scholarly journals Evidence of two types of balance between stem cell mitosis and enterocyte nucleus growth in the Drosophila midgut

Development ◽  
2020 ◽  
Vol 147 (11) ◽  
pp. dev189472
Author(s):  
Vasilia Tamamouna ◽  
Myrofora Panagi ◽  
Andria Theophanous ◽  
Maria Demosthenous ◽  
Maria Michail ◽  
...  
Keyword(s):  
Stem Cell ◽  
Nucleus Growth ◽  
Cell Mitosis

scholarly journals Live-cell Imaging and Analysis of Germline Stem Cell Mitosis in Caenorhabditis elegans

BIO-PROTOCOL ◽  
2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Réda Zellag ◽  
Yifan Zhao ◽  
Abigail Gerhold
Keyword(s):  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Germline Stem Cell ◽  
Cell Mitosis

scholarly journals Control of Outer Radial Glial Stem Cell Mitosis in the Human Brain

Cell Reports ◽  
2014 ◽  
Vol 8 (3) ◽  
pp. 656-664 ◽  
Author(s):  
Bridget E.L. Ostrem ◽  
Jan H. Lui ◽  
Caitlyn C. Gertz ◽  
Arnold R. Kriegstein
Keyword(s):  
Stem Cell ◽  
Human Brain ◽  
Radial Glial ◽  
Cell Mitosis

scholarly journals Intertwined trade-offs coordinate Drosophila midgut mitosis vs. endoreplication and host defense vs. dysplasia

2019 ◽  
Author(s):  
Vasilia Tamamouna ◽  
Myrofora Panagi ◽  
Andria Theophanous ◽  
Maria Demosthenous ◽  
Maria Michail ◽  
...  
Keyword(s):  
Stem Cell ◽  
Host Defense ◽  
Cyclin E ◽  
Regeneration Capacity ◽  
Inflammatory Signaling ◽  
Trade Offs ◽  
Fine Tune ◽  
Cell Mitosis

AbstractInflammatory signaling supports host defense against infection, not only through immune cells, but also via regeneration of damaged tissue. Heightened regeneration, nevertheless, predisposes for all types of cancer and thus a trade-off exists between regeneration capacity and long-term tissue homeostasis. Here, we study the role of tissue-intrinsic regenerative inflammatory signaling in stem cell mitosis of the adult Drosophila midgut at the baseline and the infected state and its impact on intestinal host defense to infection and stem cell-mediated dysplasia. Through a quantitative genetics screen we find that stem cell mitosis is positively linked with the expression of eiger, Delta, upd3 and vein in the midgut, as well as with dysplasia and host defense, but negatively with enterocyte endoreplication. We provide evidence that intertwined trade-offs fine-tune midgut homeostasis, according to which stem cell mitosis through cyclin E in stem cells promotes the optimal host defense to infection, unless dysplasia ensues. However, cyclin E in enteroblasts promotes enterocyte endoreplication and counterbalances stem cell mitosis and dysplasia, providing an alternative but less efficient mechanism to support host defense.

Biotin Controls Intestinal Stem Cell Mitosis and Host-Microbiome Interactions

2021 ◽  
Author(s):  
Constantina Neophytou ◽  
Chrysoula Pitsouli
Keyword(s):  
Stem Cell ◽  
Intestinal Stem Cell ◽  
Cell Mitosis

scholarly journals Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases

2021 ◽  
Vol 9 ◽  
Author(s):  
Yiqiang Zhi ◽  
Xiaokun Zhou ◽  
Jurui Yu ◽  
Ling Yuan ◽  
Hongsheng Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neurological Disorders ◽  
Therapeutic Strategy ◽  
Human Diseases ◽  
Wd40 Repeat ◽  
Jnk Signaling ◽  
Evolutionarily Conserved ◽  
Human Disorders ◽  
Jnk Signaling Pathway ◽  
Cell Mitosis

The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different components of the JNK signaling pathway to regulate several human diseases including neurological disorders, infertility, and tumorigenesis. Recent studies revealed that WDR62 regulates the process of neural stem cell mitosis and germ cell meiosis through JNK signaling. In this review we summarize the roles of WDR62 and JNK signaling in neuronal and non-neuronal contexts and discuss how JNK-dependent signaling regulates both processes. WDR62 is involved in various human disorders via JNK signaling regulation, and may represent a promising therapeutic strategy for the treatment of related diseases.

scholarly journals Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: Implications for stem cell mitosis and centrosome dynamics

2014 ◽  
Vol 13 (1) ◽  
pp. 135-143 ◽  
Author(s):  
Mariella Mannino ◽  
Natividad Gomez-Roman ◽  
Helfrid Hochegger ◽  
Anthony J. Chalmers
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Aurora Kinase ◽  
Differential Sensitivity ◽  
Glioma Stem Cells ◽  
Aurora Kinase A ◽  
Cell Mitosis ◽  
Kinase A

scholarly journals SC-12 * CD133 SURFACE EXPRESSION INDICATES ASYMMETRIC INHERITANCE OF SIGNALING RECEPTORS DURING GLIOBLASTOMA CANCER STEM CELL MITOSIS

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v199-v199
Author(s):  
M. Hitomi ◽  
S. Jarvis ◽  
V. Yogeswaran ◽  
K. Pfaff ◽  
J. Lathia
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Surface Expression ◽  
Signaling Receptors ◽  
Cell Mitosis

scholarly journals C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosis

2009 ◽  
Vol 326 (2) ◽  
pp. 295-304 ◽  
Author(s):  
Mohd Ariz ◽  
Rana Mainpal ◽  
Kuppuswamy Subramaniam
Keyword(s):  
Stem Cell ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Germline Stem Cell ◽  
C Elegans ◽  
Cell Mitosis

Author response for "Inhibition of neural stem cell aging through the transient induction of reprogramming factors"

2020 ◽  
Author(s):  
Min Ji Han ◽  
Won Ji Lee ◽  
Joonhyuk Choi ◽  
Yean Ju Hong ◽  
Sang Jun Uhm ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Author Response ◽  
Cell Aging ◽  
Stem Cell Aging ◽  
Reprogramming Factors
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