scholarly journals Quantified growth of the human embryonic heart

Biology Open ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. bio057059 ◽  
Author(s):  
Jaeike W. Faber ◽  
Jaco Hagoort ◽  
Antoon F. M. Moorman ◽  
Vincent M. Christoffels ◽  
Bjarke Jensen
Keyword(s):  
Heart Development ◽  
Three Dimensional ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Embryonic Heart ◽  
Growth Patterns ◽  
Right Atrial ◽  
Left Ventricular Myocardium ◽  
Atrioventricular Canal ◽  
The Right

ABSTRACTThe size and growth patterns of the components of the human embryonic heart have remained largely undefined. To provide these data, three-dimensional heart models were generated from immunohistochemically stained sections of ten human embryonic hearts ranging from Carnegie stage 10 to 23. Fifty-eight key structures were annotated and volumetrically assessed. Sizes of the septal foramina and atrioventricular canal opening were also measured. The heart grows exponentially throughout embryonic development. There was consistently less left than right atrial myocardium, and less right than left ventricular myocardium. We observed a later onset of trabeculation in the left atrium compared to the right. Morphometry showed that the rightward expansion of the atrioventricular canal starts in week 5. The septal foramina are less than 0.1 mm2 and are, therefore, much smaller than postnatal septal defects. This chronological, graphical atlas of the growth patterns of cardiac components in the human embryo provides quantified references for normal heart development. Thereby, this atlas may support early detection of cardiac malformations in the foetus.This article has an associated First Person interview with the first author of the paper.

Fatal "Iron Heart" in an Adolescent: Biochemical and Ultrastructural Aspects of the Heart

PEDIATRICS ◽  
1975 ◽  
Vol 55 (3) ◽  
pp. 336-341
Author(s):  
Shyamal K. Sanyal ◽  
Warren Johnson ◽  
B. Jayalakshmamma ◽  
Alexander A. Green
Keyword(s):  
Myocardial Dysfunction ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Right Atrial ◽  
Left Ventricular Myocardium ◽  
Biochemical Basis ◽  
Iron Storage ◽  
Ultrastructural Studies ◽  
Significant Difference ◽  
Iron Deposits

Histochemical and ultrastructural aspects of the heart were investigated in an adolescent with fatal congestive heart failure resulting from exogenous hemochromatosis. Extensive iron deposits were found in all four chambers, papillary muscles, and the conduction system. These deposits were most prominent over the outer third of the left ventricular myocardium, with no significant difference between deposits in the middle and inner thirds. Quantitative analysis of iron from different chambers and all zones of the left ventricular myocardium confirmed the aforementioned pattern of iron distribution. Iron deposits in sinoauricular and atrioventricular nodes were similar to those in the right atrial myocardium. Degenerative changes and fibrosis were minimal. Ultrastructural studies showed that intracytoplasmic iron deposition followed a perinuclear, paranuclear, or diffuse pattern. In addition, some iron was consistently present in the nucleus and mitochondria. It is postulated that the presence of iron in the mitochondria may adversely affect the cellular enzyme system; this could provide a biochemical basis for myocardial dysfunction in patients with acquired iron-storage disease.

scholarly journals Quantitative Assessment of Myocardial Ischemia in Multi-Vessel Coronary Artery Disease by Multimodal Stress Echocardiography with Semi-Supine Bicycle Ergometry

2020 ◽  
Vol 15 (6) ◽  
pp. 813-819
Author(s):  
S. N. Koretskiy ◽  
O. M. Drapkina ◽  
F. B. Shukurov ◽  
D. K. Vasiliev
Keyword(s):  
Stress Echocardiography ◽  
Peak Load ◽  
Three Dimensional ◽  
Ventricular Myocardium ◽  
Cardiovascular Complications ◽  
Artery Occlusion ◽  
Left Ventricular ◽  
Myocardial Imaging ◽  
Left Ventricular Myocardium ◽  
Bicycle Ergometry

Stress echocardiography is a modern widely used method of noninvasive diagnosis of coronary heart disease and stratification of the risk of cardiovascular complications. In addition, exercise echocardiography is an important tool to clarify the localization of ischemia and establish a symptomassociated artery for management of patient with known coronary angiography data. This is especially important in multivessel lesions, the presence of an occluded artery or borderline stenosis. Currently, various stress agents are used for stress echocardiography in clinical practice: pharmacological drugs (dobutamine or adenosine), transesophageal or endocardial pacing, treadmill, semi-supine bicycle. To detect signs of ischemia usually used only visual estimation of local contractility in the two-dimensional gray-scale mode. Modern modes of myocardial imaging, such as speckletracking echocardiography or three-dimensional visualization, are practically not used. In the presented clinical case, the possibility of combining standard and modern imaging modes to clarify the localization and quantification of ischemia in multivessel coronary lesions, including chronic artery occlusion, is shown. As a stress agent, a semi-supine bicycle was chosen, the use of which allowed to obtain a qualitative image of the left ventricular myocardium at rest and at peak load, suitable for assessing deformation and threedimensional visualization. Evaluation of left ventricular myocardial deformation by speckle-tracking echocardiography was more accurate than standard diagnosis in detecting signs of ischemia in a patient with multivessel lesions. Three-dimensional imaging was inferior in sensitivity to speckletracking stress echocardiography and, at present, seems to have more research value.

scholarly journals DIAGNOSTIC OF THE ATHLETE’S HEART AND FACTORS AFFECTING ITS DEVELOPING

2021 ◽  
Vol 74 (5) ◽  
pp. 1158-1163
Author(s):  
Serhiy V. Popov ◽  
Oleksandr I. Smiyan ◽  
Andrii M. Loboda ◽  
Viktoriia O. Petrashenko ◽  
Olena K. Redko ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Heart Development ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Athlete’S Heart ◽  
Left Ventricular Myocardium ◽  
Factors Affecting ◽  
Ultrasound Study ◽  
And Function ◽  
Athlete's Heart

The aim: Studying the features of the structure and function of the heart in athletes and identifying the factors that influence the development of these changes. Materials and methods: The study included 54 athletes, 29 men and 25 women. The ultrasound study was performed according to standard methods with determining the size of the main structures of the heart, indicators normalized to body surface area, height. Results: The heart of dilatation and hypertrophy of the left ventricular myocardium were found in 25.93% of the athletes. When comparing the diameter of the left ventricle of individual athletes with the average values of the norm, their excess was found in 94.44% of athletes. The Odds ratio (OR) of the relationship between left ventricle diameter (LVd) and time of the exercise less than 10 y was 16.13, time of the exercise less than 5 y – 0.17 (p <0.05). OR of increase LVd to age less than 20 years was 3.56 units (p <0.05). The ejection fraction was above the normative mean in 75.93%, as well as the ratio of the periods of filling of the ventricles. Conclusions: The most common sign of an athlete’s heart development was left ventricular dilatation, which occurred at a rate of 25 percent. Age less than 20 years and the duration of sports activities from 5 to 10 years is associated with a higher frequency of the athlete’s heart.

Laminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium

1999 ◽  
Vol 276 (2) ◽  
pp. H595-H607 ◽  
Author(s):  
Kevin D. Costa ◽  
Yasuo Takayama ◽  
Andrew D. McCulloch ◽  
James W. Covell
Keyword(s):  
Three Dimensional ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Wall Thickening ◽  
Left Ventricular Myocardium ◽  
Fiber Architecture ◽  
Left Ventricular Free Wall ◽  
Ventricular Mechanics ◽  
Interlaminar Shear ◽  
Canine Ventricular Myocardium

Previous studies suggest that the laminar architecture of left ventricular myocardium may be critical for normal ventricular mechanics. However, systolic three-dimensional deformation of the laminae has never been measured. Therefore, end-systolic finite strains relative to end diastole, from biplane radiography of transmural markers near the apex and base of the anesthetized open-chest canine anterior left ventricular free wall ( n = 6), were referred to three-dimensional laminar microstructural axes reconstructed from histology. Whereas fiber shortening was uniform [−0.07 ± 0.04 (SD)], radial wall thickening increased from base (0.10 ± 0.09) to apex (0.14 ± 0.13). Extension of the laminae transverse to the muscle fibers also increased from base (0.08 ± 0.07) to apex (0.11 ± 0.08), and interlaminar shear changed sign [0.05 ± 0.07 (base) and −0.07 ± 0.09 (apex)], reflecting variations in laminar architecture. Nevertheless, the apex and base were similar in that at each site laminar extension and shear contributed ∼60 and 40%, respectively, of mean transmural thickening. Kinematic considerations suggest that these dual wall-thickening mechanisms may have distinct ultrastructural origins.

scholarly journals Possibly Late-Onset Arrhythmogenic Right Ventricular Cardiomyopathy: Unique Triglyceride Deposition by Analysis of Lipid Contents

2019 ◽  
Vol 12 ◽  
pp. 117954761982871
Author(s):  
Kentaro Yamamoto ◽  
Xin Guo ◽  
Ken-ichi Mizutani ◽  
Nozomu Kurose ◽  
Motona Kumagai ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Late Onset ◽  
Arrhythmogenic Right Ventricular Cardiomyopathy ◽  
Ventricular Myocardium ◽  
Cholesterol Content ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Ventricular Cardiomyopathy ◽  
Lipid Contents ◽  
The Right

We presented an unusual arrhythmogenic right ventricular cardiomyopathy (ARVC) case of a late-60s elderly man’s death, due to severe pericardial/pleural effusion and ascites, and arrhythmic events, with unique pathological features. The hypertrophic heart grossly displayed yellowish to yellow-whitish predominantly in the variably thinned wall of the dilated right ventricle. Microscopic findings showed diffuse fatty/fibrofatty replacement in not only the right but left ventricular myocardium, together with an outer lymphoplasmacytic infiltrate. According to the lipid contents analysis, the triglyceride content, but not the cholesterol content, in our patient’s right and left ventricular cardiac muscle was much higher than that in the control subject. We propose that this unique triglyceride deposition in our possibly late-onset ARVC case might be one of new clues to understand its enigmatic cause. Further prospective studies are needed to validate the presence and significance of a greater volume of triglyceride deposit, after collecting and investigating a larger number of early and late-onset ARVC cases examined.

Noncompaction of the myocardium associated with Roifman syndrome

2001 ◽  
Vol 11 (2) ◽  
pp. 240-243 ◽  
Author(s):  
Karen Mandel ◽  
Eyal Grunebaum ◽  
Lee Benson
Keyword(s):  
Interventricular Septum ◽  
Retinal Dystrophy ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Antibody Deficiency ◽  
Left Ventricular Myocardium ◽  
Facial Dysmorphism ◽  
Ventricular Wall ◽  
Immune Deficiencies ◽  
The Right

Noncompaction of the ventricular myocardium, sometimes referred to as “spongy myocardium”, appears as excessive and prominent trabeculations and deep intratrabecular recesses within the ventricular wall, usually involving the left ventricle, although the right ventricle and interventricular septum can also be affected. It may occur with or without additional heart malformations. Roifman syndrome is a constellation of antibody deficiency, spondyloepiphyseal dysplasia, facial dysmorphism, growth retardation, and retinal dystrophy. We report a patient with Roifman syndrome who presented with noncompaction of the left ventricular myocardium. Our findings expand the spectrum of diseases associated with noncompaction. The recognition of noncompaction among patients with Roifman syndrome is important, as the immune deficiencies may be subtle and undiagnosed until adulthood. Thus, some patients may first present with cardiac failure.

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