scholarly journals Pain, Depression, and Quality of Life in Neuromyelitis Optica Spectrum Disorder

2021 ◽  
Vol 8 (3) ◽  
pp. e985
Author(s):  
Ilya Ayzenberg ◽  
Daniel Richter ◽  
Eugenia Henke ◽  
Susanna Asseyer ◽  
Friedemann Paul ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Neuromyelitis Optica ◽  
Clinical Characteristics ◽  
Short Form ◽  
Spectrum Disorder ◽  
Pain Severity ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Upper Thoracic

ObjectivesTo evaluate prevalence, clinical characteristics, and predictors of pain, depression, and their impact on the quality of life (QoL) in a large neuromyelitis optica spectrum disorder (NMOSD) cohort.MethodsWe included 166 patients with aquaporin-4–seropositive NMOSD from 13 tertiary referral centers. Patients received questionnaires on demographic and clinical characteristics, PainDetect, short form of Brief Pain Inventory, Beck Depression Inventory–II, and Short Form 36 Health Survey.ResultsOne hundred twenty-five (75.3%) patients suffered from chronic NMOSD-associated pain. Of these, 65.9% had neuropathic pain, 68.8% reported spasticity-associated pain and 26.4% painful tonic spasms. Number of previous myelitis attacks (OR = 1.27, p = 0.018) and involved upper thoracic segments (OR = 1.31, p = 0.018) were the only predictive factors for chronic pain. The latter was specifically associated with spasticity-associated pain (OR = 1.36, p = 0.002). More than a third (39.8%) suffered from depression, which was moderate to severe in 51.5%. Pain severity (OR = 1.81, p < 0.001) and especially neuropathic character (OR = 3.44, p < 0.001) were associated with depression. Pain severity and walking impairment explained 53.9% of the physical QoL variability, while depression and walking impairment 39.7% of the mental QoL variability. No specific medication was given to 70.6% of patients with moderate or severe depression and 42.5% of those with neuropathic pain. Two-thirds (64.2%) of patients with symptomatic treatment still reported moderate to severe pain.ConclusionsMyelitis episodes involving upper thoracic segments are main drivers of pain in NMOSD. Although pain intensity was lower than in previous studies, pain and depression remain undertreated and strongly affect QoL. Interventional studies on targeted treatment strategies for pain are urgently needed in NMOSD.

Impact of neuromyelitis optica spectrum disorder on quality of life: Assessing the patients' perspective

2021 ◽  
Vol 429 ◽  
pp. 118844
Author(s):  
José Meca-Lallana ◽  
Rocío Gómez-Ballesteros ◽  
Francisco Pérez-Miralles ◽  
Lucía Forero ◽  
María Sepúlveda ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neuromyelitis Optica ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Patients Perspective

scholarly journals Fatigue in patients with neuromyelitis optica spectrum disorder and its impact on quality of life

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177230 ◽  
Author(s):  
Jin Myoung Seok ◽  
Misong Choi ◽  
Eun Bin Cho ◽  
Hye Lim Lee ◽  
Byoung Joon Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neuromyelitis Optica ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder

Neuropathic pain in neuromyelitis optica affects activities of daily living and quality of life

2014 ◽  
Vol 20 (12) ◽  
pp. 1658-1661 ◽  
Author(s):  
Sizheng Zhao ◽  
Kerry Mutch ◽  
Liene Elsone ◽  
Turo Nurmikko ◽  
Anu Jacob
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Activities Of Daily Living ◽  
Neuromyelitis Optica ◽  
Daily Living ◽  
Short Form ◽  
Transverse Myelitis ◽  
Brief Pain Inventory ◽  
Cross Sectional

Though pain in neuromyelitis optica (NMO) has been described in two recent reports, the proportion with true neuropathic pain (NP), its features, impact on activities of daily living (ADL) and quality of life has not been well characterised. A cross-sectional study of 50 NMO patients with transverse myelitis was performed using Douleur Neuropathique 4, Brief Pain Inventory, Extended Disability Status Scale and Short Form 36. NP was identified in 62% of patients. Pain was constant in 68% affecting most ADL. Pain was associated with significant reduction of the SF36 Mental Composite Score. The high prevalence of NP and associated disability necessitates an in-depth enquiry in patients with NMO.

scholarly journals Assessment of Patients with Neuromyelitis Optica Spectrum Disorder Using the EQ-5D

2019 ◽  
Vol 21 (3) ◽  
pp. 129-134 ◽  
Author(s):  
Maureen A. Mealy ◽  
Audra Boscoe ◽  
Jaime Caro ◽  
Michael Levy
Keyword(s):  
Quality Of Life ◽  
Neuromyelitis Optica ◽  
Brief Pain Inventory ◽  
Substantial Effect ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Significant Independent Predictor ◽  
Neurology Clinic ◽  
Anxiety Depression

Abstract Background: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease characterized by unpredictable attacks of the optic nerves and spinal cord that cause neurologic deficits, including weakness, numbness, bowel/bladder dysfunction, and pain and reduced vision and can ultimately lead to blindness and paralysis. We assessed the effects of NMOSD on quality of life. Methods: Adult patients with NMOSD treated at a US academic neurology clinic completed the EQ-5D and several other measures of functional status and quality of life. The EQ-5D scores and correlations across measures were evaluated, and scores were compared with those of patients with multiple sclerosis and US norms. Results: Twenty-one patients (90% women; mean age, 42.8 years; mean disease duration, 8.2 years) were included. The mean EQ-5D score was 0.74. Most patients reported at least some problems with mobility, pain/discomfort, usual activities, and/or anxiety/depression. Greater proportions of patients reported moderate or severe problems with mobility and pain/discomfort than they did with self-care, usual activities, or anxiety/depression. In a multivariate model, only the Brief Pain Inventory was a significant independent predictor of overall EQ-5D score. Conclusions: Neuromyelitis optica spectrum disorder has a substantial effect on multiple domains of quality of life. Pain seems to be among the primary drivers of the EQ-5D scores in NMOSD.

scholarly journals Pain in AQP4-IgG-positive and MOG-IgG-positive neuromyelitis optica spectrum disorders

2018 ◽  
Vol 4 (3) ◽  
pp. 205521731879668 ◽  
Author(s):  
Susanna Asseyer ◽  
Felix Schmidt ◽  
Claudia Chien ◽  
Michael Scheel ◽  
Klemens Ruprecht ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Neuromyelitis Optica ◽  
Immunoglobulin G ◽  
Short Form ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Cross Sectional ◽  
Frequent Symptom ◽  
Spectrum Disorders

Background Pain is a frequent symptom in aquaporin-4-immunoglobulin-G-positive neuromyelitis optica spectrum disorders (AQP4-IgG-pos. NMOSD). Data on pain in myelin-oligodendrocyte-glycoprotein-immunoglobulin-G autoimmunity with a clinical NMOSD phenotype (MOG-IgG-pos. NMOSD) are scarce. Objective The objective of this paper is to investigate pain in MOG-IgG-pos. NMOSD, AQP4-IgG-pos. NMOSD and NMOSD without AQP4/MOG-IgG detection (AQP4/MOG-IgG-neg. NMOSD). Methods Forty-nine MOG-IgG-pos. ( n = 14), AQP4-IgG-pos. ( n = 29) and AQP4/MOG-IgG-neg. ( n = 6) NMOSD patients were included in this cross-sectional baseline analysis from an ongoing observational study. We identified spinal cord lesions on magnetic resonance imaging, assessed pain by the painDETECT and McGill Pain questionnaires, quality of life by Short Form Health Survey, and depression by Beck Depression Inventory. Results Twelve MOG-IgG-pos. NMOSD patients (86%), 24 AQP4-IgG-pos. NMOSD patients (83%), and all AQP4/MOG-IgG-neg. NMOSD patients (100%) suffered from pain. MOG-IgG-pos. NMOSD patients had mostly neuropathic pain and headache; AQP4-IgG-pos. and AQP4/MOG-IgG-neg. NMOSD patients had mostly neuropathic pain. A history of myelitis was less frequent in MOG-IgG-pos. NMOSD than in AQP4-IgG-pos. NMOSD patients. Pain influenced quality of life in all patients. Thirty-six percent of patients with pain received pain medication; none of them were free of pain. Conclusions Pain is a frequent symptom of patients with MOG-IgG-pos. NMOSD and is as important as in AQP4-IgG-pos. and AQP4/MOG-IgG-neg. NMOSD. Despite its impact on quality of life, pain is insufficiently alleviated by medication.

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