Early Endovascular Coiling of Posterior Communicating Artery Saccular Aneurysm in the Setting of Staphylococcus Bacteremia

OBJECTIVE Although infectious complications of endovascular aneurysm treatment are in general rare, platinum coil therapy for patients with ruptured cerebral aneurysms and active bacteremia could be expected to carry increased risk. The literature on the timing and safety of endovascular treatment in this setting, however, is limited. In this report, the authors present a case of aneurysmal subarachnoid hemorrhage and active bacteremia in which intravenous antibiotics and early endovascular therapy were successfully used. A review of the literature is also provided. CLINICAL PRESENTATION A 79-year-old woman presented with Hunt-Hess grade 4, Fisher grade 3 + 4 subarachnoid hemorrhage. Blood cultures obtained on admission revealed gram-positive cocci, which later proved to be coagulase-negative Staphylococcus. INTERVENTION Intravenous cefepime and vancomycin were begun soon after admission. A right posterior communicating artery saccular aneurysm was identified on diagnostic cerebral angiography and was treated with bare platinum coils 28 hours after antibiotic therapy was initiated. An extended course of vancomycin was completed. No intracranial infectious complications were noted at 34-month clinical and radiographic follow-up. CONCLUSION This is the first case report to document the efficacy and safety of early endovascular coil embolization of a ruptured saccular cerebral aneurysm presenting in the context of active bacteremia. Review of the available literature suggests that a similar strategy for ruptured infectious aneurysms may also be safe. Further validation of this approach for both saccular and infectious aneurysms, however, is required.