scholarly journals Reader response: Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community

2018 ◽  
Vol 8 (6) ◽  
pp. 464.1-464
Author(s):  
George K. Vilanilam ◽  
Neethu Gopal ◽  
Anjali Agarwal ◽  
Mohammed K. Badi
Keyword(s):  
Risk Factors ◽  
Reader Response ◽  
Cerebral Microbleeds ◽  
Japanese Elderly

scholarly journals Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community

2018 ◽  
Vol 8 (3) ◽  
pp. 223-231 ◽  
Author(s):  
Tomohiro Yubi ◽  
Jun Hata ◽  
Tomoyuki Ohara ◽  
Naoko Mukai ◽  
Yoichiro Hirakawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Mri ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Cross Sectional Study ◽  
Cerebral Microbleeds ◽  
Health Examination ◽  
Cross Sectional ◽  
Comprehensive Health ◽  
Japanese Elderly

BackgroundWe investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly.MethodsIn 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2*-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis.ResultsThe crude prevalences of total, deep/infratentorial, and lobar CMBs were 18.7% (n = 240), 13.5% (n = 173), and 9.6% (n = 123), respectively. The prevalence of total CMBs was 23.0% in men and 15.5% in women and increased with aging in both sexes (both p for trend <0.01). Hypertension was significantly associated with the presence of both deep/infratentorial and lobar CMBs. Lower serum total cholesterol was a significant risk factor for deep/infratentorial CMBs, but not for lobar CMBs, while APOE ε4 carriers had a significantly higher likelihood only of lobar CMBs compared with noncarriers.ConclusionsOur study suggests that approximately 1 of 5 Japanese elderly people have CMBs, and that risk factors for deep/infratentorial and lobar CMBs are different, indicating the distinct pathologic backgrounds of these lesions.

Prevalence and Risk Factors of Silent Cerebral Microbleeds in Patients with Coronary Artery Disease

2022 ◽  
Vol 31 (1) ◽  
pp. 106211
Author(s):  
Ryo Yokoyama ◽  
Yumiko Kanzaki ◽  
Tomohiko Watanabe ◽  
Kenichiro Yamamura ◽  
Tsuyoshi Komori ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cerebral Microbleeds ◽  
Artery Disease

Reader Response: Location-Specific Risk Factors for Intracerebral Hemorrhage: Systematic Review and Meta-Analysis

Neurology ◽  
2021 ◽  
Vol 96 (21) ◽  
pp. 1010.2-1011
Author(s):  
Feng Zheng ◽  
Jianfeng Zhou ◽  
Cui'e Wang ◽  
Weipeng Hu ◽  
Boris Krischek
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Intracerebral Hemorrhage ◽  
Reader Response ◽  
Meta Analysis ◽  
Response Location ◽  
Specific Risk

scholarly journals The study on analysis of risk factors for severity of white matter lesions and its correlation with cerebral microbleeds in the elderly with lacunar infarction

Medicine ◽  
2020 ◽  
Vol 99 (4) ◽  
pp. e18865
Author(s):  
Yu-Ni Zhou ◽  
Hao-Yuan Gao ◽  
Fang-Fang Zhao ◽  
Ying-Chun Liang ◽  
Yuan Gao ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Lesions ◽  
The Elderly ◽  
Cerebral Microbleeds ◽  
Lacunar Infarction

Risk factors for 6-year mortality by gender in a Japanese elderly population

2007 ◽  
Vol 45 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Kazushi Okamoto ◽  
Yuko Harasawa ◽  
Yumiko Momose ◽  
Kiyomi Sakuma
Keyword(s):  
Risk Factors ◽  
Elderly Population ◽  
Japanese Elderly

scholarly journals Prevalence of and Risk Factors for Cerebral Microbleeds in Moyamoya Disease and Syndrome in the American Population

2019 ◽  
Vol 9 (3) ◽  
pp. 139-147
Author(s):  
Nadeem I. Khan ◽  
Ali A. Saherwala ◽  
Mo Chen ◽  
Sepand Salehian ◽  
Hisham Salahuddin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Moyamoya Disease ◽  
Hemorrhagic Stroke ◽  
Medical Center ◽  
Cerebral Microbleeds ◽  
Age At Diagnosis ◽  
University Hospital ◽  
Vascular Events ◽  
Increased Risk

Background and Purpose: Cerebral microbleeds (CMB) are reported to be frequent in moyamoya disease (MMD) and moyamoya syndrome (MMS) in the Asian population. It is associated with an increased risk of intracerebral hemorrhage. The significance of CMB in MMD/MMS in non-Asian populations has not been well established. Our study aimed to investigate the prevalence of CMB in MMD/MMS in a moymoya cohort with a majority of non-Asians and to identify risk factors for developing a CMB and its predictive value for subsequent vascular events. Methods: The moyamoya database was compiled by screening for MMD/MMS among patients admitted to the Zale-Lipshy University Hospital at the University of Texas Southwestern Medical Center. We identified and analyzed data of 67 patients with MMD or MMS. Patients were characterized as CMB+ or CMB– based on MRI findings. In CMB+ patients, the total number and location of CMB were identified. Univariate and multivariate logistic regression were used to identify risk factors for developing CMB and whether CMB are associated with the development of subsequent vascular events. Results: Out of a total of 67 patients, 11 (16%) had CMB. Males had significantly higher odds of having CMB as compared to females (OR 1.76; 95% CI 1.40–24.3, p = 0.021). The incidence of CMB was also associated with age at diagnosis (mean age of CMB+ patients vs. CMB– patients: 44 vs. 34 years, respectively, p = 0.024), smoking (p = 0.006), and hemorrhagic stroke at presentation (p = 0.034). Logistic regression with multivariate analysis found that gender and age at diagnosis remained statistically significant. New ischemic events occurred in 2 (20%) out of 10 CMB+ patients and 13 (23%) out of 55 CMB– patients, respectively (p = 0.79). While 2 (3%) CMB– patients had a new cerebral hemorrhage during follow-up, none of the CMB+ patients did. Conclusions: CMB are less prevalent in MMD/MMS in the USA than in Asia. An older age at diagnosis and male gender were associated with CMB. The presence of CMB was not associated with an increased risk of a subsequent ischemic or hemorrhagic stroke.

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