First person – Lauren Brilli Skvarca and Hwa Han

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms (DMM), helping early-career researchers promote themselves alongside their papers. Lauren Brilli Skvarca and Hwa Han are co-first authors on ‘Enhancing regeneration after acute kidney injury by promoting cellular dedifferentiation in zebrafish’, published in DMM. Lauren is a Pathologist Investigator Residency Research Training (PIRRT) Fellow at the University Pittsburgh Medical Center (UPMC), USA, in the lab of Carl Hubel, investigating maternal-fetal cell interactions contributing to placental vascular changes in preeclampsia and postpartum maternal cardiovascular risk. Hwa is a PhD graduate student in the lab of Neil Hukriede at the University of Pittsburgh School of Medicine, USA, and is involved in characterizing regenerative cellular mechanisms in gentamicin-induced acute kidney injury using larval zebrafish as a model organism.

Download Full-text

First person – Gideon Hughes

Disease Models & Mechanisms ◽

10.1242/dmm.047415 ◽

2020 ◽

Vol 13 (10) ◽

pp. dmm047415

Keyword(s):

Machine Learning ◽

Tissue Regeneration ◽

Model Organism ◽

Early Career ◽

Disease Models ◽

First Person ◽

Zebrafish Model ◽

Early Career Researchers ◽

The University ◽

Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Gideon Hughes is first author on ‘Machine learning discriminates a movement disorder in a zebrafish model of Parkinson's disease’, published in DMM. Gideon conducted the research described in this article while a PhD student in Betsy Pownall's lab at the University of York, York, UK. He is now a postdoc in the lab of Henry Roehl at the University of Sheffield, Sheffield, UK, using the zebrafish as a model organism to study human disease and tissue regeneration, combining his research with his interest in computer science.

Download Full-text

First person – Victor Palacios

Journal of Cell Science ◽

10.1242/jcs.258592 ◽

2021 ◽

Vol 134 (7) ◽

Keyword(s):

Chromosome Segregation ◽

Germ Cells ◽

Medical Center ◽

Early Career ◽

First Person ◽

University Of Texas ◽

Early Career Researchers ◽

The University ◽

Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Victor Palacios is first author on ‘Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells’, published in JCS. Victor conducted his PhD research in the lab of Michael Buszczak at the University of Texas Southwestern Medical Center, Dallas, TX, where he investigated the essential role of Importin-9 in Drosophila fertility.

Download Full-text

First person – Stéphanie Cottier

Biology Open ◽

10.1242/bio.054171 ◽

2020 ◽

Vol 9 (6) ◽

pp. bio054171

Keyword(s):

Cell Wall ◽

Model Organism ◽

Cell Wall Protein ◽

Early Career ◽

First Person ◽

Conserved Residues ◽

Early Career Researchers ◽

The University ◽

Insight Into ◽

Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Stéphanie Cottier is first author on ‘The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain’, published in BiO. Stéphanie is a post-doc in the lab of Roger Schneiter at the University of Fribourg, Fribourg, Switzerland, investigating using yeast model organism to gain insight into the function of the widespread CAP protein superfamily.

Download Full-text

First person – Ivo de Vos

Biology Open ◽

10.1242/bio.057935 ◽

2020 ◽

Vol 9 (12) ◽

pp. bio057935

Keyword(s):

Patient Care ◽

Medical Center ◽

Early Career ◽

Clinical Genetics ◽

First Person ◽

Zebrafish Model ◽

Common Skin ◽

Skin Conditions ◽

The University ◽

Improving Patient Care

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Ivo de Vos is first author on ‘The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome’, published in BiO. Ivo conducted the research described in this article while a Research Fellow in Professor Maurice van Steensel's lab at the Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore. He is now a Postgraduate House Officer in Clinical Genetics, currently working in patient care in the Department of Genetics, at the University Medical Center Groningen (UMCG), The Netherlands, investigating pathophysiological mechanisms underlying common skin conditions by studying rare genetic skin disorders, ultimately improving patient care.

Download Full-text

First person – Frederike Riemslagh

Disease Models & Mechanisms ◽

10.1242/dmm.048920 ◽

2021 ◽

Vol 14 (2) ◽

pp. dmm048920

Keyword(s):

Muscular Atrophy ◽

Medical Center ◽

Genetic Diseases ◽

Early Career ◽

Clinical Genetics ◽

First Person ◽

University Of Colorado ◽

Erasmus Medical ◽

The University ◽

Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Frederike Riemslagh is first author on ‘Inducible expression of human C9ORF72 36× G4C2 hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in mice’, published in DMM. Frederike conducted the research described in this article while a PhD Candidate in Prof. Dr Rob Willemse's lab at Erasmus Medical Center, Department of Clinical Genetics, Rotterdam, The Netherlands. She is now a Postdoctoral Fellow in the lab of Dr Christian Mosimann at the University of Colorado, USA, investigating genetic diseases that affect the heart and brain.

Download Full-text

First person – Karen Boschen

Disease Models & Mechanisms ◽

10.1242/dmm.049131 ◽

2021 ◽

Vol 14 (6) ◽

Keyword(s):

North Carolina ◽

Prenatal Alcohol Exposure ◽

Differential Susceptibility ◽

Alcohol Exposure ◽

Early Career ◽

First Person ◽

Cellular Mechanisms ◽

Chapel Hill ◽

The University ◽

Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Karen Boschen is first author on ‘Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol’, published in DMM. Karen is a postdoctoral trainee in the lab of Dr Scott Parnell at The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, investigating the cellular mechanisms of prenatal alcohol exposure, and genetic factors that influence risk and resiliency to developing alcohol-related birth defects.

Download Full-text

Comparison of Static and Dynamic Baseline Creatinine Surrogates for Defining Acute Kidney Injury

Nephron ◽

10.1159/000516953 ◽

2021 ◽

pp. 1-11

Author(s):

David G. Warnock ◽

Javier A. Neyra ◽

Etienne Macedo ◽

Ayme D. Miles ◽

Ravindra L. Mehta ◽

...

Keyword(s):

Acute Kidney Injury ◽

Kidney Injury ◽

Day Length ◽

University Of Alabama ◽

Inpatient Mortality ◽

Baseline Serum ◽

Net Reclassification Improvement ◽

Baseline Creatinine ◽

The University ◽

Final Cohort

Background: “Dynamic” baseline serum creatinine (sCr), based on a rolling 48-h window, and a static baseline sCr (previous outpatient sCr) were used to define acute kidney injury (AKI). Methods: Retrospective cohort study of adult admissions to the University of Alabama (UAB) Health System hospitals for years 2016–2018. Included admissions had >1- and <180-day length of stay, >2 inpatient sCr measurements, and an averaged estimated glomerular filtration rate >15 mL/min/1.73 m2. The final cohort of 62,380 patients included 100,570 admissions, 3,509 inpatient deaths, and 1,916 admissions with inpatient dialysis. AKI was defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria and a static or dynamic baseline sCr. Discrimination was evaluated with area under receiver operator curves (AUC), logistic regression, and net reclassification improvement (NRI). Results: Preadmission outpatient “static” sCr values were available for 43,433 admissions. The lowest sCr value during a rolling 48-h window before each inpatient sCr defined a “dynamic” baseline sCr. Using point-wise comparisons, the dynamic baseline sCr performed better than static baseline sCr for inpatient mortality (AUC [0.819 vs. 0.741; p < 0.001] and NRI ≥0.306 [p < 0.001]) and inpatient dialysis (AUC [0.903 vs. 0.864; p < 0.001] and NRI ≥0.317 [p < 0.001]). Conclusions: The dynamic baseline sCr is available without reference to preadmission sCr values and avoids confounding associated with missing outpatient sCr values. AKI defined with the dynamic baseline sCr significantly improved discrimination of risk for inpatient mortality and dialysis compared to static baseline sCr.

Download Full-text

First person – Fanny Jaudon and Martina Albini

Journal of Cell Science ◽

10.1242/jcs.259251 ◽

2021 ◽

Vol 134 (16) ◽

Keyword(s):

Neurotrophic Factor ◽

Neurological Disorders ◽

Molecular Mechanisms ◽

Neurological Diseases ◽

Early Career ◽

First Person ◽

Early Career Researchers ◽

And Function ◽

The University ◽

Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Fanny Jaudon and Martina Albini are co-first authors on ‘ A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor’, published in JCS. Fanny is a postdoc at the University of Trieste in the lab of Lorenzo A. Cingolani at Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy, investigating the molecular mechanisms controlling development and function of neuronal circuits and implementing genome-editing approaches for the treatment of neurological disorders. Martina is a PhD student at the Istituto Italiano di Tecnologia in the lab of Fabio Benfenati and Fabrizia Cesca investigating neurotrophin biology and its involvement in neurological diseases.

Download Full-text

Influence of β-Lactam Infusion Strategy on Acute Kidney Injury

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00871-17 ◽

2017 ◽

Vol 61 (10) ◽

Cited By ~ 10

Author(s):

Sarah E. Cotner ◽

W. Cliff Rutter ◽

Donna R. Burgess ◽

Katie L. Wallace ◽

Craig A. Martin ◽

...

Keyword(s):

Acute Kidney Injury ◽

Medical Center ◽

Academic Medical Center ◽

Kidney Injury ◽

Intermittent Infusion ◽

Prolonged Infusion ◽

Infusion Group ◽

Academic Medical ◽

Baseline Creatinine ◽

End Stage

ABSTRACT Limited literature is available assessing nephrotoxicity with prolonged β-lactam infusions. This study compared the incidence of acute kidney injury (AKI) associated with a prolonged β-lactam infusion or an intermittent infusion. This was a retrospective, matched-cohort study at an academic medical center from July 2006 to September 2015. Adult patients who received piperacillin-tazobactam (TZP), cefepime (FEP), or meropenem (MEM) for at least 48 h were evaluated. Patients were excluded for preexisting renal dysfunction or pregnancy. The primary outcome was difference in incidence of AKI evaluated using the RIFLE (risk, injury, failure, loss, and end-stage) criteria. Patients in the intermittent group were matched 3:1 to patients in the prolonged-infusion group based on the following: β-lactam agent, age, gender, Charlson comorbidity index, baseline creatinine clearance, hypotension, receipt of vancomycin, and treatment in an intensive care unit. A total of 2,390 patients were included in the matched analysis, with 1,700 receiving intermittent infusions and 690 receiving prolonged infusion. The incidence of AKI was similar in the prolonged-infusion group to that in the intermittent-infusion group (21.6% versus 18.6%; P = 0.1). After multivariate regression, prolonged infusion was not associated with increased odds of AKI (odds ratio [OR], 1.07; 95% confidence interval [95% CI], 0.83 to 1.39). Independent predictors of AKI included TZP therapy, concomitant nephrotoxins, hypotension, and heart failure. Although AKIs were numerically more common in patients receiving prolonged β-lactam infusions than those receiving intermittent infusions, prolonged infusion was not an independent risk factor for AKI.

Download Full-text

First person – Alessandra da Silva Dantas

Journal of Cell Science ◽

10.1242/jcs.259654 ◽

2021 ◽

Vol 134 (24) ◽

Keyword(s):

Fungal Pathogens ◽

Research Council ◽

Medical Research Council ◽

Early Career ◽

Medical Mycology ◽

First Person ◽

Postdoctoral Fellow ◽

Early Career Researchers ◽

The University ◽

Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Alessandra da Silva Dantas is first author on ‘ Crosstalk between the calcineurin and cell wall integrity pathways prevents chitin overexpression in Candida albicans’, published in JCS. Alessandra is a postdoctoral fellow in the lab of Prof. Neil Gow at the Medical Research Council Centre for Medical Mycology at the University of Exeter, UK, and is interested in the mechanisms controlling cell division and death in human fungal pathogens.

Download Full-text