The individual responsiveness to growth hormone (GH) treatment in GH- deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender

To evaluate the impact on the somatotropic axis of endogenous cortisol excess in the absence of primary pituitary disease, we investigated spontaneous 24-h growth hormone (GH) secretion in 12 adult patients with ACTH-independent hypercortisolism. Plasma GH concentration profiles (10-min samples) were analyzed by deconvolution to reconstruct secretion and approximate entropy to quantitate orderliness of the release process. Comparisons were made with a body mass index (BMI)-, age-, and gender-matched control group and an age- and gender-matched lean control group. GH secretion rates did not differ from BMI-matched controls but were twofold lower compared with lean subjects, mainly due to a 2.5-fold attenuation of the mean secretory burst mass ( P = 0.001). In hypercortisolemic patients, GH secretion was negatively correlated with BMI ( R = −0.55, P = 0.005) but not cortisol secretion. Total serum IGF-I concentrations were similar in the three groups. Approximate entropy (ApEn) was increased in patients with Cushing's syndrome compared with both control groups (vs. BMI-matched, P = 0.04; vs. lean, P = 0.001), denoting more irregular GH secretion patterns. ApEn in patients correlated directly with cortisol secretion ( R = 0.77, P = 0.003). Synchrony between cortisol and GH concentration series was analyzed by cross-correlation, cross-ApEn, and copulsatility analyses. Patients showed loss of pattern synchrony compared with BMI-matched controls, but copulsatility was unchanged. We conclude that hyposomatotropism in primary adrenal hypercortisolism is only partly explained (∼30%) by increased body weight and that increased GH secretory irregularity and loss of synchrony suggest altered coordinate regulation of GH release.

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Body Mass Index and Helicobacter pylori among Obese and Non-Obese Patients in Najran, Saudi Arabia: A Case-Control Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15112586 ◽

2018 ◽

Vol 15 (11) ◽

pp. 2586 ◽

Cited By ~ 1

Author(s):

Ali Al-Zubaidi ◽

Abdo Alzobydi ◽

Saeed Alsareii ◽

AbdulazizTurky Al-Shahrani ◽

Naweed Alzaman ◽

...

Keyword(s):

Body Mass Index ◽

Helicobacter Pylori ◽

Saudi Arabia ◽

Body Mass ◽

Upper Endoscopy ◽

Obese Patients ◽

Age And Gender ◽

Total Prevalence ◽

And Gender ◽

Saudi Patients

Objective: We examine obese and non-obese patients with respect to Helicobacter pylori (H. pylori) positive-infection (HPPI) and associated factors, specifically body mass index (BMI). Methods: This study took place in the Department of Endoscopy of a central hospital in the Najran region of Saudi Arabia (SA). A total of 340 obese Saudi patients (BMI ≥ 30 kg/m2) who had undergone diagnostic upper endoscopy before sleeve gastrectomy, were compared with 340 age and gender-matched control patients (BMI < 30 kg/m2) who had undergone diagnostic upper endoscopy for other reasons. Data collected included diagnosis of HPPI. Descriptive and multivariable binary logistic regression was conducted. Results: Mean patient age was 31.22 ± 8.10 years, and 65% were males. The total prevalence of HPPI was 58% (95% CI = 54–61%) with obese patients presenting significantly more HPPI than non-obese patients (66% vs. 50%, OR = 1.98, 95% CI = 1.45–2.70, p < 0.0005). Age and gender did not associate significantly with HPPI (p = 0.659, 0.200, respectively) and increases in BMI associated significantly with increases in HPPI (p < 0.0005). BMI remained a significant factor in HPPI when modelled with both age and gender (OR = 1.022, 95% CI = 1.01–1.03, p < 0.0005). Conclusions: Within the limitations of this study, the significance of HPPI in obese Saudi patients residing in the Najran region in SA was demonstrated alongside the significance role of BMI in HPPI.

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Making the Objectives of Individuals Sports Body Mass Index, by Age and Gender Analysis

International journal of Science Culture and Sport ◽

10.14486/ijscs197 ◽

2014 ◽

Vol 2 (6) ◽

pp. 255-255

Author(s):

İbrahim Kubilay TÜRKAY

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Gender Analysis ◽

Age And Gender ◽

And Gender

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Percentile Charts for Body Mass Index of Indian Down Syndrome Children

Journal of Pediatric Genetics ◽

10.1055/s-0041-1724115 ◽

2021 ◽

Author(s):

Harvinder Kaur ◽

Anil Kumar Bhalla ◽

Inusha Panigrahi

Keyword(s):

Body Mass Index ◽

Down Syndrome ◽

Body Mass ◽

Overweight And Obesity ◽

World Health ◽

Growth Charts ◽

Indian Children ◽

Age And Gender ◽

And Gender ◽

Gender Specific

AbstractGrowth charts are used to detect growth impairment, overweight, and obesity among Down syndrome (DS) children belonging to different population groups. Due to nonavailability of similar information, age, and gender specific body mass index (BMI) charts for DS children of Indian origin, based on serial data, have been developed. A total of 752 boys and 373 girls diagnosed as cases of DS at <1 month to 10 years of age enrolled from the “genetic clinic” were followed up in the “growth clinic/growth laboratory” of the institute, following a mixed-longitudinal growth research design. BMI was calculated from body weight and length/height measured at 6-month-age intervals by using standardized techniques and instruments. Age and sex-specific percentile growth charts for BMI were generated for age range <1 month to 10 years by using the LMS method. DS children remained wasted (BMI <3rd percentile) up to 6 months of age; thereafter, BMI increased to exhibit close similarity with their normal Multicentre Growth Reference Study (World Health Organization 2006) and Indian Academy of Pediatrics (2015) counterparts up to 5 to 10 years, respectively. The percentage of obese DS girls (8.76%) outnumbered boys with DS (4.1%). The use of age and gender specific BMI growth charts may be made for comparative purpose, to assess nutritional status of Indian children with DS, to initiate suitable need-based intervention to improve their overall health and for timely institution of target interventions to prevent growth faltering in this vulnerable population.

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Changes regarding Age and Correlations between Serum Lipids and Body Mass Index in Humankind

Methods of Information in Medicine ◽

10.1055/s-0038-1634435 ◽

2002 ◽

Vol 41 (03) ◽

pp. 202-208 ◽

Cited By ~ 2

Author(s):

I. Yamasawa ◽

S. Kamohara ◽

M. Shiota ◽

T. Komori ◽

Y. Watanabe ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Serum Lipids ◽

Density Lipoprotein ◽

Atherogenic Index ◽

Health Examination ◽

Age And Gender ◽

Gender And Age ◽

Specialized Care ◽

And Gender

Summary Objectives: To improve insight into age and gender related distributions of serum lipids and their correlation with body mass index (BMI). Methods: Serum lipids embracing atherogenic index (AI) and BMI were analyzed from the results obtained in 19,823 men and 14,788 women undergoing a health examination between 1986 and 1996. Results: The changes in total cholesterol (TC), triglyceride (TG), AI and BMI differed regarding gender. Although high-density lipoprotein-cholesterol (HDL-C) showed a flat pattern for all ages in both genders, its level in women was higher than in men. The ratio of the number in the unsuitable range to those in the suitable range increased with age as to TC in both sexes, then more than half of the population have an unsuitable level in the sixth decade. As for the correlation between serum lipids and BMI: TC, TG and AI correlated positively, but HDL-C correlated negatively. There were significant gaps between both age and gender. Conclusions: We suggest that the normal range of values of serum lipids needs to be revised according to gender and age to evaluate the risk status for a cardio-cerebrovascular disease more precisely in the field of preventive medicine. Simpler guidelines are preferable in specialized care as well as in general practice, particularly since computer technology is not yet universally adapted. In the near future, when computed information technology will be as common as the electricity and the telephone are current on the whole earth, all guidelines will have to be computed on the spot and personally.

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Growth hormone binding protein and growth hormone availability in acromegalic patients treated with long-acting octreotide (Sandostatin-LAR)

Acta Endocrinologica ◽

10.1530/eje.0.1360061 ◽

1997 ◽

Vol 136 (1) ◽

pp. 61-66 ◽

Cited By ~ 5

Author(s):

Sanne Fisker ◽

Andreas Kaal ◽

Marcella Montini ◽

Alberto Pedroncelli ◽

Giorgio Pagani ◽

...

Keyword(s):

Growth Hormone ◽

Binding Protein ◽

Hormone Binding ◽

Age And Gender ◽

Growth Hormone Binding Protein ◽

Igf I ◽

Octreotide Treatment ◽

Hormone Binding Protein ◽

And Gender ◽

Long Acting

Abstract Objective: In the medical treatment of acromegaly different factors are influencial; among these the impact on growth hormone binding protein (GHBP) has not been clarified. Design: Twenty acromegalic patients and nineteen age- and gender-matched normal subjects participated in this study. The patients were treated for 21 months with depot long-acting microsphere-enclosed octreotide (Sandostatin-LAR). Previously, all the patients were treated s.c. with octreotide t.i.d. After a 2-week wash-out period (baseline) the patients received the first i.m. injection of the long-acting octreotide. The first two injections were administered at 60-day intervals; thereafter the injections were at 28-day intervals. Methods: The levels of GHBP, complexed GHBP, growth hormone (GH) and insulin-like growth factor-I (IGF-I) were determined in fasting serum samples. Results: In the 2-week wash-out period GHBP levels decreased from 1·13 ± 0·17 to 0·92 ± 0·15 nmol/l (P < 0·05). During the 21-months treatment, GHBP increased again to 1·10 ± 0·16 nmol/l. In the age- and gender-matched control group GHBP levels were significantly higher at all times (1·95 ± 0·21 nmol/l, P(all) < 0·02). Mean levels of 8-h GH decreased from 12·6 ± 2·58 μg/l at baseline to 1·97 ± 0·20 μg/l after 21 months of treatment (P < 0·05). Mean 8-h GH levels were unchanged during long-acting octreotide treatment compared with levels during s.c. treatment (1·97 ± 0·20 μg/l and 1·90 ± 0·20 μg/l respectively). In fasting blood samples GH-complexed GHBP ranged from 13·8 ± 2·4% (9 months) to 25·4 ± 4·5% (baseline) of total GHBP. Serum IGF-I increased from 367 ± 45 to 764 ± 80 μg/l (P < 0·05) during the 2-week wash-out period and decreased to 290 ± 35 μg/l (P < 0·05) after 21 months of treatment with long-acting octreotide. IGF-I levels after 21 months were significantly lower than during s.c. octreotide treatment (P < 0·05). Conclusion: Serum GHBP levels are similar during treatment with long-acting octreotide as compared with regular octreotide. Furthermore, significant changes in GHBP can occur within 2 weeks. Finally, in addition to the lowering effect on GH levels, the induced increase in GHBP levels may imply a further advantage in octreotide treatment of acromegaly, circulating GH bound to GHBP may less readily reach the tissues. European Journal of Endocrinology 136 61–66

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Child Nutritional Status—Alternative Metrics to Body Mass Index

Proceedings ◽

10.3390/proceedings2019008033 ◽

2019 ◽

Vol 8 (1) ◽

pp. 33

Author(s):

E. Rush ◽

L. Young ◽

C. Cairncross

Keyword(s):

Body Mass Index ◽

Nutritional Status ◽

Body Mass ◽

Age And Gender ◽

Relative Growth ◽

Under Nutrition ◽

And Gender ◽

Child Nutritional Status ◽

Alternative Metrics

Background: For children, body mass index, adjusted for age and gender is the globally acceptedmeasure of relative growth and risk of over and under-nutrition [...]

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