Natriuretic peptides in hormonal regulation of hypoxia responses

2009 ◽  
Vol 296 (2) ◽  
pp. R257-R264 ◽  
Author(s):  
Olli Arjamaa ◽  
Mikko Nikinmaa
Keyword(s):  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Hormonal Regulation ◽  
Aquatic Organisms ◽  
Future Studies ◽  
Hypoxic Conditions ◽  
Clinical Observations ◽  
Terrestrial Environments ◽  
The Relationship

The possibility that natriuretic peptides' effects are important in hypoxia responses of vertebrates is reviewed. Both the transcription and release of natriuretic peptides are affected by oxygen tension. Furthermore, many of the effects observed in hypoxia, such as diuresis and a reduction of plasma volume, are also caused by treatment of the animal with natriuretic peptides. Also, several clinical observations about changes in natriuretic peptide levels in, e.g., sleep apnea and cyanotic congenital heart disease, are consistent with the idea that hypoxia is involved in the etiology of conditions, in which natriuretic peptide levels increase. Virtually all published information on the relationship between oxygen and natriuretic peptides is based on human studies. Because hypoxic conditions are more common in aquatic than terrestrial environments, future studies about the possible role of natriuretic peptides in hypoxia, as well as the role of hypoxia in the evolution of natriuretic peptides, including the different subtypes, should increasingly involve also aquatic organisms.

scholarly journals Brain natriuretic peptide: Diagnostic potential in dogs

2009 ◽  
Vol 63 (5-6) ◽  
pp. 381-392
Author(s):  
Ljubica Spasojevic-Kosic
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Arterial Disease ◽  
Cardiac Insufficiency ◽  
Everyday Clinical Practice ◽  
Coronary Arterial Disease ◽  
Diagnostic Potential ◽  
Adequate Method

The endocrine role of the heart is evident in the secretion of noradrenaline and natriuretic peptides. The secretion of natriuretic peptides presents a useful mechanism for different conditions of cardiac dysfunction. Brain natriuretic peptide (BNP) has been accepted in human cardiology as a biomarker for cardiac insufficiency and coronary arterial disease. The specificity of the BNP structure is specie-specific, so that the testing of diagnostic and prognostic potential in dogs requires the existence of a test that is a homologue for that animal specie. The existence of an adequate method for measuring BNP concentration makes possible its implementation as a screening test in everyday clinical practice. .

scholarly journals Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

2022 ◽  
Vol 14 ◽  
Author(s):  
Shuang Chen ◽  
Da Xu ◽  
Liu Fan ◽  
Zhi Fang ◽  
Xiufeng Wang ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Glutamate Receptors ◽  
Neurological Disorders ◽  
Nerve Conduction ◽  
Ionotropic Glutamate Receptors ◽  
Future Studies ◽  
Excitatory Neurotransmission ◽  
The Relationship ◽  
Neuron Injury

Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury and inflammation, thereby they may participate in epileptogenesis. NMDARs belong to a family of ionotropic glutamate receptors that play essential roles in excitatory neurotransmission and synaptic plasticity in the mammalian CNS. Despite numerous studies focusing on the role of NMDAR in epilepsy, the relationship appeared to be elusive. In this article, we reviewed the regulation of NMDAR and possible mechanisms of NMDAR in epilepsy and in respect of onset, development, and treatment, trying to provide more evidence for future studies.

scholarly journals Pathogen Threat and In-group Cooperation

2021 ◽  
Vol 12 ◽  
Author(s):  
Hirotaka Imada ◽  
Nobuhiro Mifune
Keyword(s):  
Selection Pressure ◽  
Potential Role ◽  
Cooperative Behavior ◽  
Future Studies ◽  
Behavioral Immune System ◽  
Group Cooperation ◽  
Group Members ◽  
The Relationship ◽  
Intergroup Behavior

Disease-causing parasites and pathogens play a pivotal role in intergroup behavior. Previous studies have suggested that the selection pressure posed by pathogen threat has resulted in in-group assortative sociality, including xenophobia and in-group favoritism. While the current literature has collated numerous studies on the former, strikingly, there has not been much research on the relationship between pathogen threat and in-group cooperation. Drawing upon prior studies on the function of the behavioral immune system (BIS), we argued that the BIS might facilitate cooperation with in-group members as a reactive behavioral immune response to pathogen threat. More specifically, we held that individuals might utilize cooperative behavior to ensure that they can receive social support when they have contracted an infectious disease. We reviewed existing findings pertaining to the potential role of the BIS in in-group cooperation and discussed directions for future studies.

scholarly journals Inflammation in the lungs of patients diagnosed with Cystic Fibrosis: Association with iron deficiency

SURG Journal ◽  
1969 ◽  
Vol 2 (1) ◽  
pp. 3-10
Author(s):  
Dawn Armstrong ◽  
Lindsay Robinson
Keyword(s):  
Cystic Fibrosis ◽  
Iron Deficiency ◽  
Inflammatory Cytokines ◽  
Wide Spectrum ◽  
Iron Status ◽  
Tissue Destruction ◽  
Hypoxic Conditions ◽  
Mediators Of Inflammation ◽  
The Relationship

Cystic Fibrosis (CF) is characterized by a wide spectrum of phenotypic characteristics such as; deep coughing, increased mucous production, and weight loss. However, only recently was the role of inflammation on the etiology of the disease recognized. CF is characterized as a cyclic progression of infective exacerbations and stable periods initiated by the presence of Pseudomonas Aeruginosa (PA). An increase in inflammatory cytokines/mediators and a decrease in anti-inflammatory cytokines contribute to the net inflammation and overall tissue destruction of the lungs. PA is associated with the low iron status that is seen in 60-75% of the CF population, through the presence of iron sequestering siderophores which distract iron from the tissues. Iron deficiency (ID) initiates further symptoms such as; fatigue, tachycardia, weakness, brittle nails etc, in addition to those caused by CF. The colonization of PA may be the cause or a result of increased iron (ferritin) concentrations in the lungs, but independent of the original relationship, results in a decreased iron status. Iron is used by PA under hypoxic conditions such as in the fibrosis lung, as a source of energy. Studies on the relationship between CF and ID contribute a variety of possible causes although currently no direct connection has been discovered. At this stage, further studies in this area are needed. This review will primarily focus on the affects of CF on iron status in humans, and secondarily examine the effect of mediators of inflammation in respects to ID.

Impact and Role of Motivation Theories in Continuous Improvement Environments

2020 ◽  
Vol 11 (1) ◽  
pp. 1-13
Author(s):  
Brian J. Galli
Keyword(s):  
Continuous Improvement ◽  
Working Conditions ◽  
Job Design ◽  
Internal Communication ◽  
Future Studies ◽  
The World ◽  
Multiple Variables ◽  
Quality And Reliability ◽  
The Relationship

A large number of the well-performing organizations in the world are believed to have better environments that produce highly motivated employees to attain their goals. As noted in the various literatures reviewed in this study, improved working conditions in companies, such as Dell Technologies and Apple Inc., are responsible for the overall organizational success within the highly contested market. When employees are motivated, they also work towards improving the conditions within the workplaces, so the relationship between the two is mutual. In addition, pay satisfaction, job design, and internal communication of an organization contributes to its workforce motivation, which results in improved productivity for the entire organization. On the other hand, highly motivated employees encourage organizational managers to offer better payment to their organizations, to attain satisfactory job design, and to improve internal communication. Even though this study utilized few articles in the literature review, its findings significantly contribute to the modern literature. However, future studies should consider using more materials and multiple variables to improve the quality and reliability of the outcomes.

scholarly journals Physiology and clinical importance of the natriuretic peptide system

2011 ◽  
Vol 152 (26) ◽  
pp. 1025-1034
Author(s):  
Gábor Szabó ◽  
János Rigó jr. ◽  
Bálint Nagy
Keyword(s):  
Natriuretic Peptide ◽  
Natriuretic Peptides ◽  
Physiological Role ◽  
Clinical Importance ◽  
The Body ◽  
Diagnosis And Prognosis ◽  
Peptide Family ◽  
Peptide System ◽  
Pressure Changes

In the last three decades many members of the natriuretic peptide family was isolated. The function and physiological role of these peptides are pleiotropic. All natriuretic peptides are synthesized from polypeptide precursors. Together with the sympathetic nervous system and other hormones they play key roles, like an endogenous system in the regulation of the body fluid homeostasis and blood pressure. Changes in this balance lead to dysfunction in the endothel and left ventricle, which can cause severe complications. In many cardiovascular diseases natriuretic peptides serve not only as marker for diagnosis and prognosis but they have therapeutic importance. In the last years the potential use of the elevated BNP levels for diagnosis of pre-eclampsia was examined. In our review we discuss the current understanding of molecular biology, biochemistry and clinical relevance of natriuretic peptides. Orv. Hetil., 2011, 152, 1025–1034.

Crisis communication in key account relationships

2014 ◽  
Vol 19 (3) ◽  
pp. 234-246 ◽  
Author(s):  
Satu Nätti ◽  
Suvi Rahkolin ◽  
Saila Saraniemi
Keyword(s):  
Crisis Communication ◽  
Communication Strategy ◽  
Content Type ◽  
Future Studies ◽  
Account Management ◽  
Key Account ◽  
The Relationship ◽  
Business To Business ◽  
Practical Implications

Purpose – A deliberate and planned crisis communication strategy is an important part of key account management. The purpose of this paper is to draw links between key account managers (KAM) and crisis communication and explore the elements critical to crisis communication in key account relationships. Design/methodology/approach – The approach is qualitative. Data were gathered from people experienced in crisis communication and responsible for strategic accounts. The paper analysed managers’ stories of crisis processes and related communication in relationships. Findings – Successful crisis communication requires an open and active crisis communicator, one willing to solve problems, and also the company being a partner worth trusting and the retention of the relationship being worthwhile for the customer. Research limitations/implications – The present study focuses on the managerial view, and therefore a dyadic approach is suggested for future studies. Practical implications – The role of the KAM as a crisis communicator and primary identifier of the crisis is emphasized. Originality/value – Existing crisis communication discussions have been very media focused. This study focuses on the key account relationship and the related crisis communication. In addition, although earlier studies examine the influences of crises on business relationships (e.g. Salo et al., 2009; Thiessen and Ingenhoff, 2010; Tähtinen and Vaaland, 2006), research on crisis communication in business-to-business key account relationships is still scarce. The results will help to understand the characteristics of crisis communication in key account relationships and enhance communication with strategic accounts.

Exploring the relationships among tacit knowledge sharing, communities of practice and employees’ abilities: The case of KADDB in Jordan

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Mohammad Orsan Alzoubi ◽  
Ala’aldin Alrowwad ◽  
Ra’ed Masa’deh
Keyword(s):  
Communities Of Practice ◽  
Knowledge Sharing ◽  
Tacit Knowledge ◽  
Research Model ◽  
Content Type ◽  
Future Studies ◽  
Mediating Role ◽  
Tacit Knowledge Sharing ◽  
The Relationship

Purpose This study aims to assess the relationships among tacit knowledge sharing, communities of practice (CoPs) and employees’ abilities to solve problems, customer’s satisfaction and innovation. Design/methodology/approach This quantitative research aims to examine the causal relationships among the key study variables. A questionnaire-based survey was developed to evaluate the research model by drawing a convenience sample that includes 219 employees working in the King Abdullah Design and Development Bureau which is located in Amman, Jordan. Surveyed information was examined following the structural equation modelling procedures. Findings Results revealed that sharing tacit knowledge in defence organizations had no direct effect on employees’ abilities to solve problems, customer’s satisfaction and innovation, while there was an affirmative effect to CoPs on employees’ abilities in those areas. Also, this study showed that CoPs had a significant mediating role to play in the relationship between sharing knowledge and employees’ abilities in terms of solving work problems, customer’s satisfaction and innovation. Research limitations/implications Findings of this study have laid the basis for future studies related to examining the effect of tacit knowledge sharing and the CoPs on improving employees’ abilities as preconditions for organization performance. These findings can be supported by conducting further research studies to examine the large samples of defence companies to give deeper meanings and insights to the relationship among the key study variables. The authors recommend expanding future studies and examine the mediating role of other social learning methods such as mentoring and storytelling on the relationship between sharing tacit knowledge and employees’ abilities. Practical implications The research model may enable managers and practitioners to make decisions related to the improvement of collective learning by encouraging employees’ engagement in the process of tacit knowledge sharing. The model also helps managers to understand the role of CoPs as a knowledge sharing tool that contributes to increasing employees’ abilities and organizational competitiveness. Furthermore, the research model can be a step forward for further research studies on the relationships among tacit knowledge sharing, CoPs and employees’ abilities. Social implications The suggested model can act as the promising step for continuous improvement to the defence industry in terms of producing high-quality products and services that protect national security, humans’ lives and society at large from enemies and terrorist groups. Originality/value In spite of the fact that most academic studies on knowledge management show a positive relationship between tacit knowledge sharing and organizational performance, a few studies have examined the effect of mediating the CoPs on relationships between sharing tacit knowledge and employees’ abilities as preconditions for raising the performance of the organizations working in security and defence industry. Hence, this research attempts to fill these gaps and gives a new direction for future research.

Temporal leadership and employee workplace deviance: The role of perceived illegitimate tasks

2021 ◽  
Author(s):  
Wei Wan ◽  
Aimin Wang ◽  
Li Li
Keyword(s):  
Indirect Effect ◽  
Workplace Deviance ◽  
Goal Congruence ◽  
Future Studies ◽  
Mediating Role ◽  
The Relationship ◽  
Practical Implications

Drawing on the literature on perceived illegitimate tasks, we investigated, with 216 participants, how temporal leadership affects employee workplace deviance. Our findings show that temporal leadership effectively reduced employee workplace deviance. In addition, perceived illegitimate tasks played a mediating role in the relationship between temporal leadership and employee workplace deviance, and goal congruence moderated the indirect effect of temporal leadership on employee workplace deviance through perceived illegitimate tasks. Practical implications and suggestions for future studies are discussed.

Strategic Uncertainty and Firm Performance: The Mediating Role of Competitive Intelligence Practices

2013 ◽  
Vol 12 (04) ◽  
pp. 1350028 ◽  
Author(s):  
Ching Seng Yap ◽  
Md Zabid Abdul Rashid ◽  
Dewi Amat Sapuan
Keyword(s):  
Firm Performance ◽  
Mediating Effect ◽  
Strategic Decision ◽  
Competitive Intelligence ◽  
Strategic Decision Making ◽  
Strategic Uncertainty ◽  
Future Studies ◽  
Mediating Role ◽  
The Relationship

This study aims to identify the strategic roles of competitive intelligence and to examine the mediating effect of competitive intelligence practices on the relationship between perceived strategic uncertainty and firm performance. Data are collected from 123 public listed companies in Malaysia using mail questionnaire survey. The study highlights the essential role of competitive intelligence in supporting strategic decision making and strategic planning as well as in identifying opportunities and threats. Results reveal that perceived strategic uncertainty relates positively to competitive intelligence practices, which in turn, relates positively to firm performance. This paper includes implications, limitations, and recommendations for future studies.

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