signaling pathway and resistance to TGF-β-mediated inhibition of proliferation are frequently observed in human cancers. Although these alterations define a tumor suppressor role for the TGF-β pathway in human cancer, TGF-β also mediates tumor-promoting effects, either through differential effects on tumor and stromal cells or through a fundamental alteration in the TGF-β responsiveness of the tumor cells themselves. TGF-β and members of the TGF-β signaling pathway are being evaluated as prognostic or predictive markers for cancer patients. Ongoing advances in understanding the TGF-β signaling pathway will enable targeting of this pathway for the chemoprevention and treatment of human cancers.

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