Natriuretic peptides in the human testis: evidence for a potential role of C-type natriuretic peptide in Leydig cells

1996 ◽  
Vol 81 (12) ◽  
pp. 4324-4328 ◽  
Author(s):  
R. Middendorff
Keyword(s):  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Leydig Cells ◽  
Potential Role ◽  
Human Testis

scholarly journals Brain natriuretic peptide: Diagnostic potential in dogs

2009 ◽  
Vol 63 (5-6) ◽  
pp. 381-392
Author(s):  
Ljubica Spasojevic-Kosic
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Arterial Disease ◽  
Cardiac Insufficiency ◽  
Everyday Clinical Practice ◽  
Coronary Arterial Disease ◽  
Diagnostic Potential ◽  
Adequate Method

The endocrine role of the heart is evident in the secretion of noradrenaline and natriuretic peptides. The secretion of natriuretic peptides presents a useful mechanism for different conditions of cardiac dysfunction. Brain natriuretic peptide (BNP) has been accepted in human cardiology as a biomarker for cardiac insufficiency and coronary arterial disease. The specificity of the BNP structure is specie-specific, so that the testing of diagnostic and prognostic potential in dogs requires the existence of a test that is a homologue for that animal specie. The existence of an adequate method for measuring BNP concentration makes possible its implementation as a screening test in everyday clinical practice. .

scholarly journals Expression pattern and potential role of Nanos3 in regulating testosterone biosynthesis in Leydig cells of sheep

2020 ◽  
Vol 154 ◽  
pp. 31-42
Author(s):  
Jie Zhao ◽  
Hua Yang ◽  
Mingtian Deng ◽  
Jianyu Ma ◽  
Zhibo Wang ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Leydig Cells ◽  
Potential Role ◽  
Testosterone Biosynthesis

Natriuretic peptides in hormonal regulation of hypoxia responses

2009 ◽  
Vol 296 (2) ◽  
pp. R257-R264 ◽  
Author(s):  
Olli Arjamaa ◽  
Mikko Nikinmaa
Keyword(s):  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Hormonal Regulation ◽  
Aquatic Organisms ◽  
Future Studies ◽  
Hypoxic Conditions ◽  
Clinical Observations ◽  
Terrestrial Environments ◽  
The Relationship

The possibility that natriuretic peptides' effects are important in hypoxia responses of vertebrates is reviewed. Both the transcription and release of natriuretic peptides are affected by oxygen tension. Furthermore, many of the effects observed in hypoxia, such as diuresis and a reduction of plasma volume, are also caused by treatment of the animal with natriuretic peptides. Also, several clinical observations about changes in natriuretic peptide levels in, e.g., sleep apnea and cyanotic congenital heart disease, are consistent with the idea that hypoxia is involved in the etiology of conditions, in which natriuretic peptide levels increase. Virtually all published information on the relationship between oxygen and natriuretic peptides is based on human studies. Because hypoxic conditions are more common in aquatic than terrestrial environments, future studies about the possible role of natriuretic peptides in hypoxia, as well as the role of hypoxia in the evolution of natriuretic peptides, including the different subtypes, should increasingly involve also aquatic organisms.

scholarly journals The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Alberto Palazzuoli ◽  
Matteo Beltrami ◽  
Gaetano Ruocco ◽  
Marco Pellegrini ◽  
Ranuccio Nuti
Keyword(s):  
Natriuretic Peptides ◽  
Potential Role ◽  
Low Cost ◽  
Pressure Overload ◽  
High Specificity ◽  
Left Ventricular ◽  
Cardiac Insufficiency ◽  
Cardiac Condition ◽  
Measurement Biases

Natriuretic peptides (NPs) are entered in current guidelines for heart failure (HF) diagnosis and management because of their high specificity and sensibility in screening patients with acute dyspnea. Due to their availability and relatively low cost, they became the first step examinations in HF patients evaluation at hospital admission together with clinical and chest radiography examination. NPs are released following any cardiac haemodynamic stress due to volume or pressure overload and should be considered as a mirror of cardiac condition helping in recognizing patients with poor outcome. Moreover, the exact role of NPs in early HF stages, in isolated diastolic dysfunction, and in general population is questioned. Several promising reports described their potential role; however, the wide cut-off definition, inclusion criteria, and intrinsic measurement biases do not actually consent to their clinical application in these settings. A multimodality strategy including both NPs and imaging studies appears to be the best strategy to define the cardiac dysfunction etiology and its severity as well as to identify patients with higher risk. In this review, we describe the current and potential role of NPs in patients with asymptomatic cardiac insufficiency, evaluating the requirement to obtain a better standardization for imaging as for laboratory criteria.

scholarly journals Physiology and clinical importance of the natriuretic peptide system

2011 ◽  
Vol 152 (26) ◽  
pp. 1025-1034
Author(s):  
Gábor Szabó ◽  
János Rigó jr. ◽  
Bálint Nagy
Keyword(s):  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Physiological Role ◽  
Clinical Importance ◽  
The Body ◽  
Diagnosis And Prognosis ◽  
Peptide Family ◽  
Peptide System ◽  
Pressure Changes

In the last three decades many members of the natriuretic peptide family was isolated. The function and physiological role of these peptides are pleiotropic. All natriuretic peptides are synthesized from polypeptide precursors. Together with the sympathetic nervous system and other hormones they play key roles, like an endogenous system in the regulation of the body fluid homeostasis and blood pressure. Changes in this balance lead to dysfunction in the endothel and left ventricle, which can cause severe complications. In many cardiovascular diseases natriuretic peptides serve not only as marker for diagnosis and prognosis but they have therapeutic importance. In the last years the potential use of the elevated BNP levels for diagnosis of pre-eclampsia was examined. In our review we discuss the current understanding of molecular biology, biochemistry and clinical relevance of natriuretic peptides. Orv. Hetil., 2011, 152, 1025–1034.

Prevention of acute kidney injury

2018 ◽  
Author(s):  
Norbert Lameire
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Growth Factor ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Potential Role ◽  
Kidney Injury ◽  
Pharmacological Interventions ◽  
Selection Of

This chapter summarizes the pharmacological interventions that can be used in the prevention of acute kidney injury (AKI). These following interventions are discussed: the use and selection of vasopressors; the administration of loop diuretics and mannitol; vasodilating drugs including dopamine, atrial natriuretic peptide, nesiritide, fenoldopam, and adenosine antagonists. The role of N-acetylcysteine in the prevention of contrast-induced AKI and cardiac surgery is discussed. The chapter concludes with a summary of the potential role of insulin-like growth factor and erythropoietin in the prevention of AKI.

scholarly journals Expression of mRNA for the LH and FSH receptors in mouse oocytes and preimplantation embryos

Reproduction ◽  
2001 ◽  
pp. 455-461 ◽  
Author(s):  
E Patsoula ◽  
D Loutradis ◽  
P Drakakis ◽  
K Kallianidis ◽  
R Bletsa ◽  
...  
Keyword(s):  
Leydig Cells ◽  
Potential Role ◽  
Endocrine Function ◽  
Preimplantation Embryos ◽  
Rt Pcr ◽  
Mouse Development ◽  
Lh Receptor ◽  
Mouse Oocytes ◽  
Early Mouse

The gonadotrophins LH and FSH are known to regulate gonadal growth, and differentiation, endocrine function and gametogenesis. The LH receptor is expressed in ovarian theca, granulosa and luteal cells, and in testicular Leydig cells. The FSH receptor is expressed only in ovarian granulosa cells and in testicular Sertoli cells. The expression of the FSH and LH receptors was analysed by RT-PCR to study the role of these receptors in early mouse development. After reverse transcription, strategically designed nested primers were used for amplification from cDNA. Transcripts for the receptors were present in mouse oocytes and preimplantation embryos. The presence of mRNA for FSH and LH receptors in oocytes, zygotes and preimplantation embryos indicates a potential role for the gonadotrophins in the modulation of meiotic resumption and completion of oocyte maturation, as well as a beneficial effect on early embryonic development in mice.

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