scholarly journals Regulation of Androgen Receptor Signaling by PTEN (Phosphatase and Tensin Homolog Deleted on Chromosome 10) Tumor Suppressor through Distinct Mechanisms in Prostate Cancer Cells

2004 ◽  
Vol 18 (10) ◽  
pp. 2409-2423 ◽  
Author(s):  
Hui-Kuan Lin ◽  
Yueh-Chiang Hu ◽  
Dong Kun Lee ◽  
Chawnshang Chang
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Receptor Signaling ◽  
Prostate Cancer Cells ◽  
Chromosome 10 ◽  
Androgen Receptor Signaling ◽  
Phosphatase And Tensin Homolog ◽  
Tensin Homolog

Abstract 2629: Constitutive AhR signaling enhances androgen receptor signaling and growth in prostate cancer cells

2019 ◽  
Author(s):  
Maryam Ghotbaddini ◽  
Sakura McLaughlin ◽  
Kailen Turner ◽  
Devyn Pirtle ◽  
Joann B. Powell
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Signaling ◽  
Prostate Cancer Cells ◽  
Androgen Receptor Signaling

scholarly journals HOXB13 Induces Growth Suppression of Prostate Cancer Cells as a Repressor of Hormone-Activated Androgen Receptor Signaling

2004 ◽  
Vol 64 (24) ◽  
pp. 9185-9192 ◽  
Author(s):  
Chaeyong Jung ◽  
Ran-Sook Kim ◽  
Hong-Ji Zhang ◽  
Sang-Jin Lee ◽  
Meei-Huey Jeng
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Growth Suppression ◽  
Receptor Signaling ◽  
Prostate Cancer Cells ◽  
Androgen Receptor Signaling

scholarly journals Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells

The Prostate ◽  
2009 ◽  
Vol 69 (14) ◽  
pp. 1481-1492 ◽  
Author(s):  
Katayoon H. Emami ◽  
Lisha G. Brown ◽  
Tiffany E.M. Pitts ◽  
Xizhang Sun ◽  
Robert L. Vessella ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Signaling ◽  
Prostate Cancer Cells ◽  
Androgen Receptor Signaling

scholarly journals Role of CYP3A5 in Modulating Androgen Receptor Signaling and Its Relevance to African American Men with Prostate Cancer

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 989
Author(s):  
Priyatham Gorjala ◽  
Rick A. Kittles ◽  
Oscar B. Goodman Jr. ◽  
Ranjana Mitra
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Androgen Receptor ◽  
Cell Growth ◽  
Cancer Cells ◽  
Nuclear Translocation ◽  
Receptor Signaling ◽  
Wild Type ◽  
Prostate Cancer Cells ◽  
Androgen Receptor Signaling

Androgen receptor signaling is crucial for prostate cancer growth and is positively regulated in part by intratumoral CYP3A5. As African American (AA) men often carry the wild type CYP3A5 and express high levels of CYP3A5 protein, we blocked the wild type CYP3A5 in AA origin prostate cancer cells and tested its effect on androgen receptor signaling. q-PCR based profiler assay identified several AR regulated genes known to regulate AR nuclear translocation, cell cycle progression, and cell growth. CYP3A5 processes several commonly prescribed drugs and many of these are CYP3A5 inducers or inhibitors. In this study, we test the effect of these commonly prescribed CYP3A5 inducers/inhibitors on AR signaling. The results show that the CYP3A5 inducers promoted AR nuclear translocation, downstream signaling, and cell growth, whereas CYP3A5 inhibitors abrogated them. The observed changes in AR activity is specific to alterations in CYP3A5 activity as the effects are reduced in the CYP3A5 knockout background. Both the inducers tested demonstrated increased cell growth of prostate cancer cells, whereas the inhibitors showed reduced cell growth. Further, characterization and utilization of the observation that CYP3A5 inducers and inhibitors alter AR signaling may provide guidance to physicians prescribing CYP3A5 modulating drugs to treat comorbidities in elderly patients undergoing ADT, particularly AA.

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