Transcutaneous Blood Gas CO2 Monitoring of Induced Ventilatory Depression in Mice

2006 ◽  
Vol 103 (3) ◽  
pp. 620-625 ◽  
Author(s):  
Peyman Sahbaie ◽  
Shohreh Madanlou ◽  
Parham Gharagozlou ◽  
J David Clark ◽  
Jelveh Lameh ◽  
...  
Keyword(s):  
Blood Gas ◽  
Co2 Monitoring ◽  
Ventilatory Depression

scholarly journals P123 Accuracy and Reliability of the Transcutaneous Carbon Dioxide (TcCO2) Signal in the Sleep Laboratory

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A61-A61
Author(s):  
A Rossely ◽  
A Turton ◽  
T Roebuck ◽  
S Ho ◽  
M Naughton ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Sleep Laboratory ◽  
Blood Gas ◽  
Sleep Study ◽  
Arterial Blood Gas ◽  
Transcutaneous Carbon Dioxide ◽  
Arterial Blood ◽  
Co2 Monitoring ◽  
Sleep Laboratories ◽  
Carbon Dioxide Co2

Abstract Carbon Dioxide (CO2) monitoring is an essential part of assessing and treating disorders of hypoventilation in the sleep laboratory. While reliablity issues have been previously reported with the Transcutaneous Carbon Dioxide (TcCO2) signal, there is limited data assessing the validity of this signal or its trend in the sleep laboratory context. Therefore, this study aimed to investigate the change in TcCO2 accuracy from the beginning to the end of the sleep study in real world conditions across two different Victorian public hospital sleep laboratories that used two different TcCO2 monitors. The sample included 13 consecutive patients from Monash Health and 44 consecutive patients from Alfred Health with an average age of 64 and 56 years respectively. Arterial Blood Gas (ABG) measurements were taken prior to and following each sleep study and compared concurrently with the TcCO2 value. Bland-Altman analysis revealed an average difference between TcCO2 and PaCO2 of 3.29mmHg with agreement between -11.44 and 16.64mmHg for the TCM4 device and 1.31mmHg with agreement between -7.64 and 9.05mmHg for the TCM5 device. When accuracy was compared across time points for each patient, 46% of patients had an overnight accuracy change of ≥ 8mmHg when using the TCM4 compared with 20% when using the TCM5. It was concluded that the TcCO2 signal was un-reliable across the different monitors and that the TcCO2 trend may be difficult to interpret with confidence without blood gas calibration at the commencement and conclusion of the sleep study.

scholarly journals Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michael W. Jenkins ◽  
Faiza Khalid ◽  
Santhosh M. Baby ◽  
Walter J. May ◽  
Alex P. Young ◽  
...  
Keyword(s):  
Ethyl Ester ◽  
Minute Ventilation ◽  
Whole Body ◽  
Tail Flick ◽  
Blood Gas ◽  
Male Adult ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Ventilatory Parameters ◽  
Ventilatory Depression

AbstractThere is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible, preserving the analgesic actions of the opioids. We report that L-glutathione ethyl ester (GSHee) may be such a novel compound. In this study, we measured tail flick latency (TFL), arterial blood gas (ABG) chemistry, Alveolar-arterial gradient, and ventilatory parameters by whole body plethysmography to determine the responses elicited by bolus injections of fentanyl (75 μg/kg, IV) in male adult Sprague–Dawley rats that had received a bolus injection of GSHee (100 μmol/kg, IV) 15 min previously. GSHee given alone had minimal effects on TFL, ABG chemistry and A-a gradient whereas it elicited changes in some ventilatory parameters such as an increase in breathing frequency. In vehicle-treated rats, fentanyl elicited (1) an increase in TFL, (2) decreases in pH, pO2 and sO2 and increases in pCO2 (all indicative of ventilatory depression), (3) an increase in Alveolar-arterial gradient (indicative of a mismatch in ventilation-perfusion in the lungs), and (4) changes in ventilatory parameters such as a reduction in tidal volume, that were indicative of pronounced ventilatory depression. In GSHee-pretreated rats, fentanyl elicited a more prolonged analgesia, relatively minor changes in ABG chemistry and Alveolar-arterial gradient, and a substantially milder depression of ventilation. GSHee may represent an effective member of a novel class of thiolester drugs that are able to prevent the ventilatory depressant effects elicited by powerful opioids such as fentanyl and their deleterious effects on gas-exchange in the lungs without compromising opioid analgesia.

Blood gas analysis in newborns with low cardiac output syndrome after cardiac surgery.

2018 ◽  
Vol 19 (5) ◽  
pp. 676-687
Author(s):  
G.G. Khubulava ◽  
A.B. Naumov ◽  
S.P. Marchenko ◽  
O.Yu. Chupaeva ◽  
A.A. Seliverstova ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Cardiac Surgery ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Blood Gas ◽  
Low Cardiac Output Syndrome ◽  
Low Cardiac Output
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